1995 Whitaker lecture: Delivery of molecules, particles, and cells to solid tumors

Annals of Biomedical Engineering

Volumn 24, Issue 4, 1996, Pages 457-473

  Jain, Rakesh K ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Angiogenesis; Blood flow; Cancer detection and treatment; Cell adhesion and deformation; Diffusion and convection; Interstitial pressure; Lymphatics; Receptor ligand binding; Tumor microcirculation; Vascular permeability

Indexed keywords

ADHESION; AGENTS; CELLS; DIAGNOSIS; DIFFUSION; HEMODYNAMICS; MICROCIRCULATION; MOLECULES; PATIENT TREATMENT; RADIATION; TISSUE;

ANGIOGENESIS; CANCER DETECTION; CELL ADHESION; INTERSTITIAL PRESSURE; LYMPHATICS; RECEPTOR LIGAND BINDING; SOLID TUMORS; THERAPEUTIC AGENTS; VASCULAR PERMEABILITY;

ONCOLOGY;

ANIMAL CELL; BLOOD FLOW; BLOOD VESSEL PERMEABILITY; CANCER DIAGNOSIS; CELL ADHESION; CELL MEMBRANE TRANSPORT; DIFFUSION COEFFICIENT; LEUKOCYTE ADHERENCE; LIGAND BINDING; LYMPHATIC SYSTEM; MICROCIRCULATION; NONHUMAN; REVIEW; SOLID TUMOR; TISSUE PRESSURE;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD FLOW VELOCITY; CAPILLARY PERMEABILITY; CELL ADHESION; CELL MOVEMENT; HUMANS; MICROCIRCULATION; MODELS, BIOLOGICAL; NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC;

EID: 0030198988     PISSN: 00906964     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02648108     Document Type: Article

References (132)

