Chronic allograft rejection: Do the TH2 cells preferentially induced by indirect alloantigen recognition play a dominant role

Transplantation

Volumn 68, Issue 6, 1999, Pages 715-726

  Shirwan, Haval ^a,b  

^a University of Louisville School of Medicine   (United States)

^b University of Louisville   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; HISTOCOMPATIBILITY ANTIGEN;

ALLOIMMUNITY; ANTIGEN RECOGNITION; CYTOKINE PRODUCTION; GRAFT REJECTION; GRAFT SURVIVAL; HELPER CELL; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; PATHOGENESIS; PRIORITY JOURNAL; REVIEW;

ANTIGEN-PRESENTING CELLS; CHRONIC DISEASE; GRAFT REJECTION; HUMANS; ISOANTIGENS; TH2 CELLS; TRANSPLANTATION, HOMOLOGOUS;

EID: 0033610271     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199909270-00001     Document Type: Review

References (146)

1. Azuma H, Tilney NL. Chronic graft rejection. Curr Opin Immunol 1994; 6: 770.
2. VanBuskirk AM, Pidwell DJ, Adams PW, Orosz CG. Transplantation immunology. JAMA 1997; 278: 1993.
3. Cramer DV, Qian S, Harnaha J, et al. Cardiac transplantation in the rat. I. The effect of histocompatibility differences on graft arteriosclerosis. Transplantation 1989; 47: 414.
4. Cramer DV, Chapman FA, Wu GD, Harnaha JB, Qian S, Makowka L. Cardiac transplantation in the rat. II. Alteration of the severity of donor graft arteriosclerosis by modulation of the host immune response. Transplantation 1990; 50: 554.
5. Tullius SG, Tilney NL. Both alloantigen-dependent and -independent factors influence chronic allograft rejection. Transplantation 1995; 59: 313.
6. Myllarniemi M, Raisanen-Sokolowski A, Vuoristo P, Kallio E, Land W, Hayry P. Lack of effect of recombinant human superoxide dismutase on cold ischemia-induced arteriosclerosis in syngeneic rat aortic transplants. Transplantation 1996; 61: 1018.
7. Yilmaz S, Paavonen T, Hayry P. Chronic rejection of rat renal allografts. II. The impact of prolonged ischemia time on transplant histology. Transplantation 1998; 53: 823.
8. Russell ME, Wallace AF, Wyner LR, Newell JB, Karnovsky MJ. Upregulation and modulation of inducible nitric oxide synthase in rat cardiac allografts with chronic rejection and transplant arteriosclerosis. Circulation 1995; 92: 457.
9. Shirwan H, Wu GD, Barwari L, Liu A, Cramer DV. Induction of allograft nonresponsiveness after intrathymic inoculation with donor class I allopeptides. II. Evidence for persistent chronic rejection despite high levels of donor microchimerism. Transplantation 1997; 64: 1671.
10. Zwacka RM, Zhang Y, Halldorson J, Schlossberg H, Dudus L, Engelhardt JF. CD4(+) T-lymphocytes mediate ischemia/ reperfusion-induced inflammatory responses in mouse liver. J Clin Invest 1997; 100: 279.
11. Takada M, Chandraker A, Nadeau KC, Sayegh MH, Tilney NL. The role of the B7 costimulatory pathway in experimental cold ischemia/reperfusion injury. J Clin Invest 1997; 100: 1199.
12. Tilney NL, Whitley WD, Diamond JR, Kupiec-Weglinski JW, Adams DH. Chronic rejection-an undefined conundrum. Transplantation 1993; 52: 389.
13. Hayry P, Isoniemi H, Yilmaz S, et al. Chronic allograft rejection. Immunol Rev 1993; 134: 33.
14. Hayry P, Aavik E, Loubtchhenkov M, Myllarniemi M, Koskinen P, Lemstrom K. Problem of chronic rejection. Graft 1999; 1: 154.
