Differential effect of nitric oxide synthase inhibitors on acetylcholine-induced relaxation of rat pulmonary and celiac artery rings

Canadian Journal of Physiology and Pharmacology

Volumn 75, Issue 4, 1997, Pages 279-286

  Yaghi, Asma ^a   Paterson, Nigel A M ^a   McCormack, David G ^a  

^a LONDON HEALTH SCIENCES CENTRE   (Canada)

Author keywords

Acetylcholine; Meclofenamate; N(G) monomethyl L arginine (L NMMA); N( ) nitro L arginine methyl ester (L NAME); Small intrapulmonary artery

Indexed keywords

ACETYLCHOLINE; MECLOFENAMIC ACID; N(G) METHYLARGININE; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL TISSUE; ARTICLE; CELIAC ARTERY; DRUG EFFECT; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; RAT; VASODILATATION;

EID: 0030871367     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y97-042     Document Type: Article

References (33)

1. G-Monomethyl-L-arginine causes nitric oxide synthesis in isolated arterial rings - trouble in paradise. Biochem. Biophys. Res. Commun. 188: 590-596.
2. Beetens, J.R., Van Hove, C., Rampart, M., and Herman, A.G. 1983. Acetylcholine stimulates the release of prostacyclin by rabbit aorta endothelium. J. Pharm. Pharmacol. 35: 251-252.
3. Boczkowski, J., Vicaut, E., Danialou, G., and Aubier, M. 1994. Role of nitric oxide and prostaglandins in the regulation of diaphragmatic arteriolar tone in the rat. J. Appl. Physiol. 77: 590-596.
4. Bogle, R.G., Moncada, S., Pearson, J.D., and Mann, G.E. 1992. Identification of inhibitors of nitric oxide synthase that do not interact with the endothelial cell L-arginine transporter. Br. J. Pharmacol. 105: 768-770.
5. G-Nitro L-arginine methyl ester and other alkyl esters of arginine are muscarinic receptor antagonists. Circ. Res. 72: 387-395.
6. Chen, G., Yamamoto, Y., Miwa, K., and Suzuki, H. 1991. Hyperpolarization of arterial smooth muscle induced by endothelial humoral substances. Am. J. Physiol. 260(6): H1888-H1892.
7. Cowan, C.L., Palacino, J.J., Najibi, S., and Cohen, R.A. 1993. Potassium channel-mediated relaxation to acetylcholine in rabbit arteries. J. Pharmacol. Exp. Ther. 266: 1482-1489.
8. G-monomethyl-L-arginine on endothelium-dependent relaxations in the perfused mesenteric vascular bed of the rat. Biochem. Biophys. Res. Commun. 169(3): 873-879.
9. Fanburg, H.L. 1988. Relationship of the pulmonary vascular endothelium to altered pulmonary vascular resistance. Chest, 93(3): 101S-111S.
10. Feng, Q., and Hedner, T. 1990. Endothelium-derived relaxing factor (EDRF) and nitric oxide (NO). I. Physiology, pharmacology and pathophysiological implications. Clin. Physiol. 10: 407-426.
11. Forstermann, U., and Neufang, B. 1984. The endothelium-dependent vasodilator effect of acetylcholine: characterization of the endothelial relaxing factor with inhibitors of arachidonic acid metabolism. Eur. J. Pharmacol. 103: 65-70.
12. Furchgott, R.F. 1984. The role of the endothelium in the responses of vascular smooth muscle to drugs. Annu. Rev. Pharmacol. Toxicol. 24: 175-197.
13. Gardiner, S.M., Kemp, P.A., and Bennett, T. 1991. Effects of N-nitro-L-arginine methyl ester on vasodilator responses to acetylcholine, 5-N-ethylcarboxamidoadenosine or salbutamol in conscious rats. Br. J. Pharmacol. 103: 1725-1732.
14. Garland, C.J., and McPherson, G.A. 1992. Evidence that nitric oxide does not mediate the hyperpolarization and relaxation to acetylcholine in the rat small mesenteric artery. Br. J. Pharmacol. 105: 429-435.
