Clonal analysis of a human antibody response. III. Nucleotide sequences of monoclonal IgM, IgG, and IgA to rabies virus reveal restricted Vκ gene utilization, junctional VκJκ and VλJλ diversity, and somatic hypermutation

Journal of Immunology

Volumn 161, Issue 6, 1998, Pages 2895-2905

  Ikematsu, Wataru ^a   Kobarg, Jörg ^a   Ikematsu, Hideyuki ^a   Ichiyoshi, Yuji ^a   Casali, Paolo ^b,c  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b Weill Cornell Graduate School of Biomedical Sciences   (United States)

^c Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; IMMUNOGLOBULIN M ANTIBODY; IMMUNOVAX; LYMPHOCYTE RECEPTOR; MONOCLONAL ANTIBODY; RABIES VACCINE; UNCLASSIFIED DRUG;

ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; BINDING SITE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOLECULAR CLONING; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RABIES; RABIES VIRUS; THYMUS;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; ANTIBODY DIVERSITY; BASE SEQUENCE; CLONE CELLS; CLONING, MOLECULAR; GENE REARRANGEMENT, B-LYMPHOCYTE, LIGHT CHAIN; GENES, IMMUNOGLOBULIN; HAEMOPHILUS INFLUENZAE TYPE B; HIV ANTIBODIES; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN JOINING REGION; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN M; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR SEQUENCE DATA; MUTATION; PARAPROTEINEMIAS; PEPTIDE FRAGMENTS; POLYSACCHARIDES, BACTERIAL; RABIES VIRUS; RHEUMATOID FACTOR;

EID: 0032531086     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (81)

1. Andris, J. S., P. H. Ehrlich, L. Ostberg, and J. D. Capra. 1992. Probing the human antibody repertoire to exogenous antigens; characterization of the H and L chain V region gene segments from anti-hepatitis B virus antibodies. J. Immunol. 149:4053.
2. H6 heavy chain variable region gene families. Mol. Immunol. 30:1601.
3. Newkirk, M. M., G. F. Gram, G. F. Heinrich, L. Ostberg, and J. D. Capra. 1988. Complete protein sequences of the variable regions of the cloned heavy and light chains of a human anti-cytomegalovirus antibody reveal a striking similarity to human monoclonal rheumatoid factors of the Wa idiotypic family. J. Clin Invest. 81:1511.
4. Ohlin, M., V. A. Sundqvist, M. Mach, B. Wahren, and A. K. Borrebaeck. 1993. Fine specificity of the human immune response to the major neutralization epitopes expressed on cytomegalovirus gp58/116 (gB), as determined with human monoclonal antibodies. J Virol. 67:703.
5. Ueki, Y., I. Goldfarb, N. Harindranath, M. Gore, H. Koprowski, A. L. Notkins, and P. Casali. 1990. Clonal analysis of a human antibody response. I. Quantitation of precursors of antibody-producing cells and generation and characterization of monoclonal IgM, IgG and IgA to rabies virus. J. Exp. Med. 171:19.
6. Nakamura, M., and P. Casali. 1992. Generation of human monoclonal autoantibody-producing cell lines by Epstein-Barr virus (EBV)-transformation and somatic cell hybridization techniques: application to the analysis of the autoimmune B cell repertoire. Immunomethods 1:159.
7. H3 segments and somatic hypermutation. J. Immunol. 150:1325.
8. Ikematsu, W., F.-L. Luan, L. L. Rosa, B. Beltrami, F. Nicoletti, J. P. Buyon, P. L. Meroni, G. Balestrieri, and P. Casali. 1998. Human anti-cardiolipin monoclonal antibodies cause placental necrosis and fetal loss in BALB/c mice. Arthritis Rheum. 41:1026.
9. Scott, M. G., J. J. Tarrand, D. L. Crimmins, D. W. McCourt, N. R. Siegel, C. E. Smith, and M. H. Nahm. 1989. Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide. II. IgG antibodies contain VH genes from a single VH family and VL genes from at least four VL families. J. Immunol. 143:293.