15. Lou H, Zhao Y, Delafontaine P, et al. Estrogen effects on insulin-like growth factor-I (IGF-I)-induced cell proliferation and IGF-I expression in native and allograft vessels. Circulation 1997; 96: 927.
16. Sasaguri S, Eishi Y, Tsukada T, et al. Role of smooth-muscle cells and macrophages in cardiac allograft arteriosclerosis in rabbits. J Heart Transplant 1990; 9: 18.
17. Shi C, Lee WS, Russell ME, et al. Hypercholesterolemia exacerbates transplant arteriosclerosis via increased neointimal smooth muscle cell accumulation: studies in apolipoprotein E knockout mice. Circulation 1997; 96: 2722.
18. Adams DH, Russell ME, Hancock WW, Sayegh MH, Wyner LR, Karnovsky MJ. Chronic rejection in experimental cardiac transplantation: studies in the Lewis-F344 model. Immunol Rev 1993; 134: 5.
19. Russell ME, Wallace AF, Hancock WW, et al. Upregulation of cytokines associated with macrophage activation in the Lewis-to-F344 rat transplantation model of chronic cardiac rejection. Transplantation 1995; 59: 572.
20. Hancock WW, Shi C, Picard MM, Bianchi C, Russell ME. LEW-to-F344 carotid artery allografts: analysis of a rat model of posttransplant vascular injury involving cell-mediated and humoral responses. Transplantation 1995; 60: 1565.
21. Cramer DV, Shirwan H. The importance of humoral immune responses in chronic rejection. Transplant Rev 1998; 12: 166.
22. Hancock WW, Whitley WD, Tullius SG, et al. Cytokines, adhesion molecules, and the pathogenesis of chronic rejection of rat renal allografts. Transplantation 1993; 56: 643.
23. Shirwan H, Barwari L, Cramer DV. Alloantigen recognition is mediated by T cell receptors expressing restricted Vb gene and diverse CDR3 loop and Jb gene repertoires. Immunology 1997; 90: 572.
24. + T cell-dependent antibody-mediated graft rejection. Immunol Today 1992; 13: 434.
25. b by alloreactive cytotoxic T lymphocytes. Nature 1989; 341: 749.
26. Gould DS, Auchincloss HJ. Direct and indirect recognition: the role of MHC antigens in graft rejection. Immunol Today 1999; 20: 77.
27. + T cell and B cell responses after cardiac allografts rejection. Transplantation 1995; 59: 401.
28. Braun MY, McCormack A, Webb G, Batchelor JR. Mediation of acute but not chronic rejection of MHC-incompatible rat kidney grafts by alloreactive CD4 T cells activated by the direct pathway of sensitization. Transplantation 1993; 55: 177.
29. Lechler RI, Batchelor JR. Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells. J Exp Med 1982; 155: 31.
30. Ciubotariu R, Liu Z, Colovai AI, et al. Persistent allopeptide reactivity and epitope spreading in chronic rejection of organ allografts. J Clin Invest 1998; 101: 398.
31. Vella JP, Spadafora-Ferreira M, Murphy B, et al. Indirect allorecognition of major histocompatibility complex allopeptides in human renal transplant recipients with chronic graft dysfunction. Transplantation 1997; 64: 795.
32. Liu Z, Sun YK, Xi YP, et al. Contribution of direct and indirect recognition pathways to T cell alloreactivity. J Exp Med 1993; 177: 1643.
33. Benham AM, Sawyer GJ, Pabre JW. Indirect T cell allorecognition of donor antigens contributes to the rejection of vascularized kidney allografts. Transplantation 1995; 59: 1028.
34. Steptoe RJ, Fu F, Li W, et al. Augmentation of dendritic cells in murine organ donors by flt3 ligand alters the balance between transplant tolerance and immunity. J Immunol 1998; 159: 5483.