15. Greenblatt, E.P., Loeb, A.L., and Longnecker, D.E. 1993. Marked regional heterogeneity in the magnitude of EDRF/NO-mediated vascular tone in awake rats. J. Cardiovasc. Pharmacol. 21: 235-240.
16. Hecker, M., Sessa, W.C., Harris, H.J., Anggard, E.E., and Vane, J.R. 1990. The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine. Proc. Natl. Acad. Sci. U.S.A. 87: 8612-8616.
17. Ignarro, L.J., Buga, G.M., Wood, K.S., Byrns, R.E., and Chaudhuri, G. 1987. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl. Acad. Sci. U.S.A. 84: 9265-9269.
18. Loeb, A.L., and Longnecker, D.E. 1992. Inhibition of endothelium-derived relaxing factor-dependent circulatory control in intact rats. Am. J. Physiol. 262: H1494-H1500.
19. Martin, G.R., Bolofo, M.L., and Giles, H. 1992. Inhibition of endothelium-dependent vasorelaxation by arginine analogues - a pharmacological analysis of agonist and tissue dependence. Br. J. Pharmacol. 105: 643-652.
20. Martin, C.M., Yaghi, A., McCormack, D.G., Sibbald, W.J., and Paterson, N.A.M. 1993. Differential impairment of vascular reactivity of small pulmonary and systemic arteries in hyperdynamic sepsis. Am. Rev. Respir. Dis. 148: 164-172.
21. McMahon, T.J., Hood, J.S., Bellan, J.A., and Kadowitz, P.J. 1991. N-omega-nitro-L-arginine methyl ester selectively inhibits pulmonary vasodilator responses to acetylcholine and bradykinin. J. Appl. Physiol. 71: 2026-2031.
22. Mügge, A., Lopez, J.A.Z., Piegors, D.J., Breese, K.R., and Heistad, D.D. 1991. Acetylcholine-induced vasodilation in rabbit hindlimb in vivo is not inhibited by analogues of arginine. Am. J. Physiol. 260(29): H242-H247.
23. Nagao, T., and Vanhoutte, P.M. 1991. Hyperpolarization contributes to endothelium-dependent relaxations to acetylcholine in femoral veins of rats. Am. J. Physiol. 261(4): H1034-H1037.
24. G-nitro-L-arginine in rats. Am. J. Physiol. 263: H1090-H1094.
25. Palmer, R.M.J., Ferrige, A.G., and Moncada, S. 1987. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature (London), 327: 524-526.
26. Rees, D.D., Palmer, R.M.J., Schulz, R., Hodson, H.F., and Moncada, S. 1990. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br. J. Pharmacol. 101: 746-752.
27. Reif, D.W., and McCreedy, S.A. 1995. N-Nitro-L-arginine and N-monomethyl-L-arginine exhibit a different pattern of inactivation toward the three nitric oxide synthases. Arch. Biochem. Biophys. 320: 170-176.
28. Ross, G., Chaudhuri, G., Ignarro, L.J., and Chyu, K. 1991. Acetylcholine vasodilation of resistance vessels in vivo may not entirely depend on newly synthesized nitric oxide. Eur. J. Pharmacol. 195: 291-293.
29. Schmidt, H.H.H.W. 1990. L-Arginine and arginine analogues: effects on isolated blood vessels and cultured endothelial cells. Br. J. Pharmacol. 101: 145-151.
30. Smith, W.L., Meade, E.A., and DeWitt, D.L. 1994. Pharmacology of prostaglandin endoperoxide synthase isozymes-1 and -2. Ann. N.Y. Acad. Sci. 714: 136-142.
31. Tracey, W.R., Bend, J.R., Hamilton, J.T., and Paterson, N.A.M. 1989. Role of lipoxygenase, cyclooxygenase and cytochrome-P-450 metabolites in contractions of isolated guinea-pig pulmonary venules induced by hypoxia and anoxia. J. Pharmacol. Exp. Ther. 250(3): 1097-1104.
32. Vane, J.R., Anggard, E.E., and Botting, R.M. 1990. Regulatory functions of the vascular endothelium. N. Engl. J. Med. 323(1): 27-36.
33. Zygmunt, P.M., Grundemar, L., and Hogestatt, E.D. 1994. Endothelium-dependent relaxation resistant to N omega-nitro-L-arginine in the rat hepatic artery and aorta. Acta Physiol. Scand. 152: 107-114.