-
1
-
-
0030297919
-
Adipogenesis and obesity: Rounding out the big picture
-
1 Spiegelman BM, Flier JS. Adipogenesis and obesity: rounding out the big picture. Cell 1996; 87: 377-89.
-
(1996)
Cell
, vol.87
, pp. 377-389
-
-
Spiegelman, B.M.1
Flier, J.S.2
-
2
-
-
0029773351
-
Transcription, adipocyte differentiation, and obesity
-
2 Auwerx J, Martin G, Guerre-Millo M, Staels B. Transcription, adipocyte differentiation, and obesity. J Mol Med 1996; 74: 347-52.
-
(1996)
J Mol Med
, vol.74
, pp. 347-352
-
-
Auwerx, J.1
Martin, G.2
Guerre-Millo, M.3
Staels, B.4
-
3
-
-
0029859099
-
Leptin: The tale of an obesity gene
-
3 Caro J, Sinha MK, Kolaczynski LW, Zhang PL, Considine RV. Leptin: the tale of an obesity gene. Diabetes 1996; 45: 1455-62.
-
(1996)
Diabetes
, vol.45
, pp. 1455-1462
-
-
Caro, J.1
Sinha, M.K.2
Kolaczynski, L.W.3
Zhang, P.L.4
Considine, R.V.5
-
4
-
-
0030467446
-
The ob protein (leptin) pathway -a link between adipose tissue mass and central neural networks
-
4 Campfield LA, Smith FJ, Burn P. The ob protein (leptin) pathway -a link between adipose tissue mass and central neural networks. Horm Metab Res 1996; 28: 619-32.
-
(1996)
Horm Metab Res
, vol.28
, pp. 619-632
-
-
Campfield, L.A.1
Smith, F.J.2
Burn, P.3
-
5
-
-
0030902584
-
Leptin expression and action: New experimental paradigms
-
5 Flier JS. Leptin expression and action: new experimental paradigms. Proc Natl Acad Sci USA 1997; 94: 4242-45.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 4242-4245
-
-
Flier, J.S.1
-
6
-
-
0030942844
-
The leptin receptor
-
6 Tartaglia L. The leptin receptor. J Biol Chem 1997; 272: 6093-96.
-
(1997)
J Biol Chem
, vol.272
, pp. 6093-6096
-
-
Tartaglia, L.1
-
7
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
7 Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425-32.
-
(1994)
Nature
, vol.372
, pp. 425-432
-
-
Zhang, Y.1
Proenca, R.2
Maffei, M.3
Barone, M.4
Leopold, L.5
Friedman, J.M.6
-
8
-
-
0029048408
-
Recombinant mouse OB protein; evidence for a peripheral signal linking adiposity and central neural networks
-
8 Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse OB protein; evidence for a peripheral signal linking adiposity and central neural networks. Science 1995; 269: 546-49.
-
(1995)
Science
, vol.269
, pp. 546-549
-
-
Campfield, L.A.1
Smith, F.J.2
Guisez, Y.3
Devos, R.4
Burn, P.5
-
9
-
-
0029073613
-
Weight-reducing effects of the plasma protein encoded by the obese gene
-
9 Halaas JL, Gajiwala KS, Maffei M, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995; 269: 543-46.
-
(1995)
Science
, vol.269
, pp. 543-546
-
-
Halaas, J.L.1
Gajiwala, K.S.2
Maffei, M.3
-
10
-
-
0029066265
-
Effect of the obese gene product on body weight regulation in ob/ob mice
-
10 Pelleymounter MA, Cullen MJ, Baker MB, et al. Effect of the obese gene product on body weight regulation in ob/ob mice. Science 1995; 269: 540-43.
-
(1995)
Science
, vol.269
, pp. 540-543
-
-
Pelleymounter, M.A.1
Cullen, M.J.2
Baker, M.B.3
-
11
-
-
0029098589
-
The role of neuropeptide Y in the antiobesity action of the obese gene product
-
11 Stephens TW, Basinski M, Bristow PK, et al. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 1995; 377: 530-32.
-
(1995)
Nature
, vol.377
, pp. 530-532
-
-
Stephens, T.W.1
Basinski, M.2
Bristow, P.K.3
-
12
-
-
0028825577
-
Recombinant ob protein reduces feeding and body weight in the ob/ob mouse
-
12 Weigle DS, Bukowski TR, Foster DC, et al. Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J Clin Invest 1995; 96: 2065-70.