35. Benichou G, Takizawa PA, Olson CA, McMillan M, Sercarz EE. Donor major histocompatibility complex (MHC) peptides are presented by recipient MHC molecules during graft rejection. J Exp Med 1992; 175: 305.
36. Rose EA, Smith CR, Petrossian GA, Barr ML, Reemtsma K. Humoral immune responses after cardiac transplantation: correlation with fatal rejection and graft atherosclerosis. Surgery 1989; 106: 203.
37. Hornick PI, Mason PD, Yacoub mH, Rose ML, Batchelor R, Lechler RI. Assessment of the contribution that direct allorecognition makes to the progression of chronic cardiac transplant rejection in humans. Circulation 1998; 97: 1257.
38. Yin D, Fathman CG. CD4-positive suppressor cells block allotransplant rejection. J Immunol 1995; 154: 6339.
39. Mosmann TR, Coffman RL. Two types of mouse helper T-cell clone: implications for immune regulation. Immunol Today 1987; 8: 223.
40. Kopf M, Brombacher F, Kohler G, et al. IL-4-deficient Balb/c mice resist infection with Leishmania major. J Exp Med 1996; 184: 1127.
41. Satoskar A, Brombacher F, Dai WJ, et al. SCID mice reconstituted with IL-4-deficient lymphocytes, but not immunocompetent lymphocytes, are resistant to cutaneous leishmaniasis. J Immunol 1997; 159: 5005.
42. Swihart K, Fruth U, Messmer N, et al. Mice from a genetically resistant background lacking the interferon γ receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1-type CD4+ T cell response. J Exp Med 1995; 181: 961.
43. Katz JD, Benoist C, Mathis D. T helper cell subsets in insulin-dependent diabetes. Science 1995; 268: 1185.
44. Mueller R, Krahl T, Sarvetnick N. Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice. J Exp Med 1996; 184: 1093.
45. Karin N, Mitcherll DJ, Brocke S, Ling N, Steinman L. Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon γ and tumor necrosis factor a production. J Exp Med 1994; 180: 2227.
46. Chu CQ, Londei M. Induction of Th2 cytokines and control of collagen-induced arthritis by nondepleting anti-CD4 Abs. J Immunol 1996; 157: 2685.
47. Ishida H, Muchamuel T, Sakaguchi S, Andrade S, Menon S, Howard M. Continuous administration of anti-interleukin 10 antibodies delays onset of autoimmunity in NZBAV F1 mice. J Exp Med 1994; 179: 305.
48. Chen N, Gao Q, Field EH. Prevention of Th1 responses is critical for tolerance. Transplantation 1996; 61: 1076.
49. Hancock WW, Lord RH, Colby AJ, et al. Identification of IL 2R+ cells and macrophages within rejecting rat cardiac allografts, and comparison of the effects of treatment with anti-IL 2R monoclonal antibody or cyclosporin. J Immunol 1987; 138: 164.
50. Onodera K, Hancock WW, Graser E, et al. Type 2 helper T cell-type cytokines and the development of "infectious" tolerance in rat cardiac allograft recipients. J Immunol 1997; 158: 1572.
51. Takeuchi T, Lowry RP, Konieczny B. Heart allografts in murine systems: the differential activation of Th2-like effector cells in peripheral tolerance. Transplantation 1992; 53: 1281.
52. Sayegh MH, Akalin E, Hancock WW, et al. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J Exp Med 1995; 181: 1869.
53. Shirwan H, Barwari L, Sattar-Khan N. Predominant expression of Th2 and altered expression of Th1 cytokines in long-term allograft survival induced by intrathymic immune modulation with donor class I MHC peptides. Transplantation 1998.
54. + T cells results in Th2 cytokine production and alternate mechanisms of allograft rejection. Transplantation 1995; 59: 1155.
55. Lang T, Krams SM, Martinez OM. Production of IL-4 and IL-10 does not lead to immune quiescence in vascularized human organ grafts. Transplantation 1996; 62: 776.
