Assessment of tumor microcirculation: A new role of dynamic contrast MR imaging

Journal of Magnetic Resonance Imaging

Volumn 7, Issue 1, 1997, Pages 111-119

  Griebel, Jürgen ^a   Mayr, Nina A ^b   De Vries, Alexander ^c   Knopp, Michael V ^d   Gneiting, Thomas ^a   Kremser, Christian ^c   Essig, Marco ^d   Hawighorst, Hans ^d   Lukas, Peter H ^c   Yuh, William T C ^b,e  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF INNSBRUCK   (Austria)

^d GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^e UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

Dynamic contrast MR; Radiation therapy; Tumor microcirculation; Tumor responsiveness

Indexed keywords

GADOLINIUM CHELATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; BREAST ADENOCARCINOMA; CENTRAL NERVOUS SYSTEM TUMOR; CONTRAST ENHANCEMENT; DYNAMICS CONTRAST NUCLEAR MAGNETIC RESONANCE IMAGING; EXTRACELLULAR SPACE; MICROCIRCULATION; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RECTUM CANCER; REVIEW; TUMOR BLOOD FLOW; TUMOR VASCULARIZATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CONTRAST MEDIA; GADOLINIUM; HUMANS; IMAGE ENHANCEMENT; MAGNETIC RESONANCE IMAGING; MICROCIRCULATION; MODELS, BIOLOGICAL; NEOPLASMS; PROGNOSIS; RADIOACTIVE TRACERS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 13144294020     PISSN: 10531807     EISSN: None     Source Type: Journal    
DOI: 10.1002/jmri.1880070115     Document Type: Review

References (73)

