Identification of potential diagnostic and vaccine candidates of Helicobocter pylori by "proteome" technologies

Helicobacter

Volumn 3, Issue 3, 1998, Pages 163-169

  McAtee, C Patrick ^a,c   Fry, Kirk E ^a   Berg, Douglas E ^b  

^a Genelabs Incorporated   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL PROTEIN; BACTERIAL VACCINE;

ARTICLE; CHEMISTRY; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; IMMUNOLOGY; MASS SPECTROMETRY; METHODOLOGY; PEPTIDE MAPPING; PH; TWO DIMENSIONAL GEL ELECTROPHORESIS; WESTERN BLOTTING;

ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BACTERIAL VACCINES; BLOTTING, WESTERN; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; HYDROGEN-ION CONCENTRATION; MASS SPECTROMETRY; PEPTIDE MAPPING;

EID: 0032161919     PISSN: 10834389     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Riegg SJ, Dunn BE, Blaser M. Microbiology and pathogenesis of Helicobacter pylori. In: Infections of the Gastrointestinal Tract, Blaser M.J., Smith P.D., Ravdin J.I., Greenberg H.B., and Guerrant R.L., eds. New York: Raven Press, Ltd., 1995; 535-50.
2. Tomb J-F, et al. The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 1997;388:539-47.
3. Papini E, de Bernard M, Milia E, Bugnoli M, Zerial M, Rappuoli R, Montecucco C. Cellular vacuoles induced by Helicobacter pylori originate from late endosomal compartments. Proc Natl Acad Sci USA 1994;91:9720-4.
4. O'Farrell PH. High resolution two-dimensional electrophoresis of proteins. J Biol Chem 1975; 250: 4007-21.
5. O'Farrell PZ, Goodman HM, O'Farrell PH. High resolution two-dimensional electrophoresis of basic as well as acidic proteins. Cell 1977;12:1133-41.
6. Dunn BE, Campbell GP, Perez-Perez GI, Blaser MJ. Purification and characterization of urease from Helicobacter pylori. J Biol Chem 1990;265: 9464-9.
7. Dunn BE, Roop R, Sung C-C, Sharma S, PerezPerez GI, Blaser MJ. Identification and purification of a cpn60 heat shock protein homolog from Helicobacter pylori. Infect Immun 1992;60:1946-51.
8. Hughes NJ, Chalk PA, Clayton CL, Kelly DJ. Identification of carboxylation enzymes and characterization of a novel four-subunit pyruvate: flavodoxin oxidoreductase from Helicobacter pylori. J Bacteriol 1995;177:3953-9.
9. Kostrzynska M, Betts JD, Austin JW, Trust TJ. Identification, characterization, and spatial localization of two flagellin species in Helicobacter pylori flagella. J Bacteriol 1991;173:937-46.
10. Missiakas D, Schwager F, Betton JM, Georgopoulos C, Raina S. Identification and characterization of HsIV HsIU (ClpQ ClpY) proteins involved in overall proteolysis of misfolded proteins in Escherichia coli. EMBO J 1996;15:6899-909.
11. Hazell SL, Evans DJ Jr, Graham DY. Helicobacter pylori catalase. J Gen Microbiol 1991;137:57-61.
12. McAtee CP, Young ML, Foung K, Velligan M, Chow T, Fry K, Berg DE. Characterization of a Helicobacter pylori vaccine candidate by proteome techniques. J Chromatog B 1998 (in press).
13. Evans DJ Jr, Evans DG, Kirkpatrick SS, Graham DY. Characterization of the Helicobacter pylori urease and purification of its subunits. Microb Pathog 1991;10:15-26.
14. Lee A. Animal models and vaccine development. Baillieres Clin Gastroenterol 1995;9:615-32.
15. Lee CK, Weltzin R, Thomas WD Jr, Kleanthous H, Ermak TH, Soman G, Hill JE, Ackerman SK, Monath TP. Oral immunization with recombinant Helicobacter pylori urease induces secretory IgA antibodies and protects mice from challenge with Helicobacter felis. JInfect Dis 1995;172:161-72.