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PPAR: A key nuclear factor in nutrient/gene interactions?
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Edited by Bauerie PA. Boston: Birkhauser
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1 Desvergne B, Wahli W: PPAR: a key nuclear factor in nutrient/gene interactions? In: Inducible gene expression. Edited by Bauerie PA. Boston: Birkhauser, 1995 (Vol 1):142-176.
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Desvergne, B.1
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An update on the mechanisms of action of the peroxisome proliferator-activated receptors (PPARs) and their roles in inflammation and cancer
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2 Gelman L, Fruchart JC, Auwerx J: An update on the mechanisms of action of the peroxisome proliferator-activated receptors (PPARs) and their roles in inflammation and cancer. Cell Mol Life Sci 1999, 55:932-943. Overview of the molecular biologic aspects of the interactions of PPARs with transcriptional factors and cofactors.
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Peroxisome proliferators-activated receptors: A nuclear receptor signaling pathway in lipid physiology
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4 Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schütz G, Umesono K, et al.: The nuclear receptor superfamily: the second decade. Cell 1995, 83:835-839.
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Interdomain communication regulating ligand binding by PPAR-γ
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5 Shao D, Rangwala SM, Bailley ST, Krakow SL, Reginato MJ, Lazar MA: Interdomain communication regulating ligand binding by PPAR-γ. Nature 1998, 396:377-380. A good characterization of the ligand-independant transactivation domain of PPARγ.
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Shao, D.1
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Regulation of the transcriptional activity of the peroxisome proliferator-activated receptor α by phosphorylation of a ligand-independent trans-activating domain
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6 Juge-Aubry CE, Hammar E, Siegrist-Kaiser C, Pernin A, Takeshita A, Chin WW, Burger AG, Meier CA: Regulation of the transcriptional activity of the peroxisome proliferator-activated receptor α by phosphorylation of a ligand-independent trans-activating domain. J Biol Chem 1999, 274:10505-10510. A decisive advance in the mechanisms governing ligand-independent transactivation mechanisms of PPARα.
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Juge-Aubry, C.E.1
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Phosphorylation of peroxisome proliferator-activated receptor α in rat Fao cells and stimulation by ciprofibrate
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7 Passily P, Schohn H, Jannin B, Malki MC, Boscoboinik D, Dauça M, Latruffe N: Phosphorylation of peroxisome proliferator-activated receptor α in rat Fao cells and stimulation by ciprofibrate. Biochem Pharmacol 1999, 58:1001-1008.
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Passily, P.1
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Malki, M.C.4
Boscoboinik, D.5
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Latruffe, N.7
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The nuclear receptors peroxisome proliferator-activated receptor α and rev-erbα mediate the species-specific regulation of apolipoprotein 1-I expression by fibrates
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8 Vu-Dac N, Chopin-Delannoy S, Gervois P, Bonnelye E, Martin G, Fruchart JC, Laudet V, Staels B: The nuclear receptors peroxisome proliferator-activated receptor α and rev-erbα mediate the species-specific regulation of apolipoprotein 1-I expression by fibrates. J Biol Chem 1998, 273:25713-25720.
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Vu-Dac, N.1
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Bonnelye, E.4
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Laudet, V.7
Staels, B.8
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Fibrates increase human REV-ERBa expression in liver via a novel peroxisome proliferator-activated receptor response element
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9 Gervois P, Chopin-Delannoy S, Fadel A, Dubois G, Kosykh V, Fruchart JC, Najib J, Laudet V, Staels B: Fibrates increase human REV-ERBa expression in liver via a novel peroxisome proliferator-activated receptor response element. Mol Endocrinol 1999, 13:400-409. Demonstration that PPREs may obey a DR2 pattern (in addition to previously documented DR1 patterns for these responsive elements).
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Mol Endocrinol
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Gervois, P.1
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Kosykh, V.5
Fruchart, J.C.6
Najib, J.7
Laudet, V.8
Staels, B.9
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DNA sequences responsible for reduced promoter activity of human phospholipid transfer protein by fibrate
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10 Tu AY, Albers JJ: DNA sequences responsible for reduced promoter activity of human phospholipid transfer protein by fibrate. Biochem Biophys Res Commun 1999, 264:802-807. Direct down-regulatory properties of PPARs through PPRE (PPAR/PPRE interactions being classically considered as having up-regulatory properties on gene expression).
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Biochem Biophys Res Commun
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Tu, A.Y.1
Albers, J.J.2
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PPARγ ligand-dependent induction of STAT1, STAT5A and STAT5B during adipogenesis
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11 Stephens JM, Morrison RF, Wu Z, Farmer SR: PPARγ ligand-dependent induction of STAT1, STAT5A and STAT5B during adipogenesis. Biochem Biophys Res Commun 1999, 262:216-222. A good example of interactions between PPAR and STAT pathways.
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Biochem Biophys Res Commun
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Stephens, J.M.1
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0033570094
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STAT5b down-regulates peroxisome proliferator-activated receptor α transcription by inhibition of ligand-independent activation function region-1 trans-activation domain
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12 Zhou YC, Waxman DJ: STAT5b down-regulates peroxisome proliferator-activated receptor α transcription by inhibition of ligand-independent activation function region-1 trans-activation domain. J Biol Chem 1999, 274:29874-29882. A important example of interactions between PPAR and STAT pathways.
