Role of Hpn and NixA of Helicobacter pylori in susceptibility and resistance to bismuth and other metal ions

Helicobacter

Volumn 4, Issue 3, 1999, Pages 162-169

  Mobley, Harry L T ^a   Garner, Rachel M ^a   Chippendale, Gwynn R ^a   Gilbert, Joanne V ^b   Kane, Anne V ^b   Plaut, Andrew G ^b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b Tupper Research Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BISMUTH; BISMUTH CITRATE; CARRIER PROTEIN; CATION TRANSPORT PROTEIN; DRUG DERIVATIVE; HEAVY METAL; HISTIDINE RICH PROTEINS; HISTIDINE-RICH PROTEINS; MEMBRANE PROTEIN; NIXA PROTEIN, HELICOBACTER PYLORI; ORGANOMETALLIC COMPOUND; PROTEIN; RANITIDINE; RANITIDINE BISMUTH CITRATE;

ANTIBIOTIC RESISTANCE; ARTICLE; DRUG EFFECT; GENETICS; GROWTH, DEVELOPMENT AND AGING; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; METABOLISM; MICROBIOLOGICAL EXAMINATION; MICROBIOLOGY;

BACTERIAL PROTEINS; BISMUTH; CARRIER PROTEINS; CATION TRANSPORT PROTEINS; DRUG RESISTANCE, MICROBIAL; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MEMBRANE PROTEINS; METALS, HEAVY; MICROBIAL SENSITIVITY TESTS; ORGANOMETALLIC COMPOUNDS; PROTEINS; RANITIDINE;

EID: 0033192731     PISSN: 10834389     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-5378.1999.99286.x     Document Type: Article

References (26)

1. Breuer T, Malaty HM, Graham DY. The epidemiology of H. pYLori-associated gastroduodenal diseases. In: The Immunobiology of H. pylori, Ernst PB, Michetti P, Smith PD, eds. Philadelphia: Lippincott-Raven, 1997:1-14.
2. Eaton KA, Brooks CL, Morgan DR, Krakowka S. Essential role of urease in pathogenesis of gastritis induced by Helicobacter pylori in gnotobiotic piglets. Infect Immun 1991;59:2470-5.
3. Mobley HLT. Structure and function of H. pylori urease. In: The Immunobiology of H pylori, Ernst PB, Michetti P, Smith PD, eds. Philadelphia: Lippincott-Raven, 1997:59-73.
4. Garner RG, Fulkerson JF Jr, Mobley HLT. Helicobacter pylori glutamine synthetase lacks features associated with transcriptional and posttranslational regulation. Infect Immun 1998;66:1839-47.
5. Mobley HL, Island MD, Hausinger RP. Molecular biology of microbial ureases. Microbiol Rev 1995;59:451-80.
6. Mobley HL, Garner RM, Bauerfeind P. Helicobacter pylori nickel-transport gene nixA: Synthesis of catalytically active urease in Escherichia coli independent of growth conditions. Mol Microbiol 1995;16:97-109.
7. Gilbert JV, Ramakrishna J, Sunderman FW Jr, Wright A, Plaut AG. Protein Hpn: Cloning and characterization of a histidine-rich metal binding polypeptide in Helicobacter pylori and H. mustelae. Infect Immun 1995;63:2682-8.
8. Lambert JR. Pharmacology of bismuth-containing compounds. Rev Infect Dis 1991;13(suppl 8):S691-S695.
9. Nies DH, et al. Ion efflux systems involved in bacterial metal resistances. J Ind Microbiol 1995;14:186-99.
10. Silver S. Bacterial resistances to toxic metal ions - a review. Gene 1996;179:9-19.
11. Stohs SJ, Bagchi D. Oxidative mechanisms in the toxicity of metal ions. Free Radic Biol Med 1995;18:321-36.
12. Ferrero RL, Cussac V, Courcoux P, Labigne A. Construction of isogenic urease-negative mutants of Helicobacter pylori by allelic exchange. J Bacteriol 1992;174:4212-7.
13. Bauerfeind P, Garner RM, Mobley HLT. Allelic exchange mutagenesis of nixA in Helicobacter pylori results in reduced nickel transport and urease activity. Infect Immun 1996;64:2877-80.
14. Goodwin CS, Armstrong JA, Chilvers T, et al. Transfer of Campylobacter pylori and Campylobacter mustelae to Helicobacter gen. nov. as Helicobacter pylori com. nov. and Helicobacter muste-lae comb, nov., respectively. Int J Syst Bacteriol 1989;39:397.
15. National Committee for Clinical Laboratory Standards. Performance Standards for Antimicrobial Susceptibility Testing [9th informational supplement]. NCCLS doc. no. M100-S9. Wayne, PA: NCCLS, 1999.
16. Utrup LJ, Flamm R, Osato M, et al. Susceptibility testing standardization and quality control ranges for Helicobacter pylori. C-31. In: Program and Abstracts of the 98th General Meeting for the American Society for Microbiology. Washington, DC: American Society for Microbiology, 1998.
17. Coudron PE, Stratton CW. Utilization of time-kill kinetic methodologies for assessing the bactericidal activities of ampicillin and bismuth, alone and in combination, against Helicobacter pylori in stationary and logarithmic growth phases. Antimicrob Agents Chemother 1995;39:66-9.
18. Fulkerson JF Jr, Garner RM, Mobley HLT. Conserved residues and motifs in the NixA protein of Helicobacter pylori are critical for the high affinity transport of nickel ions. J Biol Chem 1998;273:235-41.
19. Solomons NW, Viteri F, Shuler TR, Nielsen FH. Bioavailability of nickel in man: Effects of foods and chemically-defined dietary constituents on the absorption of inorganic nickel. J Nutr 1982;112:39-50.
20. Sunderman FW Jr, et al. Nickel absorption and kinetics in human volunteers. Proc Soc Exp Biol Med 1989;191:5-11.
21. Kansau I, Guillain F, Thiberge JM, Labigne A. Nickel binding and immunological properties of the C-terminal domain of the Helicobacter pylori GroES homologue (HspA). Mol Microbiol 1996;22:1013-23.
22. Cussac V, Ferrero RL, Labigne A. Expression of Helicobacter pylori urease genes in Escherichia coli grown under nitrogen-limiting conditions. J Bacteriol 1992;174:2466-73.
23. Melchers K, Weitzenegger T, Buhmann A, et al. Cloning and membrane topology of a P-type ATPase from Helicobacter pylori. J Biol Chem 1996;271:446-57.
24. Tomb J-F, White O, Kerlavage AR, et al. The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 1997;388:539-47.
25. Sousa C, de Cebolla A, Lorenzo V. Enhanced metalloadsorption of bacterial cells displaying poly-His peptides. Nat Biotechnol 1996;14:1017-20.
26. Kramer U, Cotter-Howells JD, Charnock JM, et al. Free histidine as a metal chelator in plants that accumulate nickel. Nature 1996;379:635-8.