Corepressors and nuclear hormone receptor function

Current Topics in Microbiology and Immunology

Volumn 254, Issue , 2000, Pages 101-116

  Ordentlich, P ^a   Downes, M ^a   Evans, R M ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; HORMONE RECEPTOR; REPRESSOR PROTEIN;

GENE CONTROL; GENE FUNCTION; GENETIC CONSERVATION; GENETIC TRANSCRIPTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; REVIEW; RNA TRANSLATION;

AMINO ACID SEQUENCE; ANIMALS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REPRESSOR PROTEINS; TRANSCRIPTION, GENETIC;

EID: 0033635688     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Review

References (105)

1. The Sant domain: A putative DNA-binding domain in the SWI-SNF and ADA complexes, the transcriptional corepressor N-CoR and TFIIIB
2. Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site
3. Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression
4. Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3
5. Transcriptional repression by COUP-TF II is dependent on the C-terminal domain and involves the N-CoR variant, RIP13deltal
6. The nuclear receptor corepressor N-CoR regulates differentiation: N-CoR directly interacts with MyoD
7. The CBP coactivator is a histone acetyltransferase
8. Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation
9. Identification and characterization of a novel corepressor interaction region in RVR and Rev-erbA alpha
10. Regulation of peroxisome proliferator-activated receptor gamma activity by mitogen-activated protein kinase
11. The HDA1 and HDA3 are components of a yeast histone deacetylase (HAD) complex
12. Functional evidence for ligand-dependent dissociation of thyroid hormone and retinoic acid receptors from an inhibitory cellular factor
13. A transcriptional co-repressor that interacts with nuclear hormone receptors
14. SMRT isoforms mediate repression and anti-repression of nuclear receptor heterodimers
15. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with p/CAF and CBP/p300
16. Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase
17. Nuclear receptor DAX-1 recruits nuclear receptor corepressor N-CoR to steroidogenic factor 1
18. Identification of a domain required for oncogenic activity and transcriptional suppression by v-erbA and thyroid-hormone receptor alpha
19. Structure and specificity of nuclear receptor-coactivator interactions
20. Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein
21. Two receptor interaction domains in the corepressor, N-CoR/RIPI3, are required for an efficient interaction with Rev-erbA alpha and RVR: Physical association is dependent on the E region of the orphan receptors
22. Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily
23. Characterization of a human RPD3 ortholog, HDAC3
24. A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA Ip
25. Unliganded thyroid hormone receptor alpha can target TATA-binding protein for transcriptional repression
26. Unliganded thyroid hormone receptor inhibits formation of a functional preinitiation complex: Implications for gene repression
27. Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO
28. Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukemia
29. Three proteins define a class of human histone deacetylases related to yeast Hda1p
30. Histone acetylation in chromatin structure and transcription
31. Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: Integration of hormone Signaling in reproduction and stress
32. Transcriptional activation and repression by RORalpha, an orphan nuclear receptor required for cerebellar development
33. Histone deacetylase activity is required for full transcriptional repression by mSin3A
34. Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL
35. A signature motif in transcriptional co-activators mediates binding to nuclear receptors
36. A complex containing N-CoR, mSin3, and histone deacetylase mediates transcriptional repression
37. SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia
38. Signaling by tyrosine kinases negatively regulates the interaction between transcription factors and SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) corepressor
39. GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors
40. Ligand independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
41. Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma
42. The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors
43. Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway
44. The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT
45. The partial agonist activity of antagonist-occupied steroid receptors is controlled by a novel hinge domain-binding coactivator L7/SPA and the corepressors N-CoR or SMRT
46. Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo
47. A CBP integrator complex mediates transcriptional activation and AP-I inhibition by nuclear receptors
48. A histone deacetylase corepressor complex regulates the Notch signal transduction pathway
49. Isolation of a novel histone deacetyhtse reveals that class I and class II deacetylases promote SMRT-mediated repression
50. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase
51. Sin meets NuRD and other tails of repression
52. Histone deacetylases associated with the Sin3 co-repressor mediate Mad transcriptional repression
53. SAP30, a component of the mSin3 corepressor complex involved in N-CoR mediated repression by specific transcription factors
54. Diverse signalling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes
55. Role of the histone deacetylase complex in acute promyelocytic leukemia
56. The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling
57. ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors
58. Repression: Targeting the heart of the matter
59. The nuclear receptor superfamily: The second decade
60. Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation
61. Retinoid receptors in health and disease: Co-regulators and the chromatin connection
62. HDAC4 deacetylase associates with and represses the MEF2 transcription factor
63. The corepressor N-CoR and its variants RIPI3a and RIPI3A1 directly interact with the basal transcription factors, TFIIB, TAF(tt)32 and TAF(u)70
64. Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3 enhancer
65. Mechanism of corepressor binding and release from nuclear hormone receptors
66. Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase
67. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma
68. The transcriptional coactivators p300 and CBP are histone acetyltransferases
69. Unique forms of human and mouse nuclear receptor corepressor SMRT
70. SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor
71. Molecular determinants of nuclear receptor-corepressor interaction
72. Stimulation of RAR alpha activation function AF-1 through binding to the general transcription factor TFIIH and phosphorylation by CDK7
73. HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription
74. Identification of TRACs (T3 Receptor-Associating Cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors
75. An amino terminal domain of Mxil mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3
76. The phantom ligand effect: Allosteric control of transcription by the retinoid X receptor
77. Two receptor interacting domains in the nuclear hormone receptor corepressor RIPI3/N-CoR
78. Interdomain communication regulating ligand binding by PPAR-gamma
79. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
80. Gene silencing by chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI) is mediated by transcriptional corepressors, nuclear receptor-corepressor (N-CoR) and silencing mediator for retinoic acid receptor and thyroid hormone receptor (SMRT)
81. Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action
82. Steroid receptor coactivator-1 is a histone acetyltransferase
83. Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen
84. Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein
85. A mammalian histonc deacetylase related to the yeast transcriptional regulator RPD3
86. Nuclear receptors: Structure, function and involvement in disease
87. Co-activators and co-repressors in the integration of transcriptional responses
88. The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function
89. Ligand-independent recruitment of SRC-1 to estrogen receptor beta through phosphorylation of activation function AF-1
90. SMRTER, a Drosophila nuclear coregulator, reveals that EcR-mediated repression is critical for development
91. The 'dark side' of chromatin remodeling: Repressive effects on transcription
92. Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers
93. The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor
94. ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex
95. HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor
96. Activators and repressors: Making use of chromatin to regulate transcription
97. Transcriptional repression by the SMRT-mSin3 corepressor: Multiple interactions, multiple mechanisns, and a potential role for TFIIB
98. Signal specific co-activator domain requirements for Pit-1 activation
99. Coactivator and corepressor complexes in nuclear receptor function
100. NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities
101. A nuclear hormone receptor corepressor mediates transcriptional silencing by receptors with distinct repression domains
102. Proteasomal regulation of nuclear receptor corepressor-mediated repression
103. Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex
104. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation
105. SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex