Role of nitric oxide in the pathogenesis of chronic pulmonary hypertension

Physiological Reviews

Volumn 80, Issue 4, 2000, Pages 1337-1372

  Hampl, Václav ^a   Herget, Jan ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; N(G) METHYLARGININE; N(G) NITROARGININE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; REACTIVE OXYGEN METABOLITE;

ADULT; BLOOD VESSEL INJURY; BLOOD VESSEL TONE; CELL PROLIFERATION; COLLAGEN DEGRADATION; CYTOLYSIS; DRUG EFFECT; ENZYME ACTIVITY; FETUS; FETUS CIRCULATION; FIBROBLAST; HUMAN; LUNG BLOOD VESSEL; LUNG CIRCULATION; LUNG VASOCONSTRICTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; REVIEW; VASCULAR SMOOTH MUSCLE; VASODILATATION;

EID: 0033779692     PISSN: 00319333     EISSN: None     Source Type: Journal    
DOI: 10.1152/physrev.2000.80.4.1337     Document Type: Review

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291. Constitutive NOS expression in cultured endothelial cells is elevated by fluid shear stress
292. Role of endothelium-derived nitric oxide in the regulation of blood pressure
293. Approach to the patient with pulmonary hypertension
294. Experimental models of pulmonary hypertension
295. Structure and function in pulmonary hypertension: New perceptions
296. Structural remodeling of the pulmonary vasculature by environmental change and disease
297. Determination of K(m) for oxygen of nitric oxide synthase isoforms
298. Maintained upregulation of pulmonary eNOS gene and protein expression during recovery from chronic hypoxia
299. Selective upregulation of arterial endothelial nitric oxide synthase in pulmonary hypertension
300. Unaltered vasoconstrictor responsiveness after iNOS inhibition in lungs from chronically hypoxic rats
301. Orally administered L-arginine does not alter right ventricular hypertrophy in chronically hypoxic rats
302. Chronic hypoxia selectively augments endothelium-dependent pulmonary arterial vasodilation
303. Innervation of the pulmonary circulation: An overview
304. Recombinant human superoxide dismutase reduces lung injury caused by inhaled nitric oxide and hyperoxia
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306. Continuous nitric oxide inhalation reduces pulmonary arterial structural changes, right ventricular hypertrophy, and growth retardation in the hypoxic newborn rat
307. Inhibition of nitric oxide synthesis potentiates hypoxic vasoconstriction in isolated rat lungs
308. + channel-mediated relaxation
309. Chronic inhaled nitric oxide: Effects on pulmonary vascular endothelial function and pathology in rats
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312. Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation
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314. Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling
315. Effects of vasodilator drugs on normal and serotonin-constricted pulmonary vessels of the dog
316. Maintained endothelium-dependent pulmonary vasodilation following chronic hypoxia in the rat
317. Attenuation of chronic hypoxic pulmonary hypertension in rats by cyclooxygenase products and by nitric oxide
318. Endothelial cells: A source and target of oxidant damage
319. Free radicals and lung disease
320. Differences in acute hypoxic pulmonary vasoresponsiveness between rat strains: Role of endothelium
321. Complex role of protein phosphorylation in gene activation by hypoxia
322. Investigation and management of pulmonary hypertension in chronic obstructive pulmonary disease
323. Hypoxia inhibits increased ET(B) receptor-mediated NO synthesis in hypertensive rat lungs
324. Factors influencing the idiopathic development of pulmonary hypertension in the fawn hooded rat
325. The role of endothelial nitric oxide synthase expression in the development of pulmonary hypertension in chronically hypoxic infant swine
326. Nitric oxide, an autocrine regulator of wound fibroblast synthetic function
327. The nitric oxide and cGMP signal transduction system: Regulation and mechanism of action
328. Intracellular signalling pathways that regulate vascular cell proliferation: Effect of hypoxia
329. Extracellular matrix: The cellular environment
330. FK409, a new nitric oxide donor, suppresses smooth muscle proliferation in the rat model of balloon angioplasty
331. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
332. Endothelial dysfunction in venous pulmonary hypertension in the neonatal piglet
333. Chronic exercise in dogs increases coronary vascular nitric oxide
334. Decreased pulmonary vascular resistance during nasal breathing: Modulation by endogenous nitric oxide from the paranasal sinuses
335. NON gene transfer inhibits expression of cell cycle regulatory molecules in vascular smooth muscle cells
336. Prolonged in vivo hypoxia enhances nitric oxide synthase type I and type III gene expression in adult rat lung
337. Acute and prolonged hypoxia attenuate endothelial nitric oxide production in rat pulmonary arteries by different mechanisms
338. Nitric oxide synthase isoform expression in the developing lung epithelium
339. Structural and biochemical adaptive changes in rat lung after exposure to hypoxia
340. Oxygen-induced lung damage
341. Changes in arteriole in acute and chronic hypoxic, pulmonary hypertension and recovery rat
342. Smooth muscle cell expression of type I cyclic GMP-dependent protein kinase is suppressed by continuous exposure to nitrovasodilators, theophylline, cyclic GMP, and cyclic AMP
343. Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia
344. ATP: The red blood cell link to NO and local control of the pulmonary circulation
