Induction of allograft nonresponsiveness after intrathymic inoculation with donor class I allopeptides: II. Evidence for persistent chronic rejection despite high levels of donor microchimerism

Transplantation

Volumn 64, Issue 12, 1997, Pages 1671-1676

  Shirwan, Haval ^a   Wu, Guo D ^b   Barwari, Luqman ^a   Liu, Allen ^b   Cramer, Donald V ^b  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b ST VINCENT MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIBODY; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; OLIGONUCLEOTIDE; PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; CONFERENCE PAPER; CONTROLLED STUDY; GRAFT REJECTION; GRAFT SURVIVAL; HAMSTER; HEART GRAFT; IMMUNE SYSTEM; IMMUNOLOGICAL TOLERANCE; MICROCHIMERISM; MULTIPLE ORGAN FAILURE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; SPLEEN CELL; THYMUS;

ANIMALS; ARTERIOSCLEROSIS; CHIMERA; CHRONIC DISEASE; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; HISTOCOMPATIBILITY ANTIGENS CLASS I; MYOCARDIUM; PEPTIDES; RATS; RATS, INBRED STRAINS; THYMUS GLAND; TIME FACTORS;

EID: 0031448755     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199712270-00007     Document Type: Conference Paper

References (34)

1. Fangmann J, Dalchau R, Fabre JW. Rejection of skin allografts by indirect allorecognition of donor class I major histocompatibility complex peptides. J Exp Med 1992; 175: 1521.
2. Benichou G, Takizawa PA, Olson CA, McMillan M, Sercarz EE. Donor major histocompatibility complex (MHC) peptides are presented by recipient MHC molecules during graft rejection. J Exp Med 1992; 175: 305.
3. + T cell and B cell responses after cardiac allograft rejection. Transplantation 1995; 59: 401.
4. Watschinger B, Gallon L, Carpenter CB, Sayegh MH. Mechanisms of allo-recognition: recognition by in vivo-primed T cells of specific major histocompatibility complex polymorphisms presented as peptides by responder antigen-presenting cells. Transplantation 1994; 57: 572.
5. Braun MY, McCormack A, Webb G, Batchelor JR. Mediation of acute but not chronic rejection of MHC-incompatible rat kidney grafts by alloreactive CD4 T cells activated by the direct pathway of sensitization. Transplantation 1993; 55: 177.
6. Tilney NL, Whitley WD, Diamond JR, Kupiec-Weglinski JW, Adams DH. Chronic rejection - an undefined conundrum. Transplantation 1993; 52: 389.
7. + T cell-dependent anti-body-mediated graft rejection. Immunol Today 1992; 13: 434.
8. Shirwan H, Mhoyan A, Learner M, Wang C, Cramer DV. The role of donor class I major histocompatibility complex peptides in the induction of allograft tolerance. Transplant Proc 1997; 29: 1134.
9. Mhoyan A, Cramer DV, Baquerizo A, Shirwan H. Induction of allograft nonresponsiveness after intrathymic inoculation with donor class I allopeptides: 1. Correlation of graft survival with anti-donor IgG antibody subclasses. Transplantation 1997; 64: 1665.
10. Campos L, Alfrey EJ, Posselt AM, Odorico JS, Barker CF, Naji A. Prolonged survival of rat orthotopic liver allografts after intrathymic inoculation of donor-strain cells. Transplantation 1993; 55: 866.
11. Posselt AM, Barker CF, Friedman AL, Naji A. Prevention of autoimmune diabetes in the BB rat by intrathymic islet transplantation at birth. Science 1992; 256: 1321.
12. Nakafusa Y, Goss JA, Mohanakumar T, Flye MW. Induction of donor-specific tolerance to cardiac but not skin or renal allografts by intrathymic injection of splenocyte alloantigen. Transplantation 1993; 55: 877.
13. Oluwole SF, Chowdhury NC, Jin MX, Hardy MA. Induction of transplantation tolerance to rat cardiac allografts by intrathymic inoculation of allogeneic soluble peptides. Transplantation 1993; 56: 1523.
14. Sayegh MH, Perico N, Imberti O, Hancock WW, Carpenter CB, Remuzzi G. Thymic recognition of class II major histocompatibility complex allopeptides induces donor-specific unresponsiveness to renal allografts. Transplantation 1993; 56: 461.
