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Volumn 16, Issue 12, 1996, Pages 6677-6686

An alternative splicing event in the Pax-3 paired domain identifies the linker region as a key determinant of paired domain DNA-binding activity

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GLUTAMINE; HOMEODOMAIN PROTEIN; LINK PROTEIN; THYMIDINE KINASE; TRANSCRIPTION FACTOR;

EID: 0029860454     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.12.6677     Document Type: Article
Times cited : (94)

References (39)
  • 1
    • 0026584439 scopus 로고
    • An exonic mutation in the HuP2 paired domain gene causes Waardenburg's syndrome
    • Baldwin, C. T., C. F. Hoth, J. A. Amos, E. O. da-Silva, and A. Milunsky. 1992. An exonic mutation in the HuP2 paired domain gene causes Waardenburg's syndrome. Nature (London) 355:637-638.
    • (1992) Nature (London) , vol.355 , pp. 637-638
    • Baldwin, C.T.1    Hoth, C.F.2    Amos, J.A.3    Da-Silva, E.O.4    Milunsky, A.5
  • 2
    • 0027534945 scopus 로고
    • Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma
    • Barr, F. G., N. Galili, J. Holick, J. A. Biegel, G. Rovera, and B. S. Emanuel. 1993. Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma. Nat. Genet. 3:113-117.
    • (1993) Nat. Genet. , vol.3 , pp. 113-117
    • Barr, F.G.1    Galili, N.2    Holick, J.3    Biegel, J.A.4    Rovera, G.5    Emanuel, B.S.6
  • 3
    • 0028205002 scopus 로고
    • Pax-3 is required for the development of limb muscles: A possible role for the migration of dermomyotomal muscle progenitor cells
    • Bober, E., T. Franz, H.-H. Arnold, P. Gruss, and P. Tremblay. 1994. Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells. Development 120:603-612.
    • (1994) Development , vol.120 , pp. 603-612
    • Bober, E.1    Franz, T.2    Arnold, H.-H.3    Gruss, P.4    Tremblay, P.5
  • 4
    • 0024468972 scopus 로고
    • Conservation of the paired domain in metazoans and its structure in three isolated human genes
    • Burri, M., Y. Tromvoukis, D. Bopp, G. Frigerio, and M. Noll. 1989. Conservation of the paired domain in metazoans and its structure in three isolated human genes. EMBO J. 8:1183-1190.
    • (1989) EMBO J. , vol.8 , pp. 1183-1190
    • Burri, M.1    Tromvoukis, Y.2    Bopp, D.3    Frigerio, G.4    Noll, M.5
  • 5
    • 0029151172 scopus 로고
    • Identification of DNA recognition sequences for the Pax3 paired domain
    • Chalepakis, G., and P. Gruss. 1995. Identification of DNA recognition sequences for the Pax3 paired domain. Gene 162:267-270.
    • (1995) Gene , vol.162 , pp. 267-270
    • Chalepakis, G.1    Gruss, P.2
  • 6
    • 0028587375 scopus 로고
    • Pax-3 contains domains for transcription activation and transcription inhibition
    • Chalepakis, G., F. S. Jones, G. M. Edelman, and P. Gruss. 1994. Pax-3 contains domains for transcription activation and transcription inhibition. Proc. Natl. Acad. Sci. USA 91:12745-12749.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 12745-12749
    • Chalepakis, G.1    Jones, F.S.2    Edelman, G.M.3    Gruss, P.4
  • 7
    • 0018639079 scopus 로고
    • Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
    • Chirgwin, J. M., A. A. Przybyla, R. J. MacDonald, and W. J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5306.