1. Arbit, E., J. Lee, and G. DiResta, Interstitial hypertension in human brain tumors: possible role in peritumoral edema formation. In: Intracranial Pressure, edited by H. Nagai, K. Kamiya, and S. Ishii. Tokyo: Springer-Verlag, 1994, pp. 609-614.
2. Baish, J. W., Y. Gazir, D. A. Berk, M. Nozue, L. T. Baxter, and R. K. Jain. Role of tumor vascular architecture in nutrient and drug delivery: An invasion percolation based network model. Microvasc. Res., in press.
3. Baxter, B. T., and R. K. Jain. Pharmacokinetic analysis of the microscopic distribution of enzyme-conjugated antibodies and prodrugs: Comparison with experimental data. Br. J. Cancer 73:447-456, 1996.
4. Baxter, L. T., and R. K. Jain. Transport of fluid and macromofecules in tumors. I. Role of interstitial pressure and convection. Microvasc. Res. 37:77-104, 1989.
5. Baxter, L. T., and R. K. Jain. Transport of fluid and macromolecules in tumors. II. Role of heterogeneous perfusion and lymphatics. Microvasc. Res. 40:246-263, 1990.
6. Baxter, L. T., and R. K. Jain. Transport of fluid and macromolecules in tumors. III. Role of binding and metabolism. Microvasc. Res. 41:5-23, 1991.
7. Baxter, L. T., and R. K. Jain. Transport of fluid and macromolecules in tumors. IV. A microscopic model of the perivascular distribution. Microvasc. Res. 41:252-272, 1991.
8. Baxter, L. T., F. Yuan, and R. K. Jain. Pharmacokinetic analysis of the perivascular distribution of bifunctional antibodies and haptens: Comparison with experimental data. Cancer Res. 52:5838-5844, 1992.
9. Baxter. L. T., H. Zhu, D. G. Mackensen. W. F. Butler, and R. K. Jain. Biodistribution of monoclonal antibodies: Scale-up from mouse to man using a physiologically based pharmacokinetic model. Cancer Res. 55:4611-4622, 1995.
10. Baxter, L. T., H. Zhu, D. G. Mackensen, and R. K. Jain. Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice. Cancer Res. 54:1517-1528, 1994.
11. Beardsley, T. Trends in cancer epidemiology: A war not won. Sci. Am. 270:118-126, 1994.
12. Berk, D. A., M. A. Swartz, A. J. Leu, and R. K. Jain. Transport in lymphatic capillaries. II. Microscopic velocity measurement with fluorescence recovery after photobleaching. Am. J. Physiol. 270:H330-H337, 1996.
13. Berk, D. A., F. Yuan, M. Leunig, and R. K. Jain. Fluorescence photobleaching with spatial Fourier analysis: Measurement of diffusion in light-scattering media. Biophys. J. 65:2428-2436, 1993.
14. Berk, D. A., F. Yuan, M. Leunig, and R. K. Jam. Interstitial protein transport in a human tumor xenograft: Direct in vivo measurement of specific and nonspecific binding (abstract). Biomedical Engineering Society Meeting, Boston, 1995.
15. Boucher, Y., L. T. Baxter, and R. K. Jam. Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: Implications for therapy. Cancer Res. 50:4478-4484, 1990.
16. Boucher, Y., C. Brekken, P. A. Netti, L. T. Baxter, and R. K. Jam. Hydraulic conductivity of solid tumors: A novel in vivo measurement technique and implications for drug delivery (abstract). Biomedical Engineering Society Meeting, Boston. 1995.
17. Boucher. Y., and R. K. Jain. Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: Implications for vascular collapse. Cancer Res. 52:5110-5114, 1992.
18. Boucher, Y., J. M. Kirkwood, D. Opacic. M. Desantis, and R. K. Jain. Interstitial hypertension in superficial metastatic melanomas in humans. Cancer Res. 51:6691-6694, 1991.
19. Boucher, Y., H. Salehi, B. P. Witwer, G. R. Harsh, and R. K. Jain. Interstitial fluid pressure in intracranial tumors in patients and in rodents (abstract). American Association for Cancer Research Meeting, Toronto, 1995.
20. Chary, S. R., and R. K. Jain. Direct measurement of interstitial convection and diffusion of albumin in normal and neoplastic tissues by fluorescence photobleaching. Proc. Natl. Acad. Sci. USA 86:5385-5389, 1989.
21. Curti, B. D., W. J. Urba, W. G. Alvord, J. E. Janik, J. W. Smith, K. Madara, and D. L. Longo. Interstitial pressure of subcutaneous nodules in melanoma and lymphoma patients: Changes during treatment. Cancer Res. 53:22048-22078, 1993.
22. Dedrick, R. L. Animal scale-up. J. Pharmacokinet. Biopharm. 1:435-461, 1973.
23. Dellian, M., G. Helmlinger, F. Yuan, and R. K. Jain. Interstitial pH in solid tumors measured by fluorescence ratio imaging and optical sectioning: Effect of glucose on spatial and temporal gradients (abstract). Biomedical Engineering Society Meeting, Boston. 1995.
