Both the paired domain and homeodomain are required for in vivo function of Drosophila Paired

Development

Volumn 122, Issue 9, 1996, Pages 2709-2718

  Miskiewicz, Pawel ^a   Morrissey, David ^a,c   Lan, Yu ^a,d   Raj, Lakshmi ^a   Kessler, Steven ^a   Fujioka, Miki ^b   Goto, Tadaatsu ^b   Weir, Michael ^a  

^a WESLEYAN UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c HYBRIDON INC   (United States)

^d JACKSON LABORATORY   (United States)

Author keywords

Drosophila; Homeodomain; Paired; Paired domain; Pax 3; Segmentation

Indexed keywords

HOMEODOMAIN PROTEIN; MUTANT PROTEIN; REGULATOR PROTEIN;

ARTICLE; BINDING AFFINITY; DNA BINDING; DROSOPHILA; EMBRYO DEVELOPMENT; EMBRYO SEGMENTATION; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN;

ANIMALS; BASE SEQUENCE; DNA; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, HOMEOBOX; GENES, INSECT; HOMEODOMAIN PROTEINS; IN SITU HYBRIDIZATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PAIRED BOX TRANSCRIPTION FACTORS; POINT MUTATION; POLYMERASE CHAIN REACTION; RNA; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

ERINACEIDAE; MAMMALIA;

EID: 0029793586     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (63)

