Production of IL-4 and IL-10 does not lead to immune quiescence in vascularized human organ grafts

Transplantation

Volumn 62, Issue 6, 1996, Pages 776-780

  Lang, Thomas ^a,b   Krams, Sheri M ^a,c   Martinez, Olivia M ^a,c  

^a CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^b UNIVERSITY OF MUNICH   (Germany)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; CYTOKINE; GAMMA INTERFERON; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; TACROLIMUS;

ALLOGRAFT; ARTICLE; BILE; CLINICAL ARTICLE; GRAFT REJECTION; HUMAN; IMMUNE RESPONSE; IMMUNOREGULATION; LIVER TRANSPLANTATION; PRIORITY JOURNAL; SERUM;

EID: 0029780354     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199609270-00014     Document Type: Article

References (42)

1. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clones. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986; 136: 2348.
2. Del Prete GF, De Carli M, Mastromauro C, et al. Purified protein derivative (PPD) of Mycobacterium tuberculosis and excretory-secretory antigen(s) (TES) of Toxocara canis expand in in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profiles of cytokine production. J Clin Invest 1991; 88: 346.
3. Yssel H, de Waal Malefyt R, Roncarolo M-G, et al. Interleukin 10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells. J Immunol 1992; 149: 2378.
4. Gajewski TF and Fitch FW. Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. J Immunol 1988; 140: 4245.
5. Fernandez-Botran R, Sanders VM, Mosmann TR, Vitetta ES. Lymphokine-mediated regulation of the proliferation response of clones of T helper 1 and T helper 2 cells. J Exp Med 1988; 168: 543.
6. Macatonia SE, Hsieh C-S, Murphy KM, O'Garra A. Dendritic cells and macrophages are required for Th1 devolopment of CD4+ T cells from αβ transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ dependent. Int Immunol 1993; 5: 1119.
7. Peleman R, Wu J, Fargeas C, Delespesse G. Recombinant interleukin 4 suppresses the production of interferon gamma by human mononuclear cells. J Exp Med 1989; 170: 1751.
8. Martinez OM, Gibbons R, Garovoy MR, Aronson FR. IL-4 inhibits IL-2 receptor expression and IL-2-dependent proliferation of human T cells. J Immunol 1990; 144: 2211.
9. Fiorentino DF, Zlotnik A, Vieiera P, et al. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J Immunol 1991; 146: 3444.
10. Papp I, Wieder KJ, Sablinski T, et al. Evidence for functional heterogeneity of rat CD4+ T cells in vivo: differential expression of IL-2 and IL-4 mRNA in recipients of cardiac allografts. J Immunol 1992; 148: 1308.
11. Takeuchi T, Lowry RP, Konieczny B. Heart allografts in murine systems: the differential activation of Th2-like effector cells in peripheral tolerance. Transplantation. 1992; 53: 1281.
12. Sayegh MH, Akalin E, Hancock WW, et al. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J Exp Med 1995; 181: 1869.
13. Gianello PR, Blancho G, Fishbein JF, et al. Mechanism of cyclosporin-induced tolerance to primarily vascularized allografts in miniature swine: effect of administration of exogenous IL-2. J Immunol 1994; 153: 4788.
14. Ferraresso M, Tian L, Ghobrial R, Stepkowski SM, Kahan BD. Rapamycin inhibits production of cytotoxic but not noncytotoxic antibodies and preferentially activates T helper 2 cells that mediate long-term survival of heart allografts in rats. J Immunol 1994; 153: 3307.
15. Baan CC, van Emmerik NE, Balk AH, et al. Cytokine mRNA expression in endomyocardial biopsies during acute rejection from human heart transplants. Clin Exp Immunol 1994; 97: 293.
16. Whitehead BF, Stoehr C, Wu Cjet al. Cytokine gene expression in human lung transplant recipients. Transplantation. 1993; 56: 956.
17. Cunningham D, Dunn MJ, Yacoub, MH, Rose ML. Local production of cytokines in the human cardiac allograft. A sequential study. Transplantation. 1994; 57: 1333.
18. Martinez OM, Krams SM, Sterneck M, et al. Intragraft cytokine profile during human liver allograft rejection. Transplantation. 1992; 53: 449.
19. Zhao XM, Frist WH, Yeoh TK, Miller GG. Expression of cytokine genes in human cardiac allografts: correlation of IL-6 and transforming growth factor-beta (TGF-beta) with histological rejection. Clin Exp Immunol 1993; 93: 448.
