Inhibition of floor plate differentiation by Pax3: Evidence from ectopic expression in transgenic mice

Development

Volumn 122, Issue 8, 1996, Pages 2555-2567

  Tremblay, Patrick ^a,b   Pituello, Fabienne ^a,c   Gruss, Peter ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITÉ DE TOULOUSE   (France)

Author keywords

Floor plate; Holoprosencephaly; Mouse; Neural tube; Notochord; Pax genes; Polydactyly; Transgenic mice

Indexed keywords

ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; DEVELOPMENTAL DISORDER; DEVELOPMENTAL GENETICS; EMBRYO; EMBRYO DEVELOPMENT; EYE DEVELOPMENT; HOMEOBOX; LIMB DEVELOPMENT; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEURAL TUBE; NEUROEPITHELIUM; NONHUMAN; NOTOCHORD; PRIORITY JOURNAL; PROMOTER REGION; TRANSGENIC MOUSE;

ANIMALS; BASE SEQUENCE; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CENTRAL NERVOUS SYSTEM; DNA PRIMERS; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MALE; MESENCEPHALON; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PAIRED BOX TRANSCRIPTION FACTORS; SPINAL CORD; TRANSCRIPTION FACTORS;

ANIMALIA; MUS MUSCULUS;

EID: 0029813240     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (75)