1. Jain R. Barriers to drug delivery in solid tumors. Sci Am 1994; 58-65.
2. Jain R, Ward-Hartley K. Tumor blood flow: characterization, modifications, and role in hyperthermia. IEEE Trans Son Ultrason 1984; 31:504-526.
3. Song C. Effect of local hyperthermia in blood flow and microenvironment: a review. Cancer Res 1984; 44:4721S-4730S.
4. Thomlinson R, Gray L. The histologic structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer 1955; 9:935-549.
5. Peters L, Brock W, Chapman J, Wilson G, Fowler J. Predictive assays of tumor radiocurability. Am J Clin Oncol 1988; 11:275-287.
6. Gray LH, Conger AD, Ebert M. The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol 1953; 26:638-648.
7. Kallinowski F, Schlenger KH, Kloes M, Stohrer M, Vaupel P. Tumor blood flow: the principal modulator of oxidative and glycolytic metabolism, and of the metabolic micromileu of human tumor xenografts in vivo. Int J Cancer 1989; 44:266-272.
8. Kallinowski F, Schlenger K, Runkel S, et al. Blood flow, metabolism, cellular micro-environment, and growth rate of human tumor xenografts. Cancer Res 1989; 49:3759-3764.
9. Vaupel P, Fortmeyer H, Runkel S, Kallinowski F. Blood flow, oxygen consumption and tissue oxygenation of human breast cancer xenografts in nude rats. Cancer Res 1987; 47:3496-3503.
10. Blitzer P, Wang C. Suit H. Blood pressure and hemoglobin concentration: multivariate analysis of local control after irradiation for head and neck cancer. Int J Radiat Oncol Biol Phys 1984; 10(Suppl):98.
11. Bush RS, Jenkin RDT, Allt WEC. Definitive evidence for hypoxic cells influencing cure in cancer therapy. Br J Cancer 1978; 37(Suppl):302-306.
12. Chaplin DJ, Olive PL, Durand RE. Intermittent blood flow in a murine tumor: radiobiological effects. Cancer Res 1987; 47: 597-601.
13. Evans J, Bergso P. The influence of anemia and results of radiotherapy in carcinoma of the cervix. Radiology 1965; 48:709-717.
14. Gatenby RA, Kessler HB, Rosenblum JS, et al. Oxygen distribution in squamous cell carcimona metastases and its relationship in outcome to radiation therapy. Int J Radiat Oncol Biol Phys 1988; 14:831-838.
15. Höckel M, Schienger K, Aral B, Mitze M, Schaffer U, Vaupel P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 1996; 56:4509-4515.
16. Kolstad P. Intercapillary distance, oxygen tension and local recurrence in cervix cancer. Scand J Clin Lab Invest 1968; 106(Suppl):145-157.
17. 2-histography. Int J Radiat Oncol Biol Phys 1990; 19:953-961.
18. Lartigau E, Randrianarivelo H, Martin L, Stern S, et al. Oxygen tension measurements in human tumors: The Institute Gustave-Roussy experience. Radiat Oncol Invest 1994; 1:285-291.
19. Tannock IF. Oxygen diffusion and the distribution of cellular radiosensitivity in tumors. Br J Radiol 1972; 45:515-524.
20. Ludgate SM, Crandon AJ, Hudson CN, Walker Q, Langlands AO. Synchronous 5-fluorouracil, mitomycin-C and radiation therapy in the treatment of locally advanced carcinoma of the cervix. Int J Radiat Oncol Biol Phys 1988; 15:893-899.
21. Roberts WS, Kavanagh JJ, Greenberg H, et al. Concomitant radiation therapy and chemotherapy in the treatment of advanced squamous carcinoma of the lower female genital tract. Gynecol Oncol 1989; 34:183-186.
22. Souhami L, Seymour R, Roman TN, et al. Weekly cisplatin plus external beam radiotherapy and high dose rate brachytherapy in patients with locally advanced carcinoma of the cervix. Int J Radiat Oncol Biol Phys 1993; 27:871-878.
23. Beaney RP, Lammertsma AA, Jones T, McKenzie CG, Halnan KE. Positron emission tomography for in vivo measurement of regional blood flow, oxygen utilisation, and blood volume in patients with breast carcinoma. Lancet 1984; 1:131-134.
24. Ito M, Lammertsma AA, Wise RJS, et al. Measurement of regional cerebral blood flow and oxygen utilisation in patients with cerebral tumours using O-15 and positron emission tomography: analytical techniques and preliminary results. Neuroradiology 1982; 23:63-74.
25. Urtasun RC, Chapman JD, Raleigh JA, Franko AJ, Koch CJ. Binding of H-3-misonidazole to solid human tumors as a measure of tumor hypoxia. Int J Radiat Oncol Biol Phys 1986; 12:1263-1267.
26. Belfi C, Ting L-L, Hassenbusch S, Tefft M, Ngo FQ. Determination of changes in tumor blood perfusion after hydralazine treatment by dynamic paramagnetic-enhanced magnetic resonance imaging. Int J Radiat Oncol Biol Phys 1992; 22:477-482.
27. Belfi C, Paul CR, Shan S, Ngo FQ. Comparison of the effects of hydralazine on tumor and normal tissue blood perfusion by MRI. Int J Radiat Oncol Biol Phys 1994; 29:473-479.