-
(1995)
J Clin Invest
, vol.96
, pp. 2065-2070
-
-
Weigle, D.S.1
Bukowski, T.R.2
Foster, D.C.3
-
13
-
-
0029908857
-
Dissapearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy
-
13 Chen G, Koyama K, Yuan X, et al. Dissapearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy. Proc Natl Acad Sci USA 1996; 93: 14795-99.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 14795-14799
-
-
Chen, G.1
Koyama, K.2
Yuan, X.3
-
14
-
-
0029962467
-
Correction of obesity and diabetes in genetically obese mice by leptin gene therapy
-
14 Muzzin P, Eisensmith RC, Copeland KC, Woo SLC. Correction of obesity and diabetes in genetically obese mice by leptin gene therapy. Proc Natl Acad Sci USA 1996; 93: 14804-08.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 14804-14808
-
-
Muzzin, P.1
Eisensmith, R.C.2
Copeland, K.C.3
Woo, S.L.C.4
-
15
-
-
0030847432
-
Acute stimulation of glucose metabolism in mice by leptin treatment
-
15 Kamohara S, Burcelin R, Halaas JL, Friedman JM, Charron MJ. Acute stimulation of glucose metabolism in mice by leptin treatment. Nature 1997; 389: 379-77.
-
(1997)
Nature
, vol.389
, pp. 379-477
-
-
Kamohara, S.1
Burcelin, R.2
Halaas, J.L.3
Friedman, J.M.4
Charron, M.J.5
-
16
-
-
2442654859
-
Identification and expression cloning of a leptin receptor, OB-R
-
16 Tartaglia LA, Dembski M, Weng X, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995; 83: 1263-1271.
-
(1995)
Cell
, vol.83
, pp. 1263-1271
-
-
Tartaglia, L.A.1
Dembski, M.2
Weng, X.3
-
17
-
-
0030039272
-
Abnormal splicing of the leptin receptor in diabetic mice
-
17 Lee GH, Proenca R, Montez JM, et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996; 379: 632-35.
-
(1996)
Nature
, vol.379
, pp. 632-635
-
-
Lee, G.H.1
Proenca, R.2
Montez, J.M.3
-
18
-
-
13344259300
-
Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice
-
18 Chen H, Charlat O, Tartaglia LA, et al. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 1996; 84: 491-95.
-
(1996)
Cell
, vol.84
, pp. 491-495
-
-
Chen, H.1
Charlat, O.2
Tartaglia, L.A.3
-
19
-
-
0030046753
-
STATs: Signal transducers and activators of transcription
-
19 Ihle J. STATs: signal transducers and activators of transcription. Cell 1996; 84: 331-34.
-
(1996)
Cell
, vol.84
, pp. 331-334
-
-
Ihle, J.1
-
20
-
-
0030956390
-
The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line
-
20 Ghilardi N, Skoda RC. The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line. Mol Endocrinol 1997; 11: 393-399.
-
(1997)
Mol Endocrinol
, vol.11
, pp. 393-399
-
-
Ghilardi, N.1
Skoda, R.C.2
-
21
-
-
0029776030
-
The full length leptin receptor has signalling capabilities of interleukin 6-type receptors
-
21 Baumann H, Morella KK, White DW, et al. The full length leptin receptor has signalling capabilities of interleukin 6-type receptors. Proc Natl Acad Sci USA 1996; 93: 8374-78.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 8374-8378
-
-
Baumann, H.1
Morella, K.K.2
White, D.W.3
-
22
-
-
0030015417
-
Defective STAT signalling by the leptin receptor in diabetic mice
-
22 Ghilardi N, Ziegler S, Wiestner A, Stoffel R, Heim MH, Skoda RC. defective STAT signalling by the leptin receptor in diabetic mice. Proc Natl Acad Sci USA 1996; 93: 6231-35.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 6231-6235
-
-
Ghilardi, N.1
Ziegler, S.2
Wiestner, A.3
Stoffel, R.4
Heim, M.H.5
Skoda, R.C.6
-
23
-
-
0029739826
-
Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice
-
23 Vaisse C, Halaas JL, Horvath CM, Darnell JE, Stoffel M, Friedman JM. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat Genet 1996; 14: 95-97.
-
(1996)
Nat Genet
, vol.14
, pp. 95-97
-
-
Vaisse, C.1
Halaas, J.L.2
Horvath, C.M.3
Darnell, J.E.4
Stoffel, M.5
Friedman, J.M.6
-
24
-
-
0029900899
-
Reflections on STAT3, STAT5, and STAT6 as fat STATs
-
24 Darnell JE. Reflections on STAT3, STAT5, and STAT6 as fat STATs. Proc Natl Acad Sci USA 1996; 93: 6221-24.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 6221-6224
-
-
Darnell, J.E.1
-
25
-
-
0030028959
-
Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor
-
25 Chua SC, Chung WK, Wu-Peng S, et al. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 1996; 271: 994-96.
-
(1996)
Science
, vol.271
, pp. 994-996
-
-
Chua, S.C.1
Chung, W.K.2
Wu-Peng, S.3
-
26
-
-
0030137757
-
Leptin receptor missense mutations in the fatty Zucker rat
-
26 Philips MS, Liu Q, Hammond HA, et al. Leptin receptor missense mutations in the fatty Zucker rat. Nat Genet 1996; 13: 18-19.
