Processing of O6-methylguanine by mismatch correction in human cell extracts

Current Biology

Volumn 6, Issue 11, 1996, Pages 1528-1531

  Ceccotti, Sabrina ^a   Aquilina, Gabriele ^a   Macpherson, Peter ^b   Yamada, Masami ^b   Karran, Peter ^b   Bignami, Margherita ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL EXTRACT; DNA; DRUG DERIVATIVE; GUANINE; O (6) METHYLGUANINE; O-(6)-METHYLGUANINE;

ARTICLE; BIOSYNTHESIS; CELL CULTURE; DNA REPAIR; HELA CELL; HUMAN; METABOLISM;

CELL EXTRACTS; DNA REPAIR; DNA, NEOPLASM; GUANINE; HELA CELLS; HUMANS; TUMOR CELLS, CULTURED;

EID: 0030299847     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(96)00758-0     Document Type: Article

References (18)

1. 6-methylguanine residues elicit DNA repair synthesis by human cell extracts. J Biol Chem 1993, 268:15878-15886.
2. Karran P, Bignami M: DNA damage tolerance, mismatch repair and genome instability. BioEssays 1994, 16:833-839.
3. 6-methylguanine in DNA inhibits replication in vitro by human cell extracts. Biochemistry 1993, 32:13664-13672.
4. Umar A, Boyer JC, Thomas DC, Nguyen DC, Risinger JI, Boyd J, et al.: Defective mismatch repair in extracts of colorectal and endometrial cell lines exhibiting microsatellite instability. J Biol Chem 1994, 269:14367-14370.
5. + tumor cells. Cell 1993, 75:1227-1236.
6. Papadopoulos N, Nicolaides NC, Liu B, Parsons R, Lengauer C, Palombo F et al.: Mutations of GTBP in genetically unstable cells. Science 1995, 268:1915-1917.
7. Kolodner RD: Mismatch repair: mechanisms and relation to cancer susceptibility. Trends Biochem Sci 1995, 20:397-401.
8. Branch P, Hampson R, Karran P: DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines. Cancer Res. 1995, 55:2304-2309.
9. Liu B, Nicolaides NC, Markowitz S, Willson JKW, Parsons RE, Jen J, et al.: Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nat Genetics 1995, 9:48-55.
10. Drummond JT, Li G-M, Longley MJ, Modrich P: Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. Science 1995, 268:1909-1912.
11. Aquilina G, Hess P, Fiumicino S, Ceccotti S, Bignami M: A mutator phenotype characterizes one of two complementation groups in human cells tolerant to methylation damage. Cancer Res 1995, 55:2569-2575.
12. Branch P, Aquilina G, Bignami M, Karran P: Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage. Nature 1993, 362:652-654.
13. Varlet I, Radman M, Brooks P: DNA mismatch repair in Xenopus egg extracts: repair efficiency and DNA repair synthesis for all single base-pair mismatches. Proc Natl Acad Sci USA 1990, 87:7883-7887.
14. Kat A, Thilly WG, Fang W-H, Longley MJ, Li G-M, Modrich P: An alkylation-tolerant, mutator human cell line is deficient in strandspecific mismatch repair Proc Natl Acad Sci USA 1993, 90:6424-6428.
15. Aquilina G, Hess P, Branch P, MacGeoch C, Casciano I, Bignami M, Karran P: A mismatch recognition defect in colon carcinoma confers DNA microsatellite instability and a mutator phenotype. Proc Natl Acad Sci USA 1994, 91:8905-8909.
16. de Wind N, Dekker M, Berns A, Radman M, te Riele H: Inactivation of the mouse Msh2 gene results in postreplicational mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to tumorigenesis. Cell 1995, 82:321-330
17. Karran P, Bignami M: Self-destruction and tolerance in resistance of mammalian cells to alkylation damage. Nucleic Acids Res. 1992, 20:2933-2940.
18. O'Regan NE, Branch P, MacPherson P, Karran P: hMSH2-independent mismatch recognition by human proteins. J Biol Chem 1996,271:1789-1796.