10. Scott, M. G., D. L. Crimmins, D. W. McCourt, R. Zocher, R. Thiebe, H. G. Zachau, and M. H. Nahm. 1989. Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide. III. A single VκII gene and one of several Jκ genes are joined by an invariant arginine to form the most common L chain V region. J. Immunol. 143:4110.
11. Scott, M. G., D. L. Crimmins, D. W. McCourt, G. Chung, K. F. Schäbte, R. Thiebe, E.-M. Quenzel, H. G. Zachau, and M. H. Nahm. 1991. Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide. IV. The less frequently expressed VL are heterogeneous. J. Immunol. 147:4007.
12. Pinchuk, G. V., C. Nottenburg, and E. C. B. Milner. 1995. Predominant V-region gene configurations in the human antibody response to Haemophilus influenzae capsule polysaccharide. Scand. J. Immunol. 41:324.
13. Adderson, E. E., P. G. Shackelford, A. Quinn, and W. L. Carroll. 1991. Restricted IgH chain V gene usage in the human antibody response to Haemophilus infuenzae type b capsular polysaccharide. J. Immunol. 147:1667.
14. Adderson, E. E., P. G. Shackelford, R. A. Insel, A. Quinn, P. M. Wilson, and W. L. Carroll. 1992. Immunoglobulin light chain variable region gene sequences for human antibodies to Haemophilus influenzae type b capsular polysaccharide are dominated by a limited number of V kappa and V lambda segments and VJ combinations. J. Clin. Invest. 89:729.
15. H3b gene subfamily is highly polymorphic. J. Immunol. 151:800.
16. Adderson, A. H., J. W. Larrick, and D. C. Reason. 1994. Variable region sequences of a protective human monoclonal antibody specific for the Haemophilus influenzae type b capsular polysaccharide. Infect. Immun. 62:3873.
17. Dietzschold, B., M. Gore, P. Casali, Y. Ueki, C. E. Rupprecht, A. L. Notkins, and H. Koprowski. 1990. Biological characterization of human monoclonal antibodies to rabies virus. J. Virol. 64:3087.
18. K segment structure of anti-insulin IgG autoantibodies in patients with insulin-dependent diabetes mellitus: evidence for somatic selection. J. Immunol. 152:1430.
19. L segments of monoreactive and polyreactive IgA autoantibodies to DNA in patients with systemic lupus erythematosus. J. Immunol. 152:3137.
20. H genes are inherently susceptible to amino acid replacement. Immunol. Today 15:367.
21. Hieter, P. A., J. V. Maizel, and P. Leder. 1982. Evolution of human immunoglobulin κ J region gene. J. Biol. Chem. 257:1516.
22. Pargent, W., A. Meindl, R. Thiebe, S. Mitzel, and H. G. Zachau. 1991. The human immunoglobulin κ locus: characterization of the duplicated O regions. Eur. J. Immunol. 21:1821.
23. Lautner-Rieske, A., C. Huber, A. Meindl, W. Pargent, K. F. Schäble, R. Thiebe, I. Zocher, and H. G. Zachau. 1992. The human immunoglobulin κ locus: characterization of the duplicated A regions. Eur. J. Immunol. 22:1023.
24. Klein, R., R. Jaenichen, and H. G. Zachau. 1993. Expressed human immunoglobulin κ genes and their hypermutation. Eur. J. Immunol. 23:3248.
25. Huber, C., K. F. Schable, E. Huber, A. Meindl, R. Thiebe, R. Lamm, and H. G. Zachau. 1993. The Vκ genes of the L regions and the repertoire of Vκ gene sequences in the human germ line. Eur. J. Immunol. 23:2868.
26. Cox, J. P. L., I. M. Tomlinson, and G. Winter. 1994. A directory of human germ-line Vκ segments reveals a strong bias in their usage. Eur. J. Immunol. 24:827.
27. Klein, R., and H. G. Zachau. 1995. Expression and hypermutation of human immunoglobulin κ genes. Ann. NY Acad. Sci. 746:74.
28. Tomlinson, I. M., P. L. Cox, E. Gherardi, A. M. Lesk, and C. Chothia. 1996. The structure repertoire of the human Vκ domain. EMBO J. 14:4628.