-
(1996)
Nat Genet
, vol.13
, pp. 18-19
-
-
Philips, M.S.1
Liu, Q.2
Hammond, H.A.3
-
27
-
-
0029895421
-
Phenotype-linked amino acid alteration in leptin receptor cDNA from Zucker fatty (fa/fa) rat
-
27 Iida M, Murakami T, Ishida K, Mizuno A, Kuwajima M, Shima K. Phenotype-linked amino acid alteration in leptin receptor cDNA from Zucker fatty (fa/fa) rat. Biochem Biophys Res Commun 1996; 222: 19-26.
-
(1996)
Biochem Biophys Res Commun
, vol.222
, pp. 19-26
-
-
Iida, M.1
Murakami, T.2
Ishida, K.3
Mizuno, A.4
Kuwajima, M.5
Shima, K.6
-
28
-
-
0030570741
-
Molecular cloning of rat leptin receptor isoform complementary DNAs-identification of a missense mutation in Zucker fatty (fa/fa) rats
-
28 Takaya K, Ogawa Y, Isse N, et al. Molecular cloning of rat leptin receptor isoform complementary DNAs-identification of a missense mutation in Zucker fatty (fa/fa) rats. Biochem Biophys Res Commun 1996; 225: 75-83.
-
(1996)
Biochem Biophys Res Commun
, vol.225
, pp. 75-83
-
-
Takaya, K.1
Ogawa, Y.2
Isse, N.3
-
29
-
-
0030267744
-
Nonsense mutation of the leptin receptor in the obese spontaneously hypertensive Koletsky rat
-
29 Takaya K, Ogawa Y, Hiraoka J, et al. Nonsense mutation of the leptin receptor in the obese spontaneously hypertensive Koletsky rat. Nat Genet 1996; 14: 130-31.
-
(1996)
Nat Genet
, vol.14
, pp. 130-131
-
-
Takaya, K.1
Ogawa, Y.2
Hiraoka, J.3
-
31
-
-
0029864416
-
Leptin enters the brain by a saturable system independent of insulin
-
31 Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM. Leptin enters the brain by a saturable system independent of insulin. Peptides 1996; 17: 305-11.
-
(1996)
Peptides
, vol.17
, pp. 305-311
-
-
Banks, W.A.1
Kastin, A.J.2
Huang, W.3
Jaspan, J.B.4
Maness, L.M.5
-
32
-
-
0031017561
-
Human blood-barrier leptin receptor; binding and endocytosis in isolated human brain microvessels
-
32 Golden PL, Maccagnan TJ, Pardridge WM. Human blood-barrier leptin receptor; binding and endocytosis in isolated human brain microvessels. J Clin Invest 1997; 99: 14-18.
-
(1997)
J Clin Invest
, vol.99
, pp. 14-18
-
-
Golden, P.L.1
Maccagnan, T.J.2
Pardridge, W.M.3
-
33
-
-
0029804743
-
Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y
-
33 Erickson JC, Hollopeter G, Palmiter RD. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 1996; 274: 1704-07.
-
(1996)
Science
, vol.274
, pp. 1704-1707
-
-
Erickson, J.C.1
Hollopeter, G.2
Palmiter, R.D.3
-
34
-
-
0029946644
-
Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y
-
34 Erickson JC, Clegg KE, Palmiter RD. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 1996; 381: 415-18.
-
(1996)
Nature
, vol.381
, pp. 415-418
-
-
Erickson, J.C.1
Clegg, K.E.2
Palmiter, R.D.3
-
35
-
-
0030614331
-
Role of melanocotinergic neurons in feeding and the agouti obesity syndrome
-
35 Fan W, Boston BA, Kesterton RA, Hruby VJ, Cone RD. Role of melanocotinergic neurons in feeding and the agouti obesity syndrome. Nature 1996; 385: 165-68.
-
(1996)
Nature
, vol.385
, pp. 165-168
-
-
Fan, W.1
Boston, B.A.2
Kesterton, R.A.3
Hruby, V.J.4
Cone, R.D.5
-
36
-
-
0030889192
-
Targeted disruption of the melancocortin-4 receptor results in obesity in mice
-
36 Huszar D, Lynch CA, Fairchild-Huntress V, et al. Targeted disruption of the melancocortin-4 receptor results in obesity in mice. Cell 1997; 88: 131-41.
-
(1997)
Cell
, vol.88
, pp. 131-141
-
-
Huszar, D.1
Lynch, C.A.2
Fairchild-Huntress, V.3
-
37
-
-
13344282056
-
A role for glucagon-like peptide-1 in the central regulation of feeding
-
37 Turton MD, O'Shea D, Gunn I, et al. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 1996; 379: 69-72.
-
(1996)
Nature
, vol.379
, pp. 69-72
-
-
Turton, M.D.1
O'Shea, D.2
Gunn, I.3
-
38
-
-
0023767089
-
Effect of corticotropin-releasing factor on food intake and brown tissue thermogenesis in rats
-
38 Arase K, York DA, Shimizu H, Shargill N, Bray GA. Effect of corticotropin-releasing factor on food intake and brown tissue thermogenesis in rats. Am J Physiol 1988; 255: E255-E259.
