The new biology of body weight regulation

Journal of the American Dietetic Association

Volumn 97, Issue 1, 1997, Pages 54-58

  Schwartz, Michael W ^a,c   Seeley, Randy J ^b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; INSULIN; LEPTIN; NEUROPEPTIDE Y; PROTEIN;

ANIMAL; BODY WEIGHT; BRAIN; FEEDBACK SYSTEM; GENETICS; HUMAN; OBESITY; PHYSIOLOGY; REVIEW;

ANIMALS; BODY WEIGHT; BRAIN; CORTICOTROPIN-RELEASING HORMONE; FEEDBACK; HUMANS; INSULIN; LEPTIN; NEUROPEPTIDE Y; OBESITY; PROTEINS;

EID: 0030641036     PISSN: 00028223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-8223(97)00018-7     Document Type: Review

References (41)

1. Considine RV, Sinha MK, Heiman ML, Kriaucinas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996;334:292-295.
2. Maffei M, Halaas J, Rayussin E, Pratley RE, Lee GM, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, Kern PA, Friedman JM. Leptin levels in human and rodent: measurement, of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Med. 1995;1:1155-1161.
3. Schwarte MW, Peskind E, Raskind M, Nicolson M, Moore J, Morawiecki A, Boyko EJ, Porte DJ. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nature Med. l996;2:589-593.
4. Zhang Y, Proenca R, Maffie M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372:425-432.
5. Kennedy GC. The role of depot fat in the hypothalamus control of food intake in the rat. Proc R Soc Lond [Biol]. 1953;140:579-592.
6. Hervey GR. The effects of lesions in the hypothalamus in parabiotic rats. JPhysiol 1952;145:336-352.
7. Coleman DL. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia. 1973;9:294-298.
8. Campfield AL, Smith FJ, Gulsez Y, Devos R, Burn P. Mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 1995;269:546-549.
9. Halaas JL, Gajiwala KS, Maffel M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM. Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 1995;269:543-546,
10. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 1995;269:540-543,
11. Weigle DS, Bukowski TR, Foster DC, Holderman S, Kramer JM, Lasser G, Lofton-Day CE, Prunkard DE, Raymond C, Kuijper JL, Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J Clin Invest. 1995;96:2065-2070.
12. Chua SCJ, Chung WK, Wu-Peng XS, Zhang Y, Liu SM, Tartaglia L, Leibel RL. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science. 1996;271:994-996.
13. Devos R, Richards JG, Campfield LA, Tartaglia LA, Guisez Y, Burn P. OB protein binds specifically to the choroid plexus of mice and rats. Proc Hau Acad Sci U S A. 1996;93:5668-5673.
14. Stanley BG, Kyrkouli SE, Lampert S, Leibowitz SF. NeuropeptideY chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides. 1986;7:1189-1192.
15. Billington CJ, Briggs JE, Grace M, Levine AS. Effects of intracerebroventricular injection of neuropeptide Y on energy metabolism. Am J Pysiol. 1991;260:R321-R327.
16. Kalra SP, Dube MG, Sahu A, Phelps CP, Kalra P. Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc Nate Acad Sci USA. 1991;88:10931-10935.
17. Schwartz MW, Sipols AJ, Marks JL, Sanacora G, White JD, Scheurinck A, Kahn SE, Baste DG, Woods SC, Figlewicz DP, Porte D Jr. Inhibition of hypothalamic neuropeptide Y gene expression by insulin. Endocrinologij. 1992;130:3608-3616.
18. Sipols AJ, Baskin DG, Schwarte MW. Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression. Diabetes. 1995;44:147-151.
19. Malabu UH, Kilpatrick A, Ware M, Vernon RG, Williams G. Increased neuropeptide Y concentrations in specific hypothalamic regions of lactating rats : possible relationship to hyperphagia and adaptive changes in energy balance. Peptides. l994;15:83-87.
20. Lewis DE, ShellardL, KoeslagDG, Boer DE, McCarthy HD, McKibbin PE, Russell JC, Williams G. Intense exercise and food restriction cause similar hypothalamic neuropeptide Y increases in rats. Am J Physiol 1993;264:PE279-PE284.