29. Feeney, A. J., G. Lugo, and G. Escuro. 1997. Human cord blood κ repertoire. J. Immunol. 158:3761.
30. Taub, R. A., G. F. Hollis, P. A. Hieter, S. Korsmeyer, T. A. Waldmann, and P. Leder. 1983. Variable amplification of immunoglobulin λ light-chain genes in human populations. Nature 304:172.
31. Vasicek, T. J., and P. Leder. 1990. Structure and expression of the human immunoglobulin λ genes. J. Exp. Med. 172:609.
32. Chuchana, P. A., A. Blancher, F. Brockly, D. Alexandre, G. Lefranc, and M.-P. Lefranc. 1990. Definition of the human immunoglobulin variable lambda (IGLV) gene subgroups. Eur. J. Immunol. 20:1317.
33. Combriato, G., and H. G. Klobeck. 1991. Vλ and Jλ-Cλ gene segments of the human immunoglobulin λ chain locus are separated by 14 kb and rearrange by a deletion mechanism. Eur. J. Immunol. 21:1513.
34. Frippiat, J.-P., S. C. Williams, I. M. Tomlinson, G. P. Cook, D. Cherif, D. L. Paslier, J. E. Collins, I. Dunham, G. Winter, and M.-P. Lefranc. 1995. Organization of the human immunoglobulin lambda-chain locus on chromosome 22q11.2. Hum. Mol. Genet. 4:983.
35. Chang, L. Y., C. P. Yen, L. Besl, M. Schell, and A. Solomon. 1994. Identification and characterization of a functional human Ig VλVI germline gene. Mol. Immunol. 31:531.
36. Stiernholm, N. B. J., B. Kuzniar, and N. L. Bernstein. 1994. Identification of a new Vλ gene family-VλX. J. Immunol. 152:4969.
37. Williams, S. C., and G. Winter. 1993. Cloning and sequencing of human immunoglobulin Vλ gene segments. Eur. J. Immunol. 23:1456.
38. Williams, S. C., J.-P. Frippiat, I. M. Tomlinson, O. Ignatovich, M.-P. Lefranc. and G. Winter. 1996. Sequence and evolution of the human germline Vλ repertoire. J. Mol. Biol. 264:220.
39. Ignatovich, O., I. M. Tomlinson, P. J. Jones, and G. Winter. 1997. The creation of diversity in the human immunoglobulin Vλ repertoire. J. Mol. Biol. 268:69.
40. + B cells. J. Clin. Invest. 99:1614.
41. Frippiat, J.-P., and M.-P. Lefranc. 1994. Genomic organization of 34kb of the human immunoglobulin lambda locus (IGLV): restriction map and sequences of new VλIII genes. Mol. Immunol. 31:657.
42. Kabat, E. A., T. T. Wu, H. M. Perry, K. S. Gottesman, and C. Foeller. 1991. Sequences of Proteins of Immunological Interest, 5th Ed. U.S. Department of Health and Human Services Printing Office, Bethesda, M.D.
43. Lewis, S. M. 1994. The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses. Adv. Immunol. 56:27.
44. Felgenhauer, M., J. Kohl, and F. Ruker. 1990. Nucleotide sequences of the cDNAs encoding the V-regions of H-and L-chain of a human monoclonal antibody specific to HIV-gp41. Nucleic Acids Res. 18:4927.
45. Andris, J. S., and J. D. Capra. 1995. The molecular structure of human antibodies specific for the human immunodeficiency virus. J. Clin. Invest. 15:17.
46. Marasco, W. A., J. Bagley, C. Zani, M. Posner, L. Cavacini, W. A. Haseltine, and J. Sodroski. 1992. Characterization of the cDNA of a broadly reactive neutralizing human anti-gp120 monoclonal antibody. J. Clin. Invest. 90:1467.
47. Moran, M. J., J. S. Andris, Y.-I. Malsumato, J. D. Capra, and E. M. Hersh. 1993. Variable region genes of anti-HIV monoclonal antibodies: non-restricted use of the V gene repertoire and extensive somatic mutation. Mol. Immunol. 30:1543.
48. David, D., and M. Zoulali. 1995. Variable region light chain genes encoding human antibodies to HIV. Mol. Immunol. 32:77.
