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0030662523
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F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin - Ligase complex
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of outstanding interest. A very elegant and convincing study showing that seven purified components, an E1, ubiquitin, Cdc34, Cdc4, Cdc53, Skp1 and Cln - Cdc28 kinase, are necessary and sufficient to promote the multiubiquitination of the CDK inhibitor Sic1 in vitro. This work provides conclusive evidence that a complex composed of Skp1, Cdc53 and the F-box protein Cdc4 can function as a Sic1 E3 ligase. These studies illustrate the importance of F-box proteins in providing substrate specificity to ubiquitination reactions [9].
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1 with low Cln - Cdc28 kinase activity. Whereas wild-type Far1 is a readily ubiquitinated in a Cdc34-dependent manner, the mutant is not. This defect is linked to the failure of Cln - Cdc28 kinase to phosphorylate the mutant Far1 protein.
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Won KA, Reed SI. Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E. of special interest EMBO J. 15:1996;4182-4193 This paper, together with [36], presents evidence that cyclin E is degraded by the ubiquitin - proteasome system and that this degradation is regulated by phosphorylation. The cyclin E-bound CDK2 initiates this degradation by phosphorylating cyclin E at a specific site. Phosphorylation causes cyclin E to disassemble from CDK2, resulting in the ubiquitination and degradation of free cyclin E. Interestingly, the binding of CDK2 to cyclin E appears to protect the latter from degradation.
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48
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The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin - Proteasome pathway
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of special interest. A gene is identified that is important for the maintenance of ploidy in fission yeast. The gene, pop1, is highly related to the gene for budding yeast CDC4, an F-box protein. In pop1 mutants, Cdc18 and Rum1 are not ubiquitinated and accumulate to high levels. Pop1 contains an F-box motif and associates with Cdc18, suggesting that Pop1 functions as a recognition factor in a ubiquitination pathway.
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