21. Wilding JPH, Gilbey SG, Bailey CJ, Batt RAL, Williams G, Ghatei MA, Bloom SR. Increased neuropeptide-Y messenger ribonucleic acid mRNA) and decreased neurotensin mRNA in the hypothalamus of the obese (ob/ob) mouse, Endocrinology. 1993;132:1939-1944.
22. Chua SC, Brown AW, Kim J, Hennessey KL, Leibel RL, Hirsch J. Food deprivation and hypothalamic neuropeptide gene expression: effects of strain background and the diabetes mutation. Mol Brain Res. 1991;11:291-299.
23. Schwartz MW, Baskin DG, Bukowski TR, Kuijper JL, Foster D, Lasser G, Prunkard DE, Porte DJ, Woods SC, Seeley RJ, Weigle DS. Specificity of ob protein action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes. 1996;45:531-535.
24. Stephens TW, Bashmski M, Bristow PK, Bue-Vallesky JM, Burgetti SG, Craft L, Prater J, Hoffman J, Huang HM, Kriasticinas A, Mackeltar W, Rostack PR, Schoner B, Smith D, Tinarley FC, Zhang XY, Metman M. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature. 1995;377:530-534.
25. Erickson JC, Klegg KE, Palmiter PD. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature. 1996;381:415-418.
26. Woods SC, Stem LJ, McKay LD, Porte D Jr. Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature. 1979;282:503-505.
27. Polonsky BD, Given E, Carter V. Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects. J Clin Invest. 1988;81;442-448.
28. Baura G, Foster D, Porte D Jr, Kahn SE, Bergman RN, Cobelli C, Schwartz MW. Saturable transport of insulin from plasma into the central nervous system of clogs in vivo: a mechanism for regulated insulin delivery to the brain. J Clin Invest. 1993;92:1824-1830.
29. Chavez M, Seeley RJ, Woods SC. A comparison between the effects of intraventricular insulin and intraperitoneal LiCl on three measures sensitive to emetic agents. Behav Neurosci. 1995;109:547-550.
30. Riedy CA, Chavez M, Figlewicz DP, Woods SC. Central insulin enhances sensitivity to cholecystokinin. Physiol Behav. 1995;58:755760.
31. Schwartz MW,Figlewicz DP, Baskin DG, Woods SC, Porte D. Insulin in the brain: a hormonal regulator of energy balance. Endocr Rev. 1992;13:387-414.
32. Becker DJ, Ongemba LN, Brichard V, Henquin JC, Brichard SM. Diet and diabetes-induced changes of ob gene expression in rat adipose tissue. FEBS Lett. 1995;371:324-328.
33. Cusin I, SainsburyA, Doyle P, Rohner-JeanrenaudF, Jeanrenaud B. The ob géne and insulin: a relationship leading to clues to the understanding of obesity. Diabetes. 1995;44:1467~1470.
34. Rothwell N. Central effects of CRF on metabolism and energy balance. Neurosci Biobehav Rev. 1989; 14:263-271.
35. Brady LS, Smith MA, Gold PW, Herkenham M. Altered expression of hypothalamic neuropeptide mRNAs in food restricted and fooddeprived rats. Neuroendocrinology, 1990;52:441-447.
36. Schwartz MW, Seeley RJ, Campfield LA, Burn P, Baskin DG. Identification of targets of leptin action in rat hypothalamus. J Clin Invest. 1996;98;1101-1106.
37. Seeley RJ, Chavez M, Dallman MF, Matson CA, Woods SC, Schwartz MW. Behavioral, endocrine and hypothalamic responses to involuntary overfeeding. Am J Physiol 1996;40(3);R819-R823.
38. Spina M,Merlo-Pich E, Chan RKW, Basso AM, Rivier J,ValeW, Koob GF, Appetite-suppressing effects of urocortin, a CRF-related neuropeptide. Science. 1996;273:156l-l563.
39. Donaldson CJ, Sutton SW, Perrin MH, Corrigan AZ, Lewis KA, Rivier JE, Vaughan JM, Vale WW. Cloning and characterization of human urocortin. Endocrinology. 1996;137:2167-2170.
40. Vaughan J, Donaldson C, Bittencourt J, Perrin MH, Lewis J, Sutton S, Chan R, Turnbull AV, Lovejoy D, Rivier C, Rivier J, Sawchenko PE, Vale W. Urocortin, a mammalian neuropeptide related to fish urotensin 1 and to corticotropin-releasing factor. Nature. 1995;378:287-292.
41. Garner DM, Wooley SC. Confronting the failure of behavioral and dietary treatments for obesity. Clin Psychol Rev. 1991;11:729-780.