-
(1988)
Am J Physiol
, vol.255
-
-
Arase, K.1
York, D.A.2
Shimizu, H.3
Shargill, N.4
Bray, G.A.5
-
39
-
-
0029741238
-
Appetite-suppressing effects of urocortin a CRF-related neuropeptide
-
39 Spina M, Merlo-Pich E, Chan RKW, et al. Appetite-suppressing effects of urocortin a CRF-related neuropeptide. Science 1996; 273: 1561-1564.
-
(1996)
Science
, vol.273
, pp. 1561-1564
-
-
Spina, M.1
Merlo-Pich, E.2
Chan, R.K.W.3
-
40
-
-
0028815089
-
Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need
-
40 Muglia L, Jacobson L, Dikkes P, Majzoub JA. Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. Nature 1995; 373: 427-32.
-
(1995)
Nature
, vol.373
, pp. 427-432
-
-
Muglia, L.1
Jacobson, L.2
Dikkes, P.3
Majzoub, J.A.4
-
41
-
-
13344279395
-
A role for melanin-concentrating hormone in the central regulation of feeding behaviour
-
41 Qu D, Ludwig DS, Gammeltoft S, et al. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 1996; 380: 243-47.
-
(1996)
Nature
, vol.380
, pp. 243-247
-
-
Qu, D.1
Ludwig, D.S.2
Gammeltoft, S.3
-
42
-
-
0029860791
-
Modulation of insulin activities by leptin
-
42 Cohen B, Novick D, Rubinstein M. Modulation of insulin activities by leptin. Science 1996; 274: 1185-88.
-
(1996)
Science
, vol.274
, pp. 1185-1188
-
-
Cohen, B.1
Novick, D.2
Rubinstein, M.3
-
43
-
-
15844410399
-
Obese gene expression alters the ability of 30A5 preadipocytes to respond to lipogenic hormones
-
43 Bai Y, Zhang S, Kim KS, Lee JK, Kim KH. Obese gene expression alters the ability of 30A5 preadipocytes to respond to lipogenic hormones. J Biol Chem 1996; 271: 13939-42.
-
(1996)
J Biol Chem
, vol.271
, pp. 13939-13942
-
-
Bai, Y.1
Zhang, S.2
Kim, K.S.3
Lee, J.K.4
Kim, K.H.5
-
44
-
-
0040381066
-
Leptin impairs metabolic actions of insulin in isolated rat adipocytes
-
44 Muller G, Ertl J, Gerl M, Preibisch G. Leptin impairs metabolic actions of insulin in isolated rat adipocytes. J Biol Chem 1997; 272: 10585-93.
-
(1997)
J Biol Chem
, vol.272
, pp. 10585-10593
-
-
Muller, G.1
Ertl, J.2
Gerl, M.3
Preibisch, G.4
-
45
-
-
0029952911
-
Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells
-
45 Gainsford T, Wilson TA, Metcalf D, et al. Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc Natl Acad Sci USA 1996; 93: 14564-68.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 14564-14568
-
-
Gainsford, T.1
Wilson, T.A.2
Metcalf, D.3
-
46
-
-
0030898516
-
Direct antidiabetic effect of leptin through triglyceride depletion of tissues
-
46 Shimabukuro M, Koyama K, Chen G, et al. Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci USA 1997; 94: 4637-41.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 4637-4641
-
-
Shimabukuro, M.1
Koyama, K.2
Chen, G.3
-
47
-
-
0029020677
-
Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity
-
47 Considine RV, Considine EL, Williams CJ, et al. Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. J Clin Invest 1995; 95: 2986-88.
-
(1995)
J Clin Invest
, vol.95
, pp. 2986-2988
-
-
Considine, R.V.1
Considine, E.L.2
Williams, C.J.3
-
48
-
-
15844373886
-
Absence of mutations in the human OB gene in obese/diabetic subjects
-
48 Maffei M, et al. Absence of mutations in the human OB gene in obese/diabetic subjects. Diabetes 1996; 45: 679-682.
-
(1996)
Diabetes
, vol.45
, pp. 679-682
-
-
Maffei, M.1
-
49
-
-
0029938057
-
Extreme obesity may be linked to markers flanking the human ob gene
-
49 Reed DR, Ding Y, Xu W, Cather C, Green ED, Price RA. Extreme obesity may be linked to markers flanking the human ob gene. Diabetes 1996; 45: 691-94.
-
(1996)
Diabetes
, vol.45
, pp. 691-694
-
-
Reed, D.R.1
Ding, Y.2
Xu, W.3
Cather, C.4
Green, E.D.5
Price, R.A.6
-
50
-
-
0029150525
-
Identification of microsatellite markers near the human ob gene and linkage studies in NIDDM-affected sib pairs
-
50 Stirling B, Cox NJ, Bell GI, Hanis CL, Spielman RS, Concannon P. Identification of microsatellite markers near the human ob gene and linkage studies in NIDDM-affected sib pairs. Diabetes 1995; 44: 999-1001.