1. Akam, M. (1987). The molecular basis for metameric patterning in the Drosophila embryo. Development 101, 1-22.
2. Ananthan, J., Baler, R., Morrissey, D., Zuo, J., Lan, Y., Weir, M. and Voellmy, R. (1993). Synergistic activation of transcription is mediated by the N-terminal domain of Drosophila fushi tarazu homeoprotein and can occur without DNA binding by the protein. Molec. Cell. Biol. 13, 1599-1609.
3. Baldwin, C. T., Hoth, C. F., Amos, J. A., da-Silva, E. O. and Milunski, A. (1992). An exonic mutation in HuP2 paired domain gene causes Waardenburg's syndrome. Nature 355, 637-638.
4. Balling, R., Deutsch, U. and Gruss, P. (1988). Undulated, a mutation affecting the development of the mouse skeleton, has a point mutation in the paired box of Pax-1. Cell 55, 531-535.
5. Baumgartner, S., Bopp, D., Burri, M. and Noll, M. (1987). Structure of two genes at the gooseberry locus related to the paired gene and their spatial expression during Drosophila embryogenesis. Genes Dev. 1, 1247-1267.
6. Benedyk, M. J., Mullen, J. R. and DiNardo, S. (1994). odd-paired: a zinc finger pair-rule protein required for the timely activation of engrailed and wingless in Drosophila embryos. Genes Dev. 8, 105-117.
7. Bertuccioli, C., Fasano, L., Jun, S., Wang, S., Sheng, G. and Desplan, C. (1996). In vivo requirement for the paired domain and homeodomain of the paired segmentation gene product. Development 122, 2673-2685.
8. Bopp, D., Burri, M., Baumgartner, S., Frigerio, G. and Noll, M. (1986). Conservation of a large protein domain in the segmentation gene paired and in functionally related genes in Drosophila. Cell 47, 1033-1049.
9. Bopp, D., Jamet, E., Baumgartner, S., Burri, M. and Noll, M. (1989). Isolation of two tissue-specific Drosophila paired box genes, pax meso and pox neuro. EMBO J. 8, 3447-3457.
10. Burri, M., Tromvoukis, Y., Bopp, D., Frigerio, G. and Noll, M. (1989). Conservation of the paired domain in metazoans and its structure in three isolated human genes. EMBO J. 8, 1183-1190.
11. Cadigan, K. M., Grossniklaus, U. and Gehring, W. J. (1994). Functional redundancy: The respective roles of the two sloppy paired genes in Drosophila segmentation. Proc. Natl. Acad. Sci. USA 91, 6324-6328.
12. Cai, J., Lan, Y., Appel, L. F. and Weir, M. (1994). Dissection of Drosophila Paired protein: Functional requirements for conserved motifs. Mech. Dev. 47, 139-150.
13. Chalepakis, G., Fritsch, R., Fickenscher, H., Deutsch, U., Goulding, M. and Gruss, P. (1991). The molecular basis of the undulated/Pax-1 mutation. Cell 66, 873-884.
14. Chalepakis, G., Goulding, M., Read, A., Strackan, T. and Gruss, P. (1994). Molecular basis of splotch and Waardenburg Pax-3 mutations. Proc. Natl. Acad. Sci. USA 91, 3685-3689.
15. Chan, S.-K., Jaffe, L., Capovilla, M., Botas, J. and Mann, R. S. (1994). The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with Extradenticle, another homeoprotein. Cell 78, 603-615.
16. Czerny, T., Schaffner, G. and Busslinger, M. (1993). DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site. Genes Dev. 7, 2048-2061.
17. DiNardo, S. and O'Farrell, P. H. (1987). Establishment and refinement of segmental pattern in the Drosophila embryo: spatial control of engrailed expression by pair-rule genes. Genes Dev. 1, 1212-1225.
18. Driever, W., Thoma, G. and Nusslein-Volhard, C. (1989). Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen. Nature 340, 363-367.
19. 2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3. Cell 67, 767-774.
20. Frigerio, G., Burri, M., Bopp, D., Baumgartner, S. and Noll, M. (1986). Structure of the segmentation gene paired and the Drosophila PRD gene set as part of a gene network. Cell 47, 735-746.
21. Fujioka, M., Jaynes, J. B. and Goto, T. (1995). Early even-skipped stripes act as morphogenetic gradients at the single cell level to establish engrailed expression. Development 121, 4371-4382.
22. Fujioka, M., Miskiewicz, P., Raj, L., Gulledge, A. A., Weir, M. and Goto, T. (1996). Drosophila Paired regulates late even-skipped expression through a composite binding site for the paired domain and the homeodomain. Development 122, 2697-2707.
23. Gergen, J. P., Coulter, D. and Wieschaus, E. (1986). Segmental pattern and blastoderm cell identities. In Gametogenesis and the Early Embryo, (ed. J. G. Gall), pp. 195-220. Symp. Soc. Dev. Biol.
24. Goutte, C. and Johnson, A. D. (1988). a1 protein alters the DNA binding specificity of α2 repressor. Cell 52, 875-882.
25. Grueneberg, D. A., Natesan, S., Alexandre, C. and Gilman, M. Z. (1992). Human and Drosophila homeodomain proteins that enhance the DNA- binding activity of serum response factor. Science 257, 1089-1095.
26. Gutjahr, T., Frei, E. and Noll, M. (1993). Complex regulation of early paired expression: initial activation by gap genes and pattern modulation by pair- rule genes. Development 117, 609-623.
27. Han, K., Levine, M. S. and Manley, J. L. (1989). Synergistic activation and repression of transcription by Drosophila homeobox proteins. Cell 56, 573-583.
28. Hanes, S. D. and Brent, R. (1991). A genetic model for interaction of the homeodomain recognition helix with DNA. Science 251, 426-430.
29. Harding, K., Rushlow, C., Doyle, H. J., Hoey, T. and Levine, M. (1986). Cross-regulatory interactions among pair-rule genes in Drosophila. Science 233, 953-959.
30. Hoey, T. and Levine, M. (1988). Divergent homeo box proteins recognize similar DNA sequences in Drosophila. Nature 332, 858-861.
31. Horton, R. M., Hunt, H. D., Ho, S. N., Pullen, J. K. and Pease, L. R. (1989). Engineering hybrid genes without the use of restriction enzymes: gene spicing by overlap extension. Gene 77, 61-68.