    • (1979) Biochemistry , vol.18 , pp. 5294-5306
    • Chirgwin, J.M.1    Przybyla, A.A.2    MacDonald, R.J.3    Rutter, W.J.4
  • 8
    • 0028918392 scopus 로고
    • DNA-binding and transactivation properties of Pax-6: Three amino acids in the paired domain are responsible for the different sequence recognition of Pax-6 and BSAP (Pax-5)
    • Czerny, T., and M. Busslinger. 1995. DNA-binding and transactivation properties of Pax-6: three amino acids in the paired domain are responsible for the different sequence recognition of Pax-6 and BSAP (Pax-5). Mol. Cell. Biol. 15:2858-2871.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 2858-2871
    • Czerny, T.1    Busslinger, M.2
  • 9
    • 0027426925 scopus 로고
    • DNA sequence recognition by Pax proteins: Bipartite structure of the paired domain and its binding site
    • Czerny, T., G. Schaffner, and M. Busslinger. 1993. DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site. Genes Dev. 7:2048-2061.
    • (1993) Genes Dev. , vol.7 , pp. 2048-2061
    • Czerny, T.1    Schaffner, G.2    Busslinger, M.3
  • 10
    • 0025925068 scopus 로고
    • 2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3
    • 2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3. Cell 67:767-774.
    • (1991) Cell , vol.67 , pp. 767-774
    • Epstein, D.J.1    Vekemans, M.2    Gros, P.3
  • 11
    • 0027393598 scopus 로고
    • A mutation within intron 3 of the Pax-3 gene produces aberrantly spliced mRNA transcripts in the splotch (Sp) mouse mutant
    • Epstein, D. J., K. J. Vogan, D. G. Trasler, and P. Gros. 1993. A mutation within intron 3 of the Pax-3 gene produces aberrantly spliced mRNA transcripts in the splotch (Sp) mouse mutant. Proc. Natl. Acad. Sci. USA 90: 532-536.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 532-536
    • Epstein, D.J.1    Vogan, K.J.2    Trasler, D.G.3    Gros, P.4
  • 12
    • 0028239775 scopus 로고
    • Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes
    • Epstein, J. A., J. Cai, T. Glaser, L. Jepeal, D. S. Walton, and R. L. Maas. 1994. Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes. J. Biol. Chem. 269: 8355-8361.
    • (1994) J. Biol. Chem. , vol.269 , pp. 8355-8361
    • Epstein, J.A.1    Cai, J.2    Glaser, T.3    Jepeal, L.4    Walton, D.S.5    Maas, R.L.6
  • 13
    • 0028096639 scopus 로고
    • Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing
    • Epstein, J. A., T. Glaser, J. Cai, L. Jepeal, D. S. Walton, and R. L. Maas. 1994. Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing. Genes Dev. 17: 2022-2034.
    • (1994) Genes Dev. , vol.17 , pp. 2022-2034
    • Epstein, J.A.1    Glaser, T.2    Cai, J.3    Jepeal, L.4    Walton, D.S.5    Maas, R.L.6
  • 15
    • 0028118764 scopus 로고
    • Hin recombinase bound to DNA: The origin of specificity in major and minor groove interactions
    • Feng, J., R. C. Johnson, and R. E. Dickerson. 1994. Hin recombinase bound to DNA: the origin of specificity in major and minor groove interactions. Science 263:348-355.
    • (1994) Science , vol.263 , pp. 348-355
    • Feng, J.1    Johnson, R.C.2    Dickerson, R.E.3
  • 16
    • 0024004720 scopus 로고
    • Purification of a RAS-responsive adenylyl cyclase from Saccharomyces cerevisiae by use of an epitope addition method
    • Field, J., J. Nikawa, D. Broek, B. MacDonald, L. Rodgers, I. A. Wilson, R. A. Lerner, and M. Wigler. 1988. Purification of a RAS-responsive adenylyl cyclase from Saccharomyces cerevisiae by use of an epitope addition method. Mol. Cell. Biol. 8:2159-2165.
    • (1988) Mol. Cell. Biol. , vol.8 , pp. 2159-2165
    • Field, J.1    Nikawa, J.2    Broek, D.3    MacDonald, B.4    Rodgers, L.5    Wilson, I.A.6    Lerner, R.A.7    Wigler, M.8
  • 18
    • 0025875226 scopus 로고
    • Pax-3, a novel murine DNA binding protein expressed during early neurogenesis
    • Goulding, M. D., G. Chalepakis, U. Deutsch, J. Erselius, and P. Gruss. 1991. Pax-3, a novel murine DNA binding protein expressed during early neurogenesis. EMBO J. 10:1135-1147.
