메뉴 건너뛰기




Volumn 19, Issue 1, 1999, Pages 594-601

The oncogenic potential of the Pax3-FKHR fusion protein requires the Pax3 homeodomain recognition helix but not the Pax3 paired-box DNA binding domain

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN;

EID: 0032906216     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.1.594     Document Type: Article
Times cited : (98)

References (35)
  • 2
    • 0024277960 scopus 로고
    • Undulated, a mutation affecting the development of the mouse skeleton, has a point mutation in the paired box of Pax1
    • Balling, R., U. Deutsch, and P. Gruss. 1988. Undulated, a mutation affecting the development of the mouse skeleton, has a point mutation in the paired box of Pax1. Cell 55:531-535.
    • (1988) Cell , vol.55 , pp. 531-535
    • Balling, R.1    Deutsch, U.2    Gruss, P.3
  • 3
    • 0029154584 scopus 로고
    • Wild type Pax3 protein and the Pax3-FKHR fusion protein of alveolar rhabdomyosarcoma contain potent, structurally distinct transcriptional activation domains
    • Bennicelli, J. L., W. J. Fredericks, R. B. Wilson, F. J. Rauscher III, and F. G. Barr. 1995. Wild type Pax3 protein and the Pax3-FKHR fusion protein of alveolar rhabdomyosarcoma contain potent, structurally distinct transcriptional activation domains. Oncogene 11:119-130.
    • (1995) Oncogene , vol.11 , pp. 119-130
    • Bennicelli, J.L.1    Fredericks, W.J.2    Wilson, R.B.3    Rauscher F.J. III4    Barr, F.G.5
  • 4
    • 0029980113 scopus 로고    scopus 로고
    • Mechanism for transcriptional gain of function resulting from chromosomal translocation in alveolar rhabdomyosarcoma
    • Bennicelli, J. L., R. H. Edwards, and F. G. Barr. 1996. Mechanism for transcriptional gain of function resulting from chromosomal translocation in alveolar rhabdomyosarcoma. Proc. Natl. Acad. Sci. USA 93:5455-5459.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 5455-5459
    • Bennicelli, J.L.1    Edwards, R.H.2    Barr, F.G.3
  • 5
    • 0027323876 scopus 로고
    • Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: Roles of calcineurin binding and cellular location
    • Braum, R. J., D. T. Hung, P. K. Martin, S. L. Schreiber, and G. R. Crabtree. 1993. Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location. Mol. Cell. Biol. 13:4760-4769.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 4760-4769
    • Braum, R.J.1    Hung, D.T.2    Martin, P.K.3    Schreiber, S.L.4    Crabtree, G.R.5
  • 6
    • 0027275485 scopus 로고
    • The winged-helix DNA-binding motif: Another helix-turn-helix takeoff
    • Brennan, R. G. 1993. The winged-helix DNA-binding motif: another helix-turn-helix takeoff. Cell 74:773-776.
    • (1993) Cell , vol.74 , pp. 773-776
    • Brennan, R.G.1
  • 8
    • 0029939199 scopus 로고    scopus 로고
    • Pbx modulation of Hox homeodomain amino-terminal arms establishes different DNA-binding specificities across the Hox locus
    • Chang, C.-P., L. Brocchieri, W.-F. Shen, C. Largman, and M. L. Cleary. 1996. Pbx modulation of Hox homeodomain amino-terminal arms establishes different DNA-binding specificities across the Hox locus. Mol. Cell. Biol. 16:1734-1745.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1734-1745
    • Chang, C.-P.1    Brocchieri, L.2    Shen, W.-F.3    Largman, C.4    Cleary, M.L.5
  • 9
    • 0031031879 scopus 로고    scopus 로고
    • The Hox cooperativity motif of the chimeric oncoprotein E2a-Pbx1 is necessary and sufficient for oncogenesis
    • Chang, C.-P., I. de Vivo, and M. L. Cleary. 1997. The Hox cooperativity motif of the chimeric oncoprotein E2a-Pbx1 is necessary and sufficient for oncogenesis. Mol. Cell. Biol. 17:81-88.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 81-88
    • Chang, C.-P.1    De Vivo, I.2    Cleary, M.L.3
  • 10
    • 0030860934 scopus 로고    scopus 로고
    • Fusion genes resulting from alternative chromosomal translocations are overexpressed by gene-specific mechanisms in alveolar rhabdomyosarcoma
    • Davis, R. J., and F. G. Barr. 1997. Fusion genes resulting from alternative chromosomal translocations are overexpressed by gene-specific mechanisms in alveolar rhabdomyosarcoma. Proc. Natl. Acad. Sci. USA 94:8047-8051.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 8047-8051