1. Ang, S. L. and Rossant, J. (1994). HNF-3 beta is essential for node and notochord formation in mouse development. Cell 78, 561-74.
2. Asano, M. and Gruss, P. (1992). Pax5 is expressed at the midbrain-hindbrain boundary during mouse development. Mech. Dev. 39, 29-39.
3. Auerbach, R. (1954). Analysis of the developmental effects of a lethal mutation in the house mouse. J. Exp. Zool. 127, 305-329.
4. Beddington, R. S. P. (1994). Induction of a second neural axis by the mouse node. Development 120, 613-620.
5. Bober, E., Franz, T., Arnold, H. H., Gruss, P. and Tremblay, P. (1994). Pax3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells. Development 120, 603-612.
6. Bovolenta, P. and Dodd, J. (1991). Perturbation of neuronal differentiation and axon guidance in the spinal cord of mouse embryos lacking a floor plate: analysis of Danforth≪s short-tail mutation. Development 113, 625-639.
7. Cohen, M. M. (1982). An update on the holoprosencephalic disorders. J. Pediatr. 101, 865-869.
8. Dickinson, M. E., Krumlauf, R. and McMahon, A. P. (1994). Evidence for a mitogenic effect of Wnt-1 in the developing mammalian central nervous system. Development 120, 1453-1471.
9. Dickinson, M. R., Selleck, M. A. J., McMahon, A. P. and Bronner-Fraser, M. (1995). Dorsalization of the neural tube by the non-neural ectoderm. Development 121, 2099-2106.
10. Dietrich, S., Schubert, F. R. and Gruss, P. (1993). Altered Pax gene expression in murine notochord mutants: the notochord is required to initiate and maintain ventral identity in the somite. Mech. Dev. 44, 189-207.
11. Echelard, Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., Me Mahon, J. A. and Me Mahon, A. (1993). Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75, 1417-1430.
12. Epstein, D. J., Vekemans, M. and Gros, P. (1991). Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax3. Cell 67, 767-774.
13. Epstein, D. J., Vogan, K. J., Trasler, D. G. and Gros, P. (1993). A mutation within the intron 3 of Pcu3 gene produced aberrantly spliced mRNA transcripts in the Splotch (Sp) mutant. Proc. Natl. Acad. Sci. USA 90, 532-536.
14. Ericson, J., Thor, S., Edlund, T., Jessel, T. M. and Yamada, T. (1992). Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1. Science 256, 1555-1560.
15. Franz, T. (1989). Persistent truncus arteriosus in the Splotch mutant mouse. Anat. Embryol. 180, 457-464.
16. Franz, T. (1990). Defective ensheathment of motoric nerves in the Splotch mutant mouse. Acta Anat. 138, 246-253.
17. Goulding, M. D., Chalepakis, G., Deutsch, U., Erselius, J. R. and Grass P. (1991). Pax-3, a novel murine DNA binding protein expressed during early neurogenesis. EMBO J. 10, 1135-1147.
18. Goulding, M. D., Lumsden, A. and Gruss P. (1993a). Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord. Development 117, 1001-1016.
19. Goulding, M., Lumsden, A. and Paquette A. J. (1994). Regulation of Pax-3 expression in the dermomyotome and its role in muscle development. Development 120, 957-71.
20. Goulding, M., Sterrer, S., Fleming, J., Balling, R., Nadeau, J., Moore, K.J., Brown, A. D. M., Steel, K. P. and Gruss, P. (1993b). Analysis of the Pax3 mutant Splotch. Genomics 17, 355-363.
21. Hill, R. E., Jones, P. F., Rees, A. R., Sime, C. M., Justice, M. J., Copeland, N. G., Jenkins, N. A., Graham, E. and Davidson, D. R. (1989). A new family of mouse homeobox containing genes: molecular structure, chromosomal location, and developmental expression of Hox-7.1. Genes Dev. 3, 26-37.
22. Hogan, B., Beddington, R, Costantini, F. and Lacy, E. (1994). In Manipulating the Mouse Embryo. Cold Spring Harbor New York: Cold Spring Harbor Laboratory.
23. Ishii, K., Oda, Y., Ichikawa, T. and Deguchi, T. (1990). Complementary DNAs for choline acetyl transferase from spinal cords of rat and mouse: nucleotide sequences expression in mammalian cells, and in situ hybridisation. Molecular Brain Res. 7, 151-159.
24. Jostes, B., Walther, C. and Gruss, P. (1991). The murine paired box gene, Pax-7, is expressed specifically during the development of the nervous and muscular systems. Mech. Dev. 33, 27-38.
25. Karamitopoulou, E., Perentes, E., Diamantis, I. and Maraziotis, T. (1994). Ki-67 immunoreactivity in human central nervous system tunors: a study MIB1 monoclonal antibody on arhival material. Acta Neuropathol. 87, 47-54.
26. Karlsson, O., Thor, S., Norbert, T., Ohlsson, H. and Edlund, T. (1990) Insulin gene enhancer protein Isl-1 is a member of a novel class of proteins containing both an homeo and a Cys-His domain. Nature 344, 879-882.
