메뉴 건너뛰기




Volumn 351, Issue 9104, 1998, Pages 737-742

Leptin

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; LEPTIN RECEPTOR;

EID: 0032492453     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(97)06348-4     Document Type: Review
Times cited : (532)

References (96)
  • 1
    • 0030297919 scopus 로고    scopus 로고
    • Adipogenesis and obesity: Rounding out the big picture
    • 1 Spiegelman BM, Flier JS. Adipogenesis and obesity: rounding out the big picture. Cell 1996; 87: 377-89.
    • (1996) Cell , vol.87 , pp. 377-389
    • Spiegelman, B.M.1    Flier, J.S.2
  • 2
    • 0029773351 scopus 로고    scopus 로고
    • Transcription, adipocyte differentiation, and obesity
    • 2 Auwerx J, Martin G, Guerre-Millo M, Staels B. Transcription, adipocyte differentiation, and obesity. J Mol Med 1996; 74: 347-52.
    • (1996) J Mol Med , vol.74 , pp. 347-352
    • Auwerx, J.1    Martin, G.2    Guerre-Millo, M.3    Staels, B.4
  • 4
    • 0030467446 scopus 로고    scopus 로고
    • The ob protein (leptin) pathway -a link between adipose tissue mass and central neural networks
    • 4 Campfield LA, Smith FJ, Burn P. The ob protein (leptin) pathway -a link between adipose tissue mass and central neural networks. Horm Metab Res 1996; 28: 619-32.
    • (1996) Horm Metab Res , vol.28 , pp. 619-632
    • Campfield, L.A.1    Smith, F.J.2    Burn, P.3
  • 5
    • 0030902584 scopus 로고    scopus 로고
    • Leptin expression and action: New experimental paradigms
    • 5 Flier JS. Leptin expression and action: new experimental paradigms. Proc Natl Acad Sci USA 1997; 94: 4242-45.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4242-4245
    • Flier, J.S.1
  • 6
    • 0030942844 scopus 로고    scopus 로고
    • The leptin receptor
    • 6 Tartaglia L. The leptin receptor. J Biol Chem 1997; 272: 6093-96.
    • (1997) J Biol Chem , vol.272 , pp. 6093-6096
    • Tartaglia, L.1
  • 8
    • 0029048408 scopus 로고
    • Recombinant mouse OB protein; evidence for a peripheral signal linking adiposity and central neural networks
    • 8 Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse OB protein; evidence for a peripheral signal linking adiposity and central neural networks. Science 1995; 269: 546-49.
    • (1995) Science , vol.269 , pp. 546-549
    • Campfield, L.A.1    Smith, F.J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 9
    • 0029073613 scopus 로고
    • Weight-reducing effects of the plasma protein encoded by the obese gene
    • 9 Halaas JL, Gajiwala KS, Maffei M, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995; 269: 543-46.
    • (1995) Science , vol.269 , pp. 543-546
    • Halaas, J.L.1    Gajiwala, K.S.2    Maffei, M.3
  • 10
    • 0029066265 scopus 로고
    • Effect of the obese gene product on body weight regulation in ob/ob mice
    • 10 Pelleymounter MA, Cullen MJ, Baker MB, et al. Effect of the obese gene product on body weight regulation in ob/ob mice. Science 1995; 269: 540-43.
    • (1995) Science , vol.269 , pp. 540-543
    • Pelleymounter, M.A.1    Cullen, M.J.2    Baker, M.B.3
  • 11
    • 0029098589 scopus 로고
    • The role of neuropeptide Y in the antiobesity action of the obese gene product
    • 11 Stephens TW, Basinski M, Bristow PK, et al. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 1995; 377: 530-32.
    • (1995) Nature , vol.377 , pp. 530-532
    • Stephens, T.W.1    Basinski, M.2    Bristow, P.K.3
  • 12
    • 0028825577 scopus 로고
    • Recombinant ob protein reduces feeding and body weight in the ob/ob mouse
    • 12 Weigle DS, Bukowski TR, Foster DC, et al. Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J Clin Invest 1995; 96: 2065-70.
    • (1995) J Clin Invest , vol.96 , pp. 2065-2070
    • Weigle, D.S.1    Bukowski, T.R.2    Foster, D.C.3
  • 13
    • 0029908857 scopus 로고    scopus 로고
    • Dissapearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy
    • 13 Chen G, Koyama K, Yuan X, et al. Dissapearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy. Proc Natl Acad Sci USA 1996; 93: 14795-99.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 14795-14799
    • Chen, G.1    Koyama, K.2    Yuan, X.3
  • 14
    • 0029962467 scopus 로고    scopus 로고
    • Correction of obesity and diabetes in genetically obese mice by leptin gene therapy
    • 14 Muzzin P, Eisensmith RC, Copeland KC, Woo SLC. Correction of obesity and diabetes in genetically obese mice by leptin gene therapy. Proc Natl Acad Sci USA 1996; 93: 14804-08.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 14804-14808
    • Muzzin, P.1    Eisensmith, R.C.2    Copeland, K.C.3    Woo, S.L.C.4
  • 16
    • 2442654859 scopus 로고
    • Identification and expression cloning of a leptin receptor, OB-R
    • 16 Tartaglia LA, Dembski M, Weng X, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995; 83: 1263-1271.
