Drosophila models of human neurodegenerative disease

Cell Death and Differentiation

Volumn 7, Issue 11, 2000, Pages 1075-1080

  Chan, H Y E ^a   Bonini, N M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Alzheimer's disease; Genetics; Molecular chaperones; Parkinson's disease; Polyglutamine

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ALPHA SECRETASE; ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ASPARTIC ACID; BETA SECRETASE; CHAPERONE; GAMMA SECRETASE; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 70; HYDROLASE; MEMBRANE PROTEIN; MUTANT PROTEIN; POLYGLUTAMINE; PROTEIN P35; UBIQUITIN;

ALZHEIMER DISEASE; AMINO ACID COMPOSITION; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DROSOPHILA; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; HUMAN; HUNTINGTON CHOREA; MACHADO JOSEPH DISEASE; MISSENSE MUTATION; NEUROMUSCULAR SYNAPSE; NONHUMAN; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; REVIEW; SEQUENCE HOMOLOGY;

ANIMALIA;

EID: 0033694785     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400757     Document Type: Review

References (59)

1. A polymorphic DNA marker genetically linked to Huntington's disease
2. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
3. Glutamine repeats and neurodegeneration
4. Expanding our understanding of polyglutamine disease through mouse models
5. Comparative genomics of the eukaryotes
6. Neural disease: Drosophila degenerates for a good cause
7. A fly's eye view of biology
8. Modeling human neurodegenerative diseases in Drosophila: On a wing and a prayer
9. Alzheimer's Disease: Genetic studies and transgenic models
10. The cause of neuronal degeneration in Alzheimer's disease
11. Proteolytic processing and cell biological functions of the amyloid precursor protein
12. Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production
13. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
14. Molecular genetics of Alzheimer Disease
15. Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1
16. A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor
17. The Drosophila transcript encoded by the β-amyloid protein precursor-like gene is restricted to the nervous system
18. Identification, secretion, and neural expression of APPL, a Drosophila protein similar to human amyloid protein precursor
19. Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene
20. Transgenic Drosophila expressing human amyloid precursor protein show γ-secretase activity and a blistered-wing phenotype
21. The Drosophila β-amyloid precursor protein homolog promotes synapse differentiation at the neuromuscular junction
22. Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport
23. Characterization of Drosophila Presenilin and its colocalization with Notch during development
24. Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants
25. Drosophila Presenilin is required for neuronal differentiation and affects Notch subcellular localization and signaling
26. Presenilin is required for activity and nuclear access of Notch in Drosophila
27. Facilitation of lin-12 mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
28. Assessment of normal and mutant human Presenilin function in Caenorhabditis elegans
29. Apoptotic activities of wild-type and Alzheimer's disease-related mutant Presenilin in Drosophila melanogaster
30. Posttranslational modification and plasma membrane localization of the Drosophila melanogaster Presenilin
31. Etiology and pathogenesis of Parkinson's disease
32. Mutation in the α-synuclein gene identified in families with Parkinson's disease
33. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
34. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
35. The ubiquitin pathway in Parkinson's disease
36. Alpha-synuclein in Lewy bodies
37. Binding of α-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation
38. Fiber diffraction of synthetic α-synuclein filaments shows amyloid-like cross-β conformation
39. Mutant and wild type human α-synuclein assemble into elongated filaments with distinct morphologies in vitro
40. A susceptibility locus for Parkinson's disease maps to chromosome 2p13
41. Oxidative mechanisms in nigral cell death in Parkinson's disease
42. A Drosophila model of Parkinson's disease
43. Poly-L-glutamine forms cation channels: Relevance to the pathogenesis of the polyglutamine diseases
44. Expanding our understanding of polyglutamine diseases through mouse models
45. Polyglutamine-expanded human Huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons
46. Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila
47. Genetic suppression of polyglutamine toxicity in Drosophila
48. Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila
49. Molecular chaperones in cellular protein folding
50. The Hsp70 and Hsp60 chaperone machines
51. Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70
52. Structural features required for the interaction of the Hsp70 molecular chaperone DnaK with its cochaperone DnaJ
53. Gene targeting by homologous recombination in Drosophila
54. Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA
55. Microarray analysis of Drosophila during metamorphosis
56. Expression and targeting of Syrian hamster pion protein induced by heat shock in transgenic Drosophila melanogaster
57. Expression of human FALS SOD in motorneurons of Drosophila
58. Cloning and analysis of expression of a ubiquitin carboxyl terminal hydrolase expressed during oogenesis in Drosophila melanogaster
59. A putative Drosophila homolog of the Huntingdon's disease gene