24. Dellian, M., B. P. Witwer, H. Salehi, F. Yuan, and R. K. Jain. Quantitation and physiological characterization of angiogenic vessels in mice: Effect of bFGF, VEGF/VPF and microenvironment. Amer. J. Pathol. in press, 1996.
25. Dudar, T. E., and R. K. Jain. Microcirculatory flow changes during tissue growth. Microvasc. Res. 25:1-21, 1983.
26. Dudar, T. E., and R. K. Jain. Differential response of normal and tumor microcirculation to hyperthermia. Cancer Res. 44:605-612, 1984.
27. Dvorak, H. F., L. F. Brown, M. Detmar, and A. M. Dvorak. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am. J. Pathol. 146:1029-1039, 1995.
28. Endrich, B., H. S. Reinhold, J. F. Gross, and M. Intaglietta. Tissue perfusion inhomogeneity during early tumor growth in rats. J. Natl. Cancer Inst. 62:387-395, 1979.
29. 2H-nuclear magnetic resonance imaging of tumor blood flow: Spatial and temporal heterogeneity in a tissueisolated mammary adenocarcinoma. Cancer Res. 52:6010-6019, 1992.
30. 31P NMR. Proc. Natl. Acad. Sci. USA 90:2646-2650, 1993.
31. Eskey, C. J., N. Wolmark, C. L. McDowell, M. M. Domach, and R. K. Jain. Residence time distributions of various tracers in tumors: Implications for drug delivery and blood flow measurement. J. Natl. Cancer Inst. 86: 293-299, 1994.
32. Fidler, I. J., and L. M. Ellis. The implications of angiogenesis for biology and therapy of cancer metastasis. Cell 79:185-188, 1994.
33. Folkman, J. Tumor angiogenesis. In: The Molecular Basis of Cancer, edited by J. Mendelsohn, P. M. Howley, M. A. Israel, and L. A. Liotta. Philadelphia: W. B. Saunders, 1995, pp. 206-232.
34. Fukumura, D., H. A. Salehi, B. Witwer, R. F. Tuma, R. J. Melder, and R. K. Jain. TNFa-induced leukocyte-adhesion in normal and tumor vessels: Effect of tumor type, transplantation site and host strain. Cancer Res. 55: 4824-4829, 1995.
35. Gamble, J. R., and Y. Khew-Goodall. Transforming growth factor-beta inhibits E-selectin expression on human endothelial cells. J. Immunol. 150:4494-4503, 1993.
36. Gamble J. R., and M. A. Vadas. Endothelial adhesiveness for blood neutrophils is inhibited by transforming growth factor-beta. Science 242:97-99, 1988.
37. Gamble, J. R., and M. A. Vadas. Endothelial cell adhesiveness for human T lymphocytes is inhibited by transforming growth factor-beta. J. Immunol. 146;1149-1154, 1991.
38. Gazit, Y., D. A. Berk, M. Leunig, L. T. Baxter, and R. K. Jain. Scale-invariant behavior and vascular network formation in normal and tumor tissue. Phys. Rev. Lett. 75:2428-2431, 1995.
39. Gerlowski, L. E., and R. K. Jain. Physiologically based pharmacokinetic modeling: Principles and applications. J. Pharm. Sci. 72:1103-1127, 1983.
40. Gerlowski, L. E., and R. K. Jain. Effect of hyperthermia on microvascular permeability to macromolecules in normal tissues. Int. J. Microcirc. Clin. Exp. 4:363-372, 1985.
41. Gerlowski, L. E., and R. K. Jain. Microvascular permeability of normal and neoplastic tissues. Microvasc. Res. 31:288-305, 1986.
42. Gullino, P. M. Techniques in tumor pathophysiology. In: Methods in Cancer Research, edited by H. Busch. New York: Academic Press, 1970, pp. 45-92.
43. Gutmann, R., M. Leunig, J. Feyh, A. E. Goetz, K. Messmer, E. Kastenbauer, and R. K. Jain. Interstitial hypertension in head and neck tumors in patients: Correlation with tumor size. Cancer Res. 52:1993-1995, 1992.
44. Hamberg, L. M., P. E. Kristjansen, G. J. Hunter, G. L. Wolf, and R. K. Jain. Spatial heterogeneity in tumor perfusion measured with functional computed tomography at 0.05 microliter resolution. Cancer Res. 54:6032-6036, 1994.
45. Haying, J. B., and S. K. Williams. Reduced adhesion of human microvascular endothelial cells to collagen in response to basic FGF is mediated by β1 integrin. FASEB J. 8: p. A45, Abstract 263, 1994.
46. Jain, R. K. Effect of inhomogeneities and finite boundaries on temperature distribution in a perfused medium with application to tumors. Trans. ASME J. Biomech. Eng. 100:235-241, 1978.
47. Jain, R. K. Transient temperature distribution in an infinite perfused medium due to a time-dependent, spherical heat source. Trans. ASME J. Biomech. Eng. 101:82-86, 1979.
48. Jain, R. K. Transport of molecules across tumor vasculature. Cancer Metastasis Rev. 6:559-593, 1987.
49. Jain, R. K. Transport of molecules in the tumor interstitium: A review. Cancer Res. 47:3039-3051, 1987.
50. Jain, R. K. Determinants of tumor blood flow: A review. Cancer Res. 48:2641-2658, 1988.
