Influence of applied tension and nitric oxide on responses to endothelins in rat pulmonary resistance arteries: Effect of chronic hypoxia

British Journal of Pharmacology

Volumn 123, Issue 5, 1998, Pages 991-999

  MacLean, Margaret R ^a   McCulloch, Kirsty M ^a,b  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Basal tension; Chronic hypoxia; Endothelin; Nitric oxide; Pulmonary arteries

Indexed keywords

ACETYLCHOLINE; ARGININE METHYL ESTER; ENDOTHELIN 1; ENDOTHELIN RECEPTOR; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM; NORADRENALIN; SARAFOTOXIN S6C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL TONE; CONTROLLED STUDY; DRUG POTENCY; HYPOXIA; LUNG VASCULAR RESISTANCE; MALE; NONHUMAN; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT; VASOCONSTRICTION; VASODILATATION;

ANIMALS; ANOXIA; ENDOTHELIN-1; ENDOTHELIUM, VASCULAR; HYPERTENSION, PULMONARY; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; PULMONARY ARTERY; RATS; RATS, WISTAR; VASODILATOR AGENTS; VIPER VENOMS;

EID: 0031908283     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701682     Document Type: Article

References (37)

1. ADNOT, S., RAFFESTIN, B., EDDAHIBI, S., BRAQUET, P. & CHARBRIER, P.E. (1991). Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia. J. Clin. Invest., 87, 155-170.
2. ARAI, I.H., HORI, S., ARAMORI, I., OHKUBO, H. & NAKINISHI, S. (1990). Cloning and expression of a cDNA encoding an endothelin receptor. Nature, 348, 731-732.
3. BARER, G., EMERY, C.J., STEWART, A., BEE, D. & HOWARD, P. (1993). Endothelial control of the pulmonary circulation in normal and chronically hypoxic rats. J. Physiol., 463, 1-16.
4. DOCHERTY, C.C. & MACLEAN, M.R. (1996). Effect of nitric oxide synthase inhibition on endothelin responses in small pulmonary arteries from the heart failure rabbit. J. Hypertension, 14 (suppl.1), P243.
5. B receptors in rabbit pulmonary resistance arteries: effect of left ventricular dysfunction. J. Pharm. Exp. Ther. (in press).
6. EICHINGER, M.R. & WALKER, B.R. (1994). Enhanced pulmonary arterial dilation to arginine vasopressin in chronically hypoxic rats. Am. J. Physiol., 267, H2413-H2419.
7. ELTON, T.S., OPARIL, S., TAYLOR, G.R., HICKS, P.H., YANG, R.-H., JIN, H. & CHEN, Y.F. (1992). Normobaric hypoxia stimulates endothelin-1 gene expression in the rat. Am. J. Physiol., 32, R1260-R1264.
8. FUKURODA, T., KOBAYASHI, M., OZAKI, S., YANO, M., MIYAUCHI, T., ONIZUKA, M., SUGISHITA, Y., GOTO, K. & MSHIKIBE, M. (1994). Endothelin receptor subtypes in human versus rabbit pulmonary arteries. J. Appl. Physiol., 76, 1976-1982.
9. GAMBONE, L.M., MURRAY, P.A. & FLAVAHAN, N.A. (1997). Synergistic interaction between endothelium-derived NO and prostacyclin in pulmonary artery: potential role for K-ATP ( + ) channels. Br. J. Pharmacol., 121, 271-279.
10. GARLAND, C.J., PLANE, F., KEMP, B.K. & COCKS, T.M. (1995). Endothelium-dependent hyperpolarisation- a role in the control of vascular tone. Trends Pharmacol. Sci., 16, 23-30.
11. B) receptors in rabbit isolated pulmonary artery and bronchus. Br. J. Pharmacol., 118, 1209-1217.
12. HAY, D.W.P. & LUTMANN, M.A. (1997). Nonpeptide endothelin receptor antagonists. IX. Characterisation of endothelin receptors in guinea-pig bronchus with SB 209670 and other endothelin receptor antagonists. J. Pharmacol. Exp. Ther., 280, 956-965.
13. HERGET, J. SUGGETT, A.J., LEACH, E. & BARER, G.R. (1978). Resolution of pulmonary hypertension and other features induced by chronic hypoxia in rats during complete and intermittent normoxia. Thorax, 33, 468 - 473.
14. HUNTER, C., BARER, G.R., SHAW, J.W. & CLEGG, E.J. (1974). Growth of the heart and lungs in hypoxic rodents: A model of human hypoxic disease. Clin. Sci. Mol. Med., 46, 375 - 391.
15. HYNES, C.L., WOOD, E.G. & WARNER, T.D. (1995). Stretch of cultured bovine aortic endothelial cells increases the production of nitric oxide and so reduces stimulated platelet adhesion. Br. J. Pharmacol., 116, P65.
