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Volumn 64, Issue 11, 1997, Pages 1559-1567

Induction of tolerance with nondepleting anti-CD4 monoclonal antibodies is associated with down-regulation of TH2 cytokines

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIBODY; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; CYTOLYSIN; GAMMA INTERFERON; GRANZYME A; GRANZYME B; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; LYMPHOTOXIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NITRIC OXIDE SYNTHASE; OKT 4; T LYMPHOCYTE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

EID: 0031470531     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199712150-00009     Document Type: Article
Times cited : (51)

References (58)
  • 3
    • 0027403865 scopus 로고
    • Induction of long-term specific tolerance to allografts in rats by therapy with an anti-CD3-like monoclonal antibody
    • Nicolls MR, Aversa GG, Pearce NW, et al. Induction of long-term specific tolerance to allografts in rats by therapy with an anti-CD3-like monoclonal antibody. Transplantation 1993; 55: 459.
    • (1993) Transplantation , vol.55 , pp. 459
    • Nicolls, M.R.1    Aversa, G.G.2    Pearce, N.W.3
  • 4
    • 0027479685 scopus 로고
    • "Infectious" transplantation tolerance
    • Qin S, Cobbold SP, Pope H, et al. "Infectious" transplantation tolerance. Science 1993; 259: 974.
    • (1993) Science , vol.259 , pp. 974
    • Qin, S.1    Cobbold, S.P.2    Pope, H.3
  • 5
    • 0025674112 scopus 로고
    • Induction of tolerance in peripheral T cells with monoclonal antibodies
    • Qin SX, Wise M, Cobbold SP, et al. Induction of tolerance in peripheral T cells with monoclonal antibodies. Eur J Immunol 1990; 20: 2737.
    • (1990) Eur J Immunol , vol.20 , pp. 2737
    • Qin, S.X.1    Wise, M.2    Cobbold, S.P.3
  • 6
    • 0022000816 scopus 로고
    • Mechanisms maintaining enhancement of allografts. I. Demonstration of a specific suppressor cell
    • Hall BM. Mechanisms maintaining enhancement of allografts. I. Demonstration of a specific suppressor cell. J Exp Med 1985; 161: 123.
    • (1985) J Exp Med , vol.161 , pp. 123
    • Hall, B.M.1
  • 7
    • 0019973336 scopus 로고
    • The roles of host and donor cells in the rejection of skin allografts by T cell-deprived rats injected with syngeneic T cells
    • Dallman MJ, Mason DW, Webb M. The roles of host and donor cells in the rejection of skin allografts by T cell-deprived rats injected with syngeneic T cells. Eur J Immunol 1982; 12: 511.
    • (1982) Eur J Immunol , vol.12 , pp. 511
    • Dallman, M.J.1    Mason, D.W.2    Webb, M.3
  • 8
    • 0025881584 scopus 로고
    • Cells mediating allograft rejection
    • published erratum appears in Transplantation 1991 Nov; 52(5): 936
    • Hall BM. Cells mediating allograft rejection [published erratum appears in Transplantation 1991 Nov; 52(5): 936]. Transplantation 1991; 51: 1141.
    • (1991) Transplantation , vol.51 , pp. 1141
    • Hall, B.M.1
  • 9
    • 0024353079 scopus 로고
    • TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
    • Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989; 7: 145.
    • (1989) Annu Rev Immunol , vol.7 , pp. 145
    • Mosmann, T.R.1    Coffman, R.L.2
  • 10
    • 0029017966 scopus 로고
    • CD4 T cell development and cytokine polarization: An overview
    • Swain SL. CD4 T cell development and cytokine polarization: an overview. J Leukocyte Biol 1995; 57: 795.
    • (1995) J Leukocyte Biol , vol.57 , pp. 795
    • Swain, S.L.1
  • 11
    • 0028933795 scopus 로고
    • The regulation of immunity to Leishmania major
    • Reiner SL, Locksley RM. The regulation of immunity to Leishmania major. Annu Rev Immunol 1995; 13: 151.
    • (1995) Annu Rev Immunol , vol.13 , pp. 151
    • Reiner, S.L.1    Locksley, R.M.2
  • 12
    • 0026729563 scopus 로고
    • Heart allografts in murine systems: The differential activation of Th2-like effector cells in peripheral tolerance
    • Takeuchi T, Lowry RP, Konieczny B. Heart allografts in murine systems: the differential activation of Th2-like effector cells in peripheral tolerance. Transplantation 1992; 53: 1281.
    • (1992) Transplantation , vol.53 , pp. 1281
    • Takeuchi, T.1    Lowry, R.P.2    Konieczny, B.3
  • 13
    • 0027332312 scopus 로고
    • CD4 mAb therapy modulates alloantibody production and intracardiac graft deposition in association with selective inhibition of Th1 lymphokines
    • Kupiec-Weglinski JW, Wasowska B, Papp I, et al. CD4 mAb therapy modulates alloantibody production and intracardiac graft deposition in association with selective inhibition of Th1 lymphokines. J Immunol 1993; 151: 5053.
    • (1993) J Immunol , vol.151 , pp. 5053
    • Kupiec-Weglinski, J.W.1    Wasowska, B.2    Papp, I.3
  • 14
    • 0028967385 scopus 로고
    • Increased expression of IL-4 and IL-10 and decreased expression of IL-2 and interferon-gamma in long-surviving mouse heart allografts after brief CD4-monoclonal antibody therapy
    • Mottram PL, Han WR, Purcell LJ, McKenzie IFC, Hancock WW. Increased expression of IL-4 and IL-10 and decreased expression of IL-2 and interferon-gamma in long-surviving mouse heart allografts after brief CD4-monoclonal antibody therapy. Transplantation 1995; 59: 559.
    • (1995) Transplantation , vol.59 , pp. 559
    • Mottram, P.L.1    Han, W.R.2    Purcell, L.J.3    McKenzie, I.F.C.4    Hancock, W.W.5
  • 15
    • 0029584683 scopus 로고
    • CD4 TH2 cells do not functionally suppress CTL generation in neonatal tolerant mice
    • Gao Q, Chen N, Field EH. CD4 TH2 cells do not functionally suppress CTL generation in neonatal tolerant mice. Transplantation 1995; 60: 1260.
    • (1995) Transplantation , vol.60 , pp. 1260
    • Gao, Q.1    Chen, N.2    Field, E.H.3
  • 16
    • 0029664599 scopus 로고    scopus 로고
    • Prevention of TH1 responses is critical for tolerance
    • Chen N, Gao Q, Field EH. Prevention of TH1 responses is critical for tolerance. Transplantation 1996; 61: 1076.
    • (1996) Transplantation , vol.61 , pp. 1076
    • Chen, N.1    Gao, Q.2    Field, E.H.3
  • 17
    • 0029967728 scopus 로고    scopus 로고
    • The effects of nondepleting CD4 targeted therapy in presensitized rat recipients of cardiac allografts
    • Binder J, Lehmann M, Graser E, et al. The effects of nondepleting CD4 targeted therapy in presensitized rat recipients of cardiac allografts. Transplantation 1996; 61: 804.
    • (1996) Transplantation , vol.61 , pp. 804
    • Binder, J.1    Lehmann, M.2    Graser, E.3
  • 18
    • 0030447301 scopus 로고    scopus 로고
    • Coexistence of TH1-and TH2-type cytokine profiles in anti-CD2 monoclonal antibody-induced tolerance
    • Krieger NR, Most D, Bromberg JS, et al. Coexistence of TH1-and TH2-type cytokine profiles in anti-CD2 monoclonal antibody-induced tolerance. Transplantation 1996; 62: 1285.
    • (1996) Transplantation , vol.62 , pp. 1285
    • Krieger, N.R.1    Most, D.2    Bromberg, J.S.3
  • 19
    • 0026613777 scopus 로고
    • Anti-CD4 monoclonal antibodies in therapy: Creation of nonclassical tolerance in the adult
    • Shizuru JA, Alters SE, Fathman CG. Anti-CD4 monoclonal antibodies in therapy: creation of nonclassical tolerance in the adult. Immunol Rev 1992; 129: 105.
    • (1992) Immunol Rev , vol.129 , pp. 105
    • Shizuru, J.A.1    Alters, S.E.2    Fathman, C.G.3
  • 20
    • 0023217828 scopus 로고
    • Islet allograft survival after a single course of treatment of recipient with antibody to L3T4
    • Shizuru JA, Gregory AK, Chao CT, Fathman CG. Islet allograft survival after a single course of treatment of recipient with antibody to L3T4. Science 1987; 237: 278.
    • (1987) Science , vol.237 , pp. 278
    • Shizuru, J.A.1    Gregory, A.K.2    Chao, C.T.3    Fathman, C.G.4
  • 21
    • 0023707239 scopus 로고
    • Strategies of monoclonal antibody therapy that induce permanent tolerance of organ transplants
    • Herbert J, Roser B. Strategies of monoclonal antibody therapy that induce permanent tolerance of organ transplants. Transplantation 1988; 46: 128S.
    • (1988) Transplantation , vol.46
    • Herbert, J.1    Roser, B.2
  • 23
    • 0028362675 scopus 로고
    • Nondepleting anti-CD4 antibodies in transplantation: Evidence that modulation is far less effective than prolonged CD4 blockade
    • Darby CR, Bushell A, Morris PJ, Wood KJ. Nondepleting anti-CD4 antibodies in transplantation: evidence that modulation is far less effective than prolonged CD4 blockade. Transplantation 1994; 57: 1419.
    • (1994) Transplantation , vol.57 , pp. 1419
    • Darby, C.R.1    Bushell, A.2    Morris, P.J.3    Wood, K.J.4
  • 24
    • 0026577832 scopus 로고
    • Tolerance in the mouse to major histocompatibility complex-mismatched heart allografts, and to rat heart xenografts, using monoclonal antibodies to CD4 and CD8
    • Chen Z, Cobbold S, Metcalfe S, Waldmann H. Tolerance in the mouse to major histocompatibility complex-mismatched heart allografts, and to rat heart xenografts, using monoclonal antibodies to CD4 and CD8. Eur. J Immunol 1992; 22: 805.
    • (1992) Eur. J Immunol , vol.22 , pp. 805
    • Chen, Z.1    Cobbold, S.2    Metcalfe, S.3    Waldmann, H.4
  • 25
    • 0025079741 scopus 로고
    • Prolonged survival of nonhuman primate renal allograft recipients treated only with anti-CD4 monoclonal antibody
    • Cosimi AB, Delmonico FL, Wright JK. Prolonged survival of nonhuman primate renal allograft recipients treated only with anti-CD4 monoclonal antibody. Surgery 1990; 108: 406.
    • (1990) Surgery , vol.108 , pp. 406
    • Cosimi, A.B.1    Delmonico, F.L.2    Wright, J.K.3
  • 26
    • 0029893961 scopus 로고    scopus 로고
    • Kinetics of the induction of transplantation tolerance with a nondepleting anti-CD4 monoclonal antibody and donor-specific transfusion before transplantation: A critical period of time is required for development of immunological unresponsiveness
    • Saitovitch D, Bushell A, Mabbs DW, Morris PJ, Woods KJ. Kinetics of the induction of transplantation tolerance with a nondepleting anti-CD4 monoclonal antibody and donor-specific transfusion before transplantation: a critical period of time is required for development of immunological unresponsiveness. Transplantation 1996; 61: 1642.
    • (1996) Transplantation , vol.61 , pp. 1642
    • Saitovitch, D.1    Bushell, A.2    Mabbs, D.W.3    Morris, P.J.4    Woods, K.J.5
  • 28
    • 0028295821 scopus 로고
    • A role for transforming growth factor-beta in the veto mechanisms in transplant tolerance
    • Verbanac KM, Carver FM, Haisch CE, Thomas JM. A role for transforming growth factor-beta in the veto mechanisms in transplant tolerance. Transplantation 1994; 57: 893.
