Overactivation of phospholipase C-γ1 renders platelet-derived growth factor β-receptor-expressing cells independent of the phosphatidylinositol 3-kinase pathway for chemotaxis

Journal of Biological Chemistry

Volumn 274, Issue 31, 1999, Pages 22089-22094

  Rönnstrand, Lars ^a   Siegbahn, Agneta ^b   Rorsman, Charlotte ^a   Johnell, Matilda ^b   Hansen, Klaus ^a   Heldin, Carl Henrik ^a  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; BISINDOLYLMALEIMIDE; DOXYCYCLINE; INOSITOL 1,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C; PHOSPHOPEPTIDE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN KINASE C INHIBITOR; TRIACYLGLYCEROL LIPASE; TRITIUM;

ANIMAL CELL; AORTA; ARTICLE; CELL MIGRATION; CHEMOTAXIS; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; GENE OVEREXPRESSION; MITOGENICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; CHEMOTAXIS; CHROMONES; DOXYCYCLINE; ENZYME ACTIVATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INDOLES; INOSITOL 1,4,5-TRISPHOSPHATE; INOSITOL PHOSPHATES; ISOENZYMES; KINETICS; MALEIMIDES; MORPHOLINES; PEPTIDE MAPPING; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; POINT MUTATION; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 0038297647     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.31.22089     Document Type: Article

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