Cytokine analysis of human renal allograft aspiration biopsy cultures supernatants predicts acute rejection

Nephrology Dialysis Transplantation

Volumn 13, Issue 2, 1998, Pages 417-422

  Oliveira, Gerardo ^a,d   Xavier, Paula ^b   Murphy, Barbara ^c   Neto, Sandra ^b   Mendes, Armando ^b   Sayegh, Mohamed H ^c   Guerra, Levi E ^a  

^a HOSPITAL DE SÃO JOÃO   (Portugal)

^b Ministerio da Saude Portuguese   (Portugal)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d NONE   (Portugal)

Author keywords

FNAB; Interleukins; Lymphoctyes; Rejection; T helper; Tolerance; Transplantation

Indexed keywords

CREATININE; CYCLOSPORIN A; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4;

ADOLESCENT; ADULT; ARTICLE; ASPIRATION BIOPSY; BLOOD LEVEL; CADAVER KIDNEY; CELL INFILTRATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CYTOKINE RELEASE; FEMALE; HELPER CELL; HUMAN; HUMAN TISSUE; IMMUNOLOGICAL TOLERANCE; KIDNEY ALLOGRAFT; KIDNEY ALLOGRAFT REJECTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCREENING;

EID: 0031975710     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.ndt.a027839     Document Type: Article

References (42)

1. Nickerson P, Steurer W, Steiger J, Zheng X, Steele AW, Strom TB. Cytokines and the Th1/Th2 paradigm in transplantation: Curr Opin Immunol 1994; 6: 757-764
2. Kamogawa Y, Minasi L, Carding SR, Bottomly K, Flavell RA. The relationship of IL-4 and IFNγ-producing T cells studied by lineage ablation of IL-4-producing cells. Cell 1993; 75: 985-995
3. Fitch FW, Mckisic MD, Lancki DW, Gajewski TF. Differential regulation of murine T lymphocyte subsets. Annu Rev Immunol 1993; 11: 29-48
4. + T cells through IL-12 produced by Listeria-induced macrophages. Science 1993; 260: 547-549
5. O'Connell PJ, Pacheco-Silva A, Nickerson PW et al. Unmodified pancreatic islet allograft rejection results in the preferential expression of certain T cell activation transcripts. J Immunol 1993; 150: 1093-1104
6. Takeuchi T, Lowry RP, Konieczny B. Heart allografts in murine systems: the differential activation of Th2-like effector cells in peripheral tolerance. Transplantation 1992; 53: 1281-1294
7. Dallman MJ, Larsen CP, Morris PJ. Cytokine gene transcription in vascularised organ grafts: analysis using semiquantitative polymerase chain reaction. J Exp Med 1991; 174: 493-496
8. Sayegh MH, Akalin E, Hancock WW et al. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J Exp Med 1995; 181: 1869-1874
9. Hancock WW, Sayegh MH, Kwok CA, Weiner HL, Carpenter CB. Oral, but not intravenous, alloantigen prevents accelerated allograft rejection by selective intragraft Th2 cell activation. Transplantation 1993; 55: 1112-1118
10. Burgeon K, Cuturi M-C, Hallet J, Paineau J, Chabannes D, Soulillou J-P. Peripheral tolerance of an allograft in adult rats-characterization by low interleukin-2 and interferon-γ mRNA levels and by strong accumulation of major histocompatability complex transcripts in the graft. Transplantation 1992; 54: 219-225
11. Binder J, Hancock WW, Wasowska B et al. Donor-specific transplantation unresponsiveness in sensitized rats following treatment with a nondepleting anti-CD4 mAb is associated with selective intragraft sparing of Th2-like cells. Transplant Proc 1995; 27: 114-116
12. Kusaka S, Grailer AP, Fechner JH Jr, Burlingham WJ. Evidence for a possible Th2 bias in human renal transplant tolerance. Transplant Proc 1995; 27: 225-226
13. Vossen ACTM. Tibbe GJM, Benner R, Savelkoul HFJ. T-lymphocyte and cytokine-directed strategies for inhibiting skin allograft rejection in mice. Transplant Proc 1995; 27: 380-382
14. Fanges O, Morris PJ, Dallman MJ. Spontaneous acceptance of liver allografts is associated with an early downregulation of intragraft IL-4mRNA expression. Hepatology 1995; 21: 767-775
15. Lee MS, Wogensen L, Shizuru J, Oldstone MBA, Sarvetnick N. Pancreatic islet production of murine interleukin-10 does not inhibit immune-mediated tissue destruction. J Clin Invest 1994; 93: 1332-1338
16. Kumano K, Irie A, Mashimo S, Endo T, Koshiba K. Changes in urinary interleukin-2 in kidney transplant recipients. Transplant Proc 1996; 3: 1248-1249
17. Simpson MA, Madras PN, Cornaby AJ et al. Sequential determinations of urinary cytology and plasma and urinary lymphokines in the management of renal allograft recipients. Transplantation 1989; 47: 218-223
18. Kita Y, Iwaki Y, Noguchi K et al. Daily serum interleukin-6 monitoring in multiple organ transplantation with or without liver allografts. Transplant Proc 1996; 3: 1229-1234
19. Johnson CP, Choharmonal A, Buchmann E, Roza AM, Adams MB. Plasma IL-2 levels and diagnosis of renal transplant rejection. Transplant Proc 1990; 22(4): 1849-1851
20. Haÿry P. Fine-needle aspiration biopsy in renal transplantation. Kidney Int 1989; 36: 130-141
21. Bogman MJTT. Fine-needle aspiration biopsy of the renal transplant - is it worthwhile or a waste of time? Nephrol Dial Transplant 1995; 10: 2182-2184
22. Helderman JH, Hernandez J, Sagalowsky A et al. Confirmation of the utility of fine needle aspiration biopsy of the renal allograft. Kidney Int 1988; 34: 376-382
23. Oliveira G, Xavier P, Mendes A, Guerra LE. Cultures of aspiration biopsy specimens in the immunological monitoring of renal transplants. Nephron 1997; 76: 310-314
24. Oliveira JGG, Xavier P, Neto S, Mendes AA, Guerra LER. Monocytes-macrophages and cytokines/chemokines in fine-needle aspiration biopsies cultures: enhanced IL-Ira synthesis in rejection-free kidney transplant patients. Transplantation 1997; 63: 1751-1756
25. Yard BA, Kooymans-Coutinho M, Paape ME et al. Analysis of cytokine production by graft-infiltrating cells isolated from rejecting renal allografts. Transplantation 1994; 57: 153-155
26. Duquesnoy RJ, Trager JDK, Zeevi A. Propagation and characterization of lymphocytes from transplant biopsies. Clin Rev Immunol 1991; 10: 455-480
27. Oliveira JGG, Ramos JP, Xavier P, Magalhães MC, Mendes AA, Guerra LER. Analysis of fine-needle aspiration biopsies by flow cytometry in kidney transplant patients. Transplantation (in press)
28. Armstrong HE, Bolton EM, McMillan I, Spencer SC, Bradley JA. Prolonged survival of actively enhanced rat renal allografts despite accelerated cellular infiltration and rapid induction of both class I and class II MHC antigens. J Exp Med 1987; 164: 891-907
29. Sun J, McCaughan GW, Matsumoto Y, Sheil AGR, Gallagher ND, Bishop GA. Tolerance to rat liver allografts. Transplantation 1994; 57: 1349-1357
30. Ode-Hakim S, Docke WD, Kern F, Ammerich F, Volk HD, Reinke P. Delayed-type hypersensitivity-like mechanisms dominate late acute rejection episodes in renal allograft recipients. Transplantation 1996; 61: 1233-1240
31. Bromberg JS. IL-10 immunosuppression in transplantation. Curr Opin Immunol 1995; 7: 639-643
32. Ding L, Linsley PS, Huang L-Y, Germain RN, Shevach EM. IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. J Immunol 1993; 151: 1224-1234
33. de Waal Malefyt R, Haanen J, Spits H et al. Interleukin-10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J Exp Med 1991; 174: 915-924
34. D'Andrea A, Aste-Amezaga, Valiante NM, Ma X, Kubin M, Trinchieri G, Interleukin-10 (IL-10) inhibits human lymphocyte interferon-γ-production by supressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med 1993; 178: 1041-1048
35. Macatonia SE, Doherty TM, Knight SC, O'Garra A. Differential effect of IL-10 on dendritic cell-induced T cell proliferation and IFN-γ production. J Immunol 1993; 150: 3755-3765
36. Croft M, Swain SL. Recently activated naive CD4 T cells can help resting B cells, and can produce sufficient autocrine IL-4 to drive differentiation to secretion of T helper 2-type cytokines. J Immunol 1995; 154: 4269-4282
37. te Weide AA, Malefyt RdeW, Huijbens RJF, de Vries JE, Figdor CG. IL-10 stimulates monocyte FcyR surface expression and cytotoxic activity. J Immunol 1992; 149: 4048-4052
38. Carter LL, Dutton RW. Type 1 and Type 2: a fundamental dichotomy for all T-cell subsets. Curr Opin Immunol 1996; 3: 336-342
39. Fanslow WC, Clifford KN, Park LS et al. Regulation of alloreactivity in vivo by IL-4 and the soluble IL-4 receptor. J Immunol 1991; 147: 535-540
40. Wang SC, Morel PA, Wang Q, Jordan ML, Simmons RL, Tweardy DJ. A dual mechanism of immunosupression by FK-506. Transplantation 1993; 56: 978-985
41. Kirk AD, Ibrahim MA, Bollinger RR, Dawson DV, Finn OJ. Renal allograft-infiltrating lymphocytes. Transplantation 1992; 53: 329-338
42. Danzer SG, Kirchner H, Rink L. Cytokine interaction in human mixed lymphocyte culture. Transplantation 1994; 57: 1638-1642