Mechanisms of indirect allorecognition: Characterization of MHC Class II allopeptide-specific T helper cell clones from animals undergoing acute allograft rejection

Transplantation

Volumn 65, Issue 7, 1998, Pages 876-883

  Waaga, Ana Maria ^a   Chandraker, Anil ^a   Spadafora Ferreira, Monica ^a   Iyengar, Anand R ^a   Khoury, Samia J ^a   Carpenter, Charles B ^a   Sayegh, Mohamed H ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN RECOGNITION; ARTICLE; KIDNEY ALLOGRAFT; KIDNEY ALLOGRAFT REJECTION; KIDNEY TRANSPLANTATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ACUTE DISEASE; ANIMALS; CLONE CELLS; GRAFT REJECTION; HISTOCOMPATIBILITY ANTIGENS; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNODOMINANT EPITOPES; KIDNEY TRANSPLANTATION; LYMPHOCYTE ACTIVATION; MALE; PHENOTYPE; RATS; RATS, INBRED WF; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 0032522524     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199804150-00004     Document Type: Article

References (42)

1. Krensky A, Weiss A, Crabtree G, Davis M, Parham P. T-lymphocyte-antigen interactions in transplant rejection. N Engl J Med 1990; 322: 510.
2. Lechler RI, Batchelor JR. Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells. J Exp Med 1982; 155: 31.
3. Lechler RI, Batchelor JR. Immunogenicity of retransplanted rat kidney allografts: effects of including chimerism in the first recipient and quantitative studies on immunosuppression of the second recipient. J Exp Med 1982; 156: 1835.
4. Sayegh MH, Watschinger B, Carpenter CB. Mechanisms of T cell recognition of alloantigen: the role of peptides. Transplantation 1994; 57: 1295.
5. Shoskes DA, Wood KJ. Indirect presentation of MHC antigens in transplantation. Immunol Today 1994; 15: 32.
6. Benichou G, Tam RC, Soares LRB, Fedoseyeva EV. Indirect T-cell allorecognition: perspectives for peptide-based therapy in transplantation. Immunol Today 1997; 18: 67.
7. Sherman AL, Chattopadhyay S. The molecular basis of allorecognition. Annu Rev Immunol 1993; 11: 385.
8. Fangmann J, Dalchau R, Sawyer GJ, Priestly CA, Fabre JW. T cell recognition of donor major histocompatibility complex class I peptides during allograft rejection. Eur J Immunol 1992; 22: 1525.
9. Benichou G, Takizawa PA, Olson CA, McMillan M, Sercarz EE. Donor major histocompatibility complex (MHC) peptides are presented by recipient MHC molecules during graft rejection. J Exp Med 1992; 175: 305.
10. Watschinger B, Gallon L, Carpenter CB, Sayegh MH. Mechanisms of allorecognition: recognition by in vivo primed T-cells of specific major histocompatibility complex polymorphisms presented as peptides by responder antigen-presenting cells. Transplantation 1994; 57: 572.
11. Gallon L, Watschinger B, Murphy B, Akalin E, Sayegh MH, Carpenter CB. Indirect pathway of allorecognition: the occurrence of self-restricted T cell recognition of allo-MHC peptides early in acute allograft rejection and its inhibition by conventional immunosuppression. Transplantation 1995; 59: 612.
12. + T cell and B cell responses after cardiac allograft rejection. Transplantation 1995; 59: 401.
13. Ghobrial R, Hamashima T, Kloc M, Etkin L, Stanislaw S, Kahan B. Membrane bound or soluble truncated RT1.A rat class I major histocompatibility antigens induce specific alloimmunity. Transplantation 1995; 60: 602.
14. Wang M, Stepkowski SM, Wang ME, et al. Induction of specific allograft immunity by soluble class IMHC heavy chain protein produced in a baclovirus expression system. Transplantation 1996; 61: 448.
15. Liu Z, Sun Y, Xi Y, et al. Contribution of direct and indirect recognition pathways to T cell alloreactivity. J Exp Med 1993; 177: 1643.
16. Fangmann J, Dalchau R, Fabre JW. Rejection of skin allografts by indirect allorecognition of donor class I major histocompatibility complex peptides. J Exp Med 1992; 175: 1521.
17. Auchincloss HJ, Lee R, Shea S, Markowitz JS, Grusby MJ, Glimcher LH. The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice. Proc Natl Acad Sci USA 1993; 90: 3373.
18. Lee RS, Grusby ML, Glimcher LH, Winn HJ, Auchincloss HJ. Indirect recognition by helper cells can induce donor-specific cytotoxic T lymphocytes in vivo. J Exp Med 1994; 179: 865.
19. Benham AM, Sawyer GJ, Fabre JW. Indirect T cell allorecognition of donor antigens contributes to the rejection of vascularized kidney allografts. Transplantation 1995; 59: 1028.