27. Krauss, S., Concordet, J.-P. and Ingham P. W. (1993). A functionally conserved homolog of the drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos. Cell 75, 1431-1444.
28. Leech, R. W. and Shuman, R. M. (1986). Holoprosencephaly and related midline cerebral anomalies: A review. J. Child Neural. 1, 3-18.
29. Liem, K. F., Jr., Tremml, G., Roelink, H. and Jessell, T.M. (1995). Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm. Cell 82, 969-979.
30. Lurie, I. W. and Wulfsberg E. A. (1993). 'Holoprosencephaly-Polydactyly' (Pseudotrisomy 13) syndrome: Expansion of the phenotypic spectrum. Am. J. Med. Genet. 47, 405-409.
31. Marti, E., Bumcrot, D. A., Takada, R. and McMahon, A. (1995b) Requirement of the 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS expiants. Nature 375, 322-325.
32. Marti, E., Takada, R., Bumcrot, D. A., Sasaki, H. and McMahon A. P. (1995a). Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo. Development 121, 2537-2547.
33. Moase, C. E. and Trasler, D. G. (1989). Spinal ganglia reduction in the Splotch-delayed mouse neural tube defect mutant. Teratology 40, 67-75.
34. Morell, R., Friedman, T. B., Moeljopawiro, S., Hartono, S. and Asher, J. H. (1992). A frameshift mutation in HuP2 paired domain of the probable human homolog of murine Pax-3 is responsible for Waardenburg syndrome type 1 in an Indonesian family. Hum. Mol. Genetics 4, 243-247.
35. Moury, J. D. and Jacobson, A. G. (1989). Neural fold formation at newly created boundaries between neural plate and epidermis in the axolotl. Dev. Biol. 133, 44-57.
36. Parr, B. A., Shea, M. J., Vassileva, G. and Mc Mahon, A. P. (1993). Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb bud. Development 119, 247-261.
37. Pituello, F., Yamada, G. and Grass, P. (1995). Activin A inhibits Pax-6 expression and perturbs cell differentiation in the developing spinal cord in vitro. Proc. Natl. Acad. Sci. USA 92, 6952-6956.
38. Placzek, M. (1995). The role of the notochord and floor plate in inductive interactions. Current Opinion in Genetics and Development 5, 499-506.
39. Placzek, M., Jessel, T. M. and Dodd, J. (1993). Induction of floor plate differentiation by contact-dependent, homeogenetic signals. Development 117, 205-218.
40. Placzek, M., Tessier-Lavigne, M., Yamada, T., Jessel, T. M. and Dodd, J. (1990). Mesodermal control of neural cell identity: floor plate induction by the notochord. Science 250, 985-988.
41. Pourquie, O., Coltey, M., Teiltet, M. A., Ordahl, C. and Le Douarin, N. M. (1993). Control of dorso-ventral patterning of somitic derivatives by notochord and floor plate. Proc. Natl. Acad. Sci. USA 90, 5242-5246.
42. Riddle, R. D., Johnson, R. L., Laufer, E. and Tabin, C. (1993). Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1401-1416.
43. Robert, B., Sassoon, D., Jacq, B., Gehring, W. and Buckingham, M. (1989) Hox-7, a mouse homeobox gene with a novel pattern of expression during embryogenesis. EMBO J. 8, 91-100.
44. Roelink, H. and Nusse, R. (1991). Expression of two members of the Wnt family during mouse development-restricted temporal and spatial pattern in the developing neural tube. Genes Dev. 5, 381-388.
45. Roelink, H., Augsburger, A., Heemskerk, J., Korzh, V., Norlin, S., Ruiz i Altaba, A., Tanabe, Y., Placzek, M., Edlund, T., Jessell, T. and Dodd, J. (1994). Floor plate and motor neuron induction by vhh-l, a vertebrate homolog of hedgehog expressed by the notochord. Cell 76, 761-775.
46. Roelink, H., Porter, J. A., Chiang, C., Tanabe, Y., Chang, D. T., Beachy, P. A. and Jessell, T. M. (1995). Floor plate and motor neuron induction by concentrations of the amino-terminal cleavage product of Sonic hedgehog autoproteolysis. Cell 81, 445-455.
47. Ruiz i Altaba, A., Cox, C., Jessell, T. M. and Klar, A. (1993). Ectopic neural expression of a floor plate marker in frog embryos injected with the midline transcription factor Pintallavis. Proc. Natl. Acad. Sci. USA 90, 8268-8272.
48. Ruiz i Altaba, A., Jessell, T. M. and Roelink, H. (1995a). Restrictions to floor plate induction by hedgehog and Winged-Helix genes in the neural tube of frog embryos. Mol. Cell. Neurosci. 6, 106-121.
49. Ruiz i Altaba, A., Placzek, M., Baldassare, M., Dodd, J. and Jessell, T. M. (1995b). Early stages of notochord and floor plate development in the chick embryo defined by normal and induced expression of HNF-3β. Dev. Biol. 170, 299-313.
50. Sasaki, H. and Hogan, B. L. M. (1993). Differential expression of multiple fork head regulated genes during gastrulation and axial patterning formation in the mouse embryo. Development 118, 47-59.