    • Davis, R.J.1    Barr, F.G.2
  • 11
    • 0026458016 scopus 로고
    • The nuclear membrane
    • Dingwall, C., and R. Laskey. 1992. The nuclear membrane. Science 258:942-947.
    • (1992) Science , vol.258 , pp. 942-947
    • Dingwall, C.1    Laskey, R.2
  • 12
    • 0029074993 scopus 로고
    • Pax3 inhibits myogenic differentiation of cultured myoblast cells
    • Epstein, J. A., P. Lam, L. Jepeal, R. L. Maas, and D. N. Shapiro. 1995. Pax3 inhibits myogenic differentiation of cultured myoblast cells. J. Biol. Chem. 270:11719-11722.
    • (1995) J. Biol. Chem. , vol.270 , pp. 11719-11722
    • Epstein, J.A.1    Lam, P.2    Jepeal, L.3    Maas, R.L.4    Shapiro, D.N.5
  • 13
    • 0028881603 scopus 로고
    • The Pax3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcoma is a more potent transcriptional activator than Pax3
    • Fredericks, W. J., N. Galili, S. Mukhopadhyay, G. Rovera, J. Bennicelli, F. G. Barr, and F. J. I. Rauscher III. 1995. The Pax3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcoma is a more potent transcriptional activator than Pax3. Mol. Cell. Biol. 15:1522-1535.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 1522-1535
    • Fredericks, W.J.1    Galili, N.2    Mukhopadhyay, S.3    Rovera, G.4    Bennicelli, J.5    Barr, F.G.6    Rauscher F.J.I. III7
  • 15
    • 0025875226 scopus 로고
    • Pax3, a novel murine DNA binding protein expressed during early neurogenesis
    • Goulding, M. D., G. Chalepakis, U. Deutsch, J. R. Erselius, and P. Gruss. 1991. Pax3, a novel murine DNA binding protein expressed during early neurogenesis. EMBO J. 10:1135-1147.
    • (1991) EMBO J. , vol.10 , pp. 1135-1147
    • Goulding, M.D.1    Chalepakis, G.2    Deutsch, U.3    Erselius, J.R.4    Gruss, P.5
  • 16
    • 0015847039 scopus 로고
    • A new technique for the assay of infectivity of human adenovirus 5 DNA
    • Graham, F. L., and A. J. van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456-467.
    • (1973) Virology , vol.52 , pp. 456-467
    • Graham, F.L.1    Van Der Eb, A.J.2
  • 18
    • 0024520745 scopus 로고
    • Site-directed mutagenesis by overlap extension using the polymerase chain reaction
    • Ho, S., H. D. Hunt, R. M. Horton, J. K. Pullen, and L. R. Pease. 1989. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77:51-59.
    • (1989) Gene , vol.77 , pp. 51-59
    • Ho, S.1    Hunt, H.D.2    Horton, R.M.3    Pullen, J.K.4    Pease, L.R.5
  • 19
    • 0024556150 scopus 로고
    • Engineering hybrid genes without the use of restriction enzymes: Gene splicing by overlap extension
    • Horton, R. M., H. D. Hunt, S. N. Ho, J. K. Pullen, and L. R. Pease. 1989. Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension. Gene 77:61-68.
    • (1989) Gene , vol.77 , pp. 61-68
    • Horton, R.M.1    Hunt, H.D.2    Ho, S.N.3    Pullen, J.K.4    Pease, L.R.5
  • 20
    • 0027439075 scopus 로고
    • Mutations in the paired domain of the human Pax3 gene cause Klein-Waardenburg Syndrome (WS-III) as well as Waardenburg syndrome type I (WS-I)
    • Hoth, C. F., A. Milunsky, N. Lipsky, R. Sheffer, S. K. Clarren, and C. T. Baldwin. 1993. Mutations in the paired domain of the human Pax3 gene cause Klein-Waardenburg Syndrome (WS-III) as well as Waardenburg syndrome type I (WS-I). Am. J. Hum. Genet. 52:455-462.
    • (1993) Am. J. Hum. Genet. , vol.52 , pp. 455-462
    • Hoth, C.F.1    Milunsky, A.2    Lipsky, N.3    Sheffer, R.4    Clarren, S.K.5    Baldwin, C.T.6
  • 21
    • 0025137176 scopus 로고
    • A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL
    • Kamps, M. P., C. Murre, X.-H. Sun, and D. Baltimore. 1990. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. Cell 60:547-555.
    • (1990) Cell , vol.60 , pp. 547-555
    • Kamps, M.P.1    Murre, C.2    Sun, X.-H.3    Baltimore, D.4
  • 22
    • 0027252649 scopus 로고
    • The oncogenic potential of Pax genes
    • Maulbecker, C. C., and P. Gruss. 1993. The oncogenic potential of Pax genes. EMBO J. 12:2361-2367.
    • (1993) EMBO J. , vol.12 , pp. 2361-2367