345. Endogenous endothelium-derived relaxing factor opposes hypoxic pulmonary vasoconstriction and supports blood flow to hypoxic alveoli in anesthetized rabbits
346. Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans
347. Response of normoxic pulmonary arteries of the rat in the resting and contracted state to NO synthase blockade
348. Models of persistent pulmonary hypertension of the newborn (PPHN) and the role of cyclic guanosine monophosphate (GMP) in pulmonary vasorelaxation
349. Hypoxia-induced increases in pulmonary transvascular protein escape in rats: Modulation by glucocorticoids
350. Increased lung endothelin-1 production in rats with idiopathic pulmonary hypertension
351. Cellular and molecular mechanisms of pulmonary vascular remodeling
352. Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene
353. Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3
354. Structure-function aspects in the nitric oxide synthases
355. Lung vessel leak preceedes right ventricular hypertrophy in monocrotaline-treated rats
356. Operation Everest II: Oxygen transport during exercise at extreme simulated altitude
357. Impaired hypoxic vasoconstriction in intra-acinar microvasculature in hyperoxia-exposed rat lungs
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367. Nitric oxide stimulates activity of 72-kDa neutral matrix metalloproteinase in cultured mesangial cells
368. Nitric oxide modulates the synthesis of extracellular matrix proteins in cultured mesangial cells
369. N(G)-monomethyl-L-arginine paradoxically relaxes precoustricted canine intrapulmonary arteries
370. Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension
371. Rat alveolar function is primed by exposure to hypoxia
372. 2+ by sarcoplasmic reticulum in vascular smooth muscle
373. Variable expression of endothelial NO synthase in three forms of rat pulmonary hypertension
374. Nitric oxide modulation of pulmonary vascular resistance is red blood cell dependent in isolated rat lungs
375. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man
376. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure
377. Mitochondrial hydrogen peroxide generation by NADH-oxidase activity following regional myocardial ischemia in the dog
378. N(G)-nitro L-arginine methyl ester: Systemic and pulmonary haemodynamics, tissue blood flow and arteriovenons shunting in the pig
379. Other endothelium-derived vasoactive factors
380. Chronic hypoxic pulmonary hypertension: Cell biology to pathophysiology
381. Adrenomedullin in patients at high risk for pulmonary hypertension
382. Chronic pharmacologic treatment of experimental hypoxic pulmonary hypertension. With observations on rate of change in pulmonary arterial pressure
383. Gene therapy inhibiting neointimal vascular lesion: In vivo transfer of endothelial cell nitric oxide synthase gene
384. The pathology of human pulmonary hypertension pattern recognition and specificity
385. 2 tension
386. Evidence that nitric oxide from the endothelium attenuates inherent tone in isolated pulmonary arteries from rats with hypoxic pulmonary hypertension
387. Pulmonary hypertension
388. Anorexic agents aminorex, fenfluramine, and dexfenfluramine inhibit potassium current in rat pulmonary vascular smooth muscle and cause pulmonary vasoconstriction
389. Experimental hypoxic pulmonary edema in the rat
390. Modulatory role of endogenous nitric oxide in pulmonary circulation in vivo
391. Production of hydrogen peroxide by alveolar macrophages from rats exposed to subacute and chronic hypoxia
392. Perfusate viscosity and hematocrit determine pulmonary vascular responsiveness to NO synthase inhibitors
393. Vasoconstriction increases pulmonary nitric oxide synthesis and circulating cyclic GMP
394. Flow regulation of ecNOS and Cu/Zn SOD mRNA expression in porcine coronary arterioles
395. Acceleration of myosin light chain dephosphorylation and relaxation of smooth muscle by telokin: Synergism with cyclic nucleotide-activated kinase
396. Cyclic GMP-dependent stimulation reverses G-protein-coupled inhibition of smooth muscle myosin light chain phosphate
397. Shear stress induction of the endothelial nitric oxide synthase gene is calcium-dependent but not calcium-activated
398. Effects of L-glutamine on pulmonary hypertension in the perfused rabbit lung
399. Endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension
400. Upregulation of nitric oxide synthase correlates temporally with onset of pulmonary vascular remodeling in the hypoxic rat
401. Distribution of NOS in normoxic vs. hypoxic rat lung: Upregulation of NOS by chronic hypoxia
402. Developmental expression of NOS isoforms in fetal rat lung: Implications for transitional circulation and pulmonary angiogenesis
403. Differential effect of nitric oxide synthase inhibitors on acetylcholine-induced relaxation of rat pulmonary and celiac artery rings
404. Response of intra-acinar pulmonary microvessels to hypoxia, hypercapnic acidosis, and isocapnic acidosis
405. Combined inhalation of nitric oxide and oxygen in chronic obstructive pulmonary disease
406. Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor- 1 in the lung
407. Endotoxin enhances hypoxic constriction of rat aorta and pulmonary artery through induction of EDRF/NO synthase
408. Interaction among ET-1, endothelium-derived nitric oxide, and prostacyclin in pulmonary arteries and veins
409. Regulation of vascular smooth muscle cell migration and proliferation in vitro and in injured rat arteries by a synthetic matrix metalloproteinase inhibitor
410. Endothelium-derived relaxing factor activity in rat lung during hypoxic pulmonary vascular remodeling