    • (1995) Cell , vol.83 , pp. 1263-1271
    • Tartaglia, L.A.1    Dembski, M.2    Weng, X.3
  • 17
    • 0030039272 scopus 로고    scopus 로고
    • Abnormal splicing of the leptin receptor in diabetic mice
    • 17 Lee GH, Proenca R, Montez JM, et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996; 379: 632-35.
    • (1996) Nature , vol.379 , pp. 632-635
    • Lee, G.H.1    Proenca, R.2    Montez, J.M.3
  • 18
    • 13344259300 scopus 로고    scopus 로고
    • Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice
    • 18 Chen H, Charlat O, Tartaglia LA, et al. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 1996; 84: 491-95.
    • (1996) Cell , vol.84 , pp. 491-495
    • Chen, H.1    Charlat, O.2    Tartaglia, L.A.3
  • 19
    • 0030046753 scopus 로고    scopus 로고
    • STATs: Signal transducers and activators of transcription
    • 19 Ihle J. STATs: signal transducers and activators of transcription. Cell 1996; 84: 331-34.
    • (1996) Cell , vol.84 , pp. 331-334
    • Ihle, J.1
  • 20
    • 0030956390 scopus 로고    scopus 로고
    • The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line
    • 20 Ghilardi N, Skoda RC. The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line. Mol Endocrinol 1997; 11: 393-399.
    • (1997) Mol Endocrinol , vol.11 , pp. 393-399
    • Ghilardi, N.1    Skoda, R.C.2
  • 21
    • 0029776030 scopus 로고    scopus 로고
    • The full length leptin receptor has signalling capabilities of interleukin 6-type receptors
    • 21 Baumann H, Morella KK, White DW, et al. The full length leptin receptor has signalling capabilities of interleukin 6-type receptors. Proc Natl Acad Sci USA 1996; 93: 8374-78.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 8374-8378
    • Baumann, H.1    Morella, K.K.2    White, D.W.3
  • 23
    • 0029739826 scopus 로고    scopus 로고
    • Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice
    • 23 Vaisse C, Halaas JL, Horvath CM, Darnell JE, Stoffel M, Friedman JM. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat Genet 1996; 14: 95-97.
    • (1996) Nat Genet , vol.14 , pp. 95-97
    • Vaisse, C.1    Halaas, J.L.2    Horvath, C.M.3    Darnell, J.E.4    Stoffel, M.5    Friedman, J.M.6
  • 24
    • 0029900899 scopus 로고    scopus 로고
    • Reflections on STAT3, STAT5, and STAT6 as fat STATs
    • 24 Darnell JE. Reflections on STAT3, STAT5, and STAT6 as fat STATs. Proc Natl Acad Sci USA 1996; 93: 6221-24.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 6221-6224
    • Darnell, J.E.1
  • 25
    • 0030028959 scopus 로고    scopus 로고
    • Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor
    • 25 Chua SC, Chung WK, Wu-Peng S, et al. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 1996; 271: 994-96.
    • (1996) Science , vol.271 , pp. 994-996
    • Chua, S.C.1    Chung, W.K.2    Wu-Peng, S.3
  • 26
    • 0030137757 scopus 로고    scopus 로고
    • Leptin receptor missense mutations in the fatty Zucker rat
    • 26 Philips MS, Liu Q, Hammond HA, et al. Leptin receptor missense mutations in the fatty Zucker rat. Nat Genet 1996; 13: 18-19.
    • (1996) Nat Genet , vol.13 , pp. 18-19
    • Philips, M.S.1    Liu, Q.2    Hammond, H.A.3
  • 28
    • 0030570741 scopus 로고    scopus 로고
    • Molecular cloning of rat leptin receptor isoform complementary DNAs-identification of a missense mutation in Zucker fatty (fa/fa) rats
    • 28 Takaya K, Ogawa Y, Isse N, et al. Molecular cloning of rat leptin receptor isoform complementary DNAs-identification of a missense mutation in Zucker fatty (fa/fa) rats. Biochem Biophys Res Commun 1996; 225: 75-83.
    • (1996) Biochem Biophys Res Commun , vol.225 , pp. 75-83
    • Takaya, K.1    Ogawa, Y.2    Isse, N.3
  • 29
    • 0030267744 scopus 로고    scopus 로고
    • Nonsense mutation of the leptin receptor in the obese spontaneously hypertensive Koletsky rat
    • 29 Takaya K, Ogawa Y, Hiraoka J, et al. Nonsense mutation of the leptin receptor in the obese spontaneously hypertensive Koletsky rat. Nat Genet 1996; 14: 130-31.
