Production of IL-10 by human natural killer cells stimulated with IL-2 and/or IL-12

Journal of Immunology

Volumn 160, Issue 6, 1998, Pages 2637-2644

  Mehrotra, Priti T ^a   Donnelly, Raymond P ^b   Wong, Susan ^a   Kanegane, Hirokazu ^b,c   Geremew, Amare ^a   Mostowski, Howard S ^a   Furuke, Keizo ^a   Siegel, Jay P ^a   Bloom, Eda T ^a  

^a Division of Bacterial Products   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c UNIVERSITY OF TOYAMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2;

ANTIBODY PRODUCTION; ANTIGEN EXPRESSION; ARTICLE; CELL PROLIFERATION; CELL STIMULATION; HEMATOPOIESIS; HUMAN; HUMAN CELL; IMMUNOREGULATION; KILLER CELL; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TARGET CELL;

CELLS, CULTURED; FLOW CYTOMETRY; HUMANS; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-2; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0032521024     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (73)

1. Spits, H., L. L. Lanier, and J. H. Phillips. 1995. Development of human T and natural killer cells. Blood 85:2654.
2. Lanier, L. L., and J. H. Phillips. 1992. Natural killer cells. Curr. Opin. Immunol. 4:38.
3. Ortaldo, J. R., and D. L. Longo. 1988. Human natural lymphocyte effector cells: definition, analysis of activity, and clinical effectiveness. J. Natl. Cancer Inst. 80:999.
4. Ritz, J. 1989. The role of natural killer cells in immune surveillance. N. Engl. J. Med. 320:1748.
5. Garrido, F., F. Ruiz-Cabello, T. Cabrera, J. J. Perez-Villar, M. Lopez-Botet, M. Duggan-Keen, and P. L. Stern. 1997. Implications for immunosurveillance of altered HLA class I phenotypes in human tumors. Immunol. Today 18:89.
6. Welsh, R. M., J. O. Brubaker, M. Vargas-Cortes, and C. L. and O'Donnell. 1991. Natural killer (NK) cell response to virus infections in mice with severe combined immunodeficiency: the simulation of NK cells and the NK cell-dependent control of virus infections occur independently of T and B cell function. J. Exp. Med. 173:1053.
7. Garcia-Penarrubia, P., A. D. Bankhurst, and F. T. Koster. 1989. Prostaglandins from human T suppressor/cytotoxic cells modulate natural killer antibacterial activity. J. Exp. Med. 170:601.
8. Tripp, S. C., F. S. Wolf, and R. E. Unanue. 1993. Interleukin 12 and tumor necrosis factor α are costimulators of interferon-γ production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc. Natl. Acad. Sci. USA 90:3725.
9. Bellone, G., N. M. Valiante, O. Viale, E. Ciccone, L. Moretta, and G. Trinchieri. 1993. Regulation of hematopoiesis in vitro by alloreactive natural killer cell clones. J. Exp. Med. 177:1117.
10. Henney, C. S., K. Kuribayashi, D. E. Kern, and S. Gillis. 1981. Interleukin-2 augments natural killer cell activity. Nature 291:135.
11. Ortaldo, J. R., A. T. Mason, J. P. Gerard, L. E. Henderson, W. Farrar, R. F. Hopkins, R. B. Herberman, and H. Rabin. 1984. Effects of natural and recombinant IL-2 on regulation of IFN-gamma production and natural killer activity: lack of involvement of the Tac antigen for these immunoregulatory effects. J. Immunol. 133:779.
12. Savary, C. A., E. Lotzova, and J. Klostergaard. 1989. Interleukin-2-activated large granular lymphocytes: cytotoxic efficiency and mechanism of killing of tumor cell lines. Immunol. Lett. 21:145.
13. Anegon, I., M. C. Cuturi, G. Trinchieri, and B. Perussia. 1988. Interaction of Fc receptor (CD16) ligands induces transcription of interleukin 2 receptor (CD25) and lymphokine genes and expression of their products in human natural killer cells. J. Eur. Med. 167:452.
14. Cuturi, M. C., I. Anegon, F. Sherman, R. Loudon, S. C. Clark, B. Perussia, and G. Trinchieri. 1989. Production of hematopoietic colony-stimulating factors by human natural killer cells. J. Exp. Med. 169:569.