51. Jam, R. K. Delivery of novel therapeutic agents in tumor: Physiological barriers and strategies. J. Natl. Cancer Inst. 81:570-576, 1989.
52. Jain, R. K. Barriers to drug delivery in solid tumors. Sci. Am. 271:58-65, 1994.
53. Jain, R. K. Transport phenomena in tumors. Adv. Chem. Eng. 20:129-200, 1994.
54. Jain, R. K., and L. T. Baxter. Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: Significance of elevated interstitial pressure. Cancer Res. 48:7022-7032, 1988.
55. Jain, R. K., Y. Boucher, A. Stacey-Clear, R. Moore, and D. Kopans. Method for locating tumors prior to needle biopsy. U.S. Patent 5,396,897, March 14, 1995.
56. Jain, R. K., G. C. Koenig, M. Dellian, D. Fukumura, L. L. Munn, and R. J. Melder. Leukocyte-endothelial adhesion and angiogenesis in tumors. Cancer Metastasis Rev. in press, 1996.
57. Jain, R. K., S. A. Shah, and P. L. Finney. Continuous noninvasive monitoring of pH and temperature in rat Walker 256 carcinoma during normoglycemia and hyperglycemia. J. Natl. Cancer Inst. 73:429-436, 1984.
58. Jain, R. K., and K. A. Ward-Hartley. Tumor blood flow: Characterization, modifications and role in hyperthermia. IEEE Trans. Sonics Ultrasonics 31:504-526, 1984.
59. Jain, R. K., and J. Wei. Dynamics of drug transport in solid tumors: Distributed parameter model. J. Bioeng. 1: 313-329, 1977.
60. Jain, R. K., J. Wei, and P. M. Gullino. Pharmacokinetics of methotrexate in solid tumors. J. Pharmacokinet. Biopharm. 7:181-194, 1979.
61. Jallal, B., F. Powell, J. Zachwieja, C. Brakebusch, L. Germain, J. Jacobs, S. Iacobelli, and A. Ullrich. Suppression of tumor growth in vivo by local and systemic 90K level increase. Cancer Res. 55:3223-3227, 1995.
62. Johnson, E. M., D. A. Berk, R. K. Jain, and W. M. Deen. Diffusion and partitioning of proteins in charged agarose gels. Biophys. J. 68:1561-1568, 1995.
63. Johnson, E. M., D. A. Berk, R. K. Jain, and W. M. Deen. Hindered diffusion in agarose gels: Test of effective medium model. Biophys. J. 70:1017-1026, 1996.
64. Juweid, M., R. Neumann, C. Paik, M. J. Perez-Bacete, J. Sato, W. Van Osdol, and J. N. Weinstein. Micropharmacology of monoclonal antibodies in solid tumor: Direct experimental evidence for a binding site barrier. Cancer Res. 52:5144, 1992.
65. Kaufman, E. N., and R. K. Jain. Quantification of transport and binding parameters using fluorescence recovery after photobleaching. Potential for in vivo applications. Biophys. J. 58:873-885, 1990.
66. Kaufman, E. N., and R. K. Jain. Measurement of mass transport and reaction parameters in bulk solution using photobleaching. Reaction limited binding regime. Biophys. J. 60:596-610, 1991.
67. Kaufman, E. N., and R. K. Jain. Effect of bivalent interaction upon apparent antibody affinity: Experimental confirmation of theory using fluorescence photobleaching and implications for antibody binding assays. Cancer Res. 52: 4157-4167, 1992.
68. Kaufman, E. N., and R. K. Jain. In vitro measurement and screening of monoclonal antibody affinity using fluorescence photobleaching. J. Immunol. Methods 155:1-17, 1992.
69. Kitayama, J., J. Nagawa, H. Yasuhara, N. Tsuno, W. Kimura, Y. Shibata, and T. Muto. Suppressive effect of basic fibroblast growth factor on transendothelial emigration of CD4(+) T-lymphocyte. Cancer Res. 54:4729-4733, 1994.
70. Kristjansen, P. E., Y. Boucher, and R. K. Jain. Dexamethasone reduces the interstitial fluid pressure in a human colon adenocarcinoma xenograft. Cancer Res. 53:4764-4766, 1993.
71. Kristjansen, P. E., S. Roberge, I. Lee, and R. K. Jain. Tissue-isolated human tumor xenografts in athymic nude mice. Microvasc. Res. 48:389-402, 1994.
72. Kristjansen, P. E. G., T. J. Brown, L. A. Shipley, and R. K. Jain. Intratumor pharmacokinetics, flow resistance, and metabolism during gemcitabine infusion in ex vivo perfused human small cell lung cancer. Clin. Cancer Res. 2:359-367, 1996.
73. Lee, I., Y. Boucher, T. J. Demhartner, and R. K. Jain. Changes in tumor blood flow, oxygenation and interstitial fluid pressure induced by pentoxifylline. Br. J. Cancer 69:492-496, 1994.
74. Lee, I., Y. Boucher, and R. K. Jain. Nicotinamide can lower tumor interstitial fluid pressure: Mechanistic and therapeutic implications. Cancer Res. 52:3237-3240, 1992.
75. Lee, I., T. J. Demhartner, Y. Boucher, R. K. Jain, and M. Intaglietta. Effect of hemodilution and resuscitation on tumor interstitial fluid pressure, blood flow, and oxygenation. Microvasc. Res. 48:1-12, 1994.