-
(1995)
Diabetes
, vol.44
, pp. 999-1001
-
-
Stirling, B.1
Cox, N.J.2
Bell, G.I.3
Hanis, C.L.4
Spielman, R.S.5
Concannon, P.6
-
51
-
-
0345335191
-
Indication for linkage of the human ob gene region with extreme obesity
-
51 Clement K, Garner C, Hager J, et al. Indication for linkage of the human ob gene region with extreme obesity. Diabetes 1996; 45: 687-690.
-
(1996)
Diabetes
, vol.45
, pp. 687-690
-
-
Clement, K.1
Garner, C.2
Hager, J.3
-
52
-
-
0030878110
-
Congenital leptin deficiency is associated with severe early-onset obesity in humans
-
52 Montague CT, Farooqi IS, Whitehead JP, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997; 387: 903-908.
-
(1997)
Nature
, vol.387
, pp. 903-908
-
-
Montague, C.T.1
Farooqi, I.S.2
Whitehead, J.P.3
-
53
-
-
13344295079
-
Serum immunoreactive-leptin concentrations in normal-weight and obese humans
-
53 Considine RV, Sinha MK, Heiman ML, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996; 334: 292-95.
-
(1996)
N Engl J Med
, vol.334
, pp. 292-295
-
-
Considine, R.V.1
Sinha, M.K.2
Heiman, M.L.3
-
54
-
-
0028845877
-
Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
-
54 Maffei M, Halaas J, Ravussin E, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Med 1995; 1: 1155-1161.
-
(1995)
Nature Med
, vol.1
, pp. 1155-1161
-
-
Maffei, M.1
Halaas, J.2
Ravussin, E.3
-
55
-
-
0029050937
-
Overexpression of the obese (ob) gene in adipose tissue of human obese subjects
-
55 Lönnqvist F, Arner P, Nordfors L, Schalling M. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Med 1995; 1: 950-53.
-
(1995)
Nat Med
, vol.1
, pp. 950-953
-
-
Lönnqvist, F.1
Arner, P.2
Nordfors, L.3
Schalling, M.4
-
56
-
-
0029083859
-
Increased obese mRNA expression in omental fat cells from massively obese humans
-
56 Hamilton BS, Paglia D, Kwan AYM, Deitel M. Increased obese mRNA expression in omental fat cells from massively obese humans. Nat Med 1995; 1: 954-56.
-
(1995)
Nat Med
, vol.1
, pp. 954-956
-
-
Hamilton, B.S.1
Paglia, D.2
Kwan, A.Y.M.3
Deitel, M.4
-
57
-
-
0030055611
-
The expression of ob gene is not acutely regulated by insulin and fasting in human abdominal subcutaneous adipose tissue
-
57 Vidal H, Auboeuf D, De Vos P, et al. The expression of ob gene is not acutely regulated by insulin and fasting in human abdominal subcutaneous adipose tissue. J Clin Invest 1996; 98: 251-55.
-
(1996)
J Clin Invest
, vol.98
, pp. 251-255
-
-
Vidal, H.1
Auboeuf, D.2
De Vos, P.3
-
58
-
-
0030594830
-
Decreased cerebrospinal fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance
-
58 Caro JF, Kolaczynski JW, Nyce MR, et al. Decreased cerebrospinal fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 1996; 348: 159-61.
-
(1996)
Lancet
, vol.348
, pp. 159-161
-
-
Caro, J.F.1
Kolaczynski, J.W.2
Nyce, M.R.3
-
59
-
-
0029881125
-
Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
-
59 Schwartz M, Peskind E, Raskind M, Boyko EJ, Porte D. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat Med 1996; 2: 589-93.
-
(1996)
Nat Med
, vol.2
, pp. 589-593
-
-
Schwartz, M.1
Peskind, E.2
Raskind, M.3
Boyko, E.J.4
Porte, D.5
-
60
-
-
0030010388
-
Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
-
60 Chehab FF, Lim ME, Lu R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet 1996; 12: 318-20.
-
(1996)
Nat Genet
, vol.12
, pp. 318-320
-
-
Chehab, F.F.1
Lim, M.E.2
Lu, R.3
-
61
-
-
0031014413
-
Early onset of reproductive function in normal female mice treated with leptin
-
61 Chehab FF, Mounzih K, Lu R, Lin ME. Early onset of reproductive function in normal female mice treated with leptin. Science 1997; 275: 88-90.
-
(1997)
Science
, vol.275
, pp. 88-90
-
-
Chehab, F.F.1
Mounzih, K.2
Lu, R.3
Lin, M.E.4
-
62
-
-
0031057818
-
Leptin is a metabolic gate for the onset of puberty in the female rat
-
62 Cheung CC, Thornton JE, Kuijper JL, Weigle DS, Clifton DK, Steiner RA. Leptin is a metabolic gate for the onset of puberty in the female rat. Endocrinology 1997; 138: 855-88.
