Phosphorylation of peroxisome proliferator-activated receptor α in rat Fao cells and stimulation by ciprofibrate

Biochemical Pharmacology

Volumn 58, Issue 6, 1999, Pages 1001-1008

  Passilly, Patricia ^a   Schohn, Hervé ^b   Jannin, Brigitte ^a   Cherkaoui Malki, Mustapha ^a   Boscoboinik, Daniel ^a   Dauça, Michel ^b   Latruffe, Norbert ^a  

^a UNIVERSITÉ DE BOURGOGNE   (France)

^b UNIVERSITÉ DE LORRAINE   (France)

Author keywords

Ciprofibrate stimulation; PPAR phosphorylation; Rat Fao cells

Indexed keywords

ACYL COENZYME A OXIDASE; ALKALINE PHOSPHATASE; CIPROFIBRATE; OKADAIC ACID; PEROXISOME PROLIFERATOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PHOSPHATE; PHOSPHOPROTEIN; PHOSPHORUS 32; PIRINIXIC ACID; RECEPTOR ANTIBODY; VANADATE SODIUM;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; GENE EXPRESSION; IMMUNOPRECIPITATION; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

ACYL-COA OXIDASE; ANIMALS; CELL LINE; CLOFIBRIC ACID; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; MICROBODIES; OXIDOREDUCTASES; PEROXISOME PROLIFERATORS; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS;

EID: 0032788431     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00182-3     Document Type: Article

References (39)

