Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins

Molecular and Cellular Biology

Volumn 19, Issue 1, 1999, Pages 724-732

  Hu, Gang ^a   Fearon, Eric R ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING;

DROSOPHILA;

EID: 0032933351     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.1.724     Document Type: Article

References (27)

1. Blackwood, M. A., and B. L. Weber. 1998. BRCA1 and BRCA2: from molecular genetics to clinical medicine. J. Clin. Oncol. 16:1969-1977.
2. Borden, K. L., M. N. Boddy, J. Lally, N. H. O'Reilly, S. Martin, K. Howe, E. Solomon, and P. S. Freemont. 1995. The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML. EMBO J. 14:1532-71541.
3. Borden, K. L. B., and P. S. Freemont. 1996. The RING finger domain: a recent example of a sequence-structure family. Curr. Opin. Struct. Biol. 6:395-401.
4. Carthew, R. W., and G. M. Rubin. 1990. seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye. Cell 63:561-577.
5. Chang, H. C., N. M. Solomon, D. A. Wassarman, F. D. Karim, M. Therrien, G. M. Rubin, and T. Wolff. 1995. phyllopod functions in the fate determination of a subset of photoreceptors in Drosophila. Cell 80:463-472.
6. Dickson, B. 1995. Nuclear factors in Sevenless signaling. Trends Genet. 11:106-111.
7. Grimwade, D., and E. Solomon. 1997. Characterization of the PML/RAR alpha rearrangement associated with t(15;17) acute promyelocytic leukemia. Curr. Top. Microbiol. Immunol. 220:81-112.
8. Higuchi, R. 1990. Recombinant PCR, p. 177-183. In M. A. Ennis (ed.), PCR protocols: a guide to methods and applications. Academic Press. Inc., San Diego, Calif.
9. Hu. G., S. Zhang, M. Vidal, J. La Baer, T. Xu, and E. R. Fearon. 1997. Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway. Genes Dev. 11:2701-2714.
10. Hu, G., Y.-L. Chung, T. Glover, V. Valentine, T. A. Look, and E. R. Fearon. 1997. Characterization of human homologs of the Drosophila seven in absentia (sina) gene. Genomics 46:103-111.
11. Jin, Y., X. L. Xu, M. C. Yang, F. Wei, T. C. Ayi, A. M. Bowcock, and R. Baer. 1997. Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domains. Proc. Natl. Acad. Sci. USA 94:12075-12080.
12. Lai, Z.-C., S. d. Harrison, F. Karim, Y. Li, and G. M. Rubin. 1996. Loss of tramtrack gene activity results in ectopic R7 cell formation, even in a sina mutant background. Proc. Natl. Acad. Sci. USA 93:5025-5030.
13. Lee, S. Y., S. Y. Lee, and Y. Choi. 1997. TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kB activation. J. Exp. Med. 185:1275-1285.
14. Li, S., Y. Li, R. W. Carthew, and Z.-C. Lai. 1997. Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor tramtrack. Cell 90:469-478.
15. Matsuzawa, S., S. Takayama, B. A. Froesch, J. M. Zapata, and J. C. Reed. 1998. P53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1. EMBO J. 17:2736-2747.
16. Moriuchi, H., M. Moriuchi, and I. J. Cohen. 1994. The RING finger domain of the varicella-zoster virus open reading frame 61 protein is required for its transregulatory functions. Virology 205:238-246.
17. Palombella, V. J., O. J. Rando, A. L. Goldberg, and T. Maniatis. 1994. The ubiquitin-proteasome pathway is required for processing the NG-kB1 precursor protein and the activation of NG-kB. Cell 78:773-785.
18. Reale, M. A., G. Hu, A. I. Zafar, R. H. Getzenberg, S. M. Levine, and E. R. Fearon. 1994. Expression and alternative splicing of the deleted in colorectal cancer (DCC) gene in normal and malignant tissues. Cancer Res. 54:4493-4501.
19. Rock, K. L., C. Gramm, L. Rothstein, K. Clark, R. Stein, L. Dick, D. Hwang, and A. L. Goldberg. 1994. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78:761-771.
20. Saurin, A. J., K. L. B. Borden, M. N. Boddy, and P. S. Freemont. 1996. Does this have a familiar ring? Trends Biochem. Sci. 21:208-214.
21. Scully, R., S. Ganesan, M. Brown, J. A. De Caprio, S. A. Cannistra, J. Feunteun, S. Schnitt, and D. M. Livingston. 1996. Location of BRCA1 in human breast and ovarian cancer cells. Science 272:123-126. (Letter.)
22. Tang, A. H., T. P. Neufeld, E. Kwan, and G. M. Rubin. 1997. PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism. Cell 90:459-467.
23. Wassarman, D. A., M. Therrien, and G. M. Rubin. 1995. The Ras signaling pathway in Drosophila. Curr. Opin. Genet. Dev. 5:44-50.
24. Wu, L. C., W. Wang, J. T. Tsan, M. A. Spillman, A. Phung, X. L. Xu, M. C. Yang, L. Y. Hwang, A. M. Bowcock, and R. Baer. 1996. Identification of a RING protein that can interact in vivo with the BRCA1 gene product. Nat. Genet. 14:430-440.
25. Xu, C. F., and E. Solomon. 1996. Mutations of the BRCA1 gene in human cancer. Semin. Cancer Biol. 7:33-40.
26. Yamamoto, D., I. Nihonmatsu, T. Matsuo, H. Miyamoto, S. Kondo, K. Hirata, and Y. Ikegami. 1996. Genetic interactions of pokkuri with seven in absentia, tramtrack and downstream components of the sevenless pathway in R7 photoreceptor induction in Drosophila melanogaster. Roux's Arch. Dev. Biol. 205:215-224.
27. Zipursky, S. L., and G. M. Rubin. 1994. Determination of neuronal cell fate: lessons from the R7 neuron of Drosophila. Annu. Rev. Neurosci. 17:373-397.