    • (1996) Nat Genet , vol.14 , pp. 130-131
    • Takaya, K.1    Ogawa, Y.2    Hiraoka, J.3
  • 30
    • 0029739970 scopus 로고    scopus 로고
    • Identification of targets of leptin action in rat hypothalamus
    • 30 Schwartz MW, Seeley RJ, Campfield LA, Burn P. Identification of targets of leptin action in rat hypothalamus. J Clin Invest 1996; 98: 1101-06.
    • (1996) J Clin Invest , vol.98 , pp. 1101-1106
    • Schwartz, M.W.1    Seeley, R.J.2    Campfield, L.A.3    Burn, P.4
  • 31
    • 0029864416 scopus 로고    scopus 로고
    • Leptin enters the brain by a saturable system independent of insulin
    • 31 Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM. Leptin enters the brain by a saturable system independent of insulin. Peptides 1996; 17: 305-11.
    • (1996) Peptides , vol.17 , pp. 305-311
    • Banks, W.A.1    Kastin, A.J.2    Huang, W.3    Jaspan, J.B.4    Maness, L.M.5
  • 32
    • 0031017561 scopus 로고    scopus 로고
    • Human blood-barrier leptin receptor; binding and endocytosis in isolated human brain microvessels
    • 32 Golden PL, Maccagnan TJ, Pardridge WM. Human blood-barrier leptin receptor; binding and endocytosis in isolated human brain microvessels. J Clin Invest 1997; 99: 14-18.
    • (1997) J Clin Invest , vol.99 , pp. 14-18
    • Golden, P.L.1    Maccagnan, T.J.2    Pardridge, W.M.3
  • 33
    • 0029804743 scopus 로고    scopus 로고
    • Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y
    • 33 Erickson JC, Hollopeter G, Palmiter RD. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 1996; 274: 1704-07.
    • (1996) Science , vol.274 , pp. 1704-1707
    • Erickson, J.C.1    Hollopeter, G.2    Palmiter, R.D.3
  • 34
    • 0029946644 scopus 로고    scopus 로고
    • Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y
    • 34 Erickson JC, Clegg KE, Palmiter RD. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 1996; 381: 415-18.
    • (1996) Nature , vol.381 , pp. 415-418
    • Erickson, J.C.1    Clegg, K.E.2    Palmiter, R.D.3
  • 35
    • 0030614331 scopus 로고    scopus 로고
    • Role of melanocotinergic neurons in feeding and the agouti obesity syndrome
    • 35 Fan W, Boston BA, Kesterton RA, Hruby VJ, Cone RD. Role of melanocotinergic neurons in feeding and the agouti obesity syndrome. Nature 1996; 385: 165-68.
    • (1996) Nature , vol.385 , pp. 165-168
    • Fan, W.1    Boston, B.A.2    Kesterton, R.A.3    Hruby, V.J.4    Cone, R.D.5
  • 36
    • 0030889192 scopus 로고    scopus 로고
    • Targeted disruption of the melancocortin-4 receptor results in obesity in mice
    • 36 Huszar D, Lynch CA, Fairchild-Huntress V, et al. Targeted disruption of the melancocortin-4 receptor results in obesity in mice. Cell 1997; 88: 131-41.
    • (1997) Cell , vol.88 , pp. 131-141
    • Huszar, D.1    Lynch, C.A.2    Fairchild-Huntress, V.3
  • 37
    • 13344282056 scopus 로고    scopus 로고
    • A role for glucagon-like peptide-1 in the central regulation of feeding
    • 37 Turton MD, O'Shea D, Gunn I, et al. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 1996; 379: 69-72.
    • (1996) Nature , vol.379 , pp. 69-72
    • Turton, M.D.1    O'Shea, D.2    Gunn, I.3
  • 38
    • 0023767089 scopus 로고
    • Effect of corticotropin-releasing factor on food intake and brown tissue thermogenesis in rats
    • 38 Arase K, York DA, Shimizu H, Shargill N, Bray GA. Effect of corticotropin-releasing factor on food intake and brown tissue thermogenesis in rats. Am J Physiol 1988; 255: E255-E259.
    • (1988) Am J Physiol , vol.255
    • Arase, K.1    York, D.A.2    Shimizu, H.3    Shargill, N.4    Bray, G.A.5
  • 39
    • 0029741238 scopus 로고    scopus 로고
    • Appetite-suppressing effects of urocortin a CRF-related neuropeptide
    • 39 Spina M, Merlo-Pich E, Chan RKW, et al. Appetite-suppressing effects of urocortin a CRF-related neuropeptide. Science 1996; 273: 1561-1564.
