Molecular genetic basis for the variable expression of Lewis Y antigen in Helicobacter pylori: Analysis of the α(1,2) fucosyltransferase gene

Molecular Microbiology

Volumn 31, Issue 4, 1999, Pages 1265-1274

  Wang, Ge ^a   Rasko, David A ^a   Sherburne, Richard ^a   Taylor, Diane E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; BACTERIUM LIPOPOLYSACCHARIDE; DNA POLYMERASE; FUCOSYLTRANSFERASE;

ARTICLE; BLOOD GROUP LEWIS SYSTEM; DNA SEQUENCE; DNA TRANSCRIPTION; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; FRAMESHIFT MUTATION; GENE CONSTRUCT; GENE CONTROL; GENE EXPRESSION; GENE MUTATION; GENETIC CODE; GENOTYPE; HELICOBACTER PYLORI; IMMUNOELECTRON MICROSCOPY; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSLATION REGULATION;

AMINO ACID SEQUENCE; ANTIGENS, CD15; BASE SEQUENCE; DNA, BACTERIAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FUCOSYLTRANSFERASES; HELICOBACTER PYLORI; HUMANS; IMMUNOBLOTTING; LEWIS BLOOD-GROUP SYSTEM; MICROSCOPY, IMMUNOELECTRON; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; PLASMIDS; SEQUENCE ANALYSIS, DNA;

ANIMALIA; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; HELICOBACTER PYLORI; PROKARYOTA;

EID: 0033031955     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1999.01268.x     Document Type: Article

References (33)

1. Appelmelk, B.J., Simoons-Smit, I.M., Negrini, R., et al. (1996) Potential role of molecular mimicry between Helicobacter pylori lipopolysaccharide and host Lewis blood group antigens in autoimmunity. Infect Immun 64: 2031-2040.
2. Appelmelk, B.J., Shiberu, B., Trinks, C., et al. (1998) Phase variation in Helicobacter pylori lipopolysaccharide. Infect Immun 66: 70-76.
3. Aspinall, G.O., and Monteiro, M.A. (1996) Lipopolysaccharides of Helicobacter pylori strains P466 and MO19: structures of the O antigen and core oligosaccharide regions. Biochemistry 35: 2498-2504.
4. Avent, N.D. (1997) Human erythrocyte antigen expression: its molecular bases. Br J Biomed Sci 54: 16-37.
5. Berg, D.E., Hoffman, P., Appelmelk, B.J., and Kuster, J.G. (1997) The Helicobacter pylori genome sequence: genetic factors for long life in the gastric mucosa. Trends Microbiol 12: 468-474.
6. Breton, C., Oriol, R., and Imberty, A. (1998) Conserved structural features in eukaryotic fucosyltransferases. Glycobiology 8: 87-94.
7. Cover, T.L., and Blaser, M.J. (1996) Helicobacter pylori infection, a paradigm for chronic mucosal inflammation: pathogenesis and implications for eradication and prevention. Adv Int Med 41: 85-117.
8. Dunn, B.E., Cohen, H., and Blaser, M.J. (1997) Helicobacter pylori. Clin Microbiol Rev 10: 720-741.
9. Farabaugh, P.J. (1996) Programmed translational frameshifting. Annu Rev Genet 30: 507-528.
10. Flower, A.M., and McHenry, C.S. (1990) The γ subunit of DNA polymerase III holoenzyme of Escherichia coil is produced by ribosomal frameshifting. Proc Natl Acad Sci USA 87: 3713-3717.
11. Ge, Z., and Taylor, D.E. (1997). H. pylori DNA transformation by natural competence and electroporation. In Methods in Molecular Medicine, Helicobacter pylori Protocols. Clayton, C.L., and Mobley, H.L.T. (eds). Totowa, NJ: Humana Press, pp. 145-152.
12. Ge, Z., Chan, N.W.C., Palcic, M.M., and Taylor, D.E. (1997) Cloning and heterologous expression of an α 1,3 fucosyl-transferase gene from the gastric pathogen Helicobacter pylori. J Biol Chem 272: 21357-21363.
13. Hakomori, S.-I. (1989) Aberrant glycosylation in tumors and tumor-associated carbohydrate antigens. Adv Cancer Res 52: 257-331.
14. Hitchcock, P.J., and Brown, T.M. (1983) Morphological heterogeneity among Salmonella lipopolysaccharide chemotypes in silver-stained polyacrylamide gels. J Bacteriol 154: 269-277.
15. Kelly, R.J., Rouquier, S., Giorgi, D., Lennon, G.G., and Lowe, J.B. (1995) Sequence and expression of a candidate for the human secretor blood group α (1,2) fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype. J Biol Chem 270: 4640-4649.
16. Kleene, R., and Berger, E.G. (1993) The molecular and cell biology of glycosyltransferases. Biochim Biophys Acta 1154: 283-325.
17. Kuipers, E.J. (1997) Helicobacter pylori and the risk and management of associated diseases: gastritis, ulcer disease, atrophic gastritis and gastric cancer. Alimen Pharmacol Therapeut 11 (Suppl. 1): 71-88.
18. Larsen, B., Wills, N.M., Gesteland, R.F., and Atkins, J.F. (1994) rRNA-mRNA base pairing stimulates a programmed -1 ribosomal frameshift. J Bacteriol 176: 6842-6851.
19. Martin, S.L., Edbrooke, M.R., Hodgman, T.C., van den Eijnden, D.H., and Bird, M.I. (1997) Lewis X biosynthesis in Helicobacter pylori. Molecular cloning of an α (1,3) fucosyltransferase gene. J Biol Chem 272: 21349-21356.
20. Monteiro, M.A., Chan, K.H.N., Rasko, D.A., Taylor, D.E., Zheng, P.Y., Appelmelk, B.J., et al. (1998) Simultaneous expression of type 1 and type 2 Lewis blood group by Helicobacter pylori lipopolysaccharides. J Biol Chem 273: 11533-11543.
21. Roche, R.J., and Moxon, E.R. (1995) Phenotypic variation of carbohydrate surface antigens and the pathogenesis of Haemophilus influenzae infections. Trends Microbiol 3: 304-309.
22. Saunders, N.J., Peden, J.F., Hood, D.W., and Moxon, E.R. (1998) Simple sequence repeats in the Helicobacter pylori genome. Mol Microbiol 27: 1091-1098.
23. Sherburne, R., and Taylor, D.E. (1995) Helicobacter pylori expresses a complex surface carbohydrate, Lewis X. Infect Immun 63: 4564-4568.
24. Tomb, J.-F., White, O., Kerlavage, A.R., Clayton, R.A., Sutton, G.G., Fleischman, R.D., et al. (1997) The complete genome sequence of the gastric pathogen Helicobacter pylori, Nature 388: 539-547.
25. Lys and an AAG lysine codon. Genes Dev 6: 511-519.
26. Van Kranenburg, R., Marugg, J.D., Van Swam, I.I., Willem, N.J., and de Vos, W.M. (1997) Molecular characterization of the plasmid-encoded eps gene cluster essential for exopolysaccharide biosynthesis in Lactococcus lactis. Mol Microbiol 24: 387-397.
27. Van Putten, J.P.M., and Robertson, B.D. (1995) Molecular mechanisms and implications for infection of lipopolysaccharide variation in Neisseria. Mol Microbiol 16: 847-853.
28. Wang, Y., and Taylor, D.E. (1990) Chloramphenicol resistance in Campylobacter coli: nucleotide sequence, expression, and cloning vector construction. Gene 94: 23-28.
29. Watkins, W.M. (1995) Biosynthesis. Molecular basis of antigenic specificity in the ABO, H, and Lewis blood group systems. In Glycoproteins. Montreuil, J., Schachter, H., and Vliegenthart, J.F.G. (eds). Amsterdam: Elsevier, pp. 313-390.
30. Wirth, H.-P., Yang, M., Karita, M., and Blaser, M.J. (1996) Expression of the human cell surface glycoconjugates Lewis X and Lewis Y by Helicobacter pylori isolates is related to cagA status. Infect Immun 64: 4598-4605.
31. Wirth, H.-P., Yang, M., Peek, R.M., Tham, K.T., and Blaser, M.J. (1997a) Helicobacter pylori Lewis expression is related to the host Lewis phenotype. Gastroenterology 113: 1091-1098.
32. Wirth, H.-P., Yang, M., Peek, R.M., Hook-Nikanne, J., and Blaser, M.J. (1997b) Phenotypic diversity in Lewis expression of H. pylori colonies derived from the same biopsy. Gastroenterology 112: A331.
33. Zhang, L., Radziejewska-Lebrecht, J., Krajewska-Pietrasik, D., Toivanen, P., and Skurnik, M. (1997) Molecular and chemical characterization of the lipopolysaccharide O-antigen and its role in the virulence of Yersinia enterocolitica serotype 0:8. Mol Microbiol 23: 63-76.