15. Warren, S. H., F. B. Kinnea, J. H. Phillips, and L. L. Lanier. 1996. Production of IL-5 by human NK cells and regulation of IL-5 secretion hy IL-4, IL-10, and IL-12. J. Immunol. 154:5144.
16. Naume, B., and T. Espevik. 1994. Immunoregulatory effects of cytokines on natural killer cells. Scand. J. Immunol. 40:128.
17. Kobayashi, M., L. Fitz, M. Ryan, R. M. Hewick, S. C. Clark, S. Chan, R. Loudon, F. Sherman, B. Perussia, and G. Trinchieri. 1989. Identification and purification of natural killer cell stimulation factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170:827.
18. Wolf, S. F., P. A. Temple, M. Kobayashi, D. Young, G. Trinchieri, and B. Perussia. 1991. Cloning of cDNA for natural cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J. Immunol. 146:3074.
19. Mehrotra, P. T., A. J. Grant, and J. P. Siegel. 1995. Synergistic effects of IL-7 and IL-P on human T cell activation. J. Immunol. 154:5093.
20. Trinchieri, G. 1993. Interleukin-12 and its role in the generation of ThI cells. Immunol. Today 14:335.
21. Manetti, R., P. Parronchi, M. G. Giudizi, M. P. Piccinni, E. Maggi, G. Trinchieri, and S. Romagnani. 1993. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (TH1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J. Exp. Med. 177:1199.
22. Howard, M., and A. O'Garra. 1992. Biological properties of interleukin-10. Immunol. Today 13:198.
23. Del Prete, G., M. De Carli, F. Almerigogna, M. G. Giudizi, R. Biagiotti, and S. Romagnani. 1993. Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliteration and cytokine production. J. Immunol. 150:353.
24. + T cell clones and peripheral blood T cells. J. Immunol. 149:2378.
25. + T cells. Annu. Rev. Immunol. 12:635.
26. Hempel, L., D. Korholz, H. Bonig, M. Schneider, A. Klein-Vehne, J. Packeisen, C. Mauz-Korholz, and S. Burdach. 1995. Interleukin-10 directly inhibits the interleukin-6 production in T-cells. Scand. J. Immunol. 41:462.
27. Daftarian, P. M., A. Kumar, M. Kryworuchko, and F. Diaz-Mitoma. 1996. IL-10 production is enhanced in human T cells by IL-12 and IL-6 and in monocytes by tumor necrosis factor-α. J. Immunol. 157:12.
28. Gerosa, F., C. Paganin, D. Peritt, F. Paiola, M. T. Scupoli, M. Aste-Amezaga, I. Frank and G. Trinchieri. 1996. Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-γ and interleukin-10. J. Exp. Med. 183:2559.
29. Meyaard, L., E. Hovenkamp, S. A. Otto, and F. Miedema. 1996. IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses. J. Immunol. 156:2776.
30. Yamauchi, A., and K. T. Bloom. 1993. Requirement of thiol compounds as reducing agents for IL-2-mediated induction of LAK activity and proliferation of human NK cells. J. Immunol. 151:5535.
31. Yodoi, J., K. Teshigawara, T. Nikaido, F. Fukui, T. Noma, T. Hongo, M. Takigawa, M. Sasaki, N. Minato, M. Tsudo, T. Uchiyama, and M. Maeda. 1985. TCGF (IL-2)-receptor inducing factor(s). I. Regulation of IL-2 receptor on natural killer-like cell line (YT cells). J. Immunol. 134:1623.
32. Prussin, C., and D. D. Metcalfe. 1995. Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies. J. Immunol. Methods 188:117.
33. Mehrotra, P. T., D. S. Lind, H. D. Bear, and B. M. Susskind. 1992. Different signaling pathways induced by anti-CD3 monoclonal antibody versus alloantigen on the basis of differential ornithine sensitivity. Cell. Immunol. 143:41.
34. Burd, P. R., W. C. Thompson, E. E. Max, and F. C. Mills. 1995. Activated mast cells produce interleukin 13. J. Exp. Med. 181:1373.
35. + T lymphocytes, and NK cells. J. Immunol. 149:3495.
36. Naume, B., M. K. Gately, B. B. Desai, A. Sundan, and T. Espevik. 1993. Synergistic effects of interleukin 4 and interleukin 12 on NK cell proliferation. Cytokine 5:38.