49. Weisbart, R. H., A. L. Wong, D. Noritake, A. Kacena, G. Chan, C. Ruland, E. Chin, I. S. Y. Chen, and J. D. Rosenblatt. 1991. The rheumatoid factor reactivity of a human IgG monoclonal autoantibody is encoded by a variant VκII light chain gene. J. Immunol. 147:2795.
50. Randen, I., K. M. Thompson, V. Pascual, K. Victor, D. Beale, J. Coadwell, O. Forre, J. D. Capra, and J. B. Natvig. 1992. Rheumatoid factor V genes from patients with rheumatoid arthritis are diverse and show evidence of an antigen-driven response. Immunol. Rev. 128:49.
51. Ermel, R. W., T. P. Kenny, P. P. Chen, and D. L. Robinsons. 1993. Molecular analysis of rheumatoid factors derived from rheumatoid synovium suggests an antigen-driven response in inflamed joints. Arthritis Rheum. 36:380.
52. Lu, E. W., M. Deftos, T. Olee, D.-F. Huang, R. W. Soto-Gil, D. A. Carson, and P. P. Chen. 1993. Generation and molecular analysis of two rheumatoid synovial fluid-derived IgG rheumatoid factors. Arthritis Rheum. 36:927.
53. Randen, I., V. Pascual, K. Victor, K. M. Thompson, O. Forre, J. D. Capra, and J. B. Natvig. 1993. Synovial IgG rheumatoid factors show evidence of an antigen-driven immune response and a shift in the V gene repertoire compared to IgM rheumatoid factors. Eur. J. Immunol. 23:1220.
54. Mantovani, L., R. L. Wilder, and P. Casali. 1993. Human rheumatoid B-la (CD5 + B) cells make somatically hypermutated high affinity IgM rheumatoid factors. J. Immunol. 151:473.
55. Ermel, R. W., T. P. Kenny, A. Wong, A. Solomon, P. P. Chen, and D. L. Robinsons. 1994. Preferential utilization of a novel Vλ3 gene in rheumatoid factors derived from the synovial cells of rheumatoid arthritis patients. Arthritis Rheum. 37:860.
56. Youngblood, K., L. Fruchter, G. Ding, J. Lopez, V. Bonagura, and A. Davidson. 1994. Rheumatoid factors from the peripheral blood of two patients with rheumatoid arthritis are genetically heterogeneous and somatically mutated. J. Clin. Invest. 93:852.
57. Olee, T., E. W. Lu, D.-F. Huang, R. W. Soto-Gil, M. Deftos, F. Kozin, D. A. Carson, and P. P. Chen. 1992. Genetic analysis of self-associating IgG rheumatoid factors from two rheumatoid synovia implicates an antigen-driven response. J. Exp. Med. 175:831.
58. Adderson, E. E., P. G. Shackelford, A. Quinn, P. M. Wilson, and W. L. Caroll. 1993. Diversity of immunoglobulin light chain usage in the human immune response to Haemophilus influenza type b capsular polysaccharide. Pept. Res. 33:307.
59. Lucas, A. H., J. W. Larrick, and D. C. Reason. 1994. Variable region sequences of a protective human monoclonal antibody specific for the Haemophilus influenzae type b capsular polysaccharide. Infect. Immun. 62:3873.
60. Ozaki, S., M. Abe, D. Wolfenbarger, D. T. Weiss, and A. Solomon. 1994. Preferential expression of human λ-light-chain variable-region subgroups in multiple myeloma. AL amyloidosis, and Waldenstrom's macroglobulinemia. Clin. Immunol. Immunopathol. 71:183.
61. + adult B cells are oligoclonal. J. Clin. Invest. 93:2093.
62. Sheehan, K. M., C. A. Mainville, S. Willert, and P. H. Brodeur. 1993. The utilization of individual VH exons in the primary response of adult BALB/c mice. J. Immunol. 151:5364.
63. Irinogen, M., A. Manheimer-Lory, B. Gaynor, and B. Diamond. 1994. Molecular analysis of the human immunoglobulin VμII gene family. J. Clin. Invest. 94:532.