56. Plain KM, Fava L, Spinelli A, et al. Induction of tolerance with nondepleting anti-CD4 monoclonal antibodies is associated with down-regulation of TH2 cytokines. Transplantation 1997; 64: 1559.
57. Fabrega AJ, Fasbender AJ, Struble S, Zabner J. Cationic lipid-mediated transfer of the hIL-10 gene prolongs survival of allogeneic hepatocytes in Nagase analbuminemic rats. Transplantation 1996; 62: 1866.
58. Qin L, Chavin KD, Ding Y, et al. Multiple vectors effectively achieve gene transfer in a murine cardiac transplantation model. Immunosuppression with TGF-βl or vIL-10. Transplantation 1995; 59: 809.
59. Maeda H, Takata M, Takahashi S, Ogoshi S, Fujimoto S. Adoptive transfer of a Th2-like cell line prolongs MHC class II antigen disparate skin allograft survival in the mouse. Int Immunol 1994; 6: 855.
60. VanBuskirk AM, Wakely ME, Orosz CG. Transfusion of polarized TH2-like cell populations into SCID mouse cardiac allograft recipients results in acute allograft rejection. Transplantation 1996; 62: 229.
61. Zelenika D, Adams E, Mellor A, et al. Rejection of H-Y disparate skin grafts by monospecific CD4+ Th1 and Th2 cells: no requirement for CDS+ T cells or B cells. J Immunol 1998; 161: 1868.
62. Qin L, Chavin KD, Ding Y, et al. Retrovirus-mediated transfer of viral IL-10 gene prolongs murine cardiac allograft survival. J Immunol 1996; 156: 2316.
63. + graft-infiltrating T lymphocytes in promptly rejected kidney allografts. Transplantation 1995; 59: 1113.
64. Blazar Br, Taylor PA, Panoskaltsis-Mortari A, et al. Interleukin-10 dose-dependent regulation of CD4+ and CD8+ T cell-mediated graft-versus-host disease. Transplantation 1998; 66: 1220.
65. Horwitz DA, Gray JD, Ohtsuka K, Hirokawa M, Takahashi T. The immunoregulatory effects of NK cells: the role of TGF-β and implications for autoimmunity. Immunol Today 1997; 18: 538.
66. Cheever AW, Williams ME, Wynn TA, et al. Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis. J Immunol 1994; 153: 753.
67. Lacraz S, Nicod LP, Chicheportiche R, Welgus HG, Dayer JM. IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes. J Clin Invest 1995; 96: 2304.
68. Ong C, Wong C, Roberts CR, Teh HS, Jirik FR. Anti-IL-4 treatment prevents dermal collagen deposition in the tight-skin mouse model of scleroderma. Eur J Immunol 1998; 28: 2619.
69. Postlethwaite AE, Holness MA, Katai H, Raghow R. Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4. J Clin Invest 1992; 90: 1479.
70. Waltenberger J, Wanders A, Fellstrom B, Miyazono K, Heldin CH, Funa K. Induction of transforming growth factor-β during cardiac allograft rejection. J Immunol 1993; 151: 1147.
71. Koskinen PK, Lemstrom KB, Hayry PJ. How cyclosporin modifies histological and molecular events in the vascular wall during chronic rejection of rat cardiac allografts. Am J Pathol 1995; 146: 972.
72. Sawyer GJ, Dalchau R, Fabre JW. Indirect T cell allorecognition: a cyclosporin A resistant pathway for T cell help for antibody production to donor MHC antigens. Transplant Immunol 1993; 1: 77.
73. Glysing-Jensen T, Raisanen-Sokolowski A, Sayegh MH, Russell ME. Chronic blockade of CD28-B7-mediated T-cell costimulation by CTLA4Ig reduces intimal thickening in MHC class I and II incompatible mouse heart allografts. Transplantation 1997; 64: 1641.
74. Mhoyan A, Cramer DV, Baquerizo A, Shirwan H. Induction of allograft nonresponsiveness after intrathymic inoculation with donor class I allopeptides: 1. correlation of graft survival with anti-donor IgG antibody subclasses. Transplantation 1997; 64: 1665.
75. Raisanen-Sokolowski A, Glysing-Jensen T, Koglin J, Russell ME. Reduced transplant arteriosclerosis in murine cardiac allografts placed in interferon-γ knockout recipients. Am J Pathol 1998; 152: 359.
76. Melrose J, Tsurushita N, Liu G, Berg EL. IFN-γ inhibits activation-induced expression of E-and P-selectin on endothelial cells. J Immunol 1998; 161: 2457.
77. Mehrotra PT, Donnelly RP, Wong S, et al. Production of IL-10 by human natural killer cells stimulated with IL-2 and/or IL-12. J Immunol 1998; 160: 2637.
78. Marriott I, Bost KL. Substance P diminishes lipopolysaccharide and interferon-γ-induced TGF-β1 production by cultured murine macrophages. Cell Immunol 1998; 183: 113.
79. Charpin JM, Valcke J, Kettaneh L, Epardeau B, Stern M, Israel-Biet D. Peaks of transforming growth factor-β mRNA in alveolar cells of lung transplant recipients as an early marker of chronic rejection. Transplantation 1998; 65: 752.
80. Suthanthiran M. Clinical application of molecular biology: a study of allograft rejection with polymerase chain reaction. Am J Med Sci 1997; 313: 264.
81. Oliveira G, Xavier P, Murphy B, et al. Cytokine analysis of human renal allograft aspiration biopsy cultures supernatants predicts acute rejection. Nephrol Dial Transplant 1998; 13: 417.
82. Li C, Goodrich JM, Yang X. Interferon-γ (IFN-γ) regulates production of IL-10 and IL-12 in human herpesvirus-6 (HHV-6)-infected monocyte/macrophage lineage. Clin Exp Immunol 1997; 109: 421.
83. Salkowski CA, Detore GR, Vogel SN. Lipopolysaccharide and monophosphoryl lipid A differentially regulate interleukin-12, γ interferon, and interleukin-10 mRNA production in murine macrophages. Infect Immun 1997; 65: 3239.
84. Moore KW, O'Garra A, de Waal Malefyt R, Vieira P, Mosmann TR. Interleukin-10. Annu Rev Immunol 1993; 11: 165.
85. Salazar-Onfray F, Charo J, Petersson M, et al. Down-regulation of the expression and function of the transporter associated with antigen processing in murine tumor cell lines expressing IL-10. J Immunol 1997; 159: 3195.
86. Qin Z, Noffz G, Mohaupt M, Blankenstein T. Interleukin-10 prevents dendritic cell accumulation and vaccination with granulocyte-macrophage colony-stimulating factor gene-modified tumor cells. J Immunol 1997; 159: 770.
87. Steinbrink K, Wolfl M, Jonuleit H, Knop J, Enk AH. Induction of tolerance by IL-10-treated dendritic cells. J Immunol 1997; 159: 4772.
88. Willems F, Marchant A, Delville JP, et al. Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes. Eur J Immunol 1994; 24: 1007.
89. D'Orazio TJ, Niederkorn Y. A novel role for TGF-β and IL-10 in the induction of immune privilege. J Immunol 1998; 160: 2089.
90. Hutchinson IV, Pravica V, Sinnott PJ. Genetic regulation of cytokine synthesis: consequences for acute and chronic organ allograft rejection. Graft 1999; 1: 186.
91. Petrossian GA, Nichols AB, Marboe CC, et al. Relation between survival and development of coronary artery disease and anti-HLA antibodies after cardiac transplantation. Circulation 1989; 80: III122.
92. Russell PS, Chase CM, Winn HJ, Colvin RB. Coronary atherosclerosis in transplanted mouse hearts. II. Importance of humoral immunity. J Immunol 1994; 152: 5135.