    • (1991) EMBO J. , vol.10 , pp. 1135-1147
    • Goulding, M.D.1    Chalepakis, G.2    Deutsch, U.3    Erselius, J.4    Gruss, P.5
  • 20
    • 0029150628 scopus 로고
    • Activation of a MMTV/mdr3 fusion transcript from a cryptic viral promoter is stimulated by mdr-derived sequences located in intron 1
    • Lepage, P., D. A. Underhill, and P. Gros. 1995. Activation of a MMTV/mdr3 fusion transcript from a cryptic viral promoter is stimulated by mdr-derived sequences located in intron 1. Virology 210:244-253.
    • (1995) Virology , vol.210 , pp. 244-253
    • Lepage, P.1    Underhill, D.A.2    Gros, P.3
  • 21
    • 0027441203 scopus 로고
    • Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties
    • Kozmik, Z., R. Kurzbauer, P. Dorfler, and M. Busslinger. 1993. Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties. Mol. Cell. Biol. 13:6024-6035.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 6024-6035
    • Kozmik, Z.1    Kurzbauer, R.2    Dorfler, P.3    Busslinger, M.4
  • 22
    • 0025982062 scopus 로고
    • Construction of T-vectors, a rapid and general system for direct cloning of unmodified PCR products
    • Marchuk, D., M. Drumm, A. Saulino, and F. S. Collins. 1991. Construction of T-vectors, a rapid and general system for direct cloning of unmodified PCR products. Nucleic Acids Res. 19:1154.
    • (1991) Nucleic Acids Res. , vol.19 , pp. 1154
    • Marchuk, D.1    Drumm, M.2    Saulino, A.3    Collins, F.S.4
  • 23
    • 0026605043 scopus 로고
    • U5 snRNA interacts with exon sequences at 5′ and 3′ splice sites
    • Newman, A. J., and C. Norman. 1992. U5 snRNA interacts with exon sequences at 5′ and 3′ splice sites. Cell 68:743-754.
    • (1992) Cell , vol.68 , pp. 743-754
    • Newman, A.J.1    Norman, C.2
  • 24
    • 0027170576 scopus 로고
    • Evolution and role of Pax genes
    • Noll, M. 1993. Evolution and role of Pax genes. Curr. Opin. Genet. Dev. 3:595-605.
    • (1993) Curr. Opin. Genet. Dev. , vol.3 , pp. 595-605
    • Noll, M.1
  • 25
    • 0026624840 scopus 로고
    • Mutations at the 3′ splice site can be suppressed by compensatory base changes in U1 snRNA in fission yeast
    • Reich, C. I., R. W. Van Hoy, G. L. Porter, and J. A. Wise. 1992. Mutations at the 3′ splice site can be suppressed by compensatory base changes in U1 snRNA in fission yeast. Cell 69:1159-1169.
    • (1992) Cell , vol.69 , pp. 1159-1169
    • Reich, C.I.1    Van Hoy, R.W.2    Porter, G.L.3    Wise, J.A.4
  • 28
    • 0029055472 scopus 로고
    • Distinct binding specificities and functions of higher eukaryotic polypyrimidine tract-binding proteins
    • Singh, R., J. Valcarcel, and M. R. Green. 1995. Distinct binding specificities and functions of higher eukaryotic polypyrimidine tract-binding proteins. Science 268:1173-1176.
    • (1995) Science , vol.268 , pp. 1173-1176
    • Singh, R.1    Valcarcel, J.2    Green, M.R.3
  • 29
    • 0027054380 scopus 로고
    • Features of spliceosome evolution and function inferred from an analysis of the information at human splice sites
    • Stephens, R. M., and T. D. Schneider. 1992. Features of spliceosome evolution and function inferred from an analysis of the information at human splice sites. J. Mol. Biol. 228:1124-1136.