    • (1996) Science , vol.273 , pp. 1561-1564
    • Spina, M.1    Merlo-Pich, E.2    Chan, R.K.W.3
  • 40
    • 0028815089 scopus 로고
    • Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need
    • 40 Muglia L, Jacobson L, Dikkes P, Majzoub JA. Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. Nature 1995; 373: 427-32.
    • (1995) Nature , vol.373 , pp. 427-432
    • Muglia, L.1    Jacobson, L.2    Dikkes, P.3    Majzoub, J.A.4
  • 41
    • 13344279395 scopus 로고    scopus 로고
    • A role for melanin-concentrating hormone in the central regulation of feeding behaviour
    • 41 Qu D, Ludwig DS, Gammeltoft S, et al. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 1996; 380: 243-47.
    • (1996) Nature , vol.380 , pp. 243-247
    • Qu, D.1    Ludwig, D.S.2    Gammeltoft, S.3
  • 42
    • 0029860791 scopus 로고    scopus 로고
    • Modulation of insulin activities by leptin
    • 42 Cohen B, Novick D, Rubinstein M. Modulation of insulin activities by leptin. Science 1996; 274: 1185-88.
    • (1996) Science , vol.274 , pp. 1185-1188
    • Cohen, B.1    Novick, D.2    Rubinstein, M.3
  • 43
    • 15844410399 scopus 로고    scopus 로고
    • Obese gene expression alters the ability of 30A5 preadipocytes to respond to lipogenic hormones
    • 43 Bai Y, Zhang S, Kim KS, Lee JK, Kim KH. Obese gene expression alters the ability of 30A5 preadipocytes to respond to lipogenic hormones. J Biol Chem 1996; 271: 13939-42.
    • (1996) J Biol Chem , vol.271 , pp. 13939-13942
    • Bai, Y.1    Zhang, S.2    Kim, K.S.3    Lee, J.K.4    Kim, K.H.5
  • 44
    • 0040381066 scopus 로고    scopus 로고
    • Leptin impairs metabolic actions of insulin in isolated rat adipocytes
    • 44 Muller G, Ertl J, Gerl M, Preibisch G. Leptin impairs metabolic actions of insulin in isolated rat adipocytes. J Biol Chem 1997; 272: 10585-93.
    • (1997) J Biol Chem , vol.272 , pp. 10585-10593
    • Muller, G.1    Ertl, J.2    Gerl, M.3    Preibisch, G.4
  • 45
    • 0029952911 scopus 로고    scopus 로고
    • Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells
    • 45 Gainsford T, Wilson TA, Metcalf D, et al. Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc Natl Acad Sci USA 1996; 93: 14564-68.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 14564-14568
    • Gainsford, T.1    Wilson, T.A.2    Metcalf, D.3
  • 46
    • 0030898516 scopus 로고    scopus 로고
    • Direct antidiabetic effect of leptin through triglyceride depletion of tissues
    • 46 Shimabukuro M, Koyama K, Chen G, et al. Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci USA 1997; 94: 4637-41.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4637-4641
    • Shimabukuro, M.1    Koyama, K.2    Chen, G.3
  • 47
    • 0029020677 scopus 로고
    • Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity
    • 47 Considine RV, Considine EL, Williams CJ, et al. Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. J Clin Invest 1995; 95: 2986-88.
    • (1995) J Clin Invest , vol.95 , pp. 2986-2988
    • Considine, R.V.1    Considine, E.L.2    Williams, C.J.3
  • 48
    • 15844373886 scopus 로고    scopus 로고
    • Absence of mutations in the human OB gene in obese/diabetic subjects
    • 48 Maffei M, et al. Absence of mutations in the human OB gene in obese/diabetic subjects. Diabetes 1996; 45: 679-682.
    • (1996) Diabetes , vol.45 , pp. 679-682
    • Maffei, M.1
  • 49
    • 0029938057 scopus 로고    scopus 로고
    • Extreme obesity may be linked to markers flanking the human ob gene
    • 49 Reed DR, Ding Y, Xu W, Cather C, Green ED, Price RA. Extreme obesity may be linked to markers flanking the human ob gene. Diabetes 1996; 45: 691-94.
    • (1996) Diabetes , vol.45 , pp. 691-694
    • Reed, D.R.1    Ding, Y.2    Xu, W.3    Cather, C.4    Green, E.D.5    Price, R.A.6
  • 50
    • 0029150525 scopus 로고
    • Identification of microsatellite markers near the human ob gene and linkage studies in NIDDM-affected sib pairs
    • 50 Stirling B, Cox NJ, Bell GI, Hanis CL, Spielman RS, Concannon P. Identification of microsatellite markers near the human ob gene and linkage studies in NIDDM-affected sib pairs. Diabetes 1995; 44: 999-1001.
    • (1995) Diabetes , vol.44 , pp. 999-1001
    • Stirling, B.1    Cox, N.J.2    Bell, G.I.3    Hanis, C.L.4    Spielman, R.S.5    Concannon, P.6
  • 51
    • 0345335191 scopus 로고    scopus 로고
    • Indication for linkage of the human ob gene region with extreme obesity
    • 51 Clement K, Garner C, Hager J, et al. Indication for linkage of the human ob gene region with extreme obesity. Diabetes 1996; 45: 687-690.
    • (1996) Diabetes , vol.45 , pp. 687-690
    • Clement, K.1    Garner, C.2    Hager, J.3
  • 52
    • 0030878110 scopus 로고    scopus 로고
    • Congenital leptin deficiency is associated with severe early-onset obesity in humans
    • 52 Montague CT, Farooqi IS, Whitehead JP, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997; 387: 903-908.
    • (1997) Nature , vol.387 , pp. 903-908
    • Montague, C.T.1    Farooqi, I.S.2    Whitehead, J.P.3
  • 53
    • 13344295079 scopus 로고    scopus 로고
    • Serum immunoreactive-leptin concentrations in normal-weight and obese humans
    • 53 Considine RV, Sinha MK, Heiman ML, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996; 334: 292-95.
    • (1996) N Engl J Med , vol.334 , pp. 292-295
    • Considine, R.V.1    Sinha, M.K.2    Heiman, M.L.3
  • 54
    • 0028845877 scopus 로고
    • Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
    • 54 Maffei M, Halaas J, Ravussin E, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Med 1995; 1: 1155-1161.
    • (1995) Nature Med , vol.1 , pp. 1155-1161
    • Maffei, M.1    Halaas, J.2    Ravussin, E.3
  • 55
    • 0029050937 scopus 로고
    • Overexpression of the obese (ob) gene in adipose tissue of human obese subjects
    • 55 Lönnqvist F, Arner P, Nordfors L, Schalling M. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Med 1995; 1: 950-53.
    • (1995) Nat Med , vol.1 , pp. 950-953
    • Lönnqvist, F.1    Arner, P.2    Nordfors, L.3    Schalling, M.4
  • 56
    • 0029083859 scopus 로고
    • Increased obese mRNA expression in omental fat cells from massively obese humans
    • 56 Hamilton BS, Paglia D, Kwan AYM, Deitel M. Increased obese mRNA expression in omental fat cells from massively obese humans. Nat Med 1995; 1: 954-56.
    • (1995) Nat Med , vol.1 , pp. 954-956
    • Hamilton, B.S.1    Paglia, D.2    Kwan, A.Y.M.3    Deitel, M.4
  • 57
    • 0030055611 scopus 로고    scopus 로고
    • The expression of ob gene is not acutely regulated by insulin and fasting in human abdominal subcutaneous adipose tissue
    • 57 Vidal H, Auboeuf D, De Vos P, et al. The expression of ob gene is not acutely regulated by insulin and fasting in human abdominal subcutaneous adipose tissue. J Clin Invest 1996; 98: 251-55.
    • (1996) J Clin Invest , vol.98 , pp. 251-255
    • Vidal, H.1    Auboeuf, D.2    De Vos, P.3
  • 58
    • 0030594830 scopus 로고    scopus 로고
    • Decreased cerebrospinal fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance
    • 58 Caro JF, Kolaczynski JW, Nyce MR, et al. Decreased cerebrospinal fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 1996; 348: 159-61.
    • (1996) Lancet , vol.348 , pp. 159-161
    • Caro, J.F.1    Kolaczynski, J.W.2    Nyce, M.R.3
  • 59
    • 0029881125 scopus 로고    scopus 로고
    • Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
    • 59 Schwartz M, Peskind E, Raskind M, Boyko EJ, Porte D. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat Med 1996; 2: 589-93.
    • (1996) Nat Med , vol.2 , pp. 589-593
    • Schwartz, M.1    Peskind, E.2    Raskind, M.3    Boyko, E.J.4    Porte, D.5
  • 60
    • 0030010388 scopus 로고    scopus 로고
    • Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
    • 60 Chehab FF, Lim ME, Lu R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet 1996; 12: 318-20.
    • (1996) Nat Genet , vol.12 , pp. 318-320
    • Chehab, F.F.1    Lim, M.E.2    Lu, R.3
  • 61
    • 0031014413 scopus 로고    scopus 로고
    • Early onset of reproductive function in normal female mice treated with leptin
    • 61 Chehab FF, Mounzih K, Lu R, Lin ME. Early onset of reproductive function in normal female mice treated with leptin. Science 1997; 275: 88-90.
    • (1997) Science , vol.275 , pp. 88-90
    • Chehab, F.F.1    Mounzih, K.2    Lu, R.3    Lin, M.E.4
  • 63
    • 0029953957 scopus 로고    scopus 로고
    • Leptin is a signal to the reproductive system
    • 63 Barash IA, Cheung CC, Weigle DS, et al. Leptin is a signal to the reproductive system. Endocrinology 1996; 137: 3144-47.
