Non-thiazolidinedione antihyperglycaemic agents. Part 3: The effects of stereochemistry on the potency of α-methoxy-β-phenylpropanoic acids

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 5, 1999, Pages 821-830

  Haigh, David ^a   Allen, Graham ^a   Birrell, Helen C ^a   Buckle, Derek R ^a   Cantello, Barrie C C ^a   Eggleston, Drake S ^a   Haltiwanger, R Curtis ^a   Holder, Julie C ^a   Lister, Carolyn A ^a   Pinto, Ivan L ^a   Rami, Harshad K ^a   Sime, John T ^a   Smith, Stephen A ^a   Sweeney, John D ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Antihyperglycaemic; Enzymes and enzyme reactions; Resolution; X ray crystal structures

Indexed keywords

ANTIDIABETIC AGENT; PROPIONIC ACID DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG POTENCY; ENANTIOMER; ESCHERICHIA COLI; GLUCOSE TRANSPORT; ISOMERISM; MOUSE; NONHUMAN; STEREOCHEMISTRY; X RAY CRYSTALLOGRAPHY;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; HYPOGLYCEMIC AGENTS; MODELS, CHEMICAL; MODELS, MOLECULAR; PHENYLPROPIONATES; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STEREOISOMERISM; TIME FACTORS; TRANSCRIPTION FACTORS;

RHIZOPUS ORYZAE;

EID: 0033136064     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00034-6     Document Type: Article

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