Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1

Nature Neuroscience

Volumn 3, Issue 2, 2000, Pages 157-163

  Lin, Xi ^a   Antalffy, Barbara ^a   Kang, Dongcheul ^a   Orr, Harry T ^b   Zoghbi, Huda Y ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

POLYGLUTAMINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DOWN REGULATION; GENE CONTROL; GENE EXPRESSION; MOUSE; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PURKINJE CELL; SEQUENCE ANALYSIS; SPINOCEREBELLAR DEGENERATION;

ALPHA 1-ANTICHYMOTRYPSIN; AMINO ACID TRANSPORT SYSTEM X-AG; ANIMALS; BRAIN; CALCIUM CHANNELS; CALCIUM-TRANSPORTING ATPASES; CLONING, MOLECULAR; DISEASE MODELS, ANIMAL; DOWN-REGULATION; GENE EXPRESSION REGULATION; GLUTAMATE PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR PROTEINS; ORGAN SPECIFICITY; PEPTIDES; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN METHYLTRANSFERASES; PURKINJE CELLS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, GLUTAMATE; RNA, MESSENGER; SIGNAL TRANSDUCTION; SPINOCEREBELLAR ATAXIAS; SYMPORTERS; TRINUCLEOTIDE REPEAT EXPANSION; TRPC CATION CHANNELS;

EID: 0033995175     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/72101     Document Type: Article

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