-
(1997)
Endocrinology
, vol.138
, pp. 855-888
-
-
Cheung, C.C.1
Thornton, J.E.2
Kuijper, J.L.3
Weigle, D.S.4
Clifton, D.K.5
Steiner, R.A.6
-
63
-
-
0029953957
-
Leptin is a signal to the reproductive system
-
63 Barash IA, Cheung CC, Weigle DS, et al. Leptin is a signal to the reproductive system. Endocrinology 1996; 137: 3144-47.
-
(1996)
Endocrinology
, vol.137
, pp. 3144-3147
-
-
Barash, I.A.1
Cheung, C.C.2
Weigle, D.S.3
-
64
-
-
0029896530
-
Role of leptin in the neuroendocrine response to fasting
-
64 Ahima RS, Prabakaran D, Mantzoros C, et al. Role of leptin in the neuroendocrine response to fasting. Nature 1996; 382: 250-52.
-
(1996)
Nature
, vol.382
, pp. 250-252
-
-
Ahima, R.S.1
Prabakaran, D.2
Mantzoros, C.3
-
65
-
-
0029131574
-
Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity
-
65 Frederich RC, Lollmann B, Hamann A, et al. Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. J Clin Invest 1995; 96: 1658-63.
-
(1995)
J Clin Invest
, vol.96
, pp. 1658-1663
-
-
Frederich, R.C.1
Lollmann, B.2
Hamann, A.3
-
66
-
-
0030866843
-
Non-adipose tissue production of leptin; leptin as a novel placenta-derived hormone in humans
-
66 Masuzaki H, Ogawa Y, Sagawa N, et al. Non-adipose tissue production of leptin; leptin as a novel placenta-derived hormone in humans. Nat Med 1997; 3: 1029-33.
-
(1997)
Nat Med
, vol.3
, pp. 1029-1033
-
-
Masuzaki, H.1
Ogawa, Y.2
Sagawa, N.3
-
67
-
-
0031050415
-
Relatively low plasma leptin concentrations precede weight gain in Pima Indians
-
67 Ravussin E, Pratley RE, Maffei M, et al. Relatively low plasma leptin concentrations precede weight gain in Pima Indians. Nat Med 1997; 3: 238-40.
-
(1997)
Nat Med
, vol.3
, pp. 238-240
-
-
Ravussin, E.1
Pratley, R.E.2
Maffei, M.3
-
68
-
-
0029822048
-
Leptin is cleared from the circulation primarily by the kidney
-
68 Cumin F, Baum HP. Leptin is cleared from the circulation primarily by the kidney. Int J Obes 1996; 20: 1120-26.
-
(1996)
Int J Obes
, vol.20
, pp. 1120-1126
-
-
Cumin, F.1
Baum, H.P.2
-
69
-
-
0031017938
-
Increased plasma leptin concentration in end-stage renal disease
-
69 Merabet E, Dagogo-Jack S, Coyne DW, et al. Increased plasma leptin concentration in end-stage renal disease. J Clin Endocrinol Metab 1997; 82: 847-50.
-
(1997)
J Clin Endocrinol Metab
, vol.82
, pp. 847-850
-
-
Merabet, E.1
Dagogo-Jack, S.2
Coyne, D.W.3
-
70
-
-
8244232511
-
Plasma leptin is partly cleared by the kidney and is elevated in hemodialysis patients
-
70 Sharma K, Considine RV, Michael B, et al. Plasma leptin is partly cleared by the kidney and is elevated in hemodialysis patients. Kidney Int 1997; 51: 1980-85.
-
(1997)
Kidney Int
, vol.51
, pp. 1980-1985
-
-
Sharma, K.1
Considine, R.V.2
Michael, B.3
-
71
-
-
0028641559
-
Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
-
71 Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell 1994; 79: 1147-56.
-
(1994)
Cell
, vol.79
, pp. 1147-1156
-
-
Tontonoz, P.1
Hu, E.2
Spiegelman, B.M.3
-
72
-
-
15844415080
-
Down-regulation of the expression of the obese gene by antidiabetic thiazolidinedione in Zucker diabetic fatty rats and db/db mice
-
72 Zhang B, Graziano MP, Doebber TW, et al. Down-regulation of the expression of the obese gene by antidiabetic thiazolidinedione in Zucker diabetic fatty rats and db/db mice. J Biol Chem 1996; 271: 9455-59.
-
(1996)
J Biol Chem
, vol.271
, pp. 9455-9459
-
-
Zhang, B.1
Graziano, M.P.2
Doebber, T.W.3
-
73
-
-
0000113890
-
Thiazolidinediones repress ob gene expresson via activation of PPARγ
-
73 De Vos P, Lefebvre AM, Miller SG, et al. Thiazolidinediones repress ob gene expresson via activation of PPARγ. J Clin Invest 1996; 98: 1004-09.