32. Hoth, C. F., Milunsky, A., Lipsky, N., Sheffer, R., Clarren, S. K. and Baldwin, C. T. (1993). Mutations in the paired domain of the human PAX3 gene cause Klein-Waardenburg Syndrome (WS-III) as well as Waardenburg Syndrome Type I (WS-I). Am. J. Hum. Genet. 52, 455-462.
33. Howard, K. and Ingham, P. (1986). Regulatory interactions between the segmentation genes fushi tarazu, hairy, and engrailed in the Drosophila blastoderm. Cell 44, 949-957.
34. Ingham, P. W. (1988). The molecular genetics of embryonic pattern formation in Drosophila. Nature 335, 25-34.
35. Ingham, P. W., Baker, N. E. and Martinez-Arias, A. (1988). Regulation of segment polarity genes in the Drosophila blastoderm by fushi tarazu and even-skipped. Nature 331, 73-75.
36. Jun, S. and Desplan C. (1996). Cooperative interactions between paired domain and homeodomain. Development 122, 2639-2650.
37. Karr, T. L., Weir, M. P., Ali, Z. and Kornberg, T. (1989). Patterns of engrailed protein in early Drosophila embryos. Development 105, 605-612.
38. Kilchherr, K., Baumgartner, S., Bopp, D., Frei, E. and Noll, M. (1986). Isolation of the paired gene of Drosophila and its spatial expression during early embryogenesis. Nature 321, 493-499.
39. Klemenz, R., Weber, U. and Gehring, W. J. (1987). The white gene as a marker for a new P-element vector for gene transfer in Drosophila. Nucleic Acids Res. 15, 3947-3959.
40. Lalwani, A. K., Brister, J. R., Fex, J., Grundfast, K. M., Ploplis, B., San-Agustin, T. B. and Wilcox, E. R. (1995). Further elucidation of the genomic structure of PAX3, and identification of two different point mutations within the PAX3 homeobox that cause Waardenburg syndrome type 1 in two families. Am. J. Hum. Genet. 56, 75-83.
41. Lee, J. L., von Kessler, D. P., Parks, S. and Beachy, P. A. (1992). Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene, hedgehog. Cell 71, 33-50.
42. Li, X. and Noll, M. (1994). Evolution of distinct developmental functions of three Drosophila genes by acquisition of different cis-regulatory regions. Nature 367, 83-86.
43. Macdonald, P. M., Ingham, P. and Struhl, G. (1986). Isolation, structure, and expression of even-skipped: a second pair-rule gene of Drosophila containing a homeo box. Cell 47, 721-734.
44. Malicki, J., Schughart, K. and McGinnis, W. (1990). Mouse Hox 2.2 specifies thoracic segmental identity in Drosophila embryos and larvae. Cell 63, 961-967.
45. Manoukian, A. S. and Krause, H. M. (1992). Concentration-dependent activities of the even-skipped protein in Drosophila embryos. Genes Dev. 6, 1740-1751.
46. Manoukian, A. S. and Krause, H. M. (1993). Control of segmental asymmetry in Drosophila embryos. Development 118, 785-796.
47. Mohler, J. and Vani, K. (1992). Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila. Development 115, 957-971.
48. Morrissey, D., Askew, D., Raj, L. and Weir, M. (1991). Functional dissection of the paired segmentation gene in Drosophila embryos. Genes Dev. 5, 1684-1696.
49. Nusslein-Volhard, C. and Wieschaus, E. (1980). Mutations affecting segment number and polarity in Drosophila. Nature 287, 759-801.
50. Poole, S. J., Kauvar, L. M., Drees, B. and Kornberg, T. (1985). The engrailed locus of Drosophila: Structural analysis of an embryonic transcript. Cell 40, 37-43.
51. Sarkar, G. and Sommer, S. S. (1990). The 'megaprimer' method of site- directed mutagenesis. Biotechniques 8, 404-407.
52. Scott, M. P., Tamkun, J. W. and Hartzell, G. W. (1989). The structure and function of the homeodomain. Biochim. Biophys. Acta 989, 25-48.
53. Sheffield, V. C., Cox, D. R., Lerman, L. S. and Myers, R. M. (1989) Attachment of a 40-base-pair G+C-rich sequence (GC-clamp) to genomic DNA fragments by the polymerase chain reaction results in improved detection of single-base changes. Proc. Natl. Acad. Sci. USA 86, 232-236.
54. Smith, D. L. and Johnson, A. D. (1992). A molecular mechanism for combinatorial control in yeast: MCM1 protein sets the spacing and orientation of the homeodomains of an α2 dimer. Cell 68, 133-142.
55. Tabata, T., Eaton, S. and Kornberg, T. B. (1992). The Drosophila hedgehog gene is expressed in posterior compartment cells and is a target of engrailed regulation. Genes Dev. 6, 2635-2645.
56. Tassabehji, M., Read, A. P., Newton, A. E., Harris, R., Balling, R., Gruss, P. and Strachan, T. (1992). Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene. Nature 355, 635-636.
57. Treisman, J., Gonczy, P., Vashishtha, M., Harris, E. and Desplan, C. (1989). A single amino acid change can determine the DNA binding specificity of homeodomain proteins. Cell 59, 553-562.
58. Treisman, J., Harris, E. and Desplan, C. (1991). The paired box encodes a second DNA-binding domain in the Paired homeo domain protein. Genes Dev. 5, 594-604.
59. Weir, M. P., Edgar, B. A., Kornberg, T. and Schubiger, G. (1988). Spatial regulation of engrailed expression in the Drosophila embryo. Genes Dev. 2, 1194-1203.
60. Wilson, D., Sheng, G., Lecuit, T., Dostatni, N. and Desplan, C. (1993). Cooperative dimerization of Paired class homeo domains on DNA. Genes Dev. 7, 2120-2134.
61. Wilson, D. S., Guenther, B., Desplan, C. and Kuriyan, J. (1995). High Resolution Crystal Structure of a Paired (Pax) Class Cooperative Homeodomain Dimer on DNA. Cell 82, 709-720.
62. Xu, W., Rould, M. A., Jun, S., Desplan, C. and Pabo, C. O. (1995). Crystal structure of a paired domain-DNA complex at 2.5 Å resolution reveals structural basis for Pax developmental mutations. Cell 80, 639-50.
63. Yon, J. and Fried, M. (1989). Precise gene fusion by PCR. Nuc. Acids Res. 17, 4895.