93. Hosenpud JD, Everett JP, Morris TE, Mauck KA, Shipley GD, Wagner CR. Cardiac allograft vasculopathy: association with cell-mediated but not humoral alloimmunity to donor-specific vascular endothelium. Circulation 1995; 92: 205.
94. Russell PS, Chase CM, Colvin RB. Alloantibody-and T cell-mediated immunity in the pathogenesis of transplant arteriosclerosis: lack of progression to sclerotic lesions in B cell-deficient mice. Transplantation 1997; 64: 1531.
95. Shi C, Lee WS, He Q, et al. Immunologic basis of transplant-associated arteriosclerosis. Proc Natl Acad Sci USA 1996; 93: 4051.
96. Hancock WW, Buelow R, Sayegh MH, Turka LA. Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes. Nat Med 1998; 4: 1392.
97. Le Moine A, Flamand V, Noel JC, Fayt I, Goldman M, Abramowicz D. Chronic rejection of major histocompatibility complex class Il-disparate skin grafts after anti-CD3 therapy: a model of antibody-independent transplant vasculopathy. Transplantation 1998; 66: 1537.
98. Harris PE, Bian H, Reed EF. Induction of high affinity fibroblast growth factor receptor expression and proliferation in human endothelial cells by anti-HLA antibodies: a possible mechanism for transplant atherosclerosis. J Immunol 1997; 159: 5697.
99. Mueller R, Krahl T, Sarvetnick N. Tissue-specific expression of interleukin-4 induces extracellular matrix accumulation and extravasation of B cells. Lab Invest 1997; 76: 117.
100. Mennander A, Tiisala S, Paavonen T, Halttunen J, Hayry P. Chronic rejection of rat aortic allograft. II. Administration of cyclosporin induces accelerated allograft arteriosclerosis. Transplant Int 1991; 4: 173.
101. Fellstrom B, Dimeny E, Larsson E, Claesson K, Tufveson G. Rapidly proliferative arteriopathy in cyclosporin-induced permanently surviving rat cardiac allografts simulating chronic vascular rejection. Clin Exp Immunol 1990; 80: 288.
102. Wasowska B, Wieder KJ, Hancock WW, et al. Cytokine and alloantibody networks in long term cardiac allografts in rat recipients treated with rapamycin. J Immunol 1996; 156: 395.
103. Blazar Br, Taylor PA, Panoskaltsis-Mortari A, Vallera DA. Rapamycin inhibits the generation of graft-versus-host disease-and graft-versus-leukemia-causing T cells by interfering with the production of Th1 or Th1 cytotoxic cytokines. J Immunol 1998; 160: 5355.
104. Kiani A, Viola JP, Lichtman AH, Rao A. Down-regulation of IL-4 gene transcription and control of Th2 cell differentiation by a mechanism involving NFAT1. Immunity 1997; 7: 849.
105. Rao A, Luo C, Hogan PG. Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol 1997; 15: 707.
106. + T cell population to the T helper 2 cell pathway. J Immunol 1996; 157: 3260.
107. Orosz CG. Local cellular immunology of experimental transplant vascular sclerosis. Clin Transplant 1996; 10: 100.
108. Orosz CG, Huang EH, Bergese SD, et al. Prevention of acute murine cardiac allograft rejection: anti-CD4 or anti-vascular cell adhesion molecule one monoclonal antibodies block acute rejection but permit persistent graft-reactive alloimmunity and chronic tissue remodelling. J Heart Lung Transplant 1997; 16: 889.
109. Morris CF, Simeonovic CJ, Fung MC, Wilson JD, Hapel AJ. Intragraft expression of cytokine transcripts during pig proislet xenograft rejection and tolerance in mice. J Immunol 1995; 154: 2470.
