Pax2 and homeodomain proteins cooperatively regulate a 435 bp enhancer of the mouse Pax5 gene at the midbrain-hindbrain boundary

Development

Volumn 127, Issue 5, 2000, Pages 1017-1028

  Pfeffer, Peter L ^a   Bouchard, Maxime ^a   Busslinger, Meinrad ^a  

^a RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

Author keywords

Enhancer; Gene regulation; LacZ transgenes; Mid hindbrain development; Mouse; Pax

Indexed keywords

DNA; HOMEODOMAIN PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN DEVELOPMENT; CONSENSUS SEQUENCE; CONTROLLED STUDY; DEVELOPMENTAL GENETICS; DNA FLANKING REGION; EMBRYO; ENHANCER REGION; GENE EXPRESSION; HOMEOBOX; MESENCEPHALON; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DNA BINDING; REPORTER GENE; RHOMBENCEPHALON; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE;

ANIMALS; B-CELL-SPECIFIC ACTIVATOR PROTEIN; BASE SEQUENCE; BETA-GALACTOSIDASE; CONSENSUS SEQUENCE; CONSERVED SEQUENCE; DNA-BINDING PROTEINS; EMBRYONIC AND FETAL DEVELOPMENT; ENHANCER ELEMENTS (GENETICS); EXONS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MESENCEPHALON; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, KNOCKOUT; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PAX2 TRANSCRIPTION FACTOR; RESTRICTION MAPPING; RHOMBENCEPHALON; TRANSCRIPTION FACTORS; ZINC FINGERS;

ANIMALIA; MAMMALIA; MUS MUSCULUS; VERTEBRATA;

EID: 0034023062     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Adams, B., Dörfler, P., Aguzzi, A., Kozmik, Z., Urbánek, P., Maurer-Fogy, I. and Busslinger, M. (1992). Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis. Genes Dev. 6, 1589-1607.
2. Barberis, A., Superti-Furga, G. and Busslinger, M. (1987). Mutually exclusive interaction of the CCAAT-binding factor and of a displacement protein with overlapping sequences of a histone gene promoter. Cell 50, 347-359.
3. Brand, M., Heisenberg, C.-P., Jiang, Y.-J., Beuchle, D., Lun, K., Furutani-Seiki, M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D. A., Kelsh, R. N., Mullins, M. C., Odenthal, J., van Eeden, F. J. M. and Nüsslein-Volhard, C. (1996). Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain. Development 123, 179-190.
4. Briggs, M. R., Kadonaga, J. T., Bell, S. P. and Tjian, R. (1986). Purification and biochemical characterization of the promoter-specific transcription factor, Sp1. Science 234, 47-52.
5. Busslinger, M., Klix, N., Pfeffer, P., Graninger, P. G. and Kozmik, Z. (1996). Deregulation of PAX-5 by translocation of the Eμ enhancer of the IgH locus adjacent to two alternative PAX-5 promoters in a diffuse large-cell lymphoma. Proc. Natl. Acad. Sci. USA 93, 6129-6134.
6. Czerny, T., Bouchard, M., Kozmik, Z. and Busslinger, M. (1997). The characterization of novel Pax genes of the sea urchin and Drosophila reveal an ancient evolutionary origin of the Pax2/5/8 family. Mech. Dev. 67, 179-192.
7. Czerny, T. and Busslinger, M. (1995). DNA-binding and transactivation properties of Pax-6: three amino acids in the paired domain are responsible for the different sequence recognition of Pax-6 and BSAP (Pax-5). Mol. Cell. Biol. 15, 2858-2871.
8. Czerny, T., Halder, G., Kloter, U., Souabni, A., Gehring, W. J. and Busslinger, M. (1999). Twin of eyeless, a second Pax-6 gene of Drosophila, acts upstream of eyeless in the control of eye development. Mol. Cell 3, 297-307.
9. Davis, C. A., Holmyard, D. P., Millen, K. J. and Joyner, A. L. (1991). Examining pattern formation in mouse, chicken and frog embryos with an En-specific antiserum. Development 111, 287-298.
10. Dressler, G. R., Deutsch, U., Chowdhury, K., Nornes, H. O. and Gruss, P. (1990). Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system. Development 109, 787-795.
11. Ericson, J., Rashbass, P., Schedl, A., Brenner-Morton, S., Kawakami, A., van Heyningen, V., Jessell, T. M. and Briscoe, J. (1997). Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling. Cell 90, 169-180.
12. 1Neu mutation is identical to a human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental detects of the brain, ear, eye, and kidney. Proc. Natl. Acad. Sci. USA 93, 13870-13875.
13. Funahashi, J.-I., Okafuji, T., Ohuchi, H., Noji, S., Tanaka, H. and Nakamura, H. (1999). Role of Pax-5 in the regulation of a mid-hindbrain organizer's activity. Dev. Growth Differ. 41, 59-72.
14. Gan, L., Mao, C.-A., Wikramanayake, A., Angerer, L. M., Angerer, R. C. and Klein, W. H. (1995). An orthodenticle-related protein from Strongylocentrotus purpuratus. Dev. Biol. 167, 517-528.
15. Gehring, W. J., Qian, Y. Q., Billeter, M., Furukubo-Tokunaga, K., Schier, A. F., Resendez-Perez, D., Affolter, M., Otting, G. and Wüthrich, K. (1994). Homeodomain-DNA recognition. Cell 78, 211-223.
16. Hamburger, V. and Hamilton, H. L. (1992). A series of normal stages in the development of chick embryos. Dev. Dyn. 195, 231-272.
17. Herr, W. and Cleary, M. A. (1995). The POU domain: versatility in transcriptional regulation by a flexible two-in-one DNA-binding domain. Genes Dev. 9, 1679-1693.
18. Hidalgo-Sánchez, M., Millet, S., Simeone, A. and Alvarado-Mallart, R.-M. (1999). Comparative analysis of Otx2, Gbx2, Pax2, Fgf8 and Wnt1 gene expression during the formation of the chick midbrain/hindbrain domain. Mech. Dev. 80, 175-178.
19. Jiménez, G., Paroush, Z. and Ish-Horovicz, D. (1997). Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed. Genes Dev. 11, 3072-3082.
20. Joyner, A. L., Herrup, K., Auerbach, B. A., Davis, C. A. and Rossant, J. (1991). Subtle cerebellar phenotype in mice homozygous for a targeted deletion in the En-2 homeobox. Science 251, 1239-1243.
21. Kammandel, B., Chowdhury, K., Stoykova, A., Aparicio, S., Brenner, S. and Gruss, P. (1999). Distinct cis-essential modules direct the time-space pattern of the Pax6 gene activity. Dev. Biol. 205, 79-97.
22. Mansouri, A., Chowdhury, K. and Gruss, P. (1998). Follicular cells of the thyroid gland require Pax8 gene function. Nature Genet. 19, 87-90.
23. Mansouri, A., Hallonet, M. and Gruss, P. (1996). Pax genes and their roles in cell differentiation and development. Curr. Opin. Cell Biol. 8, 851-857.
24. Matsuo, I., Kuratani, S., Kimura, C., Takeda, N. and Aizawa, S. (1995). Mouse Otx2 functions in the formation and patterning of rostral head. Genes Dev. 9, 2646-2658.
25. Mihailescu, D., Küry, P. and Monard, D. (1999). An octamer-binding site is crucial for the activation of an enhancer active at the embryonic met-/mesencephalic junction. Mech. Dev. 84, 55-67.
26. Nornes, H. O., Dressler, G. R., Knapik, E. W., Deutsch, U. and Gruss, P. (1990). Spatially and temporally restricted expression of Pax2 during murine neurogenesis. Development 109, 797-809.
27. Peltenburg, L. T. C. and Murre, C. (1996). Engrailed and Hox homeodomain proteins contain a related Pbx interaction motif that recognizes a common structure present in Pbx. EMBO J. 15, 3385-3393.
28. Pfeffer, P. L., Gerster, T., Lun, K., Brand, M. and Busslinger, M. (1998). Characterization of three novel members of the zebrafish Pax2/5/8 family: dependency of Pax5 and Pax8 expression on the Pax2.1 (noi) function. Development 125, 3063-3074.
29. Plachov, D., Chowdhury, K., Walther, C., Simon, D., Guenet, J. L. and Gruss, P. (1990). Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland. Development 110, 643-651.
30. Rowitch, D. H. and McMahon, A. P. (1995). Pax-2 expression in the murine neural plate precedes and encompasses the expression domains of Wnt-1 and En-1. Mech. Dev. 52, 3-8.
31. Schwarz, M., Alvarez-Bolado, G., Dressler, G., Urbánek, P., Busslinger, M. and Gruss, P. (1999). Pax2/5 and Pax6 subdivide the early neural tube into three domains. Mech. Dev. 82, 29-39.
32. Schwarz, M., Alvarez-Bolado, G., Urbánek, P., Busslinger, M. and Gruss, P. (1997). Conserved biological function between Pax-2 and Pax-5 in midbrain and cerebellum development: Evidence from targeted mutation. Proc. Natl. Acad. Sci. USA 94, 14518-14523.
33. Stoykova, A., Fritsch, R., Walther, C. and Gruss, P. (1996). Forebrain patterning defects in Small eye mutant mice. Development 122, 3453-3465.
34. Torres, M., Gómez-Pardo, E. and Gruss, P. (1996). Pax2 contributes to inner ear patterning and optic nerve trajectory. Development 122, 3381-3391.
35. Urbánek, P., Fetka, I., Meisler, M. H. and Busslinger, M. (1997). Cooperation of Pax2 and Pax5 in midbrain and cerebellum development. Proc. Natl. Acad. Sci. USA 94, 5703-5708.
36. Urbánek, P., Wang, Z.-Q., Fetka, I., Wagner, E. F. and Busslinger, M. (1994). Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell 79, 901-912.
37. Wassef, M. and Joyner, A. L. (1997). Early mesencephalon/metencephalon patterning and development of the cerebellum. Perspectives Dev. Neurobiol. 5, 3-16.
38. Wasserman, K. M., Lewandoski, M., Campbell, K., Joyner, A. L., Rubenstein, J. L. R., Martinez, S. and Martin, G. R. (1997). Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function. Development 124, 2923-2934.
39. Wurst, W., Auerbach, A. B. and Joyner, A. L. (1994). Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum. Development 120, 2065-2075.
40. Yee, S.-P. and Rigby, R. W. J. (1993). The regulation of myogenin gene expression during the embryonic development of the mouse. Genes Dev. 7, 1277-1289.