Identification and characterization of a novel corepressor interaction region in RVR and Rev-erbAα

Molecular Endocrinology

Volumn 12, Issue 2, 1998, Pages 248-262

  Burke, Les J ^a   Downes, Michael ^a   Laudet, Vincent ^b   Muscat, George E O ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR;

ARTICLE; GENE TARGETING; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPRESSOR GENE; TRANSCRIPTION REGULATION;

EID: 0032230176     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.12.2.0061     Document Type: Article

References (33)

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5. Rev-erbβ, a new member of the nuclear receptor superfamily, is expressed in the nervous system during chicken development
6. Cross-talk amoung RORα1 and the Rev-erb family of orphan receptors
7. A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-erb
8. Isoform-specific amino-terminal domains dictate DNA-binding properties of RORα, a novel family of orphan receptors
9. Constitutive expression of the orphan receptor, Rev-erbAα, inhibits muscle differentiation and abrogates the expression of the myoD gene family
10. Transcriptional repression by the orphan receptor RVR/Rev-erb-beta is dependent on the signature motif and helix-5 in the E region: Functional evidence for a biological role of RVR in myogenesis
11. Induction of Rev-erbAα, an orphan receptor encoded on the opposite strand of the α-thyroid hormone receptor gene, during adipocyte differentiation
12. The orphan receptor Rev-ErbAα activates transcription via a novel response element
13. The monomer-binding orphan receptor Rev-erb represses transcription as a dimer on a novel direct repeat
14. A functional Rev-erbAα responsive element located in the human Rev-erbAα promoter mediates a repressing activity
15. A transcriptional co-repressor that interacts with nuclear hormone receptors
16. SMRT isoforms mediate repression and anti-repression of nuclear receptor heterodimers
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18. Two receptor interaction domains in the nuclear hormone receptor corepressor RIP13/N-CoR
19. 3 Receptor-Associating Cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors
20. Two receptor interaction domains in the co- repressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbAα and RVR: Physical association is dependent on the E-region of the orphan receptors
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24. Crystal structure of the RAR-γ ligand binding domain bound to all-trans retinoic acid
25. Transcriptional repression by Rev-erbAα is dependent on the signature motif and helix 5 in the ligand binding domain: Silencing does not involve an interaction with N-CoR
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27. A canonical structure for the ligand-binding domain of nuclear receptors
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33. Recombination genomes which express chloramphenicol acetyl-transferase in mammalian cells