64. Dietzschold, B., M. Gore, H. Ertl, E. Celis, L. Otvos, Jr., and H. Koprowski. 1989. Analysis of protective immune mechanisms induced by rabies nucleoprotein. In Genetics and Pathogenicity of Negative-strand Viruses. B. W. J. Mahy and D. Kolakowsky, eds. Elsevier, New York, p. 295.
65. Ibrahim, S. M., M. G. Weigert, C. Basu, J. Erikson, and M. Z. Radic. 1995. L chain contribution to specificity in anti-DNA antibodies. J. Immunol. 155:3223.
66. Braden, B. C., and R. J. Poljak. 1995. Structural features of the reactions between antibodies and protein antigens. FASEB J. 9:9.
67. Ichiyoshi, Y., and P. Casali. 1994. Analysis of the structural correlates for antibody polyreactivity by multiple reassortments of chimeric human immunoglobulin heavy and light chain v segments. J. Exp. Med. 180:885.
68. Ichiyoshi, Y., and P. Casali. 1995. Analysis of the structural correlates for self-antigen binding by natural and disease-related autoantobidies: in vitro expression of recombinant and/or mutagenized human IgG. Ann. NY Acad. Sci. 764:328.
69. Ichiyoshi, Y., M. Zhou, and P. Casali. 1995. A human anti-insulin IgG autoantibody apparently arises through clonal selection from an insulin-specific "germ-line" natural antibody template: analysis by V gene segment reassortment and site-directed mutagenesis. J. Immunol. 154:226.
70. Schettino, E. W., Y. Ichiyoshi, and P. Casali. 1996. Structure-function relation in natural and disease-associated human autoantibodies. In The Antibodies, Vol. 2, M. Zanetti and J. D. Capra, eds. Harwood Publishers, p. 155.
71. Radic, M. Z., M. A. Mascelli, J. Erikson, H. Shan, and M. C. Weigert. 1991. IgH and L chain contributions to autoimmune specificities. J. Immunol. 146:176.
72. Vargas-Madrazo, E., F. Lara-Ochoa, and J. C. Almagro. 1995. Canonical structure repertoire of the antigen-binding site of immunoglobulins suggests strong geometrical restrictions associated to the mechanism of immune recognition. J. Mol. Biol. 254:497.
73. Chothia, C., and A. M. Lesk. 1987. Canonical structures for the hypervariable regions of immunoglobulins. J. Mol. Biol. 196:901.
74. Chothia, C., A. M. Lesk, A. Tramontano, M. Levitt, S. J. Smith-Gill, G. Air, S. Sheriff, E. A. Padlan, D. Davies, W. R. Tulip, et al. 1989. Conformations of immunoglobulin hypervariable regions. Nature 342:877.
75. H gene sequences and antigen reactivity of monoclonal antibodies produced by human B-1 cells: evidence for somatic selection. J. Immunol. 158:2477.
76. Desiderio, S. V., G. D. Yancopoulos, M. Paskind, E. Thomas, M. A. Boss, N. Landau, F. W. Alt, and D. Baltimore. 1984. Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransfersase in B cells. Nature 311:752.
77. Loken, M. R., V. O. Shah, K. L. Dattilio, and C. I. Civin. 1987. Flow cytometric analysis of human bone marrow II. Normal B. lymphocyte development. Blood 70:1316.
78. Martin, T., G. Blaison, H. Levallois, and J. L. Pasquali. 1992. Molecular analysis of the VκIII-Jκ junctional diversity of polyclonal rheumatoid factors during rheumatoid arthritis frequently reveals N addition. Eur. J. Immunol. 22:1773.
79. L junction. Mol. Immunol. 31:39.
80. +B cells, the major B cell subset in the peripheral blood, express Vκ genes with no or little somatic mutation throughout life. Eur. J. Immunol. 23:3272.
81. Billips, L. F. K. Lassoued, C. Nunez, J. Wang, H. Kubagawa, G. L. Gartland, P. D. Burrows, and M. D. Cooper. 1995. Human B-cell development. In Immunoglobulin Gene Expression in Development and Disease. P. Casali and L. E. Silberstein, eds. Ann. NY Acad. Sci. 746:1.