-
(1996)
J Clin Invest
, vol.98
, pp. 1004-1009
-
-
De Vos, P.1
Lefebvre, A.M.2
Miller, S.G.3
-
74
-
-
0029894050
-
Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes
-
74 Kallen CB, Lazar MA. Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes. Proc Natl Acad Sci USA 1996; 93: 5793-96.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 5793-5796
-
-
Kallen, C.B.1
Lazar, M.A.2
-
75
-
-
0029795431
-
Effect of troglitazone on leptin production: Studies in vitro and in human subjects
-
75 Nolan JJ, Olefsky JM, Nyce MR, Considine RV, Caro JF. Effect of troglitazone on leptin production: studies in vitro and in human subjects. Diabetes 1996; 45: 1276-78.
-
(1996)
Diabetes
, vol.45
, pp. 1276-1278
-
-
Nolan, J.J.1
Olefsky, J.M.2
Nyce, M.R.3
Considine, R.V.4
Caro, J.F.5
-
76
-
-
0029863684
-
Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters: A role for leptin in the anorexia of infection
-
76 Grunfeld C, Zhao C, Fuller J, et al. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters: a role for leptin in the anorexia of infection. J Clin Invest 1996; 97: 2152-57.
-
(1996)
J Clin Invest
, vol.97
, pp. 2152-2157
-
-
Grunfeld, C.1
Zhao, C.2
Fuller, J.3
-
77
-
-
0029021599
-
Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake
-
77 De Vos P, Saladin R, Auwerx J, Staels B. Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. J Biol Chem 1995; 270: 15958-61.
-
(1995)
J Biol Chem
, vol.270
, pp. 15958-15961
-
-
De Vos, P.1
Saladin, R.2
Auwerx, J.3
Staels, B.4
-
78
-
-
0029972928
-
The adipocyte specific transcription factor, C/EBPa modulates human ob gene expression
-
78 Miller SG, De Vos P, Guerre-Millo M, et al. The adipocyte specific transcription factor, C/EBPa modulates human ob gene expression. Proc Natl Acad Sci USA 1996; 93: 5507-11.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 5507-5511
-
-
Miller, S.G.1
De Vos, P.2
Guerre-Millo, M.3
-
79
-
-
0028849084
-
The mouse obese gene. Genomic organization, promoter activity, and activation by CCAAT/enhancer-binding protein alpha
-
79 He Y, Chen H, Quon MJ, Reitman M. The mouse obese gene. Genomic organization, promoter activity, and activation by CCAAT/enhancer-binding protein alpha. J Biol Chem 1995; 270: 28887-91.
-
(1995)
J Biol Chem
, vol.270
, pp. 28887-28891
-
-
He, Y.1
Chen, H.2
Quon, M.J.3
Reitman, M.4
-
80
-
-
0031051523
-
Functional antagonism between CCAAT/enhancer binding protein-α and peroxisome proliferator-activated receptor-γ on the leptin promoter
-
80 Hollenberg AN, Susulic VS, Madura JP, et al. Functional antagonism between CCAAT/enhancer binding protein-α and peroxisome proliferator-activated receptor-γ on the leptin promoter. J Biol Chem 1997; 272: 5283-90.
-
(1997)
J Biol Chem
, vol.272
, pp. 5283-5290
-
-
Hollenberg, A.N.1
Susulic, V.S.2
Madura, J.P.3
-
81
-
-
0030458404
-
Negative regulation of peroxisome proliferator-activated receptor-γ gene expression contributes to the adipogenic effect of tumor necrosis factor-α
-
81 Zhang B, Berger J, Hu E, et al. Negative regulation of peroxisome proliferator-activated receptor-γ gene expression contributes to the adipogenic effect of tumor necrosis factor-α. Mol Endocrinol 1996; 10: 1457-66.
-
(1996)
Mol Endocrinol
, vol.10
, pp. 1457-1466
-
-
Zhang, B.1
Berger, J.2
Hu, E.3
-
82
-
-
0031017322
-
A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2
-
82 Comuzzie AG, Hixson JE, Almasy L, et al. A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2. Nat Genet 1997; 15: 273-76.
-
(1997)
Nat Genet
, vol.15
, pp. 273-276
-
-
Comuzzie, A.G.1
Hixson, J.E.2
Almasy, L.3
-
84
-
-
0029157428
-
Transient increase in obese gene expression after food intake and insulin administration
-
84 Saladin R, De Vos P, Guerre-Millo M, et al. Transient increase in obese gene expression after food intake and insulin administration. Nature 1995; 377: 527-29.