    • (1994) Transplantation , vol.57 , pp. 893
    • Verbanac, K.M.1    Carver, F.M.2    Haisch, C.E.3    Thomas, J.M.4
  • 30
    • 0023578917 scopus 로고
    • Importance of immunoglobulin isotype in therapy of experimental autoimmune encephalomyelitis with monoclonal anti-CD4 antibody
    • Waldor MK, Mitchell D, Kipps TJ, Herzenberg LA, Steinman L. Importance of immunoglobulin isotype in therapy of experimental autoimmune encephalomyelitis with monoclonal anti-CD4 antibody. J Immunol 1987; 139: 3660.
    • (1987) J Immunol , vol.139 , pp. 3660
    • Waldor, M.K.1    Mitchell, D.2    Kipps, T.J.3    Herzenberg, L.A.4    Steinman, L.5
  • 31
    • 0344403538 scopus 로고
    • Analysis of antigens by immunodiffusion and immunoelectrophoresis
    • DeFoma FJ, MacDonald AB, eds. New York: Macmillan
    • DeFoma FJ, MacDonald AB. Analysis of antigens by immunodiffusion and immunoelectrophoresis. In: DeFoma FJ, MacDonald AB, eds. Experimental immunology: a guidebook. New York: Macmillan, 1987: 49.
    • (1987) Experimental Immunology: A Guidebook , pp. 49
    • DeFoma, F.J.1    MacDonald, A.B.2
  • 32
    • 0014468579 scopus 로고
    • Improved technique of heart transplantation in rats
    • Ono K, Lindsey ES. Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg 1969; 57: 225.
    • (1969) J Thorac Cardiovasc Surg , vol.57 , pp. 225
    • Ono, K.1    Lindsey, E.S.2
  • 34
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156.
    • (1987) Anal Biochem , vol.162 , pp. 156
    • Chomczynski, P.1    Sacchi, N.2
  • 35
    • 0030894789 scopus 로고    scopus 로고
    • Role of T cells in the mediation of Heymann nephritis. II. Identification of Th1 and cytotoxic cells in glomeruli
    • Penny MJ, Boyd RA, Hall BM. Role of T cells in the mediation of Heymann nephritis. II. Identification of Th1 and cytotoxic cells in glomeruli. Kidney Int 1997; 51: 1059.
    • (1997) Kidney Int , vol.51 , pp. 1059
    • Penny, M.J.1    Boyd, R.A.2    Hall, B.M.3
  • 36
    • 0028331023 scopus 로고
    • A nondepleting anti-rat CD4 monoclonal antibody that suppresses T helper 1-like but not T helper 2-like intragraft lymphokine secretion induces long-term survival of renal allografts
    • Siegling A, Lehmann M, Riedel H, et al. A nondepleting anti-rat CD4 monoclonal antibody that suppresses T helper 1-like but not T helper 2-like intragraft lymphokine secretion induces long-term survival of renal allografts. Transplantation 1994; 57: 464.
    • (1994) Transplantation , vol.57 , pp. 464
    • Siegling, A.1    Lehmann, M.2    Riedel, H.3
  • 37
    • 0025834271 scopus 로고
    • Analysis of cytokine gene expression during fetal thymic ontogeny using the polymerase chain reaction
    • Montgomery RA, Dallman MJ. Analysis of cytokine gene expression during fetal thymic ontogeny using the polymerase chain reaction. J Immunol 1991; 147: 554.
    • (1991) J Immunol , vol.147 , pp. 554
    • Montgomery, R.A.1    Dallman, M.J.2
  • 38
    • 0000111203 scopus 로고
    • Semi-quantitative PCR for the analysis of gene expression
    • McPherson MJ, Quirke P, Taylor GR, eds. Oxford: IRL Press
    • Dallman MJ, Porter ACG. Semi-quantitative PCR for the analysis of gene expression. In: McPherson MJ, Quirke P, Taylor GR, eds. PCR: a practical approach. Oxford: IRL Press, 1991: 215.
    • (1991) PCR: A Practical Approach , pp. 215
    • Dallman, M.J.1    Porter, A.C.G.2
  • 40
    • 0029054055 scopus 로고
    • + T cells in the presence of a nondepleting monoclonal antibody to CD4 induces a Th2-type response in vitro
    • + T cells in the presence of a nondepleting monoclonal antibody to CD4 induces a Th2-type response in vitro. J Exp Med 1995; 182: 5.