110. Constant SL, Bottomly K. Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Annu Rev Immunol 1997; 15: 297.
111. Sloan-Lancaster J, Steinberg TH, Allen PM. Selective loss of the calcium ion signaling pathway in T cells maturing toward a T helper 2 phenotype. J Immunol 1997; 159: 1160.
112. Tao X, Grant C, Constant S, Bottomly K. Induction of IL-4-producing CD4+ T cells by antigenic peptides altered for TCR binding. J Immunol 1997; 158: 4237.
113. Constant S, Pfeiffer C, Woodard A, Pasqualini T, Bottomly K. Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells. J Exp Med 1995; 182: 1591.
114. Delaney JR, Sykulev Y, Eisen HN, Tonegawa S. Differences in the level of expression of class I major histocompatibility complex proteins on thymic epithelial and dendritic cells influence the decision of immature thymocytes between positive and negative selection. Proc Natl Acad Sci USA 1998; 95: 5235.
115. Waaga AM, Chandraker A, Spadafora-Ferreira M, et al. Mechanisms of indirect allorecognition: characterization of MHC class II allopeptide-specific T helper cell clones from animals undergoing acute allograft rejection. Transplantation 1998; 65: 876.
116. King C, Davies J, Mueller R, et al. TGF-β1 alters APC preference, polarizing islet antigen responses toward a Th2 phenotype. Immunity 1998; 8: 601.
117. Liu L, Rich BE, Inobe J, Chen W, Weiner HL. Induction of Th2 cell differentiation in the primary immune response: dendritic cells isolated from adherent cell culture treated with IL-IO prime naive CD4+ T cells to secrete IL-4. Int Immunol 1998; 10: 1017.
118. Choo JK, Seebach JD, Nickeleit V, et al. Species differences in the expression of major histocompatibility complex class II antigens on coronary artery endothelium: implications for cell-mediated xenoreactivity. Transplantation 1997; 64: 1315.
119. McGhie AI, Radovancevic B, Capek P, et al. Major histocompatibility complex class II antigen expression in rejecting cardiac allografts: detection using in vivo imaging with radiolabeled monoclonal antibody. Circulation 1997; 96: 1605.
120. Chang SC, Hsu HK, Perng RP, Shiao GM, Lin CY. Increased expression of MHC class II antigens in rejecting canine lung allografts. Transplantation 1990; 49: 1158.
121. Hasegawa S, Becker G, Nagano H, Libby P, Mitchell RN. Pattern of graft-and host-specific MHC class II expression in long-term murine cardiac allografts: origin of inflammatory and vascular wall cells. Am J Pathol 1998; 153: 69.
122. Marelli-Berg FM, Hargreaves REG, Carmichael P, Dorling A, Lombardi G, Lechler RI. Major histocompatibility complex class II-expressing endothelial cells induce allospecific nonresponsiveness in naive T cells. J Exp Med 1996; 183: 1603.
123. Hancock WW, Sayegh MH, Zheng XG, Peach R, Linsley PS, Turka LA. Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection. Proc Natl Acad Sci U S A 1996; 93: 13967.
124. Ma W, Pober JS. Human endothelial cells effectively costimulate cytokine production by, but not differentiation of, naive CD4+ T cells. J Immunol 1998; 161: 2158.
125. Schweitzer AN, Borriello F, Wong RC, Abbas AK. Sharpe AH. Role of costimulators in T cell differentiation: studies using antigen-presenting cells lacking expression of CD80 or CD86. J Immunol 1997; 158: 2713.
126. Subramanian G, Kazura JW, Pearlman E, Jia X, Malhotra I, King CL. B7-2 requirement for helminth-induced granuloma formation and CD4 type 2 T helper cell cytokine expression. J Immunol 1997; 158: 5914.
127. Ding L, Green JM, Thompson CB, Shevach EM. B7/CD28-dependent and -independent induction of CD40 ligand expression. J Immunol 1995; 155: 5124.