37. Gately, M. K., A. G. Wolitzky, P. M. Quinn, and R. Chizzonite. 1992. Regulation of human cytolytic lymphocyte responses by interleukin-12. Cell. Immunol. 143:127.
38. Gately, M. K., B. B. Desia, A. G. Wolitxky, P. H. Quinn, and A. S. Stern. 1991. Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor). J. Immunol. 147:874.
39. Chehimi, J., N. M. Valiante, A. D'Andrea, M. Rengaraju, Z. Rosado, M. Kobayashi, B. Perussia, S. F. Wolf, S. E. Starr, and G. Trinchieri. 1993. Enhancing effect of natural killer cell stimulatory factor (NKSF/interleukin-12) on cell-mediated cytotoxicity against tumor-derived and virus-infected cells. Eur. J. Immunol. 23:1826.
40. Robertson, M. J., T. J. Manley, C. Donahue, H. Levine, and J. Ritz. 1993. Costimulatory signals are required for optimal proliferation of human natural killer cells. J. Immunol. 150:1705.
41. Fiorentino, D. F., M. W. Bond, and T. R. Mosmann. 1989. Two types of mouse helper T cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J. Exp. Med. 170:2081.
42. Fiorentino, D. F., A. Zlotnik, T. R. Mosman, M. H. Howard, and A. O'Garra. 1991. IL-10 inhibits cytokine production by activated macrophages. J. Immunol. 147:3815.
43. Jeannin, P., Y. Delneste, M. Seveso, P. Life, and J. Y. Bonnefoy. 1996. IL-12 synergizes with IL-2 and other stimuli in inducing IL-10 production by human T cells. J. Immunol 156:3159.
44. Carson, W. E., M. J. Lindemann, R. Baiocchi, M. Linen, J. C. Tan, C. C. Chou, S. Narula, and M. A. Caligiuri. 1995. The functional characterization of interleukin-10 receptor expression on human natural killer cells. Blood 85:3577.
45. Spagnoli, G. C., A. Juretic, E. Schultz-Thater, P. Dellabona, L. Filgueira, H. Horig, M. Zuber, G. Garotta, and M. Heberer. 1993. On the relative roles of interleukin-2 and interleukin-10 in the generation of lymphokine-activated killer cell activity. Cell. Immunol. 146:391.
46. Hsu, D. H., K. W. Moore, and H. Spits. 1992. Differential effects of IL-4 and IL-10 on IL-2 induced IFN-gamma synthesis and lymphokine-activated killer activity. Int. Immunol. 4:563.
47. Taga, K., and G. Tosato. 1992. IL-10 inhibits human T cell proliferation and IL-2 production. J. Immunol. 148:1143.
48. Donnelly, R. P., S. L. Freeman, and M. P. Hayes. 1995. Inhibition of IL-10 expression by IFN-γ up-regulates transcription of TNF-α in human monocytes. J. Immunol. 155:1420.
49. Go, N. F., B. E. Castle, R. Barrett, R. Kastelein, W. Dang, T. R. Mosmann, K. W. Moore, and M. and Howard. 1990. Interleukin-10, a novel B cell stimulatory factor: unresponsiveness of X-chromosome-linked immunodeficiency in B cells. J. Exp. Med. 172:1625.
50. Thompson-Snipes, L., V. Dhar, M. W. Bond, T. R. Mosmann, K. W. Moore, and D. Rennick. 1991. Interleukin-10: a novel stimulatory factor for mast cells and their progenitors. J. Exp. Med. 173:507.
51. de Waal Malefyt, R., I. Haanen, H. Spits, M.-G. Roncarolo, A. te Velde, C. Figdor, K. Johnson, R. Kastelein, H. Yssel, and J. E. De Vries. 1991. IL-10 and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via down-regulation of class II MHC expression. J. Exp. Med. 174:915.
52. Aste-Amezaga, M., A. D'Andrea, M. Kubin, and G. Trinchieri. 1994. Cooperation of natural killer cell stimulatory factor/interleukin-12 with other stimuli in the induction of cytokines and cytotoxic cell-associated molecules in human T and NK cells. Cell. Immunol. 156:480.
53. de Waal Malefyt, R., J. Abrams, B. Bennett, C. Figdor, and J. de Vries. 1991. IL-10 inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 174:12090.
54. D'Andrea, A., N. M. Aste-Amezaga, N. M. Valiante, X. Ma, M. Kubin, and G. Trinchieri. 1993. Interleukin 10 (IL-10) inhibits human lymphocyte interferon-gamma production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J. Exp. Med. 178:1041.