1. Issemann I., Green S. Activation of a member of the steroid receptor superfamily by peroxisome proliferators. Nature. 347:1990;645-650.
2. Lemberger T., Desvergne B., Wahli W. Peroxisome proliferator-activated receptor A nuclear receptor signaling pathway in lipid physiology . Annu Rev Cell Dev Biol. 12:1996;335-364.
3. Latruffe N., Vamecq J. Peroxisome proliferators and peroxisome proliferator-activated receptors (PPARs) as regulators of lipid metabolism. Biochimie. 79:1997;81-94.
4. Devchand P.R., Keller H., Peters J.M., Vasquez M., Gonzalez F.J., Wahli W. The PPAR alpha-leukotriene B4 pathway to inflammation control. Nature. 384:1996;39-43.
5. Forman B.M., Chen J., Evans R.M. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and γ Proc Natl Acad Sci USA. 94:1997;4312-4317.
6. Jackson S.P. Regulating transcription factor activity by phosphorylation. Trends Cell Biol. 2:1992;104-108.
7. Hu E., Kim J.B., Sarraf P., Spiegelman B.M. Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARγ Science. 274:1996;2100-2103.
8. Zhang B., Berger J., Zhou G.C., Elbrecht A., Biswas S., White-Carrington S., Szalkowski D., Moller D.E. Insulin and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor gamma. J Biol Chem. 271:1996;31771-31774.
9. Adams M., Reginato M.J., Shao D.L., Lazar M.A., Chatterjee V.K. Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site. J Biol Chem. 272:1997;5128-5132.
10. Camp H.S., Tafuri S.R. Regulation of peroxisome proliferator-activated receptor γ activity by mitogen-activated protein kinase. J Biol Chem. 272:1997;10811-10816.
11. Shalev A., Siegrist-Kaiser C.A., Yen P.M., Wahli W., Burger A.G., Chin W.W., Meier C.A. The peroxisome proliferator-activated receptor α is a phosphoprotein. Regulation by insulin. Endocrinology. 137:1996;4499-4502.
12. Brandes R., Arad R., Bar-Tana J. The induction of adipose conversion in 3T3-L1 cells is associated with early phosphorylation of a 60-kDa nuclear protein. FEBS Lett. 285:1991;63-65.
13. Orellana A., Hidalgo P.C., Morales M.N., Mezzano D., Bronfman M. Palmitoyl coenzyme A and the acyl coenzyme A thioester of the carcinogenic peroxisome proliferator ciprofibrate potentiate diacylglycerol-activated protein kinase C by decreasing the phosphatidylserine requirement of the enzyme. Eur J Biochem. 190:1990;57-62.
14. Orellana A., Holuigue L., Hidalgo P.C., Faundez V., Gonzalez A., Bronfman M. Ciprofibrate, a carcinogenic peroxisome proliferator, increases the phosphorylation of epidermal-growth-factor receptor in isolated rat hepatocytes. Eur J Biochem. 215:1993;903-906.
15. Motojima K., Goto S. A protein histidine kinase induced in rat liver by peroxisome proliferators. FEBS Lett. 319:1993;75-79.
16. Motojima K., Goto S. Histidyl phosphorylation and dephosphorylation of P36 in rat liver extract. J Biol Chem. 269:1994;9030-9037.
17. Motojima K., Passilly P., Jannin B., Latruffe N. Protein phosphorylation by peroxisome proliferators Species-specific stimulation of protein kinases and its role in PP-induced transcriptional activation . Ann New York Acad Sci. 804:1996;413-423.
18. Passilly P., Jannin B., Latruffe N. Influence of peroxisome proliferators on phosphoprotein levels in human and rat hepatic-derived cell lines. Eur J Biochem. 230:1995;316-321.
19. Keller H., Dreyer C., Medin J., Mahfoudi A., Ozato K., Wahli W. Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers. Proc Natl Acad Sci USA. 90:1993;2160-2164.
20. Deschatrette J., Weiss M. Characterization of differentiated and dedifferentiated clones of rat hepatoma. Biochimie. 56:1974;1603-1611.
21. Pitot H.C., Peraino C., Morse P.A., Potter V.R. Hepatoma in tissue culture compared with adapting liver in vivo. Natl Cancer Inst Monogr. 13:1964;229-245.
22. Braissant O., Foufelle F., Scotto C., Dauça M., Wahli W. Differential expression of peroxisome proliferator-activated receptors (PPARs) Tissue distribution of PPAR-α, -β, and -γ in the adult rat . Endocrinology. 137:1996;354-366.
23. Goodfriend T.L., Levine L., Fasman G.D. Antibodies to bradykinin and angiotensin A use of carbodiimides in immunology . Science. 144:1964;1344-1346.
24. Avrameas S. Coupling of enzymes to protein with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. Immunochemistry. 6:1969;43-52.
25. Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem. 73:1976;248-254.
26. Goedert M., Spillantini M.G., Cairns N.J., Crowther R.A. Tau proteins of Alzheimer-paired helical filaments Abnormal phosphorylation of all six brain isoforms . Neuron. 8:1992;159-168.
27. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
28. Brocard C., Es-Souni M., Ramirez L.C., Latruffe N., Bournot P. Stimulation of peroxisomal palmitoyl-CoA oxidase activity by ciprofibrate in hepatic cell lines Comparative studies in Fao, MH1C1 and HepG2 cells . Biol Cell. 77:1993;37-41.
29. Vamecq J. Fluorometric assay of peroxisomal oxidases. Anal Biochem. 186:1990;340-349.
30. Bayly A.C., French N.J., Dive C., Roberts R.A. Non-genotoxic hepatocarcinogenesis in vitro The Fao hepatoma line responds to peroxisome proliferators and retains the ability to undergo apoptosis . J Cell Sci. 104:1993;307-315.
31. Scotto C., Keller J.M., Schohn H., Dauça M. Comparative effects of clofibrate on peroxisomal enzymes of human (Hep EBNA2) and rat (Fao) hepatoma cell lines. Eur J Cell Biol. 66:1995;375-381.
32. Poirier H., Braissant O., Niot I., Wahli W., Besnard P. 9-cis-Retinoic acid enhances fatty acid-induced expression of the liver fatty acid-binding protein gene. FEBS Lett. 412:1997;480-484.
33. Tugwood J.D., Issemann I., Anderson R.G., Bundell K.R., McPheat W.L., Green S. The mouse peroxisome proliferator-activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl-CoA oxidase gene. EMBO J. 11:1992;433-439.
34. Dreyer C., Keller H., Mahfoudi A., Laudet V., Krey G., Wahli W. Positive regulation of the peroxisomal β-oxidation pathway by fatty acids through activation of peroxisome proliferator-activated receptors (PPAR). Biol Cell. 77:1993;67-76.
35. Aldridge T.C., Tugwood J.D., Green S. Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription. Biochem J. 306:1995;473-479.
36. Berger J., Bailey P., Biswas C., Cullinan C.A., Doebber T.W., Hayes N.S., Saperstein R., Smith R., Leibowitz M.D. Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor γ Binding and activation correlate with antidiabetic actions in db/db mice . Endocrinology. 137:1996;4189-4195.
37. Hertz R., Berman I., Keppler D., Bar-Tana J. Activation of gene transcription by prostacyclin analogues is mediated by the peroxisome proliferator-activated receptor (PPAR). Eur J Biochem. 235:1996;242-247.
38. Issemann I., Prince R.A., Tugwood J.D., Green S. The peroxisome proliferator-activated receptor Retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs . J Mol Endocrinol. 11:1993;37-49.
39. Ristow M., Muller-Wieland D., Pfeiffer A., Krone W., Kahn C.R. Obesity associated with a mutation in a genetic regulator of adipocyte differentiation. N Engl J Med. 339:1998;953-959.