Angiogenesis of uterine cervical carcinoma: Characterization by pharmacokinetic magnetic resonance parameters histological microvessel density with correlation to lymphatic involvement

Cancer Research

Volumn 57, Issue 21, 1997, Pages 4777-4786

  Hawighorst, Hans ^a   Knapstein, Paul G ^b   Weikel, Wolfgang ^b   Knopp, Michael V ^a   Zuna, Ivan ^a   Knof, Almuth ^a   Brix, Gunnar ^a   Schaeffer, Uwe ^b   Wilkens, Claudia ^b   Schoenberg, Stefan O ^a   Essig, Marco ^a   Vaupel, Peter ^b   Van Kaick, Gerhard ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 8; GADOLINIUM;

ADULT; AGED; AMPLITUDE MODULATION; ANGIOGENESIS; ARTICLE; CONTRAST ENHANCEMENT; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PRIORITY JOURNAL; UTERINE CERVIX CARCINOMA;

ADENOCARCINOMA; ADULT; AGED; CAPILLARY PERMEABILITY; CARCINOMA, SQUAMOUS CELL; FEMALE; HUMANS; LYMPHATIC SYSTEM; MAGNETIC RESONANCE IMAGING; MICROCIRCULATION; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; OBSERVER VARIATION; UTERINE CERVICAL NEOPLASMS;