16. INOUE, A., YANAGISAWA, M., KIMURA, S., KASUYA, Y., MIYAUCHI, T., GOTO, K. & MASAKI, T. (1989). The human endothelin family: Three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc. Natl. Acad. Sci. U.S.A., 86, 2863 - 2867.
17. KYSELA, S. & TOROK, J. (1996). Histamine H-1-receptor antagonists do not prevent the appearance of endothelium-dependent relaxation to acetylcholine in rat pulmonary artery. Physiol., Res., 45, 345 - 350.
18. LEACH, E., HOWARD, P. & BARER, G.R. (1977). Resolution of hypoxic changes in the heart and pulmonary arterioles of rats during intermittent correction of hypoxia. Clin. Sci. Mol. Med., 52, 153 - 162.
19. LE CRAS, T.D., XUE, C., RENGASAMY, A. & JOHNS, R.A. (1996). Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung. Am. J. Physiol., 270, L164 - L170.
20. B-receptor-mediated vasoconstriction in rat pulmonary arteries and arterioles. J. Cardiovasc. Pharmacol., 23, 838 - 845.
21. B-receptor-mediated vasoconstriction, tone and nitric oxide mediation in control and pulmonary hypertensive rats. J. Cardiovasc. Pharmacol., 26, 822 - 830.
22. MACLEAN, M.R., SWEENEY, G., BAIRD, M., MCCULLOCH, K.M., HOUSLAY, M. & MORECROFT, I. (1996). 5-Hydroxytryptamine receptors mediating vasoconstriction in pulmonary arteries from control and pulmonary hypertensive rats. Br. J. Pharmacol., 119, 917 - 930.
23. MASAKI, J., KIMURA, S., YANAGISAWA, M. & GOTO, K. (1991). Molecular and cellular mechanisms of endothelin regulation. Implications for vascular function. Circulation, 84, 1457 - 1468.
24. MCCULLOCH, K.M., DOCHERTY, C.C. & MACLEAN, M.R. (1998). Endothelin receptors mediating contraction of rat and human pulmonary resistance arteries: effect of chronic hypoxia in rat. Br. J. Pharmacol., (in press).
25. B receptors mediate contraction of human pulmonary resistance arteries. Br. J. Pharmacol., 119, 917 - 930.
26. MCCULLOCH, K.M. & MACLEAN, M.R. (1995). Endothelin B receptor-mediated contraction of human and rat pulmonary resistance arteries and the effect of pulmonary hypertension on endothelin responses in the rat. J. Cardiovasc. Pharmacol., 26, S169 - S176.
27. MULVANY, M.J. & HALPERN, W. (1977). Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ. Res., 41, 9 - 26.
28. 2 muscarinic receptors in human pulmonary arteries. Br. J. Pharmacol., 119, 149 - 157.
29. RESTA, T.C., GONZALES, R.J., DAIL, W.G., SANDERS, T.C. & WALKER, B.R. (1997). Selective upregulation of arterial endothelial nitric oxide synthase in pulmonary hypertension. Am. J. Physiol. (Heart Circ. Physiol.), 41, H806 - H813.
30. RESTA, T.C. & WALKER, B.R. (1996). Chronic hypoxia selectively augments endothelium-dependent pulmonary arterial vasodilation. Am. J. Physiol. (Heart Circ. Physiol.), 39, H888 - H896.
31. ROGERS, T.K., STEWARD, A.G. & MORICE, A.H. (1992). Effect of chronic hypoxia on rat pulmonary resistance vessels: vasodilatation by atrial natriuretic peptide. Clin. Sci., 83, 723 - 729.
32. SAKURAI, T., YANAGISAWA, M., TAKUWA, Y., MIYAZAKI, H., KIMURA, S., GOTO, K. & MASAKI, T. (1990). Cloning of a cDNA encoding a non-isopeptide selective subtype of the endothelin receptor. Nature, 348, 732 - 735.
33. STEWART, D.J., LEVY, R.D., CERNACEK, P. & LANGLEBEN, D. (1991). Increased plasma endothelin-1 in pulmonary hypertension: Marker or mediator of disease? Ann. Intern. Med., 114, 464 - 469.
34. TESFAMARIAM, B. & COHEN, R.A. (1988). Inhibition of adrenergic vasoconstriction by endothelial cell shear stress. Circ. Res., 63, 720 - 725.
35. WANSTALL, J. C., HUGHES, I.E. & O'DONNELL, S.R. (1995). Evidence that nitric oxide from the endothelium attenuates inherent tone in isolated pulmonary arteries from rats with hypoxic pulmonary hypertension. Br. J. Pharmacol., 114, 109 - 114.
36. WILLIAMS, D.L., Jr, JONES, K.L., PETTIBONE, D.J., LIS, E.V. & CLINESCHMIDT, B.V. (1991). Sarafotoxin 6c: an agent which discriminates between endothelin receptor subtypes. Biochem. Biophys. Res. Commun., 175, 556 - 561.
37. XUE, C., RENGASAMY, A., LE CRAS, T.D., KOBERNA, P.A., DAILEY, G.C. & JOHNS, R.A. (1994). Distribution of NOS in normoxic vs. hypoxic rat lung: upregulation of NOS by chronic hypoxia. Am. J. Physiol., 267, L667 - L678.