    • (1992) J. Mol. Biol. , vol.228 , pp. 1124-1136
    • Stephens, R.M.1    Schneider, T.D.2
  • 31
    • 0026602124 scopus 로고
    • Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene
    • Tassabehji, M., A. P. Read, V. E. Newton, R. Harris, R. Balling, P. Gruss, and T. Strachan. 1992. Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene. Nature (London) 355:635-636.
    • (1992) Nature (London) , vol.355 , pp. 635-636
    • Tassabehji, M.1    Read, A.P.2    Newton, V.E.3    Harris, R.4    Balling, R.5    Gruss, P.6    Strachan, T.7
  • 33
    • 0026569669 scopus 로고
    • Twin of I-POU: A two amino acid difference in the I-POU homeodomain distinguishes an activator from an inhibitor of transcription
    • Treacy, M. N., L. I. Neilson, E. E. Turner, X. He, and M. G. Rosenfeld. 1992. Twin of I-POU: a two amino acid difference in the I-POU homeodomain distinguishes an activator from an inhibitor of transcription. Cell 68:491-505.
    • (1992) Cell , vol.68 , pp. 491-505
    • Treacy, M.N.1    Neilson, L.I.2    Turner, E.E.3    He, X.4    Rosenfeld, M.G.5
  • 34
    • 0025884198 scopus 로고
    • The paired box encodes a second DNA-binding domain in the paired homeo domain protein
    • Treisman, J., E. Harris, and C. Desplan. The paired box encodes a second DNA-binding domain in the paired homeo domain protein. 1991. Genes Dev. 5:594-604.
    • (1991) Genes Dev. , vol.5 , pp. 594-604
    • Treisman, J.1    Harris, E.2    Desplan, C.3
  • 35
    • 0029024867 scopus 로고
    • Analysis of the mouse Splotch-delayed mutation indicates that the Pax-3 paired domain can influence homeodomain DNA-binding activity
    • Underhill, D. A., K. J. Vogan, and P. Gros. 1995. Analysis of the mouse Splotch-delayed mutation indicates that the Pax-3 paired domain can influence homeodomain DNA-binding activity. Proc. Natl. Acad. Sci. USA 92: 3692-3696.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3692-3696
    • Underhill, D.A.1    Vogan, K.J.2    Gros, P.3
  • 36
    • 0027338132 scopus 로고
    • d) mouse mutant carries a point mutation within the paired box of the Pax-3 gene
    • d) mouse mutant carries a point mutation within the paired box of the Pax-3 gene. Genomics 17:364-369.
    • (1993) Genomics , vol.17 , pp. 364-369
    • Vogan, K.J.1    Epstein, D.J.2    Trasler, D.G.3    Gros, P.4
  • 37
    • 0027332476 scopus 로고
    • Cooperative dimerization of Paired class homeodomains on DNA
    • Wilson, D., G. Sheng, T. Lecuit, N. Dostatni, and C. Desplan. 1993. Cooperative dimerization of Paired class homeodomains on DNA. Genes Dev. 7:2120-2134.
    • (1993) Genes Dev. , vol.7 , pp. 2120-2134
    • Wilson, D.1    Sheng, G.2    Lecuit, T.3    Dostatni, N.4    Desplan, C.5
  • 38
    • 0028919759 scopus 로고
    • Crystal structure of a paired domain-DNA complex at 2.5 A resolution reveals structural basis for Pax developmental mutants
    • Xu, W., M. A. Rould, S. Jun, C. Desplan, and C. O. Pabo. 1995. Crystal structure of a paired domain-DNA complex at 2.5 A resolution reveals structural basis for Pax developmental mutants. Cell 80:639-650.
    • (1995) Cell , vol.80 , pp. 639-650
    • Xu, W.1    Rould, M.A.2    Jun, S.3    Desplan, C.4    Pabo, C.O.5
  • 39
    • 0026738482 scopus 로고
    • Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters
    • Zannini, M., H. Francis-Lang, D. Plachov, and R. Di Lauro. 1992. Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters. Mol. Cell. Biol. 12:4230-4241.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 4230-4241
    • Zannini, M.1    Francis-Lang, H.2    Plachov, D.3    Di Lauro, R.4


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