15. Sayegh MH, Perico N, Gallon L, et al. Mechanisms of acquired thymic unresponsiveness to renal allografts: thymic recognition of immunodominant allo-MHC peptides induces peripheral T cell anergy. Transplantation 1994; 58: 125.
16. Chowdhury NC, Murphy B, Sayegh MH, et al. Acquired systemic tolerance to rat cardiac allografts induced by intrathymic inoculation of synthetic polymorphic MHC class I allopeptides. Transplantation 1996; 62: 1878.
17. Starzl TE, Demetris AJ, Murase N, Thomson AW, Trucco M, Ricordi C. Donor cell chimerism permitted by immunosuppressive drugs: a new view of organ transplantation. Immunol Today 1993; 14: 326.
18. Bushell A, Pearson TC, Morris PJ, Wood KJ. Donor-recipient microchimerism is not required for tolerance induction following recipient pretreatment with donor-specific transfusion and anti-CD4 antibody: evidence of a clear role for short-term antigen persistence. Transplantation 1995; 59: 1367.
19. Shirwan H, Wang HK, Barwari L, Makowka L, Cramer DV. Pretransplant injection of allograft recipients with donor blood or lymphocytes permits allograft tolerance without the presence of persistent donor microchimerism. Transplantation 1996; 61: 1382.
20. Ono SJ, Lindsey ES. Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg 1969; 57: 225.
21. Cramer DV, Wu GD, Chapman FA, Cajulis E, Wang HK, Makowka L. Lymphocyte subsets and histopathological changes associated with the development of heart transplant arteriosclerosis. J Heart Lung Transplant 1992; 11: 458.
22. Shirwan H, Makowka L, Blankenhorn EP, Cramer DV. Polymerase chain reaction detection of chimerism in rats based on an allelic polymorphism for T-cell antigen receptor Cb genes. Transplant Immunol 1994; 2: 253.
23. Shirwan H, Chi DL, Makowka L, Cramer DV. Lymphocytes infiltrating rat cardiac allografts express a limited repertoire of T-cell receptor Vb genes. J Immunol 1993; 151: 5228.
24. Campos L, Alfrey EJ, Posselt AM, Odorico JS, Barker CF, Naji A. Prolonged survival of rat orthotopic liver allografts after intrathymic inoculation of donor-strain cells. Transplantation 1994; 55: 866.
25. Ohzato H, Monaco AP. Induction of specific unresponsiveness (tolerance) to skin allografts by intrathymic donor-specific splenocyte injection in antilymphocyte serum-treated mice. Transplantation 1992; 54: 1090.
26. Rada C, Lorenzi R, Powis SJ, Van den Bogaerde J, Parham P, Howard JC. Concerted evolution of class I genes in the major histocompatibility complex of murine rodents. Proc Natl Acad Sci USA 1990; 87: 2167.
27. u MHC class I heavy chain by a novel PCR-based method. Immunogenetics 1995; 41: 326.
28. Tullius SG, Tilney NL. Both alloantigen-dependent and -independent factors influence chronic allograft rejection. Transplantation 1995; 59: 313.
29. Orloff MS, DeMara EM, Coppage ML, et al. Prevention of chronic rejection and graft arteriosclerosis by tolerance induction. Transplantation 1995; 59: 282.
30. Demetris AJ, Murase N, Fujisaki S, Fung JJ, Rao AS, Starzl TE. Hematolymphoid cell trafficking, microchimerism, and GVH reactions after liver, bone marrow, and heart transplantation. Transplant Proc 1993; 25: 3337.
31. Starzl TE, Trucco M, Zeevi A, et al. Systemic chimerism in human female recipient of male livers. Lancet 1992; 340: 876.
32. Suberbielle C, Caillat-Zucman S, Legendre C, et al. Peripheral microchimerism in long-term cadaveric-kidney allograft recipients. Lancet 1994; 343: 1468.
33. Schlitt HJ, Hundrieser J, Hisanaga M, et al. Patterns of donor-type microchimerism after heart transplantation. Lancet 1994; 343: 1469.
34. Schlitt HJ, Hundrieser J, Ringe B, Pichlmayr R. Donor-type microchimerism associated with graft rejection eight years after liver transplantation. N Engl J Med 1994; 330: 646.