    • (1996) Endocrinology , vol.137 , pp. 3144-3147
    • Barash, I.A.1    Cheung, C.C.2    Weigle, D.S.3
  • 64
    • 0029896530 scopus 로고    scopus 로고
    • Role of leptin in the neuroendocrine response to fasting
    • 64 Ahima RS, Prabakaran D, Mantzoros C, et al. Role of leptin in the neuroendocrine response to fasting. Nature 1996; 382: 250-52.
    • (1996) Nature , vol.382 , pp. 250-252
    • Ahima, R.S.1    Prabakaran, D.2    Mantzoros, C.3
  • 65
    • 0029131574 scopus 로고
    • Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity
    • 65 Frederich RC, Lollmann B, Hamann A, et al. Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. J Clin Invest 1995; 96: 1658-63.
    • (1995) J Clin Invest , vol.96 , pp. 1658-1663
    • Frederich, R.C.1    Lollmann, B.2    Hamann, A.3
  • 66
    • 0030866843 scopus 로고    scopus 로고
    • Non-adipose tissue production of leptin; leptin as a novel placenta-derived hormone in humans
    • 66 Masuzaki H, Ogawa Y, Sagawa N, et al. Non-adipose tissue production of leptin; leptin as a novel placenta-derived hormone in humans. Nat Med 1997; 3: 1029-33.
    • (1997) Nat Med , vol.3 , pp. 1029-1033
    • Masuzaki, H.1    Ogawa, Y.2    Sagawa, N.3
  • 67
    • 0031050415 scopus 로고    scopus 로고
    • Relatively low plasma leptin concentrations precede weight gain in Pima Indians
    • 67 Ravussin E, Pratley RE, Maffei M, et al. Relatively low plasma leptin concentrations precede weight gain in Pima Indians. Nat Med 1997; 3: 238-40.
    • (1997) Nat Med , vol.3 , pp. 238-240
    • Ravussin, E.1    Pratley, R.E.2    Maffei, M.3
  • 68
    • 0029822048 scopus 로고    scopus 로고
    • Leptin is cleared from the circulation primarily by the kidney
    • 68 Cumin F, Baum HP. Leptin is cleared from the circulation primarily by the kidney. Int J Obes 1996; 20: 1120-26.
    • (1996) Int J Obes , vol.20 , pp. 1120-1126
    • Cumin, F.1    Baum, H.P.2
  • 69
    • 0031017938 scopus 로고    scopus 로고
    • Increased plasma leptin concentration in end-stage renal disease
    • 69 Merabet E, Dagogo-Jack S, Coyne DW, et al. Increased plasma leptin concentration in end-stage renal disease. J Clin Endocrinol Metab 1997; 82: 847-50.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 847-850
    • Merabet, E.1    Dagogo-Jack, S.2    Coyne, D.W.3
  • 70
    • 8244232511 scopus 로고    scopus 로고
    • Plasma leptin is partly cleared by the kidney and is elevated in hemodialysis patients
    • 70 Sharma K, Considine RV, Michael B, et al. Plasma leptin is partly cleared by the kidney and is elevated in hemodialysis patients. Kidney Int 1997; 51: 1980-85.
    • (1997) Kidney Int , vol.51 , pp. 1980-1985
    • Sharma, K.1    Considine, R.V.2    Michael, B.3
  • 71
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
    • 71 Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell 1994; 79: 1147-56.
    • (1994) Cell , vol.79 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 72
    • 15844415080 scopus 로고    scopus 로고
    • Down-regulation of the expression of the obese gene by antidiabetic thiazolidinedione in Zucker diabetic fatty rats and db/db mice
    • 72 Zhang B, Graziano MP, Doebber TW, et al. Down-regulation of the expression of the obese gene by antidiabetic thiazolidinedione in Zucker diabetic fatty rats and db/db mice. J Biol Chem 1996; 271: 9455-59.
    • (1996) J Biol Chem , vol.271 , pp. 9455-9459
    • Zhang, B.1    Graziano, M.P.2    Doebber, T.W.3
  • 73
    • 0000113890 scopus 로고    scopus 로고
    • Thiazolidinediones repress ob gene expresson via activation of PPARγ
    • 73 De Vos P, Lefebvre AM, Miller SG, et al. Thiazolidinediones repress ob gene expresson via activation of PPARγ. J Clin Invest 1996; 98: 1004-09.