128. Matulonis U, Dosiou C, Freeman G, et al. B7-1 is superior to B7-2 costimulation in the induction and maintenance of T cell-mediated antileukemia immunity: further evidence that B7-1 and B7-2 are functionally distinct. J Immunol 1996; 156: 1126.
129. Thompson B. Distinct roles for the costimulatory ligands B7-1 and B7-2 in T helper cell differentiation? Cell 1995; 81: 979.
130. Tsuyuki S, Tsuyuki J, Einsle K, Kopf M, Coyle AJ. Costimulation through B7-2 (CD86) is required for the induction of a lung mucosal T helper cell 2 (TH2) immune response and altered airway responsiveness. J Exp Med 1997 May 5; 1997; 185: 1671.
131. Kuchroo VK, Prabhu Das M, Brown JA, et al. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 1995; 80: 707.
132. Subramanian G, Kazura JW, Pearlman E, Jia X, Malhotra I, King CL. B7-2 requirement for helminth-induced granuloma formation and CD4 type 2 T helper cell cytokine expression. J Immunol 1997; 158: 5914.
133. Boes M, Dake BL, Bar RS. Interactions of cultured endothelial cells with TGF-β, bFGF, PDGF and IGF-I. Life Sci 1991; 48: 811.
134. + T cell clones can provide B cell help. J Immunol 1995; 154: 3118.
135. - cells that make Th2 cytokines and help B cells. Science 1993; 260: 1802.
136. Erard F, Garcia-Sanz JA, Moriggl R, Wild MT. Presence or absence of TGF-β determines IL-4-induced generation of type 1 or type 2 CD8 T cell subsets. J Immunol 1999; 162: 209.
137. Schmidt-Weber CB, Alexander SI, Renault LE, James L, Lichtman AH. IL-4 enhances IL-10 gene expression in murine Th2 cells in the absence of TCR engagement. J Immunol 1999; 162: 238.
138. Sato A, Tsuji K, Yamamura M, et al. Increased type 2 cytokine expression by both CD4+ CD45RO+ T cells and CD8+ CD45RO+ T cells in blood circulation is associated with high serum IgE but not with atopic dermatitis. J Invest Dermatol 1998; 111: 1079.
139. + T cells into subpopulations with distinct cytokine profiles. J Immunol 1995; 155: 2928.
140. Cerwenka A, Carter LL, Reome JB, Swain SL, Dutton RW. In vivo persistence of CD8 polarized T cell subsets producing type 1 or type 2 cytokines. J Immunol 1998; 161: 97.
141. Brown MG, Scalzo AA, Matsumoto KYWM. The natural killer gene complex: a genetic basis for understanding natural killer cell function and innate immunity. Immunol Rev 1997; 155: 53.
142. Handa K, Suzuki R, Matsui H, Shimizu Y, Kumagai K. Natural killer (NK) cells as a responder to interleukin 2 (IL 2). II. IL 2-induced interferon γ production. J Immunol 1983; 130: 988.
143. Mehrotra PT, Donnelly RP, Wong S, et al. Production of IL-10 by human natural killer cells stimulated with IL-2 and/or IL-12. J Immunol 1998; 160: 2637.
144. Hunter CA, Bermudez L, Beernink H, Waegell W, Remington JS. Transforming growth factor-β inhibits interleukin-12-in-duced production of interferon-γ by natural killer cells: a role for transforming growth factor-β in the regulation of T cell-independent resistance to Toxoplasma gondii. Eur J Immunol 1995; 25: 994.
145. Gray JD, Hirokawa M, Ohtsuka K, Horwitz DA. Generation of an inhibitory circuit involving CD8+ T cells, IL-2, and NK cell-derived TGF-β: contrasting effects of anti-CD2 and anti-CD3. J Immunol 1998; 160: 2248.
146. Peritt D, Robertson S, Gri G, Showe L, Aste-Amezaga M, Trinchieri G. Differentiation of human NK cells into NK1 and NK2 subsets. J Immunol 1998; 161: 5821.