Clinical outcome after infection with Helicobacter pylori does not appear to be reliably predicted by the presence of any of the genes of the cag pathogenicity island

Gut

Volumn 43, Issue 6, 1998, Pages 752-758

  Jenks, P J ^a   Megraud F ^b   Labigne, A ^a  

^a INSTITUT PASTEUR   (France)

^b HÔPITAL PELLEGRIN   (France)

Author keywords

cag pathogenicity island; Duodenal ulcer; Helicobacter pylori; Non ulcer dyspepsia

Indexed keywords

ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DUODENUM ULCER; DYSPEPSIA; GENE EXPRESSION; GENE INSERTION SEQUENCE; GENE LOCUS; GRAM NEGATIVE INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PATHOGENICITY; POLYMERASE CHAIN REACTION; PREDICTION; PRIORITY JOURNAL; PROGNOSIS;

EID: 0031738184     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.43.6.752     Document Type: Article

References (39)

1. Warren JR, Marshall B. Unidentified curved bacilli on gastric epithelium in chronic active gastritis. Lancet 1983;i:1273-5.
2. Blaser MJ. Helicobacter pylori: microbiology of a 'slow' bacterial infection. Trends Microbiol 1993;1:255-60.
3. Parsonnet J, Friedman GD, Vandersteed DP, et al. Helicobacter pylori infection and the risk of gastric cancer. N Engl J Med 1991;325:1127-9.
4. Parsonnet J, Hansen S, Rodriguez L, et al. Helicobacter pylori infection and gastric lymphoma. N Engl J Med 1994; 330:1267-71.
5. IARC Working Group on the evaluation of carcinogenic risks to humans. Helicobacter pylori. In: Schistosomes, liver flukes, and Helicobacter pylori: views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Human. Lyon: IARC, 1994;177-240.
6. Apel I, Jacobs E, Kist M, et al. Antibody response of patients against a 120 kDa surface protein of Campylobacter pylori. Z Bakteriol Mikrobiol Hyg 1988;268:271-6.
7. Covacci A, Censini S, Bugnoli M, et al. Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc Natl Acad Sci USA 1993;90:5791-5.
8. Tummuru MKR, Cover TL, Blaser MJ. Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production. Infect Immun 1993;61:1799- 809.
9. Crabtree JE, Xiang Z, Lindley IJ, et al. Induction of interleukin-8 secretion from gastric epithelial cells by a cagA negative isogenic mutant of Helicobacter pylori. J Clin Pathol 1995;48:967-9.
10. Sharma SA, Tummuru MKR, Miller GG, et al. Interleukin-8 response of gastric epithelial cell lines to Helicobacter pylori stimulation in vitro. Infect Immun 1995; 63:1681-7.
11. Tummuru MKR, Cover TL, Blaser MJ. Mutation of the cytotoxin-associated cagA gene does not affect the vacuolating cytotoxin activity of Helicobacter pylori. Infect Immun 1994;62:2609-13.
12. Blaser MJ. Role of vacA and the cagA locus of Helicobacter pylori in human disease. Aliment Pharmacol Ther 1996; 10(suppl 1):73-8.
13. Xiang Z, Censini S, Bayeli PF, et al. Analysis of expression of CagA and VacA virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that CagA is not necessary for expression of the vacuolating cytotoxin. Infect Immun 1995;63:94-8.
14. Cover TL, Glupczynski Y, Lage AP, et al. Serological detection of infection with cagA Helicobacter pylori strains. J Clin Microbiol 1995;33:1496-500.
15. Crabtree JE, Taylor JD, Wyatt JI, et al. Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration, and gastric pathology. Lancet 1991;338:332-5.
16. Crabtree JE, Farmery SM, Lindley IJ, et al. CagA cytotoxic strains of Helicobacter pylori and interleukin-8 in gastric epithelial cell lines. J Clin Pathol 1994;47:945- 50.
17. Crabtree JE, Covacci A, Farmery SM, et al. Helicobacter pylori induced interleukin 8 expression in gastric epithelial cells is associated with CagA positive phenotype. J Clin Pathol 1995;48:41-5.
18. Weel JFL, van der Hulst RWM, Gerrits Y, et al. The interrelationship between cytotoxin-associated gene A, vacuolating cytotoxin, and Helicobacter pylori-related disease. J Infect Dis 1996;173:1171-5.