55. Windhagen, A., D. E. Anderson, A. Carrizosa, R. E. Williams, and D. A. Hafler. 1996. IL-12 induces human T cells secreting IL-10 with IFN-γ. J. Immunol. 157:1127.
56. Horohov, D. W., J. A. Crim, P. L. Smith, and J. P. Siegel. 1988. IL-4 (B cell-stimulatory factor 1) regulates multiple aspects of influenza virus-specific cell-mediated immunity. J. Immunol. 141:4217.
57. Chan, S. H., B. Perussia, J. W. Gupta, M. Kobayashi, M. Pospisil, H. A. Young, S. F. Wolf, D. Young, S. C. Clark, and G. Trinchieri. 1991. Induction of interferon-γ production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers. J. Exp. Med. 173:869.
58. Kubin, M., M. Kamoun, and G. Trinchieri. 1994. Interleukin 12 synergizes with B7/CD28 Interaction in inducing efficient proliferation and cytokine production of human T cells. J. Exp. Med. 180:211.
59. Cantrell, D. A., and K. A. Smith. 1984. The interleukin-2 T cell system: a new cell growth model. Science 224:1312.
60. Siegel, J. P., M. Sharon, P. L. Smith, and W. J. Leonard. 1987. The IL-2 receptor b chain (p70): role in mediating signals for LAK, NK, and proliferative activities. Science 238:75.
61. Stotter, H., M. C. Custer, E. S. Bolton, L. Guedez, and M. T. Lotze. 1991. IL-7 induces human lymphokine-activated killer cell activity and is regulated by IL-4. J. Immunol. 146:150.
62. Taga, K., B. Cherney, and G. Tosata. 1993. IL-10 inhibits apoptotic cell death in human T cells starved of IL-2. Int. Immunol 5:1599.
63. + T lymphocytes. J. Immunol. 151:2444.
64. Hanagiri, T., M. Takenoyama, T. Yoshimatsu, C. Hirashima, I. Yoshino, K. Nakanishi, A. Nagashima, K. Nomoto, and K. Yasumoto. 1996. Effects of interleukin-12 on in vitro culture with interleukin-2 of regional lymph node lymphocytes from lung cancer patients. Cancer Immunol. Immunother. 43:87.
65. Wang, P., P. Wu, M. I. Siegel, R. W. Egan, and M. M. Billah. 1994. IL-10 inhibits transcription of cytokine genes in human peripheral blood mononuclear cells. J. Immunol. 153:811.
66. Vieira, P., R. de Waal Malefyt, M. N. Dang, K. E. Johnson, R. Kastelein, D. F. Fiorentino, J. E. de Veries, M. G. Roncarolo, T. R. Mosmann, and K. W. Moore. 1991. Isolation and expression of human cytokine synthesis inhibitory factor (CSIF/IL-10) cDNA clone: homology to Epstein-Barr virus open reading frame BCRFI. Proc. Natl. Acad. Sci. USA 88:1172.
67. Tasa, K., H. Mostowski, and G. Tosato. 1993. Human Interleukin-10 can directly inhibit T-cell growth. Blood 81:2964.
68. Orange, J. S., and C. A. Biron. 1996. An absolute and restricted requirement for IL-12 in natural killer cell IFN-γ production and antiviral defense. J. Immunol. 156:1138.
69. Orange, J. S., B. Wang, C. Terhorst, and C. A. Biron. 1995. Requirement for natural killer (NK) cell-produced interferon γ in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration. J. Exp. Med. 182:1045.
70. Kanagat, H., J. Thomas, S. Gangappa, J. S. Babu, and B. T. Rouse. 1996. Herpes simplex virus type 1-mediated up-regulation of IL-12 (p40) mRNA expression: implications in immunopathogenesis and protection. J. Immunol. 156:1110.
71. Wysocka, M., M. Kubin, L. Q. Vieira, L. Ozmen, G. Garotta, P. Scott, and G. Trinchieri. 1995. Interleukin 12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice. Eur. J. Immunol. 25:672.
72. Orange, J. S., T. P. Salazar-Mather, S. M. Opal, R. L. Spencer, A. H. Miller, B. S. McEwen, and C. A. Biron. 1995. Mechanism of interleukin 12-mediated toxicities during experimental viral infections; role of tumor necrosis factor and glucocorticoids. J. Exp. Med. 181:901.
73. Orange, J. S., S. F. Wolf, and C. A. Biron. 1994. Effects of IL-12 on the response and susceptibility to experimental viral infections. J. Immunol. 152:1253.