Down-regulation of cytochrome P450 2C family members and positive acute- phase response gene expression by peroxisome proliferator chemicals

Molecular Pharmacology

Volumn 54, Issue 3, 1998, Pages 463-473

  Corton, J Christopher ^a,b   Fan, Li Qun ^a   Brown, Sherri ^a   Anderson, Steven P ^a   Bocos, Carlos ^b,c   Cattley, Russell C ^a   Mode, Agneta ^b   Gustafsson, Jan Åke ^b  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSIDAD SAN PABLO CEU   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 GLOBULIN; CYTOCHROME P450; FIBRINOGEN; GEMFIBROZIL; OROSOMUCOID; PEROXISOME PROLIFERATOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PHTHALIC ACID DIBUTYL ESTER; PIRINIXIC ACID;

ACUTE PHASE RESPONSE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; GROWTH HORMONE RELEASE; HORMONAL REGULATION; INFLAMMATION; LIVER; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROTEIN DETERMINATION; PULSATILE HORMONE RELEASE; RAT; TISSUE LEVEL;

EID: 0031715770     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.54.3.463     Document Type: Article

References (39)

1. Alvares K, Subbarao V, Rao MS, and Reddy JK (1996) Ciprofibrate represses alpha 2u-globulin expression in liver and inhibits d-limonene nephrotoxicity. Carcinogenesis 17:311-316.
2. Ashby J, Brady A, Elcombe CR, Elliott BM, Ishmael J, Odum J, Tugwood JD, Kettle S, and Purchase IFH (1994) Mechanistically-based human hazard assessment of peroxisome proliferator-induced hepatocarcinogenesis. Hum Exp Toxicol 13:S1-S117.
3. Biegel LB, Hurtt ME, Frame SR, Applegate M, O'Conner JC, and Cook JC (1992) Comparison of the effects of Wyeth-14,643 in Crl:CD BR and Fisher-344 rats. Fundam Appl Toxicol 19:590-597.
4. Biegel LB, Liu RCM, Hurtt ME, and Cook JC (1995) Effects of ammonium perfluorooctanoate on Leydig cell function: in vitro, in vivo, and ex vivo studies. Toxicol Appl Pharmacol 134:18-25.
5. Birch HE and Schreiber G (1986) Transcriptional regulation of plasma protein synthesis during inflammation. J Biol Chem 261:8077-8080.
6. Chen J, Nikolova-Karakashian M, Merrill AH Jr, and Morgan ET (1995) Regulation of cytochrome P450 2C11 (CYP2C11) gene expression by interleukin-1, sphingomyelin hydrolysis, and ceramides in rat hepatocytes. J Biol Chem 270:25233-25238.
7. Corton JC and Gustafsson J-Å (1997) Increased efficiency in screening large numbers of cDNA fragments generated by differential display. Biotechniques 22:802-810.
8. Corton JC, Bocos C, Moreno ES, Merritt A, Marsman DS, Sausen PJ, Cattley RC, and Gustafsson J-Å (1996) Rat 17β-hydroxysteroid dehydrogenase type IV is a novel peroxisome proliferator-inducible gene. Mol Pharmacol 50:1157-1166.
9. 4 pathway to inflammation control. Nature (Lond) 384: 39-43.
10. Eagon PK, Chandar N, Epley MJ, Elm MS, Brady EP, and Rao KN (1994) Di-(2-ethylhexyl)phthalate-induced changes in liver estrogen metabolism and hyperplasia. Int J Cancer 58:736-743.
11. Fan L-Q, Cattley RC, and Corton JC (1998) Tissue-specific induction of 17β-hydroxysteroid dehydrogenase type IV by peroxisome proliferator chemicals is dependent on the peroxisome proliferator-activated receptor α. J Endocrinol, in press.
12. Hertz R, Bishara-Shieban, and Bar-Tana J (1995) Mode of action of peroxisome proliferators as hypolipidemic drugs: suppression of apolipoprotein C-III. J Biol Chem 270:13470-13475.
13. Hertz R, Seckbach M, Zaki MM, and Bar-Tana J (1996) Transcriptional suppression of the transferrin gene by hypolipidemic peroxisome proliferators. J Biol Chem 271:218-224.
14. □BR rats. Drug Chem Toxicol 20:1-10.
15. Johnson D, Al-Shawi R, and Bishop JO (1995) Sexual dimorphism and growth hormone induction of murine pheromone-binding proteins. J Mol Endocrinol 14: 21-34.
16. Kedderis GL, Argenbright LS, and Miwa GT (1988) Studies with nitrogen-containing steroids and freshly isolated rat hepatocytes: role of cytochrome P-450 in detoxication. Toxicol Appl Pharmacol 93:403-412.
17. Lake BG, Tredger JM, Gray TJB, Stubberfield CR, Hodder KD, Gangolli SD, and Williams R (1984) The effect of peroxisome proliferators on the metabolism and spectral interaction of endogenous substrates of cytochrome P450 in rat hepatic microsomes. Life Sci 35:2621-2626.
18. Lapinskas PJ, and Corton JC (1998) Molecular mechanisms of hepatocarcinogenic peroxisome proliferators, in Molecular Biology of the Toxic Response (Puga A and KB Wallace, eds) in press, Taylor and Francis, Washington DC.