-
(1995)
Nature
, vol.377
, pp. 527-529
-
-
Saladin, R.1
De Vos, P.2
Guerre-Millo, M.3
-
85
-
-
0029078449
-
Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes
-
85 MacDougold OA, Hwang CS, Fan H, Lane MD. Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes. Proc Natl Acad Sci USA 1995; 92: 9034-37.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 9034-9037
-
-
MacDougold, O.A.1
Hwang, C.S.2
Fan, H.3
Lane, M.D.4
-
86
-
-
0029166158
-
Effect of fasting and refeeding on ob gene expression in white adipose tissue of lean and (ob/ob) mice
-
86 Trayhurn P, Thomas MEA, Duncan JS, Rayner VD. Effect of fasting and refeeding on ob gene expression in white adipose tissue of lean and (ob/ob) mice. FEBS Lett 1995; 368: 488-90.
-
(1995)
FEBS Lett
, vol.368
, pp. 488-490
-
-
Trayhurn, P.1
Thomas, M.E.A.2
Duncan, J.S.3
Rayner, V.D.4
-
87
-
-
0029102059
-
Modulation of obese gene expression in rat brown and white adipose tissues
-
87 Moinat M, Deng C, Muzzin P, et al. Modulation of obese gene expression in rat brown and white adipose tissues. FEBS Lett 1995; 373: 131-34.
-
(1995)
FEBS Lett
, vol.373
, pp. 131-134
-
-
Moinat, M.1
Deng, C.2
Muzzin, P.3
-
88
-
-
0029062839
-
Transcriptional regulation of gene expression during adipocyte differentiation
-
88 MacDougald O, Lane D. Transcriptional regulation of gene expression during adipocyte differentiation. Ann Rev Biochem 1995; 64: 345-73.
-
(1995)
Ann Rev Biochem
, vol.64
, pp. 345-373
-
-
MacDougald, O.1
Lane, D.2
-
89
-
-
0030063976
-
Expression of ob gene in adipose cells: Regulation by insulin
-
89 Leroy P, Dessolin S, Villageois P, et al. Expression of ob gene in adipose cells: regulation by insulin. J Biol Chem 1996; 271: 2365-68.
-
(1996)
J Biol Chem
, vol.271
, pp. 2365-2368
-
-
Leroy, P.1
Dessolin, S.2
Villageois, P.3
-
90
-
-
0029964871
-
Response of leptin to short term fasting and refeeding in humans
-
90 Kolaczynski JW, Considine RV, Ohannesian J, et al. Response of leptin to short term fasting and refeeding in humans. Diabetes 1996; 45: 1511-15.
-
(1996)
Diabetes
, vol.45
, pp. 1511-1515
-
-
Kolaczynski, J.W.1
Considine, R.V.2
Ohannesian, J.3
-
92
-
-
0029794957
-
Response of leptin to short-term and prolonged overfeeding in humans
-
92 Kolaczynski JW, Ohannesian JP, Considine RV, Marco CC, Caro JF. Response of leptin to short-term and prolonged overfeeding in humans. J Clin Endocrinol Metab 1996; 81: 4162-65.
-
(1996)
J Clin Endocrinol Metab
, vol.81
, pp. 4162-4165
-
-
Kolaczynski, J.W.1
Ohannesian, J.P.2
Considine, R.V.3
Marco, C.C.4
Caro, J.F.5
-
93
-
-
10144245924
-
Insulin and cortisol promote leptin prodution in cultured human fat cells
-
93 Wabitsch M, Jensen PB, Blum WF, et al. Insulin and cortisol promote leptin prodution in cultured human fat cells. Diabetes 1996; 45: 1435-38.
-
(1996)
Diabetes
, vol.45
, pp. 1435-1438
-
-
Wabitsch, M.1
Jensen, P.B.2
Blum, W.F.3
-
94
-
-
0029924714
-
Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM
-
94 Malmstrom R, Taskinen MR, Karonen SL, Yki-Jarvinen H. Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM. Diabetologia 1996; 39: 993-96.
-
(1996)
Diabetologia
, vol.39
, pp. 993-996
-
-
Malmstrom, R.1
Taskinen, M.R.2
Karonen, S.L.3
Yki-Jarvinen, H.4
-
95
-
-
0031031624
-
UKPDS 20: Plasma leptin, obesity, and plasma insulin in type 2 diabetic subjects
-
95 Widjaja A, Stratton IM, Horn R, Holman RR, Turner R, Brabant G. UKPDS 20: plasma leptin, obesity, and plasma insulin in type 2 diabetic subjects. J Clin Endocrinol Metab 1997; 82: 654-57.
-
(1997)
J Clin Endocrinol Metab
, vol.82
, pp. 654-657
-
-
Widjaja, A.1
Stratton, I.M.2
Horn, R.3
Holman, R.R.4
Turner, R.5
Brabant, G.6
-
96
-
-
0010572211
-
The increase in serum leptin levels after food intake is correlated with insulin levels in normal subjects
-
submitted
-
96 Dallongeville J, Le Fur C, Lebel P, et al. The increase in serum leptin levels after food intake is correlated with insulin levels in normal subjects. Diabetes 1997; (submitted).
-
(1997)
Diabetes
-
-
Dallongeville, J.1
Le Fur, C.2
Lebel, P.3
|