    • (1995) J Exp Med , vol.182 , pp. 5
    • Stumbles, P.1    Mason, D.2
  • 42
    • 0027289274 scopus 로고
    • Structural comparison and chromosomal localization of the human and mouse IL-13 genes
    • McKenzie ANJ, Li X, Largaespada DA, et al. Structural comparison and chromosomal localization of the human and mouse IL-13 genes. J Immunol 1993; 150: 5436.
    • (1993) J Immunol , vol.150 , pp. 5436
    • McKenzie, A.N.J.1    Li, X.2    Largaespada, D.A.3
  • 43
    • 0025306616 scopus 로고
    • RNKP-1, a novel killer-associated serine protease gene cloned from RNK-16 cytotoxic lymphocytes
    • Zunino SJ, Bleakley RC, Martinez J, Hudig D. RNKP-1, a novel killer-associated serine protease gene cloned from RNK-16 cytotoxic lymphocytes. J Immunol 1990; 144: 2001.
    • (1990) J Immunol , vol.144 , pp. 2001
    • Zunino, S.J.1    Bleakley, R.C.2    Martinez, J.3    Hudig, D.4
  • 45
    • 0028100689 scopus 로고
    • Expression of the gene for inducible nitric oxide synthase in experimental glomerulonephritis in the rat
    • Cook HT, Ebrahim H, Jansen AS, Foster GR, Largen P, Cattell V. Expression of the gene for inducible nitric oxide synthase in experimental glomerulonephritis in the rat. Clin Exp Immunol 1994; 97: 315.
    • (1994) Clin Exp Immunol , vol.97 , pp. 315
    • Cook, H.T.1    Ebrahim, H.2    Jansen, A.S.3    Foster, G.R.4    Largen, P.5    Cattell, V.6
  • 46
    • 0021186832 scopus 로고
    • Experimental allergic encephalomyelitis: Successful treatment in vivo with a monoclonal antibody that recognizes T helper cells
    • Brostoff SW, Mason DW. Experimental allergic encephalomyelitis: successful treatment in vivo with a monoclonal antibody that recognizes T helper cells. J Immunol 1984; 133: 1938.
    • (1984) J Immunol , vol.133 , pp. 1938
    • Brostoff, S.W.1    Mason, D.W.2
  • 47
    • 0026680392 scopus 로고
    • The use of a non-depleting anti-CD4 monoclonal antibody to reestablish tolerance to beta cells in NOD mice
    • Hutchings P, O'Reilly L, Parish NM, Waldmann H, Cooke A. The use of a non-depleting anti-CD4 monoclonal antibody to reestablish tolerance to beta cells in NOD mice. Eur J Immunol 1992; 22: 1913.
    • (1992) Eur J Immunol , vol.22 , pp. 1913
    • Hutchings, P.1    O'Reilly, L.2    Parish, N.M.3    Waldmann, H.4    Cooke, A.5
  • 48
    • 0026027479 scopus 로고
    • Peripheral tolerance to alloantigen results from altered regulation of the interleukin 2 pathway
    • Dallman MJ, Shiho O, Page TH, Wood KJ, Morris PJ. Peripheral tolerance to alloantigen results from altered regulation of the interleukin 2 pathway. J Exp Med 1991; 173: 79.
    • (1991) J Exp Med , vol.173 , pp. 79
    • Dallman, M.J.1    Shiho, O.2    Page, T.H.3    Wood, K.J.4    Morris, P.J.5
  • 49
    • 0028785917 scopus 로고
    • Graft-infiltrating T helper cells, CD45RC phenotype, and Th1/Th2-related cytokines in donor-specific transfusion-induced tolerance in adult rats
    • Josien R, Pannetier C, Douillard P, et al. Graft-infiltrating T helper cells, CD45RC phenotype, and Th1/Th2-related cytokines in donor-specific transfusion-induced tolerance in adult rats. Transplantation 1995; 60: 1131.
    • (1995) Transplantation , vol.60 , pp. 1131
    • Josien, R.1    Pannetier, C.2    Douillard, P.3
  • 50
    • 0024466674 scopus 로고
    • Molecular cloning of rat cytolysin
    • Ishikawa H, Shinkai Y, Yagita H, et al. Molecular cloning of rat cytolysin. J Immunol 1989; 143: 3069.