    • (1996) J Clin Invest , vol.98 , pp. 1004-1009
    • De Vos, P.1    Lefebvre, A.M.2    Miller, S.G.3
  • 74
    • 0029894050 scopus 로고    scopus 로고
    • Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes
    • 74 Kallen CB, Lazar MA. Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes. Proc Natl Acad Sci USA 1996; 93: 5793-96.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 5793-5796
    • Kallen, C.B.1    Lazar, M.A.2
  • 75
    • 0029795431 scopus 로고    scopus 로고
    • Effect of troglitazone on leptin production: Studies in vitro and in human subjects
    • 75 Nolan JJ, Olefsky JM, Nyce MR, Considine RV, Caro JF. Effect of troglitazone on leptin production: studies in vitro and in human subjects. Diabetes 1996; 45: 1276-78.
    • (1996) Diabetes , vol.45 , pp. 1276-1278
    • Nolan, J.J.1    Olefsky, J.M.2    Nyce, M.R.3    Considine, R.V.4    Caro, J.F.5
  • 76
    • 0029863684 scopus 로고    scopus 로고
    • Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters: A role for leptin in the anorexia of infection
    • 76 Grunfeld C, Zhao C, Fuller J, et al. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters: a role for leptin in the anorexia of infection. J Clin Invest 1996; 97: 2152-57.
    • (1996) J Clin Invest , vol.97 , pp. 2152-2157
    • Grunfeld, C.1    Zhao, C.2    Fuller, J.3
  • 77
    • 0029021599 scopus 로고
    • Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake
    • 77 De Vos P, Saladin R, Auwerx J, Staels B. Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. J Biol Chem 1995; 270: 15958-61.
    • (1995) J Biol Chem , vol.270 , pp. 15958-15961
    • De Vos, P.1    Saladin, R.2    Auwerx, J.3    Staels, B.4
  • 78
    • 0029972928 scopus 로고    scopus 로고
    • The adipocyte specific transcription factor, C/EBPa modulates human ob gene expression
    • 78 Miller SG, De Vos P, Guerre-Millo M, et al. The adipocyte specific transcription factor, C/EBPa modulates human ob gene expression. Proc Natl Acad Sci USA 1996; 93: 5507-11.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 5507-5511
    • Miller, S.G.1    De Vos, P.2    Guerre-Millo, M.3
  • 79
    • 0028849084 scopus 로고
    • The mouse obese gene. Genomic organization, promoter activity, and activation by CCAAT/enhancer-binding protein alpha
    • 79 He Y, Chen H, Quon MJ, Reitman M. The mouse obese gene. Genomic organization, promoter activity, and activation by CCAAT/enhancer-binding protein alpha. J Biol Chem 1995; 270: 28887-91.
    • (1995) J Biol Chem , vol.270 , pp. 28887-28891
    • He, Y.1    Chen, H.2    Quon, M.J.3    Reitman, M.4
  • 80
    • 0031051523 scopus 로고    scopus 로고
    • Functional antagonism between CCAAT/enhancer binding protein-α and peroxisome proliferator-activated receptor-γ on the leptin promoter
    • 80 Hollenberg AN, Susulic VS, Madura JP, et al. Functional antagonism between CCAAT/enhancer binding protein-α and peroxisome proliferator-activated receptor-γ on the leptin promoter. J Biol Chem 1997; 272: 5283-90.
    • (1997) J Biol Chem , vol.272 , pp. 5283-5290
    • Hollenberg, A.N.1    Susulic, V.S.2    Madura, J.P.3
  • 81
    • 0030458404 scopus 로고    scopus 로고
    • Negative regulation of peroxisome proliferator-activated receptor-γ gene expression contributes to the adipogenic effect of tumor necrosis factor-α
    • 81 Zhang B, Berger J, Hu E, et al. Negative regulation of peroxisome proliferator-activated receptor-γ gene expression contributes to the adipogenic effect of tumor necrosis factor-α. Mol Endocrinol 1996; 10: 1457-66.
    • (1996) Mol Endocrinol , vol.10 , pp. 1457-1466
    • Zhang, B.1    Berger, J.2    Hu, E.3
  • 82
    • 0031017322 scopus 로고    scopus 로고
    • A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2
    • 82 Comuzzie AG, Hixson JE, Almasy L, et al. A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2. Nat Genet 1997; 15: 273-76.
    • (1997) Nat Genet , vol.15 , pp. 273-276
    • Comuzzie, A.G.1    Hixson, J.E.2    Almasy, L.3
  • 83
    • 0030455364 scopus 로고    scopus 로고
    • Regulation of ob gene expression in rodents and humans
    • 83 Saladin R, Staels B, Auwerx J, Briggs M. Regulation of ob gene expression in rodents and humans. Horm Metab Res 1996; 28: 638-41.
    • (1996) Horm Metab Res , vol.28 , pp. 638-641
    • Saladin, R.1    Staels, B.2    Auwerx, J.3    Briggs, M.4
  • 84
    • 0029157428 scopus 로고
    • Transient increase in obese gene expression after food intake and insulin administration
    • 84 Saladin R, De Vos P, Guerre-Millo M, et al. Transient increase in obese gene expression after food intake and insulin administration. Nature 1995; 377: 527-29.
