Pathogenesis of Helicobacter pylori infection

Current Opinion in Gastroenterology

Volumn 16, Issue 1, 2000, Pages 24-31

  McGee, David J ^a   Mobley, Harry L T ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL VACCINE; BACTERIUM LIPOPOLYSACCHARIDE; CYTOKINE; CYTOTOXIN; NICKEL; UREASE;

ARTICLE; BACTERIAL VIRULENCE; BACTERIUM ADHERENCE; CYTOKINE PRODUCTION; FLAGELLUM; GENE MUTATION; GENE SEQUENCE; GRAM NEGATIVE INFECTION; HELICOBACTER PYLORI; HUMAN; IMMUNE RESPONSE; NONHUMAN; PATHOGENESIS; PATHOGENICITY; SIGNAL TRANSDUCTION;

EID: 0034053637     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001574-200001000-00005     Document Type: Article

References (97)

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61. 61 Slonczewski JL, McGee DJ, Phillips J, Mobley HLT: pH-dependent expression of proteins in Helicobacter pylori, identified by two-dimensional gel electrophoresis. 10th International Workshop on Campylobacter, Helicobacter, and Related Organisms 1999, Abstract HG9.
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70. 70 Kersulyte D, Chalkauskas H, Berg DE: Emergence of recombinant strains of Helicobacter pylori during human infection. Mol Microbiol 1999, 31:31-43. This gorgeous study describes the first example of in vivo H. pylori recombination between strains. Recombination occurred at a very high frequency.
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79. 79 Sommer F, Faller G, Konturek P, Kirchner T, Hahn EG, Zeus J, Rollinghoff M, et al.: Antrum-and corpus mucosa-infiltrating CD4(+) lymphocytes in Helicobacter pylori gastritis display a Th1 phenotype. Infect Immun 1998, 66:5543-5546.
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82. 82 Houghton J, Korah RM, Condon MR, Kim KH: Apoptosis in Helicobacter pylori-associated gastric and duodenal ulcer disease is mediated via the Fas antigen pathway. Dig Dis Sci 1999, 44:465-473.
83. 83 Jones NL, Day AS, Jennings HA, Sherman PM: Helicobacter pylori induces gastric epithelial cell apoptosis in association with increased Fas receptor expression. Infect Immun 1999, 67:4237-4242.
84. 84 Rudi J, Kuck D, Strand S, von Herbay A, Mariani SM, Krammer PH, Galle PR, et al.: Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis. J Clin Invest 1998, 102:1506-1514.
85. 85 Konturek PC, Pierzchalski P, Konturek SJ, Meixner H, Faller G, Kirchner T, Hahn EG: Helicobacter pylori induces apoptosis in gastric mucosa through an up regulation of Bax expression in humans. Scand J Gastroenterol 1999, 34:375-383.
86. 86 Fu S, Ramaanujam KS, Wong A, Fantry GT, Drachenberg CB, James SJ, Meltzer SJ, et al.: Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori gastritis. Gastroenterology 1999, 116:1319-1329. This is an outstanding study in which the authors convincingly show induction of COX-2 and iNOS in human gastric biopsies using RT-PCR, Northern blots (for iNOS), Western blots (for COX-2), and immunohistochemistry (for both).
87. 87 McCarthy CJ, Crofford LJ, Greeneson J, Scheiman JM: Cyclooxygenase-2 expression in gastric antral mucosa before and after eradication of Helicobacter pylori infection. Am J Gastroenterol 1999, 94:1218-1223.
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89. 89 Sawaoka H, Kawano S, Tsuji S, Tsuiji M, Sun W, Gunawan ES, Hori M: Helicobacter pylori infection induces cyclooxygenase-2 expression in human gastric mucosa. Prostaglandins Leukot Essent Fatty Acids 1998, 59:313-316.
90. 90 Wilson KT, Ramanujam KS, Mobley HLT, Musselman RF, James SP, Meltzer SJ: Helicobacter pylori stimulates inducible nitric oxide synthase expression and activity in a murine macrophage cell line. Gastroenterology 1996, 111:1524-1533.
91. 91 Kohda K, Tanaka K, Aiba Y, Yasuda M, Miwa T, Koga Y: Role of apoptosis induced by Helicobacter pylori infection in the development of duodenal ulcer. Gut 1999, 44:456-462.
92. 92 Hocking D, Webb E, Radcliff F, Rothel L, Taylor S, Pinczower G, Kapouleas C, et al.: Isolation of recombinant protective Helicobacter pylori antigens. Infect Immun 1999, 67:4713-4719.
93. c expressing urease A and B subunits. Infect Immun 1998, 66:581-586. This study and the one by Goméz-Duarte et al. [94••] are very promising for vaccine development against H. pylori.
94. 94 Goméz-Duarte OG, Lucas B, Yan Z, Panthel K, Haas R, Meyer TF: Urease subunits A and B delivered by attenuated Salmonella typhimurium vaccine strain protects mice against gastric colonization by Helicobacter pylori. Vaccine 1998, 16:460-471. See annotation for [93••].
95. 95 Goméz-Duarte OG, Bumann D, Meyer TF: The attenuated Salmonella vaccine approach for the control of Helicobacter pylori-related diseases. Vaccine 1999, 17:1667-1673.
96. 96 Guy B, Hessler C, Fourage S, Rokbi B, Quentin Millet M-J: Comparison between targeted and untargeted systemic immunizations with adjuvanted urease to cure Helicobacter pylori infection in mice. Vaccine 1999, 17:1130-1135.
97. 97 Novak MJ, Smythies LE, McPherson SA, Smith PD, Morrow CD: Poliovirus replicons encoding the B subunit of Helicobacter pylori urease elicit a TH1 associated immune response. Vaccine 1999, 17:2384-2391.