19. Lee SC, Chang CJ, Lee YM, Lei HY, Lai MY, and Chen DS (1989) Molecular cloning of cDNAs corresponding to two genes of alpha 1-acid glycoprotein and characterization of two alleles of AGP-1 in the mouse. DNA 8:245-251.
20. Lee SS-T, Pineau T, Drago J, Lee EJ, Owens JW, Koretz DL, Fernandez-Salguero PM, Westphal H, and Gonzalez FJ (1995) Targeted disruption of the α isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol 15:3012-3022.
21. Legraverend C, Mode A, Wells T, Robinson I, and Gustafsson J-Å (1992) Hepatic steroid hydroxylating enzymes are controlled by the sexually dimorphic pattern of growth hormone secretion in normal and dwarf rats. FASEB J 6:711-718.
22. Lehmann JM, Lenhard JM, Oliver BB, Ringold GM, and Kliewer SA (1997) Peroxisome proliferator-activated receptors α and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem 272:3406-3410.
23. Liu RCM, Hurtt ME, Cook JC, and Biegel LB (1996) Effect of the peroxisome proliferator, ammonium perfluorooctanoate (C8), on hepatic aromatase activity in adult male Crl:CD BR (CD) rats. Fundam Appl Toxicol 30:220-228.
24. Martucci CP and Fishman J (1993) P450 enzymes of estrogen metabolism. Pharmacol Ther 57:237-257.
25. Mode A, Gustafsson J-Å, Jansson J-O, Edén S, and Isaksson O (1982) Association between plasma level of growth hormone and sex differentiation of hepatic steroid metabolism in the rat. Endocrinology 111:1692-1697.
26. Monk JP and Todd PA (1987) Benzafibrate: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hyperlipidaemia. Drugs 33: 539-576.
27. Morgan ET, MacGeoch C, and Gustafsson J-Å (1985) Hormonal and developmental regulation of expression of the hepatic microsomal steroid 16α-hydroxylase cytochrome P450 apoprotein in the rat. J Biol Chem 260:11895-11898.
28. Morgan ET, Ronnholm M, and Gustafsson J-Å (1987) Preparation and characterization of monoclonal antibodies recognizing unique epitopes on sexually differentiated rat liver cytochrome P-450 isozymes. Biochemistry 26:4193-4200.
29. Moshage H (1997) Cytokines and the hepatic acute phase response. J Pathol 181: 257-266.
30. Reddy JK and Lalwai MD (1983) Carcinogenesis by hepatic peroxisome proliferators: evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans. CRC Crit Rev Toxicol 12:1-58.
31. Ricca GA, Hamilton RW, McLean JW, Conn A, Kalinyak JE, and Taylor JM (1981) Rat alpha1-acid glycoprotein mRNA: cloning of double stranded cDNA and kinetics of induction of mRNA levels following acute inflammation. J Biol Chem 256: 10362-10368.
32. Roy AK, Chatterjee B, Demyan WF, Milin BS, Motwani NM, Nath TS, and Schiop MJ (1983) Hormone and age-dependent regulation of alpha 2u-globulin gene expression. Recent Prog Horm Res 39:425-461.
33. Shahan K, Gilmartin M, and Derman E (1987) Nucleotide sequences of liver, lachrymal, and submaxillary gland mouse major urinary protein mRNAs: mosaic structure and construction of panels of gene-specific synthetic oligonucleotide probes. Mol Cell Biol 7:1938-1946.
34. Stone MC and Thorp JM (1984) Plasma fibrinogen: a major coronary risk factor, in Atherosclerosis and Cardiovascular Disease (Lenzi S and Descovich GC, eds), pp 3-10, Editrice Composition, Bologna.
35. Ström A, Westin S, Eguchi H, Gustafsson J-Å, and Mode A (1995) Characterization of orphan nuclear receptor binding elements in sex-differentiated members of the CYP2C gene family expressed in rat liver. J Biol Chem 270:11276-11281.
36. Tollet P, Enberg B, and Mode A (1990) Growth hormone (GH) regulation of cytochrome P-450 IIC12, insulin-like growth factor-I (IGF-I), and GH receptor messenger RNA expression in primary rat hepatocytes: a hormonal interplay with insulin, IGF-I and thyroid hormone. Endocrinology 4:1934-1942.
37. Vinazzer H and Farine JC (1983) Double-blind cross-over study of the effect of sultosilic acid piperazine salt (A-585) and benzafibrate in primary hyperlipoproteinemia. Atherosclerosis 49:109-118.
38. Waxman DJ (1992) Modes of regulation of liver-specific steroid metabolizing cytochrome P450: cholesterol 7α-hydroxylase, bile acid 6β-hydroxylase, and growth hormone-responsive steroid hormone hydroxylases. J Steroid Biochem 43:1055-1072.
39. Waxman DJ (1991) Rat hepatic P450IIA and P450IIC subfamily expression using catalytic, immunochemical, and molecular probes. Methods Enzymol 260:249-267.