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J Biol Chem
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Zhou, Y.C.1
Waxman, D.J.2
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0033613959
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Cross-talk between janus kinase-signal transducer and activator of transcription (JAK-STAT) and peroxisome proliferator-activated receptor-alpha (PPARα) signaling pathways. Growth hormone inhibition of PPARα transcriptional activity mediated by stat5b
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13 Zhou YC, Waxman DJ: Cross-talk between janus kinase-signal transducer and activator of transcription (JAK-STAT) and peroxisome proliferator-activated receptor-alpha (PPARα) signaling pathways. Growth hormone inhibition of PPARα transcriptional activity mediated by stat5b. J Biol Chem 1999, 274:2672-2681. Experimental work pointing out growth hormone-mediated effects occurring through cross-talk between PPARs and STAT pathways.
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J Biol Chem
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Zhou, Y.C.1
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Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by co-activator-dependent receptor ligand assay
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14 Krey G, Braissant O, L'Horset F, Kalkhoven E, Perroud M, Parker MG, Wahli W: Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by co-activator-dependent receptor ligand assay. Mol Endocrinol 1997, 11:779-791.
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Phytanic acid activates the peroxisome proliferator-activated receptor α (PPARα) in sterol carrier protein 2-/ sterol carrier protein x-deficient mice
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15 Ellinghaus P, Wolfrum C, Assmann G, Spener F, Seedorf U: Phytanic acid activates the peroxisome proliferator-activated receptor α (PPARα) in sterol carrier protein 2-/ sterol carrier protein x-deficient mice. J Biol Chem 1999, 274:2766-2772.
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Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ
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PPARg promotes monocyte/macrophage differentiation and uptake of oxidized LDL
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17 Tontonoz P, Nagy L, Alvarez JGA, Thomazy VA, Evans RA: PPARg promotes monocyte/macrophage differentiation and uptake of oxidized LDL Cell 1998, 93:241-252. Two important experimental works illustrating the effects of PPARγ activation (ie, foam cell formation) in atherosclerosis.
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N-(2-benzoylphenyl)-l-tyrosine PPARγ agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents
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N-(2-benzoylphenyl)-l-tyrosine PPARγ agonists. 2. Structure-activity relationship and optimalization of the phenyl alkyl ether moiety
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N-(2-benzoylphenyl)-L-tyrosine PPARγ agonists. 3. Structure-activity relationship and optimalization of the N-aryl substituent
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20 Cobb JE, Blanchard SG, Boswell EG, Brown KK, Charifson PS, Cooper JP, et al.: N-(2-Benzoylphenyl)-L-tyrosine PPARγ agonists. 3. Structure-activity relationship and optimalization of the N-aryl substituent. J Med Chem 1998, 41:5055-5069.
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A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat
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21 Brown KK, Henke BR, Blanchard SG, Cobb JE, Mook R, Kaldor I, Kliewer SA, et al.: A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat. Diabetes 1999, 48:1415-1424.
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Novel peroxisome proliferator-activated receptor (PPAR) γ and PPARδ ligands produce distinct biological effects
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Non-thiazolidinedione antihyperglycaemic agents. Part 3: The effects of stereochemistry on the potency of α-methyl-β-phenylpropanoic acids
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0029016829
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An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ)
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Thiazolidinediones: A new class of antidiabetic drugs
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25 Day C: Thiazolidinediones: a new class of antidiabetic drugs. Diabet Med 1999, 16:179-192. Review of the biologic effects and indications in diabetes for a class of drugs that are ligands of PPARγ.
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Diabet Med
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Day, C.1
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0031013395
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Peroxisome proliferator-acttivated receptors a and g are activated by indomethacin and other non-steroidal anti-inflammatory drugs
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26 Lehmann JM, Lenhard JM, Oliver BB, Ringold GM, Kliewer SA: Peroxisome proliferator-acttivated receptors a and g are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem 1997, 272:3406-3410.
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A peroxisome proliferator-activated receptor γ ligand inhibits adipocyte differentiation
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Proc Natl Acad Sci USA
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Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-α, -β and-γ in the adult rat
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Medical significance of peroxisome proliferator-activated receptors
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29 Vamecq J, Latruffe N: Medical significance of peroxisome proliferator-activated receptors. Lancet 1999, 354(9173):141-148. Review of the medical significance of PPARs.
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Activation of a member of the steroid receptor superfamily by peroxisome proliferators
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A cancer risk assessment of di(2-ethylhexyl)phthalate: Application of the new U.S. EPA risk assessment guidelines
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Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway
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32 Delerive P, Martin-Nizard F, Chinetti G, Trottein F, Fruchart JC, Najib J, et al.: Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway. Circ Res 1999, 85:394-402.
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Peroxisome proliferator-activated receptor-α activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis
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33 Fruchart JC, Duriez P, Staels B: Peroxisome proliferator-activated receptor-α activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis. Curr Opin Lipidol 1999, 10:245-257. A good review for recent advance in therapeutic benefit of PPARα ligand fibrates in cardiovascular disorders.
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Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction
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PPARα activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells
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Activation of human aortic smooth-muscles is inhibited by PPARα but not PPARγ activators
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9-Cis retinoic acid induces monocyte, chemoattractant protein-1 secretion in human monocylic THP-1 cells
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PPARγ, the ultimate thrifty gene
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Diabetologia
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Auwerx, J.1
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Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-α in humans:n No alteration in adipose tissue of obese and NIDDM patients
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