28. Feldmann H, Sievers K, Fuller J, Molls M, Lohr E. Evaluation of tumor blood perfusion by dynamic MRI and CT in patients undergoing thermoradiotherapy. Eur J Radiol 1993; 16:224-229.
29. Gneiting T, Kremser C, Griebel J, et al. Ultrafast T1 mapping on a whole body scanner: phantom evaluation and application to dynamic contrast agent studies. In: Proceedings of the 13th annual meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB), Vienna, Austria. 1996; IV(Suppl):258.
30. Gowland P, Mansfield P, Bullock P, Stehling M, Worthington B, Firth J. Dynamic studies of gadolinium uptake in brain tumors using inversion-recovery echo-planar Imaging. Magn Reson Med 1992; 26:241-258.
31. Kennedy S, Szczepaniak L, Gibson S, Hilf R, Foster T, Bryant R. Quantitative MRI of Gd-DTPA uptake in tumors: response to photodynamic therapy. Magn Reson Med 1994; 31:292-301.
32. Kremser C, Gneiting T, DeFries A, et al. Ultrafast T1 mapping on a whole body scanner: a new method for the quantification of dynamic contrast agent studies in patients with malignant neoplasms. In: Proceedings of the 81st annual scientific meeting of the Radiological Society of North America (RSNA) Chicago, IL, 1995; 197(P):390.
33. Kremser C, Gneiting T, Griebel J, et al. Dynamic T1 mapping on a whole body scanner: effects of radiation therapy on tumor microcirculation. In: Proceedings of the 13th annual meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB), Vienna, Austria, 1996; IV(Suppl):308.
34. Su M, Najafi A, Nalcioglu O. Regional comparison of tumor vascularity and permeability parameters measured by albumin-Gd-DTPA and Gd-DTPA. Magn Reson Med 1995; 34:402-411.
35. Zierler K. Theoretical basis of indicator-dilution methods for measuring flow and volume. Circ Res 1962; 10:393-407.
36. Zierler K. Equations for measuring blood flow by external monitoring of radioisotopes. Circ Res 1965; 16:309-321.
37. Meier P, Zierler K. On the theory of the indicator-dilution method for measurement of blood flow and volume. J Appl Physiol 1954; 6:731-744.
38. Rempp K, Brix G, Wenz F, Becker C, Guckel F, Lorenz W. Quantification of regional cerebral blood flow and volume with dynamic susceptibility contrast-enhanced MR imaging. Radiology 1994; 193:637-641.
39. Kety S. Measurement of regional circulation by the local clearance of radioactive sodium. Am Heart J 1949; 38:321-328.
40. Diesbourg L, Prato F, Wisenberg G, et al. Quantification of myocardial blood flow and extracellular volumes using a bolus injection of Gd-DTPA: kinetic modeling in canine ischemic disease. Magn Reson Med 1992; 23:239-253.
41. Tong C, Prato F, Wisenberg G. et al. Measurement of the extraction efficiency and distribution volume for Gd-DTPA in normal and diseased canine myocardium. Magn Reson Med 1993; 30:337-346.
42. Kety S. The theory and application of the exchange of inert gas at the lungs and tissues. Pharmacol Rev 1951; 3:1-41.
43. Larsson H, Fritz-Hansen T, Rostrup E, Sondergaard L. Myocardial perfusion modeling using MRI. Magri Reson Med 1996; 35:716-726.
44. Griebel J, Gneiting T, Botzler A, Dellian M, DeVries A. In vivo assessment of microcirculatory parameters in tumors using contrast-enhanced magnetic resonance imaging. In: Proceedings of the 13th annual meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB), Vienna, Austria. 1996; 115.
45. Zierler K. Theory of use of indicators to measure blood flow and extracellular volume and calculation of transcapillary movement of tracers. Circ Res 1963; 12:464-471.
46. Nagele T, Petersen D, Klose U, et al. Dynamic contrast enhancement of intracranlal tumors with snapshot-FLASH MR imaging. AJNR Am J Neuroradiol 1993; 14:89-98.
47. Fujii K, Fujita N, Hirabuki N, Hashimoto T, Miura T, Kozuka T. Neuromas and meningiomas: evaluation of early enhancement with dynamic MR imaging. AJNR Am J Neuroradiol 1992; 13: 1215-1220.
48. Crosby DL, Simonson TM, Fisher D, Magnotta VA, Sato Y, Rezai K. Echo-planar MR imaging: correlation of intracranial perfusion-sensitive imaging with cerebral angiography (abstract). Radiology 1994; 193(Suppl):460.
49. Crosby DL, Yuh WTC, Magnotta VA, Simonson TM, Zheng J, Ehrhardt JC. Comparison of echo-planar imaging with cerebral angiography and T2-weighted MR in the evaluation of transient ischemic attack (abstract). Proc Am Soc Neuroradiol 1995; 19-20.
50. Maeda M, Itoh S, Kimura H, et al. Vascularity of meningiomas and neuromas: assessment with dynamic susceptibility-contrast MR imaging. AJR Am J Roentgenol 1994; 163:181-186.