20. -/- mice are sufficient to mediate rejection of MHC class II or Class I disparate skin grafts. J Immunol 1996; 156: 4114.
21. Chen W, Murphy B, Waaga AM, et al. Mechanisms of indirect allorecognition in graft rejection: class II MHC allopeptide specific T cell clones transfer delayed type hypersensitivity responses in vivo. Transplantation 1996; 62: 705.
22. Sayegh MH, Akalin E, Hancock WW, Russell ME, Carpenter CB, Turka LA. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J Exp Med 1995; 181: 1869.
23. Sayegh MH, Khoury SK, Hancock WW, Weiner HL, Carpenter CB. Induction of immunity and oral tolerance with polymorphic class II MHC allopeptides in the rat. Proc Natl Acad Sci USA 1992; 89: 7762.
24. Smith L, Kono D, Theofilopoulos A. Complexity and sequence identification of 24 rat Vβ genes. J Immunol 1991; 147: 375.
25. Shirwan H, Chi D, Makowka L, Cramer D. Lymphocyte infiltrating rat cardiac allografts express a limited repertoire of T cell receptor Vβ genes. J Immunol 1993; 151: 5228.
26. Khoury SJ, Gallon L, Chen W, et al. Mechanisms of acquired thymic tolerance in experimental autoimmune encephalomyelitis: thymic dendritic-enriched cells induce specific peripheral T cell unresponsiveness in vivo. J Exp Med 1995; 182: 357.
27. Hancock WW, Khoury SJ, Carpenter CB, Sayegh MH. Differential effects of oral versus intrathymic administration of polymorphic MHC class II peptides on mononuclear and endothelial cell activation and cytokine expression during a delayed-type hypersensitivity response. Am J Pathol 1994; 144: 1149.
28. Steele DJR, Laufer TM, Smiley ST, et al. Two levels of help for B cell alloantibody production. J Exp Med 1996; 183: 699.
29. Oluwole SF, Chowdhury NC, Jin M, Hardy MA. Induction of transplantation tolerance in rat cardiac allografts by intrathymic inoculation of allogeneic soluble peptides. Transplantation 1993; 56: 1523.
30. Qian T, Schachner R, Brendel M, Kong S, Alejandro R. Induction of donor specific tolerance to rat islet allografts by intrathymic inoculation of solubilized spleen cell membrane antigens. Diabetes 1993; 42: 1544.
31. Sayegh MH, Perico N, Imberti O, Hancock WW, Carpenter CB, Remuzzi G. Thymic recognition of class II MHC allopeptides induces donor specific unresponsiveness to renal allografts. Transplantation 1993; 56: 461.
32. Sayegh MH, Perico N, Gallon L, et al. Mechanisms of acquired thymic unresponsiveness to renal allografts: thymic recognition of immunodominant allo-MHC peptides induces peripheral T cell anergy. Transplantation 1994; 58: 125.
33. Oluwole SF, Jin M-X, Chowdhury NC, Ohajekwe OA. Effectiveness of intrathymic inoculation of soluble antigens in the induction of specific unresponsiveness to rat islet allografts without transient recipient immunosuppression. Transplantation 1994; 58: 1077.
34. Hamashima T, Stepkowski S, Smith S, Kahan B. Induction of transplantation tolerance by a single intrathymic injection of 3 M KCL-extracted donor histocompatibility antigens combined with two doses of anti-rat alpha/beta T cell receptor monoclonal antibodies. Transplantation 1994; 58: 105.
35. Sayegh MH, Carpenter MH. Role of indirect allorecognition in allograft rejection. Int Rev Immunol 1996; 13: 221.
36. Liu Z, Colovai AI, Tuguloa S, et al. Indirect recognition of donor HLA peptides in organ allograft rejection. J Clin Invest 1996; 98: 1150.
37. Benham A, Fabre JW. Fine specificity of peptide determinants for indirect T cell recognition of class I MHC alloantigens. Transplantation 1994; 58: 1236.
38. Benichou G, Fedoseyeva E, Olson CA, Greysen HM, McMillan M, Sercarz EE. Limited T cell response to donor MHC peptides and the prevention of allograft rejection. J Immunol 1994; 153: 938.
39. Kim DT, Rothbard JB, Bloom DD, Fathman CG. Quantitative analysis of T cell activation. J Immunol 1996; 156: 2737.
40. Cher D, Mosmann T. Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by Th1 clones. J Immunol 1987; 138: 3688.
41. Wong R, Ruddle N, Padula S, et al. Subtypes of helper cells: non-inflammatory type I helper T cells. J Immunol 1988; 141: 3329.
42. Vella JP, Ferreira M, Murphy B, et al. Indirect allorecognition of MHC allopeptides in human renal transplant recipients with chronic graft dysfunction. Transplantation 1997; 64: 795.