    • Maulbecker, C.C.1    Gruss, P.2
  • 23
    • 0028089760 scopus 로고
    • Transformation properties of the E2a-Pbx1 chimeric oncoprotein: Fusion with E2a is essential, but the Pbx1 homeodomain is dispensable
    • Monica, K., D. P. LeBrun, D. A. Dedera, R. Brown, and M. L. Cleary. 1994. Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable. Mol. Cell. Biol. 14:8304-8314.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 8304-8314
    • Monica, K.1    LeBrun, D.P.2    Dedera, D.A.3    Brown, R.4    Cleary, M.L.5
  • 24
    • 0025959660 scopus 로고
    • BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive leukemias
    • Muller, A. J., J. C. Young, A.-M. Pendergast, M. Pondel, N. R. Landau, D. R. Littman, and O. N. Witte. 1991. BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive leukemias. Mol. Cell. Biol. 11:1785-1792.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 1785-1792
    • Muller, A.J.1    Young, J.C.2    Pendergast, A.-M.3    Pondel, M.4    Landau, N.R.5    Littman, D.R.6    Witte, O.N.7
  • 25
    • 0030779871 scopus 로고    scopus 로고
    • Structure-function analysis of Msx2-mediated transcriptional suppression
    • Newberry, E. P., T. Latifi, J. T., Battaile, and D. A. Towler. 1997. Structure-function analysis of Msx2-mediated transcriptional suppression. Biochemistry 36:10451-10462.
    • (1997) Biochemistry , vol.36 , pp. 10451-10462
    • Newberry, E.P.1    Latifi, T.2    Battaile, J.T.3    Towler, D.A.4
  • 26
    • 0025064238 scopus 로고
    • Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor
    • Nourse, J., J. D. Mellentin, N. Galili, J. Wilkinson, E. Stanbridge, S. D. Smith, and M. L. Cleary. 1990. Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. Cell 60:535-545.
    • (1990) Cell , vol.60 , pp. 535-545
    • Nourse, J.1    Mellentin, J.D.2    Galili, N.3    Wilkinson, J.4    Stanbridge, E.5    Smith, S.D.6    Cleary, M.L.7
  • 28
    • 0027970838 scopus 로고
    • Chromosomal translocations in human cancer
    • Babbitts, T. H. 1994. Chromosomal translocations in human cancer. Nature 372:143-149.
    • (1994) Nature , vol.372 , pp. 143-149
    • Babbitts, T.H.1
  • 30
    • 0029796402 scopus 로고    scopus 로고
    • The hybrid Pax3-FKHR fusion protein of alveolar rhabdomyosarcoma transforms fibroblasts in culture
    • Scheidler, S., W. J. Fredericks, F. J. Rauscher III, F. G. Barr, and P. K. Vogt. 1996. The hybrid Pax3-FKHR fusion protein of alveolar rhabdomyosarcoma transforms fibroblasts in culture. Proc. Natl. Acad. Sci. USA 93:9805-9809.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 9805-9809
    • Scheidler, S.1    Fredericks, W.J.2    Rauscher F.J. III3    Barr, F.G.4    Vogt, P.K.5
  • 31
    • 0027366917 scopus 로고
    • Fusion of Pax3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma
    • Shapiro, D. N., J. E. Sublett, B. Li, J. R. Downing, and C. W. Naeve. 1993. Fusion of Pax3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma. Cancer Res. 53:5108-5112.
    • (1993) Cancer Res. , vol.53 , pp. 5108-5112
    • Shapiro, D.N.1    Sublett, J.E.2    Li, B.3    Downing, J.R.4    Naeve, C.W.5
  • 34
    • 0029160486 scopus 로고
    • High resolution crystal structure of a paired (Pax) class cooperative homodomain dimer on DNA
    • Wilson, D. S., B. Guenther, C. Desplan, and J. Kuriyan. 1995. High resolution crystal structure of a paired (Pax) class cooperative homodomain dimer on DNA. Cell 82:709-719.
    • (1995) Cell , vol.82 , pp. 709-719
    • Wilson, D.S.1    Guenther, B.2    Desplan, C.3    Kuriyan, J.4
  • 35
    • 0028919759 scopus 로고
    • Crystal structure of a paired domain-DNA complex at 2.5 angstrom resolution reveals structural basis of Pax developmental mutations
    • Xu, W., M. A. Rold, S. Jun, C. Desplan, and C. O. Pabo. 1995. Crystal structure of a paired domain-DNA complex at 2.5 angstrom resolution reveals structural basis of Pax developmental mutations. Cell 80:639-650.
    • (1995) Cell , vol.80 , pp. 639-650
    • Xu, W.1    Rold, M.A.2    Jun, S.3    Desplan, C.4    Pabo, C.O.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.