51. Simonson TM, Yuh WTC, Crosby DL, Magnotta VA, Zheng J, Ehrhardt JC. Echo-planar diffusion and perfusion imaging of ischemia in patients without significant carotid disease (abstract). Proc Am Soc Neuroradiol 1995; 23.
52. Maeda M, Itoh S, Kimura H, et al. Tumor vascularity in the brain: evaluation with dynamic susceptibility-contrast MR imaging. Radiology 1993; 189:233-283.
53. Hittmair K, Gomiscek G, Langenberger K, Recht M, Imhof H, Kramer J. Method for the quantitative assessment of contrast agent uptake in dynamic contrast-enhanced MRI. Magn Reson Med 1994; 31:567-571.
54. Burstein D, Taratuta E, Manning W. Factors in myocardial perfusion imaging with ultrafast MRI and Gd-DTPA administration. Magn Reson Med 1991; 20:299-305.
55. Griebel J, Gneiting T, de Vries A, Debbage P, Lukas P, Kellerer AM. In vivo monitoring of microcirculatory tumor parameters during fractionated radiotherapy: a study in mouse mammary adenocarcinoma using contrast enhanced magnetic resonance imaging (abstract). Int J Radiat Oncol Biol Phys 1996; 36(Suppl):175.
56. Donahue KM, Burstein D, Manning WJ, Gray ML. Studies of Gd-DTPA relaxivity and proton exchange rates in tissue. Magn Reson Med 1994; 32:66-76.
57. Mayr NA, Yuh WTC, Magnotta VA, et al. Tumor perfusion studies using fast magnetic resonance imaging technique in advanced cervical cancer - a new noninvasive predictive assay. Int J Radiat Oncol Biol Phys 1996; 36:623-633.
58. Brix G, Rempp K, Gückel F, Huffman U, Semmler W, Lorenz WJ. Quantitative assessment of tissue microcirculation by dynamic contrast-enhanced MR imaging. Adv MRI Contrast 1994; 2:68-77.
59. Aronen H, Cohen M, Belliveau J, Fordham J, Rosen B. Ultrafast imaging of brain tumors. Top Magn Reson Imaging 1993; 5:14-24.
60. Aronen HJ, Gazit IE, Louis DN, et al. Cerebral blood volume maps of gliomas: comparison with tumor grade and histologic findings. Radiology 1994; 191:41-51.
61. Gückel F, Brix G, Rempp K, Rother J, Georgi M. Assessment of cerebral haemodynamics in patients with vascular disorders and brain tumors. Adv MRI Contrast 1994; 2:94-100.
62. Hess T, Mueller-Schimpfle M, Brix G, et al. Dynamic Gd-DTPA enhanced MRI in the follow-up of cervical carcinoma after combined radio/chemotherapy. Adv MRI Contrast 1994; 2:85-93.
63. deVries A, Judmaier W, Griebel J, et al. Monitoring of tumor microcirculation during fractionated radiotherapy in patients with rectal carcinomas: a clinical study using contrast enhanced MR imaging (abstract). Int J Radiat Oncol Biol Phys 1996; 36(Suppl):377.
64. Yuh WTC, Mayr NA, Zheng J, et al. Can combined volume and perfusion analysis improve the prediction of tumor control in cervical cancer? (abstract). Int J Radiat Oncol Biol Phys 1996; 36:323.
65. Deichman R, Haase A. Quantification of T1 values by snapshot-FLASH-NMR-imaging. J Magn Reson 1992; 96:608-615.
66. Nekolla S, Gneiting T, Syha J, Deichman R, Haase A. T1 maps by K-space reduced Snapshot-FLASH MRI. J Comput Assist Tomogr 1992; 16:327-332.
67. Chappel PM, Pelc NJ, Foo TKF, Glover GH, Haros SP, Enzmann DR. Comparison of lesion enhancement on spin-echo and gradient-echo images. AJNR Am J Neuroradiol 1994; 15:37-44.
68. Rand S, Maravilla KR, Schmiedl U. Lesion enhancement in radio-frequency spoiled gradient-echo imaging: theory, experimental evaluation, and clinical implications. AJNR Am J Neuroradiol 1994; 15:27-35.
69. Mendenhall WM, Thar TL, Bova FJ, Marcus RBJ, Morgan LS, Million RR. Prognostic and treatment factors affecting pelvic control of stage IB and IIA-B carcinoma of the intact uterine cervix treated with radiation therapy alone. Cancer 1984; 53: 2649-2654.
70. Hansgen G, Hansgen K, Dunst J. Oxygen status of cervical cancer prior and during definitive radiotherapy: possible impact of pretreatment with INF-α-2α-Retinol acid on oxygenation (abstract). Int J Radiat Oncol Biol Phys 1996; 36(Suppl.):324.
71. Knopp MV, Brix G, Junkermann H, Sinn P. MR mammography with pharmokinetic mapping for monitoring of breast cancer treatment during neoadjuvant therapy. MRI Clin North Am 1994;2:633-658.
72. Hawighorst H, Engenhart R, Knopp MV, et al. Intracranial meningiomas: time and dose dependent effects of irradiation on tumor microcirculation monitored by dynamic MR imaging. Magn Reson Imaging (in press).
73. Weng F, Rempp K, Hess T, et al. Effect of radiation on blood volume in low-grade astrocytomas and normal brain tissue. AJR Am J Roentgenol 1996;166:187-193.