19. Kuipers EJ, Perez-Perez GI, Meuwissen SG, et al. Helicobacter pylori and atrophic gastritis: importance of the cagA status. J Natl Cancer Inst 1995;87:1777-80.
20. Blaser MJ, Perez-Perez GI, Kleanthous H, et al. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res 1995;55:2111-15.
21. Parsonnet J, Friedman GD, Orentreich N, et al. Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection. Gut 1997;40:297-301.
22. Graham DY, Genta RM, Graham DP, et al. Serum CagA antibodies in asymptomatic subjects and patients with peptic ulcer: lack of correlation of IgG antibody in patients with peptic ulcer or asymptomatic Helicobacter pylori gastritis. J Clin Pathol 1996;49:829-32.
23. Heikkinen M, Janatuinen E, Mayo K, et al. Usefulness of anti-Helicobacter pylori antibodies and anti-CagA antibodies in selection of patients for gastroscopy. Am J Gastroenterol 1997;92:2225-9.
24. Heikkinen M, Mayo K, Vornanen M, et al. Association of CagA positive and CagA negative Helicobacter pylori strains with patient's symptoms and gastritis in primary care patients with functional upper abdominal complaints. Scand J Gastroenterol 1998;33:31-8.
25. Hu PJ, Li YY, Zhou MH, et al. Helicobacter pylori associated with a high prevalence of duodenal ulcer disease and a low prevalence of gastric cancer in a developing country, Gut 1995;36:198-202.
26. Censini S, Lange C, Xiang Z, et al. cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc Natl Acad Sci USA 1996;93:14648-53.
27. Tomb J-F, White O, Kervalage AR, et al. The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 1997;388:539-47.
28. Tummuru MKR, Sharma SA, Blaser MJ. Helicobacter pylori picB a homologue of the Bordatella pertussis toxin secretion protein, is required for induction of IL-8 in gastric epithelial cells. Mol Microbiol 1995;18:867-76.
29. Drazeck ES, Dubois A, Holmes RK, et al. Cloning and characterization of hemolytic genes from Helicobacter pylori. Infect Immun 1996;63:4345-9.
30. Segal ED, Falkow S, Tompkins LS. Helicobacter pylori attachment to gastric cells induces cytoskeletal rearrangements and tyrosine phosphorylation of host cell proteins. Proc Natl Acad Sci USA 1996;93:1259-64.
31. Segal ED, Lange C, Covacci A, et al. Induction of host signal transduction pathways by Helicobacter pylori. Proc Natl Acad Sci USA 1997;94:7595-9.
32. Labigne A, Cussac V, Courcoux P. Shuttle cloning and nucleotide sequence of Helicobacter pylori genes responsible for urease activity. J Bacteriol 1991;173:1920-31.
33. Kansau I, Raymond J, Bingen E, et al. Genotyping of Helicobacter pylori isolates by sequencing of PCR products and comparison with the RAPD technique. Res Microbiol 1996;147:661-9.
34. Ward JE, Akiyoshi DE, Regier D, et al. Characterization of the virB Operon from an Agrobacterium tumefaciens Ti Plasmid. J Biol Chem 1988;263:5804-14.
35. McCarter LL. Genetic and molecular characterization of the polar Flagellum of Vibrio parahaemolyticus. J Bacteriol 1995;177:1595-609.
36. Venkatesan MM, Buysse JM, Kopecko DJ. Characterization of invasion plasmid antigen genes (ipaBCD) from Shigella flexneri. Proc Natl Acad Sci USA 1988;85:9317-21.
37. Jayaswal RK, Veluthambi K, Gelvin SB, et al. Double-stranded cleavage of T-DNA and generation of single-stranded T-DNA molecules in Escherichia cold by a virD-encoded border-specific endonuclease from Agrobacterium tumefaciens. J Bacteriol 1987;169:5035-45.
38. Covacci A, Falkow S, Berg DE, et al. Did the inheritance of a pathogenicity island modify the virulence of Helicobacter pylori? Trends Microbiol 1997;5:205-8.
39. Van der Ende A, Rauws EAJ, Feller M, et al. Heterogeneous Helicobacter pylori isolates from members of a family with a history of peptic ulcer disease. Gastroenterology 1996;111: 638-47.