Genetic and biochemical diversity in the Pax gene family

Biochemistry and Cell Biology

Volumn 78, Issue 5, 2000, Pages 629-638

  Underhill, D A ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Development; Gene regulation; Homeodomain; Paired domain; Pax

Indexed keywords

GENE PRODUCT;

CONFERENCE PAPER; DNA BINDING; EMBRYO DEVELOPMENT; GENE CONTROL; MULTIGENE FAMILY; NONHUMAN; PROTEIN DOMAIN; PROTEIN FAMILY; REGULATORY MECHANISM;

DROSOPHILA; MAMMALIA;

EID: 0033679342     PISSN: 08298211     EISSN: None     Source Type: Journal    
DOI: 10.1139/o00-077     Document Type: Conference Paper

References (127)

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39. Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing
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41. Pax3 modulates expression of the c-Met receptor during limb muscle development
42. Tumor-specific Pax3-FKHR transcription factor, but not Pax3, activates the platelet-derived growth factor alpha receptor
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44. The mouse Pax2(1Neu) mutation is identical to a human Pax2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain, ear, eye, and kidney
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66. Alternatively spliced insertions in the paired domain restrict the DNA sequence specificity of Pax6 and Pax8
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68. Mapping of Pax-2 transcription activation domains
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70. HIRA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3
71. The specificity of homeotic gene function
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74. Follicular cells of the thyroid gland require Pax8 gene function
75. Uncx4.1 is required for the formation of the pedicles and proximal ribs and acts upstream of Pax9
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82. Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities
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85. The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development
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100. Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas
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102. Ectopic expression of MITF, a gene for Waardenburg syndrome type 2, converts fibroblasts to cells with melanocyte characteristics
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107. The paired box encodes a second DNA-binding domain in the paired homeo domain protein
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109. Inhibition of floor plate differentiation by Pax3: Evidence from ectopic expression in transgenic mice
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111. Analysis of the mouse Splotch-delayed mutation indicates that the Pax-3 paired domain can influence homeodomain DNA-binding activity
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113. Expression of genes for microphthalmia isoforms, Pax3 and MSG1, in human melanomas
114. The C-terminal subdomain makes an important contribution to the DNA binding activity of the Pax-3 paired domain
115. An alternative splicing event in the Pax-3 paired domain identifies the linker region as a key determinant of paired domain DNA-binding activity
116. Dependence of BSAP repressor and activator functions on BSAP concentration
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118. Epistatic relationship between Waardenburg syndrome genes MITF and Pax3
119. The highly conserved beta-hairpin of the paired DNA-binding domain is required for assembly of Pax-Ets ternary complexes
120. Interaction of the pRB-family proteins with factors containing paired-like homeodomains
121. Structural basis of Hox specificity
122. Cooperative dimerization of paired class homeo domains on DNA
123. High resolution crystal structure of a paired (Pax) class cooperative homeodomain dimer on DNA
124. Crystal structure of a paired domain-DNA complex at 2.5 A resolution reveals structural basis for Pax developmental mutations
125. Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding
126. Expression of the met receptor tyrosine kinase in muscle progenitor cells in somites and limbs is absent in Splotch mice
127. Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters