Overexpression of phosphoinositide-specific phospholipase Cγ in NIH 3T3 cells promotes transformation and tumorigenicity

Carcinogenesis

Volumn 19, Issue 1, 1998, Pages 177-185

  Smith, Mark R ^a   Court, Dan W ^a   Kim, Ha Kun ^b,c   Park, Joo Bae ^a,c,d   Rhee, Soo Goo ^b   Rhim, Johng S ^a   Kung, Hsiang Fu ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^c PaiChai University   (South Korea)

^d Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITIDE; PHOSPHOLIPASE C;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ARTICLE; CARCINOGENICITY; CELL PROLIFERATION; CELL STRAIN 3T3; CELL TRANSFORMATION; CONTROLLED STUDY; DNA TRANSFECTION; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

3T3 CELLS; ANIMALS; CELL ADHESION; CELL CYCLE; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; CULTURE MEDIA, SERUM-FREE; FEMALE; FLOW CYTOMETRY; HUMANS; ISOENZYMES; MICE; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 0031843418     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/19.1.177     Document Type: Article

References (55)

1. Berridge, M.J. and Irvine, R.F. (1984) Inositol triphosphate, a novel second messenger in cellular signal transduction. Nature, 312, 315-321.
2. Nishizuka, Y. (1984) Studies and perspectives of protein kinase C. Science, 233, 305-313.
3. Haung, J., Mohammadi, M., Rodrigues, G.A. and Schlessinger, J. (1995) Reduced activation of RAF-1 and MAP kinase by a fibroblast growth factor receptor mutant deficient in stimulation of phosphatidylinositol hydrolysis. J. Biol. Chem., 270, 5065-5072.
4. Kolch, W., Heidecker, G., Kochs, G., Hummel, R., Vahidi, H., Mischak, H., Finkenzeller, G., Marmé, D. and Rapp, U.R. (1993) Protein kinase C alpha activates RAF-1 by direct phosphorylation. Nature, 364, 249-252.
5. 2. Science, 239, 640-643.
6. Fleischman, L.F. Chahwala, S.B. and Cantley, L. (1986) ras-Transformed cells: altered levels of phosphatidylinositol-4,5-bisphosphate and catabolites. Science, 231, 407-410.
7. Kamata, T. and Kung, H. (1988) Effects of ras-encoded proteins and platelet-derived growth factor on inositol phospholipid turnover in NRK cells. Proc. Natl Acad. Sci. USA, 85, 5799-5803.
8. Lacal, J.C. Moscat, J. and Aaronson, S.A. (1987) Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogens. Nature, 330, 269-272.
9. Smith, M.R., Ryu, S., Shu, P., Rhee, S.G. and Kung, H.-F. (1989) S-phase induction and transformation of quiescent NIH 3T3 cells by microinjection of phospholipase C. Proc. Natl Acad. Sci. USA, 86, 3659-3663.
10. Su, W., Liu, W., Schaffausen, B.S. and Roberts, T.M. (1995) Association of polyomavirus middle tumor antigen with phospholipase C-gamma 1. J. Biol. Chem., 270, 12331-12334.
11. Nishibe, S., Wahl, M.I., Hernandez-Sotomayor, S.M.T., Tonks, N.K., Rhee, S.G. and Carpenter, G. (1990) Increase of the catalytic activity of phospholipase C-γ by tyrosine phosphorylation. Science, 250, 1253-1256.
12. Noh, D., Shin, S.H. and Rhee, S.G. (1995) Phosphoinositide-specific phospholipase C and mitogenic signaling. Biochim. Biophys. Acta, 1242, 99-113.
13. Schlessinger, J. and Ullrich, A. (1992) Growth factor signaling by receptor tyrosine kinases. Neuron, 9, 383-391.
14. Smith, M.R., Liu, Y., Kim, H., Rhee, S.G. and Kung, H.-F. (1990) Inhibition of serum-and Ras-stimulated DNA synthesis by antibodies to phospholipase C. Science, 247, 1074-1077.
15. Smith, M.R., Liu, Y. Matthews, N.T., Rhee, S.G., Sung, W.K. and Kung, H.-F. (1994) Phospholipase C-γ1 can induce DNA synthesis by a mechanism independent of its lipase activity. Proc. Natl Acad. Sci. USA, 91, 6554-6558.
16. Huang, P.S., Davis, L., Huber, H., Goodhart, P.J., Wegrzyn, R.E., Oliff, A. and Heimbrook, D.C. (1995) An SH3 domain is required for the mitogenic activity of microinjected phospholipase C-gamma 1. FEBS Lett., 358, 287-292.
17. Smith, M.R., Liu, Y. Kim, S.R., Bae, Y.S., Kim, C.G., Kwon, K., Rhee, S.G. and Kung, H.-F. (1996) PLCγ1 src homology domain induces mitogenesis in quiescent NIH 3T3 fibroblasts. Biochem. Biophys. Res. Commun., 222, 186-193.
18. Shu, P.G., Ryu, S.H., Moon, K.H., Suh, H.W. and Rhee, S.G. (1988) Inositol phospholipid-specific phospholipase C: complete cDNA and protein sequences and sequence homology to tyrosine kinase-related oncogene products. Proc. Natl Acad. Sci. USA, 85, 5419-5423.
19. Hill, T.D., Dean, N.M., Mordan, L.J., Lau, A.F., Kanemitsu, M.Y. and Boynton, A.L. (1990) PDGF-induced activation of phospholipase C is not required for induction of DNA synthesis. Science, 248, 1660-1663.
20. Valius, M., Bazenet, C. and Kazlauskas, A. (1993) The GTPase-activating protein of ras suppresses platelet-derived growth factor β receptor signaling by silencing phospholipase C-γ1. Mol. Cell. Biol., 13, 133-143.
21. Seedorf, K., Millauer, B., Kostka, G., Schlessinger, J. and Ullrich, A. (1992) Differential effects of carboxy-terminal sequence deletions on platelet-derived growth factor receptor signaling activities and interactions with cellular substrates. Mol. Cell. Biol., 12, 4347-4356.
22. Rönnstrand, L., Mori, S., Arridsson, A.-K., Erikson, A., Wernstedt, C., Hellman, U., Claesson-Welsh, L. and Heldin, C.-H. (1992) Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma. EMBO J., 11, 3911-3919.
23. Downing, J.R., Margolis, B., Zilberstein, A., Ashmun, R.A., Ullrich, A., Sherr, C.J. and Schlessinger, J. (1989) Phospholipase C-gamma, a substrate for PDGF receptor kinase, is not phosphorylated on tyrosine during the mitogenic response to CSF-1. EMBO J., 8, 3345-3350.
24. Valius, M. and Kazlauskas, A. (1993) Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal. Cell, 73, 321-334.
25. Grammar, T.C., Cheatham, L., Chou, M.M. and Blenis, J. (1996) The p70S6K signaling pathway: a novel signaling system involved in growth regulation. Cancer Surv., 27, 271-292.
26. Mulcahy, L.S., Smith, M.R. and Stacey, D.W. (1985) Requirements for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells. Nature, 313, 241-243.
27. Smith, M.R., Heidecker, G., Rapp, U.R. and Kung, H. (1990) Induction of transformation and DNA synthesis after microinjection of raf proteins. Mol. Cell. Biol., 10, 3828-3833.
28. Stacey, D.W. and Kung, H. (1984) Transformation of NIH 3T3 cells by microinjection of Ha-ras p21 protein. Nature, 310, 508-511.
29. Mischak, H., Goodnight, J.A., Kolch, W., Martiny-Baron, G., Schaechtle, C., Kazanietz, M.G., Blumberg, P.M., Pierce, J.H. and Mushinski, J.F. (1993) Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity. J. Biol. Chem., 268, 6090-6096.
30. Housey, G.M., Johnson, M.D., Hsiao, W.L.W. O'Brian, C.A., Murphy, J.P., Kirschmeier, P. and Weinstein, I.B. (1988) Overproduction of protein kinase C causes disordered growth control in rat fibroblasts. Cell, 52, 343-354.
31. Persons, D.A., Wilkison, W.O., Bell, R.M. and Finn, O.J. (1988) Altered growth regulation and enhanced tumorigenicity of NIH 3T3 fibroblasts transfected with protein kinase C-I cDNA. Cell, 52, 447-458.
32. Sozeri, O., Vollmer, K., Liyanage, M., Firth, D., Kour, G., Mark, G.E. and Stabel, S. (1992) Activation of the c-Raf protein kinase by protein kinase C phosphorylation. Oncogene, 7, 2259-2262.
33. Galaktionov, K., Jessus, C. and Beach, D. (1995) Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation. Genes Devel., 9, 1046-1058.
34. Morishita, T., Mitsuzawa, H., Nakafuku, M., Nakamura, S., Hattori, S. and Anraku, Y. (1995) Requirement of Saccharomyces cerevisiae Ras for completion of mitosis. Science, 270, 1213-1215.
35. 1 cyclin-cdk complexes. EMBO J., 14, 4814-4826.
36. Pines, J. (1995) Cyclins, CDKs and cancer. Semin. Cancer Biol., 6, 63-72.
37. Kastan, M.B., Canman, C.E. and Leonard, C.J. (1995) p53, cell cycle control and apoptosis: implications for cancer. Cancer Metastasis Rev., 14, 3-15.
38. Sherr, C.J. (1993) Mammalian G1 cyclins. Cell, 73, 1059-1065.
39. Weinberg, R.A. (1995) The retinoblastoma protein and cell cycle control. Cell, 81, 323-330.
40. Heichman, K.A. and Roberts, J. (1994) Rules to replicate by. Cell, 79, 557-562.
41. Hunter, T. and Pines, J. (1994) Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. Cell, 79, 573-582.
42. King, R.W., Jackson, P.K. and Kirshner, M.W. (1994) Mitosis in transition. Cell, 79, 563-571.
43. Sherr, C.J. (1994) G1 phase progression: cycling on cue. Cell, 79, 551-555.
44. Russell, P. and Nurse, P. (1987) Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog. Cell, 49, 559-567.
45. Lundgren, K., Walworth, N., Booher, R., Dembski, M., Kirschner, M. and Beach, D. (1991) mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. Cell, 64, 1111-1122.
46. Russell, P. and Nurse, P. (1986) cdc25+ functions as an inducer in the mitotic control of fission yeast. Cell, 45, 145-153.
47. Galaktionov, K. and Beach, D. (1991) Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. Cell, 67, 1181-1194.
48. Sadhu, K., Reed, S.I., Richardson, H. and Russell, P. (1990) Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2. Proc. Natl Acad. Sci. USA, 87, 5139-5143.
49. Jinno, S., Suto, K., Nagata, A., Igarashi, M., Kanaoka, Y., Nojima, H. and Okayama, H. (1994) Cdc25A is a novel phosphatase functioning early in the cell cycle. EMBO J., 13, 1549-1556.
50. Galaktionov, K., Lee, A.K., Eckstein, J., Draetta, G., Meckler, J., Loda, M. and Beach, D. (1995) CDC25 phosphatases as potential human oncogenes. Science, 269, 1575-1577.
51. Johnson, M.D., Horiba, M., Winnier, A.R. and Arteaga, C.L. (1994) The epidermal growth factor receptor is associated with phospholipase C-gamma 1 in meningiomas. Hum. Pathol., 25, 146-153.
52. Noh, D.Y., Lee, Y.H., Kim, Y.I., Ryu, S.H., Suh, P.G. and Park, J.G. (1994) Elevated content of phospholipase Cγ1 in colorectal cancer tissues. Cancer, 73, 36-41.
53. Lee, S.J., Lee, S.D., Park, J.G., Kim, C.M., Ryu, S.H. and Suh, P.G. (1995) Overexpression of phospholipase C-gamma 1 in colorectal carcinomas is associated with overexpression of factors that bind its promoter. J. Biol. Chem., 270, 16387-16384.
54. Nomoto, K., Tomita, N., Miyake, M., Xhu, D.B., LoGerfo, P.R. and Weinstien, J.B. (1995) Expression of phospholipases gamma 1, beta 1, and delta 1 in primary human colon carcinomas and colon carcinoma cell lines. Mol. Carcinogenesis, 12, 146-152.
55. Arteaga, C.L., Johnson, M.D., Todderud, G., Coffey, R.J., Carpenter, G. and Page, D.L. (1991) Elevated content of the tyrosine kinase substrate phospholipase C-γ1 in primary human breast carcinomas. Proc. Natl Acad. Sci. USA, 88, 10435-10439.