EID: 0030784939     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Folkman, J. Intratumoral microvascular density as a prognostic factor in cancer. Am. J. Pathol., 147: 9-19, 1995.
2. Weidner, N., Joseph, P. S., William, R. W., and Folkman, J. Tumor angiogenesis and metastases: correlation in invasive breast carcinoma. N. Engl. J. Med., 324: 1-8, 1991.
3. Porschen, R., Classen, S., Piontek, M., and Borchard, F. Vascularization of carcinomas of the esophagus and its correlation with tumor proliferation. Cancer Res., 54: 587-591, 1994.
4. Macciarini, P., Fontanini, G., Hardin, M. J., Squartini, F., and Angeletti, C. A. Relation of neovascularization to metastasis of non-small cell king cancer. Lancet, 340: 145-146, 1992.
5. Wiggins, D. L., Granai, C. O., Steinhoff, M. M., and Calabresi, P. Tumor angiogenesis as a prognostic factor in cervical carcinoma. Gynecol. Oncol., 56: 353-356, 1995.
6. Schlenger, K., Hoeckel, M., Mitze, M., Schaeffer, U., Weikel, W., Knapstein, P. G., and Lambert, A. Tumor vascularity: a novel prognostic factor in advanced cervical carcinoma. Gynecol. Oncol., 59: 57-66, 1995.
7. Dinh, T. V., Hannigan, E. V., Smith, E. R., Hove, M. J., Chopra, V., and To, T. Tumor angiogenesis as a predictor of recurrence in stage Ib squamous cell carcinoma of the cervix. Obstet. Gynecol., 87: 751-754, 1996.
8. Verstraete, K. L., De-Deene, Y. D., Roels, H., Dierick, A., Uyttendaele, D., and Kunnen, M. Benign and malignant musculoskeletal lesions: dynamic contrast-enhanced MR imaging: parametric first-pass images depict tissue vascularization and perfusion. Radiology, 192: 835-843, 1994.
9. Fletcher, B. D., Hanna, S. L., Fairclough, D. L., and Gronemeyer, S. A. Pediatric musculoskeletal tumors: use of dynamic, contrast-enhanced MR imaging to monitor response to chemotherapy. Radiology, 184: 243-248, 1992.
10. Koenig, H., Sieper, J., and Wolf, K. J. Rheumatoid arthritis: evaluation of hypervascular and fibrous pannus with enhanced dynamic MR imaging enhanced with Gd-DTPA. Radiology, 176: 473-477, 1990.
11. Brix, G., Semmler, W., Port, R., Schad, L. R., Layer, G., and Lorenz, W. J. Pharmacokinetic parameters in CNS Gd-DTPA-enhanced MR imaging. J. Comput. Assisted Tomogr., 15: 621-627, 1991.
12. Hoffmann, U., Brix, G., Knopp, M. V., Hess, T., and Lorenz, W. J. Pharmacokinetic mapping of the breast: a new method for dynamic MR-mammography. Magn. Reson. Med., 33: 506-514, 1995.
13. Hawighorst, H., Knapstein, P. G., Schaeffer, U., Knopp, M. V., Brix, G., Hoffmann, U., Zuna, I., Essig, M., and van Kaick, G. Pelvic lesions in patients with treated cervical carcinoma: efficacy of pharmacokinetic analysis of dynamic MR images to distinguish recurrent tumor from benign conditions. Am. J. Roentgenol., 166: 401-408, 1995.
14. Hawighorst, H., Knapstein, P. G., Weikel, W., Knopp, M. V., Schaeffer, U., Brix, G., Essig, M., Hoffmann, U., Zuna, I., Schoenberg, S., and van Kaick, G. Cervical carcinoma: comparison of standard and pharmacokinetic MR imaging. Radiology, 201: 531-539, 1996.
15. Folkman, J. What is the evidence that tumors are angiogenesis dependent? J. Natl. Cancer Inst., 82: 4-6, 1990.
16. Bicknell, R., and Harris, A. L. Novel growth regulatory factors and tumor angiogenesis. Eur. J. Cancer, 27: 781-785, 1991.
17. Toi, M., Kashitani, J., and Tominaga, T. Tumor angiogenesis is an independent prognostic indicator in primary breast carcinoma. Int. J. Cancer, 55: 371-374, 1993.
18. Bosari, S., Lee, A. K. C., DeLellis, R. A., Heatley, G., Wiley, B., and Silverman, M. L. Microvessel quantitation and prognosis in invasive breast carcinoma. Hum. Pathol., 23: 755-761, 1992.
19. Bochner, B. H., Cote, R. J., Weidner, N., Groshen, S., Chen, S. C., Skinner, D. G., and Nicolas, P. W. Angiogenesis in bladder cancer: relationship between microvessel density and tumor prognosis. J. Natl. Cancer Inst., 87: 1603-1612, 1995.
20. Fidler, I. J. Critical factors in the biology of human cancer metastasis: twenty-eighth G. H. A. Clowes Memorial Award lecture. Cancer Res., 50: 6130-6138, 1990.
21. Gullino, P. M., Grantham, F. H., and Clark, S. H. The interstitial water space of tumors. Cancer Res., 25: 727-731, 1965.
22. Deen, S., and Ball, R. Y. Basement membrane and extracellular interstitial matrix components in bladder neoplasia: evidence of angiogenesis. Histopathology (Oxf.), 25: 475-481, 1994.
23. Nagy, J. A., Brown, L. F., Senger, D. R., Lanir, N., Van de Walter, L., and Dvorak, A. M. Pathogenesis of tumor stroma generation: a critical role for leaky blood vessels and fibrin deposition. Biochim. Biophys. Acta, 948: 305-326, 1989.
24. Leung, D. W., Cachianes, G., Kuang, W., Goeddel, D. V., and Ferrara, N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science (Washington DC), 246: 1306-1309, 1989.
25. Kim, K. J., Li, B., Winer, J., Armanini, M., Gillett, N., and Phillips, H. S. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo. Nature (Lond.), 362: 841-844, 1993.
26. Berkman, R. A., Merrill, M. J., Reinhold, W. C., Monacci, W. T., Saxena, A., Clark, W. C., Robertson, J. T., Ali, I. U., and Oldfield, E. H. Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms. J. Clin. Invest., 91: 153-159, 1993.
27. Brown, L. F., Berse, B., Jackman, R. W., Tognazzi, K., Guidi, A. J., Dvorak, H. F., Senger, D. R., Connolly, J. L., and Schnitt, S. J. Expression of vascular permeability endothelial growth (factor) and its receptors in breast cancer. Hum. Pathol., 26: 86-91, 1995.
28. Boocock, C. A., Charnock-Jones, D. S., Sharkey, A. M., McLaren, J., Barker, P. J., and Wright, K. A. Expression of vascular endothelial growth factor and its receptors fit and KDR in ovarian carcinoma. J. Natl. Cancer Inst., 87: 506-516, 1995.
29. Guidi, A. J., Abu-Jawdeh, G., Berse, B., Jackman, R. W., Tognazzi, H. F., Dvorak, H. F., and Brown, L. F. Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in cervical neoplasia. J. Natl. Cancer Inst., 87: 1237-1245, 1995.
30. Fidler, I. J., Gersten, D. M., and Hart, I. R. The biology of cancer invasion and metastasis. Adv. Cancer Res., 28: 150-225, 1978.
31. Sevin, B. U., Nadji, M., Averette, H. E., Hilsenbeck, S., Smith, D., and Lampe, B. Microinvasive carcinoma of the cervix. Cancer (Phila.), 70: 2121-2128, 1992.
32. Delgado, G., Bundy, B., Zaino, R., Sevin, B. U., Creasman, W. T., Major, F. A., DiSaia, P., and Zaino, R. A prospective surgical-pathological study of disease-free interval in patients with stage Ib squamous cell carcinoma of the cervix: a Gynecologic Oncology Group Study. Gynecol. Oncol., 35: 314-320, 1989.