Site of action of endogenous nitric oxide on pulmonary vasculature in rats

Pflugers Archiv European Journal of Physiology

Volumn 432, Issue 3, 1996, Pages 523-527

  Ferrario, Lara ^a   Amin, Hesham M ^a   Sugimori, Kunio ^a   Camporesi, Enrico M ^a   Hakim, Tawfic S ^a  

^a SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

Author keywords

Acetylcholine; Double occlusion technique; Hypoxia; Nitric oxide; Pulmonary vasculature

Indexed keywords

ACETYLCHOLINE; N(G) NITROARGININE; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD GAS PARAMETERS; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DRUG EFFECT; HYPOXIC LUNG VASOCONSTRICTION; INTRAARTERIAL DRUG ADMINISTRATION; LUNG BLOOD VESSEL; LUNG VASCULAR RESISTANCE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REGIONAL PERFUSION;

ACETYLCHOLINE; ANIMALS; ANOXIA; ARGININE; BLOOD PRESSURE; ENZYME INHIBITORS; LUNG; MALE; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROARGININE; PULMONARY CIRCULATION; RATS; RATS, SPRAGUE-DAWLEY; VASCULAR RESISTANCE; VASOCONSTRICTION;

EID: 0030057169     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004240050165     Document Type: Article

References (32)

1. Al-Tinawi A, Krenz GS, Rickaby DA, Linehan JH, Dawson CA (1994) Influence of hypoxia and serotonin on small pulmonary vessels. J Appl Physiol 76 : 56-64
2. Anggard E (1994) Nitric oxide: mediator, murderer, and medicine. Lancet 343 : 1199-1206
3. Archer SL, Cowan NJ (1991) Measurement of endothelial cytosolic calcium concentration and nitric oxide production reveals discrete mechanisms of endothelium-dependent pulmonary vasodilatation. Cire Res 68 : 1569-1581
4. Archer, SL, Tolins JP, Raij L, Weir EK (1989) Hypoxic pulmonary vasoconstriction is enhanced by inhibition of the synthesis of an endothelium derived relaxing factor. Biochem Biophys Res Commun 164 : 1198-1205
5. Barer G, Emery C, Stewart A, Bee D, Howard P (1993) Endothelial control of the pulmonary circulation in normal and chronically hypoxic rats. J Physiol (Lond) 463 : 1-16
6. Brashers VL, Peach MJ, Rose CE Jr (1988) Augmentation of hypoxic pulmonary vasoconstriction in the isolated perfused rat lung by in vitro antagonists of endothelium-dependent relaxation. J Clin Invest 82 : 1495-1502
7. Chand N, Altura BM (1981) Acetylcholine and bradykinin relax intrapulmonary arteries by acting on endothelial cells: role in lung vascular diseases. Science 213 : 1376-1379
8. Dawson CA, Linehan JH, Rickaby DA (1982) Pulmonary microcirculatory hemodynamics. Ann Ny Acad Sci 384 : 90-106
9. Fike CD, Gordon JB, Kaplowitz MR (1993) Micropipette and vascular occlusion pressures in isolated lungs of newborn lambs. J Appl Physiol 75 : 1854-1860
10. Furchgott RF (1983) Role of endothelium in responses of vascular smooth muscle. Circ Res 53 : 557-573
11. Gaston B, Drazen JM, Loscalzo J, Stamler JS (1994) The biology of nitrogen oxides in the airways. Am J Respir Crit Care Med 149 : 538-551
12. ω-nitro-L-arginine on total and segmental vascular resistances in developing lamb lungs. J Appl Physiol 75 : 76-85
13. Grodon JB, Hortop J, Hakim TS (1989) Developmental effects of hypoxia and indomethacin on distribution of vascular resistances in lamb lungs. Pediatr Res 26 : 325-329
14. Hakim TS (1988) Identification of constriction in large versus small vessels using the arterial-venous and the double-occlusion techniques in isolated canine lungs. Respiration 54 : 61-69
15. Hakim TS (1994) Flow-induced release of EDRF in the pul monary vasculature: site of release and action. Am J Physiol 267 : H363-H369
16. Hakim TS, Kelly S (1989) Occlusion pressures vs. micropipette pressures in the pulmonary circulation. J Appl Physiol 67 : 1277-1285
17. Hakim TS, Sugimori K, Ferrario L (1995) Analysis of the double occlusion tracings to partition vascular resistance into four segments (abstract). FASEB J 9 : A274
18. Hasunuma K, Yamaguchi T, Rodman DM, O'Brien RF, McMurtry IF (1991) Effects of inhibitors of EDRF and EDHF on vasoreactivity of perfused rat lungs. Am J Physiol 260 : L97-L104
19. Haynes J Jr, Taylor AE, Dixon D, Voelkel N (1993) Microvascular hemodynamics in the sickle red blood cell perfused isolated rat lung. Am J Physiol 264 : H484-489
20. ω-nitro-L-arginine: a potent inhibitor of endothelium derived relaxing factor formation. Eur J Pharmacol 176 : 219-223
21. Johns RA, Linden JM, Peach MJ (1989) Endothelium-dependent relaxation and cyclic GMP accumulation in rabbit pulmonary artery are selectively impaired by moderate hypoxia. Circ Res 65 : 1508-1515
22. Liu S, Crawley DE, Barnes PJ, Evans TW (1991) Endothelium-derived relaxing factor inhibits hypoxic pulmonary vasoconstriction in rats. Am Rev Respir Dis 143 : 32-37
23. Moncada S, Palmer RMJ, Higgs EA (1991) Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43 : 109-142
24. Nathan C (1992) Nitric oxide as a secretory product of mammalian cells. FASEB J 6 : 3051-3064
25. Palmer RMJ, Ferrige AG, Moncada S (1987) Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327 : 524-526
26. Rees DD, Palmer RMJ, Hodson HF, Moncada S (1989) A specific inhibitor of nitric oxide formation from L-arginine attenuates endothelium-dependent relaxation. Br J Pharmacol 96 : 418-424
27. Reinhart WH (1994) Shear-dependence of endothelial functions. Experientia 50 : 87-93
28. Rock P, Patterson A, Permutt S, Sylvester JT (1985) Nature and distribution of vascular resistance in hypoxic pig lungs. J Appl Physiol 59 : 1891-1901
29. Rodman DM, Yamaguchi T, Hasunuma K, O'Brien RF, McMurtry IF (1990) Effects of hypoxia on endothelium-dependent relaxation of rat pulmonary artery. Am J Physiol 258 : L207-L214
30. Tod ML, O'Donnell D, Gordon JB (1995) Sites of inhaled NO-induced vasodilation during hypoxia and U-46619 infusion in isolated lamb lungs. Am J Physiol 268 : H1422-H1427
31. Xue C, Rengasamy A, Le Cras TD, Koberna PA, Dailey GC, Johns RA (1994) Distribution of NOS in normoxic vs. hypoxic rat lung: upregulation of NOS by chronic hypoxia. Am J Physiol 267 : L667-L678
32. Zhao Y, Packer CS, Rhoades RA (1993) Pulmonary vein contracts in response to hypoxia. Am J Physiol 265 : L87-L92