20. Vandenbroecke C, Caillet-Zucman S, Legendre C, et al. Differential in situ expression of cytokines in renal allograft rejection. Transplantation. 1991; 51: 602.
21. Mor E, Solomon H, Gibbs JF, et al. Acute cellular rejection following liver transplantation: clinical pathologic features and effect on outcome. Semin Liver Dis 1991; 12: 28.
22. Snover DC, Freese CK, Sharp HL, Bloomer JR, Najarian JS, Ascher NL. Liver allograft rejection: an analysis of the use of biopsy in determining outcome of rejection. Am J Surg Pathol 1987; 11: 1.
23. Martinez OM, Villanueva JC, Lawrence-Miyasaki L, Quinn MB, Cox K, Krams SM. Viral and immunologic aspects of Epstein-Barr virus infection in pediatric liver transplant recipients. Transplantation 1995; 59: 519.
24. de Waal Malefyt R, Abrams J, Bennett B, Figdor C, de Vries JE. IL-10 inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991; 174: 1209.
25. Essner R, Rhoades K, McBride WH, Morton DL, Economou JS. IL-4 down-regulates IL-1 and TNF gene expression in human monocytes. J Immunol 1989; 142: 3857.
26. Szabo SJ, Jacobson NG, Dighe AS, Gubler U, Murphy KM. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity 1995; 2: 665.
27. Lee MS, Wogensen L, Shizuru J, Oldstone MB, Sarvetnick N. Pancreatic islet production of murine interleukin 10 does not inhibit immune-mediated tissue destruction. J Clin Invest 1994; 93: 1332.
28. Widmer MB and Grabstein KH. 1987. Regulation of cytolytic T lymphocyte generation by B cell stimulatory factor. Nature 1987; 326: 795.
29. Chen W, Zlotnik A. IL-10: a novel cytotoxic T cell differentiation factor. J Immunol 1991; 147: 528.
30. Krams SM, Villanueva JC, Quinn MB, Martinez OM. Expression of the cytotoxic T cell mediator granzyme B during liver allograft rejection. Transplant Immunol 1995; 3: 162.
31. Zheng XX, Steele AW, Nickerson PW, Steurer W, Steiger J, Strom TB. Administration of noncytolytic IL-10/Fc in murine models of lipopolysaccharide-induced septic shock and allogeneic islet transplantation. J Immunol 1995; 154: 5590.
32. Schleimer R, Sterbinsky SA, Kaiser J, et al. IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium: association with expression of VCAm-1. J Immunol 1992; 148: 1086.
33. Houssin D, Gigon M, Franco D, et al. Specific transplantation tolerance induced by spontaneously tolerated liver allografts in inbred strains of rats. Transplantation 1990; 29: 418.
34. Kamada N, Davies HS, Roser B. Reversal of transplantation immunity by liver grafting. Nature 1981; 292: 840.
35. Farges O, Morris PJ, Dallman MJ. Spontaneous acceptance of rat liver allografts is associated with an early downregulation of intragraft interleukin-4 messenger RNA expression. Hepatology 1995; 21: 767.
36. Wang SC, Zeevi A, Jordan ML, Simmons RL, Tweardy DL. FK506, rapamycin and cyclosporine: effects on IL-4 and IL-10 mRNA levels in a T helper 2 cell line. Transplant Proc 1991; 23: 2920.
37. Takeuchi T, Lowry RP, Konieczny B. Heart allografts in murine systems: the differential activation of Th2-like effector cells in peripheral tolerance. Transplantation 1992; 53: 1281.
38. Martinez OM, Ascher NL, Ferrell L, et al. Evidence for a non-classical pathway of graft rejection involving interleukin 5 and eosinophils. Transplantation 1993; 55: 909.
39. Chan SY, DeBruyne LA, Goodman RE, Eichwald EJ, Bishop DK. In vivo depletion of CD8+ T cells results in Th2 cytokine production and alternate mechanisms of allograft rejection. Transplantation 1995; 59: 1155.
40. Wood PJ and Cossens EA. The influence of allo-class II MHC-specific Th2 cells on the generation of CD4 and CD8 cytotoxic T cells to associated class I and class II MHC alloantigen. Clin Exp Immunol 1995; 100: 359.
41. Cosenza CA, Shirwan H, Cramer DV, Sher L, Podesta L, Makowka L. Intragraft cytokine gene expression in human liver allografts. Liver Transplant Surg 1995; 1: 16.
42. Steiger J, Nickerson PW, Steurer W, Moscovitch-Lopatin M, Strom TB. IL-2 knockout recipient mice reject islet cell allografts. J Immunol 1995; 155: 489.