    • (1995) Nature , vol.377 , pp. 527-529
    • Saladin, R.1    De Vos, P.2    Guerre-Millo, M.3
  • 85
    • 0029078449 scopus 로고
    • Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes
    • 85 MacDougold OA, Hwang CS, Fan H, Lane MD. Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes. Proc Natl Acad Sci USA 1995; 92: 9034-37.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9034-9037
    • MacDougold, O.A.1    Hwang, C.S.2    Fan, H.3    Lane, M.D.4
  • 86
    • 0029166158 scopus 로고
    • Effect of fasting and refeeding on ob gene expression in white adipose tissue of lean and (ob/ob) mice
    • 86 Trayhurn P, Thomas MEA, Duncan JS, Rayner VD. Effect of fasting and refeeding on ob gene expression in white adipose tissue of lean and (ob/ob) mice. FEBS Lett 1995; 368: 488-90.
    • (1995) FEBS Lett , vol.368 , pp. 488-490
    • Trayhurn, P.1    Thomas, M.E.A.2    Duncan, J.S.3    Rayner, V.D.4
  • 87
    • 0029102059 scopus 로고
    • Modulation of obese gene expression in rat brown and white adipose tissues
    • 87 Moinat M, Deng C, Muzzin P, et al. Modulation of obese gene expression in rat brown and white adipose tissues. FEBS Lett 1995; 373: 131-34.
    • (1995) FEBS Lett , vol.373 , pp. 131-134
    • Moinat, M.1    Deng, C.2    Muzzin, P.3
  • 88
    • 0029062839 scopus 로고
    • Transcriptional regulation of gene expression during adipocyte differentiation
    • 88 MacDougald O, Lane D. Transcriptional regulation of gene expression during adipocyte differentiation. Ann Rev Biochem 1995; 64: 345-73.
    • (1995) Ann Rev Biochem , vol.64 , pp. 345-373
    • MacDougald, O.1    Lane, D.2
  • 89
    • 0030063976 scopus 로고    scopus 로고
    • Expression of ob gene in adipose cells: Regulation by insulin
    • 89 Leroy P, Dessolin S, Villageois P, et al. Expression of ob gene in adipose cells: regulation by insulin. J Biol Chem 1996; 271: 2365-68.
    • (1996) J Biol Chem , vol.271 , pp. 2365-2368
    • Leroy, P.1    Dessolin, S.2    Villageois, P.3
  • 90
    • 0029964871 scopus 로고    scopus 로고
    • Response of leptin to short term fasting and refeeding in humans
    • 90 Kolaczynski JW, Considine RV, Ohannesian J, et al. Response of leptin to short term fasting and refeeding in humans. Diabetes 1996; 45: 1511-15.
    • (1996) Diabetes , vol.45 , pp. 1511-1515
    • Kolaczynski, J.W.1    Considine, R.V.2    Ohannesian, J.3
  • 91
    • 0029844267 scopus 로고    scopus 로고
    • Effect of fasting on serum leptin in normal human subjects
    • 91 Boden G, Chen X, Mozzoli M, Ryan I. Effect of fasting on serum leptin in normal human subjects. J Clin Endocrinol Metab 1996; 81: 3419-23.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3419-3423
    • Boden, G.1    Chen, X.2    Mozzoli, M.3    Ryan, I.4
  • 93
    • 10144245924 scopus 로고    scopus 로고
    • Insulin and cortisol promote leptin prodution in cultured human fat cells
    • 93 Wabitsch M, Jensen PB, Blum WF, et al. Insulin and cortisol promote leptin prodution in cultured human fat cells. Diabetes 1996; 45: 1435-38.
    • (1996) Diabetes , vol.45 , pp. 1435-1438
    • Wabitsch, M.1    Jensen, P.B.2    Blum, W.F.3
  • 94
    • 0029924714 scopus 로고    scopus 로고
    • Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM
    • 94 Malmstrom R, Taskinen MR, Karonen SL, Yki-Jarvinen H. Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM. Diabetologia 1996; 39: 993-96.
    • (1996) Diabetologia , vol.39 , pp. 993-996
    • Malmstrom, R.1    Taskinen, M.R.2    Karonen, S.L.3    Yki-Jarvinen, H.4
  • 96
    • 0010572211 scopus 로고    scopus 로고
    • The increase in serum leptin levels after food intake is correlated with insulin levels in normal subjects
    • submitted
    • 96 Dallongeville J, Le Fur C, Lebel P, et al. The increase in serum leptin levels after food intake is correlated with insulin levels in normal subjects. Diabetes 1997; (submitted).
    • (1997) Diabetes
    • Dallongeville, J.1    Le Fur, C.2    Lebel, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.