51. Sasaki, H. and Hogan, B. L. M. (1994). HNF-3β as a regulator of floor plate development. Cell 76, 103-115.
52. Schoenwolf, G.C. and Sheard, P. (1990). Fate mapping the avian epiblast with focal injections of a fluorescent-histochemical marker: ectodermal derivatives. J. Exp. Zool. 255, 323-339.
53. Schubert, F. R., Fainsod, A., Gruenbaum, Y. and Gruss, P. (1995). Expression of the novel murine homeobox gene Sax-1 in the developing nervous system. Mech. Dev. 51, 99-114.
54. Selleck, M. and Bronner-Fraser, M. (1995). Origin of the avian neural crest: the role of neural plate epidermal interactions. Development 121, 525-538.
55. Sibilia, M. and Wagner, E. F. (1995). Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 269, 234-238.
56. Smith, J. L., Gesteland, K. M. and Schoenwolf, G. C. (1994). Prospective fate map of the mouse primitive streak at 7.5 days of gestation. Developmental Dynamics 201, 279-289.
57. St-Onge, L., Pituello. F. and Gruss, P. (1995). The role of Pax genes during murine development. Seminars in Dev. Biol. 6, 285-292.
58. Stoykova, A. and Gruss, P. (1994). Roles of Pax genes in developing and adult brain as suggested by expression pattern. J. Neurosci. 14, 1395-1412.
59. Sulik, K., Dehart, D. B., Inagaki, T., Carson, J. L., Vrablic, T., Gesteland, K. and Schoenwolf, G. C. (1994). Morphogenesis of the murine node and notochordal plate. Developmental Dynamics 201, 260-278.
60. Tanabe, Y., Roelink, H. and Jessell, T. M. (1995). Induction of motor neurons by Sonic hedgehog is independent of floor plate differentiation. Current Biology 5, 651-658.
61. Tassabehji, M., Read, A. P., Newton, V. E., Harris, R., Balling, R., Gruss, P. and Strachan, T. (1992). Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene. Nature 355, 635-638.
62. Tessier-Lavigne, M., Placzek, M., Lumsden, A. G. S., Dodd, J. and Jessell, T. M. (1988). Chemotropic guidance of developing axons in the mammalian central nervous system. Nature 336, 775-778.
63. Threadgill, D. W., Dlugosz, A. A., Hansen, L. A., Tennenbaum, T., Lichti, U., Yee, D., LaMantia, C., Mourton, T., Herrup, K., Harris, R. C., et al. (1995). Targeted disruption of mouse EGF receptor: Effect of genetic background on mutant phenotype. Science 269, 230-4.
64. Tremblay, P. and Gruss, P. (1994). Pax: genes for mice and men. Pharmac. Ther. 61, 205-226.
65. Tremblay, P., Kessel, M and Gruss, P. (1995). A transgenic neuroanatomical marker identifies cranial neural crest deficiencies associated with the Pax3 mutant Splotch. Dev. Biol 171, 317-329.
66. Tsuchida, T., Ensini, M., Morton, S. B., Baldassare, M., Edlund, T., Jessell, T. M. and Pfatf, S. L. (1994). Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes. Cell 79, 957-970.
67. van Straaten, H. M. W., Hekking, J. W. M., Wiertz-Hoessels, E. L., Thors, F. and Drukker J. (1988). Effect of the notochord on the differentiation of a floor plate area in the neural tube of the chick embryo. Anal. Embryol. 177, 317-324.
68. van Straaten, H. W. M. and Hekking, J. W. M. (1991). Development of floor plate, neurons and axonal outgrowth pattern in the early spinal cord of the notochord-deficient chick embryo. Anat. Embryol 184, 55-63.
69. van Straaten, H. W. M., Hekking, J. W. M., Thors, F., Wiertz-Hoessels, E. L. M. J. and Drukker, J. (1985). Induction of an additional floor plate in the neural tube. Ada Morphol Neerl.-Scand. 23, 91-97.
70. Walther, C. and Grass, P. (1991). Pax-6, a murine paired box gene is expressed in the developing CNS. Development 113, 1435-1449.
71. Whiting, J., Marshall, H., Cook, M., Krumlauf, R., Rigby, P. W. J., Stott, D. and Allemann, R. K. (1991). Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6gene expression. Genes Dev. 5, 2048-2059.
72. Wilkinson, D. G. (1992). In In Situ Hybridisation: A Practical Approach, (ed. D. G. Wilkinson), pp. 75-82, Oxford: IRL Press.
73. Yamada, T., Pfaff, S. L., Edlund, T. and Jessell, T. M. (1993). Control of cell pattern in the neural tube: motor neuron induction by diffusible factors from notochord and floor plate. Cell 73, 673-686.
74. Yamada, T., Placzek, M., Tanaka, H., Dodd, J. and Jessell, T. M. (1991). Control of cell pattern in the developing nervous system: polarizing activity of the floor plate and notochord. Cell 64, 635-647.
75. Zhadanov, A. B., Bertuzzi, S., Taira, M., Dawid, I. B. and Westphal, H. (1995). Expression pattern of the murine Lim class homeobox gene Lhx-3 inn subsets of neural and neuroendocrine tissues. Developmental Dynamics 202, 354-364.