    • (1989) J Immunol , vol.143 , pp. 3069
    • Ishikawa, H.1    Shinkai, Y.2    Yagita, H.3
  • 51
    • 0025977237 scopus 로고
    • Lymphocyte adhesion molecules in T cell-mediated lysis of human kidney cells
    • Suranyi MG, Bishop GA, Clayberger C, et al. Lymphocyte adhesion molecules in T cell-mediated lysis of human kidney cells. Kidney Int 1991; 39: 312.
    • (1991) Kidney Int , vol.39 , pp. 312
    • Suranyi, M.G.1    Bishop, G.A.2    Clayberger, C.3
  • 52
    • 0021201135 scopus 로고
    • Increased expression of HLA-DR antigens on renal tubular cells in renal transplants: Relevance to the rejection response
    • Hall BM, Bishop GA, Duggin GG, Horvath JS, Philips J, Tiller DJ. Increased expression of HLA-DR antigens on renal tubular cells in renal transplants: relevance to the rejection response. Lancet 1984; 2: 247.
    • (1984) Lancet , vol.2 , pp. 247
    • Hall, B.M.1    Bishop, G.A.2    Duggin, G.G.3    Horvath, J.S.4    Philips, J.5    Tiller, D.J.6
  • 53
    • 0019230227 scopus 로고
    • Suppression of rejection of organ allografts by alloantibody
    • Morris PJ. Suppression of rejection of organ allografts by alloantibody. Immunol Rev 1980; 49: 93.
    • (1980) Immunol Rev , vol.49 , pp. 93
    • Morris, P.J.1
  • 54
    • 0022642908 scopus 로고
    • Induction of tolerance by monoclonal antibody therapy
    • Benjamin RJ, Waldmann H. Induction of tolerance by monoclonal antibody therapy. Nature 1986; 320: 449.
    • (1986) Nature , vol.320 , pp. 449
    • Benjamin, R.J.1    Waldmann, H.2
  • 55
    • 0022461975 scopus 로고
    • Long-term humoral unresponsiveness in vivo, induced by treatment with monoclonal antibody against L3T4
    • Goronzy J, Weyand CM, Fathman CG. Long-term humoral unresponsiveness in vivo, induced by treatment with monoclonal antibody against L3T4. J Exp Med 1986; 164: 911.
    • (1986) J Exp Med , vol.164 , pp. 911
    • Goronzy, J.1    Weyand, C.M.2    Fathman, C.G.3
  • 56
    • 0024354848 scopus 로고
    • Tolerance to aggregated human IgG but not ovalbumin can be induced by concurrent administration of depleting or non-depleting anti-L3T4 monoclonal antibodies
    • Charlton B, Mandel TE. Tolerance to aggregated human IgG but not ovalbumin can be induced by concurrent administration of depleting or non-depleting anti-L3T4 monoclonal antibodies. Immunol Cell Biol 1989; 67: 1.
    • (1989) Immunol Cell Biol , vol.67 , pp. 1
    • Charlton, B.1    Mandel, T.E.2
  • 57
    • 0025029822 scopus 로고
    • Transforming growth factor-beta 1 in normal heart and in myocardial infarction
    • Casscells W, Bazoberry F, Speir E, et al. Transforming growth factor-beta 1 in normal heart and in myocardial infarction. Ann N Y Acad Sci 1990; 593: 148.
    • (1990) Ann N Y Acad Sci , vol.593 , pp. 148
    • Casscells, W.1    Bazoberry, F.2    Speir, E.3
  • 58
    • 0022394410 scopus 로고
    • Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine: Mediation of specific suppression by T helper/inducer cells
    • Hall BM, Jelbart ME, Gurley KE, Dorsch SE. Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine: mediation of specific suppression by T helper/inducer cells. J Exp Med 1985; 162: 1683.
    • (1985) J Exp Med , vol.162 , pp. 1683
    • Hall, B.M.1    Jelbart, M.E.2    Gurley, K.E.3    Dorsch, S.E.4


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