76. Less, J. R., M. C. Posner, Y. Boucher, D. Borochovitz, N. Wolmark, and R. K. Jain. Interstitial hypertension in human breast and colorectal tumors. Cancer Res. 52:6371-6374, 1992.
77. Less, J. R., M. C. Posner, N. Wolmark, and R. K. Jain. Geometric resistance to blood flow and vascular network architecture in human colorectal carcinoma (abstract). American Association for Cancer Research Meeting, Houston, 1991.
78. Less, J. R., T. C. Skalak, E. M. Sevick, and R. K. Jain. Microvascular architecture in a mammary carcinoma: Branching patterns and vessel dimensions. Cancer Res. 51:265-273, 1991.
79. Leu, A. J., D. A. Berk, F. Yuan, and R. K. Jain. Flow velocity in the superficial lymphatic network of the mouse tail. Am. J. Physiol. 267:H1507-H1513, 1994.
80. Leunig, M., A. E. Goetz, M. Dellian, G. Zetterer, F. Gamarra, R. K. Jain, and K. Messmer. Interstitial fluid pressure in solid tumors following hyperthermia: Possible correlation with therapeutic response. Cancer Res. 52:487-490, 1992.
81. Leunig, M., A. E. Goetz, F. Gamarra, G. Zetterer, K. Messmer, and R. K. Jain. Photodynamic therapy-induced alterations in interstitial fluid pressure, volume and water content of an amelanotic melanoma in the hamster. Br. J. Cancer 69:101-103, 1994.
82. Leunig, M., F. Yuan, D. A. Berk, L. E. Gerweck, and R. K. Jain. Angiogenesis and growth of isografted bone: Quantitative in vivo assay in nude mice. Lab. Invest. 71: 300-307, 1994.
83. Leunig, M., F. Yuan, M. D. Menger, Y. Boucher, A. E. Goetz, K. Messmer, and R. K. Jain. Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice. Cancer Res. 52:6553-6560, 1992.
84. Lichtenbeld, H., F. Yuan, C. C. Michel, and R. K. Jain. Perfusion of single tumor vessels (abstract). American Association for Cancer Research Meeting, Toronto, 1995.
85. Martin, G. R., and R. K. Jain. Fluorescence ratio imaging measurement of pH gradients: Calibration and application in normal and tumor tissues. Microvasc. Res. 46:216-230, 1993.
86. Martin, G. R., and R. K. Jain. Noninvasive measurement of interstitial pH profiles in normal and neoplastic tissue using fluorescence ratio imaging microscopy. Cancer Res. 54:5670-5674, 1994.
87. Melder, R. J., A. L. Brownell, T. M. Shoup, G. L. Brownell, and R. K. Jain. Imaging of activated natural killer cells in mice by positron emission tomography: Preferential uptake in tumors. Cancer Res. 53:5867-5871, 1993.
88. Melder, R. J., D. Elmaleh, A. L. Brownell, G. L. Brownell, and R. K. Jain. A method for labeling cells for positron emission tomography (PET) studies. J. Immunol. Methods 175:79-87, 1994.
89. Melder, R. J., and R. K. Jain. Kinetics of interleukin-2 induced changes in rigidity of human natural killer cells. Cell Biophys. 20:161-176, 1992.
90. Melder, R. J., and R. K. Jain. Reduction of rigidity in human activated natural killer cells by thioglycollate treatment. J Immunol. Methods 175:69-77, 1994.
91. Melder, R. J., G. Koenig, B. Witwer, N. Safabakhsh, L. L. Munn, and R. K. Jain. Activated natural killer cells bind angiogenic vessels through CD 18 and VLA4 dependent adhesion (abstract,). American Association for Cancer Research Meeting, Washington, DC, 1996.
92. Melder, R. J., L. L. Munn, S. Yamada. C. Ohkubo, and R. K. Jain. Selectin and integrin mediated T lymphocyte rolling and arrest on TNFα-activated endothelium is augmented by erythrocytes. Biophys. J. 69:2131-2138, 1995.
93. Melder, R. J., H. A. Salehi, and R. K. Jain. Localization of activated natural killer cells in MCaIV mammary carcinoma grown in cranial windows in C3H mice. Microvasc. Res. 50:35-44, 1995.
94. Munn, L., G. C. Koenig, R. K. Jain, and R. J. Melder. Kinetics of adhesion molecule expression and spatial organization using targeted sampling fluorometry. BioTechniques 19:622-631, 1995.
95. Munn, L. L., R. J. Melder, and R. K. Jain. Analysis of cell flux in the parallel plate flow chamber: Implications for cell capture studies. Biophys. J. 67:889-895, 1994.
96. Nathanson, S. D., and L. Nelson. Interstitial fluid pressure in breast cancer, benign breast conditions, and breast parenchyma. Ann. Surg. Oncol. 1:333-338, 1994.
97. Netti, P. A., L. T. Baxter, Y. Boucher, and R. K. Jain. Effect of transvascular fluid exchange on arterio-venous pressure relationship: Implication for temporal and spatial heterogeneities in tumor blood flow. Microvasc. Res. in press, 1996.
98. Netti, P. A., L. T. Baxter, Y. Boucher, R. Skalak, and R. K. Jain. Time dependent behavior of interstitial fluid pressure in solid tumors: Implications for drug delivery. Cancer Res. 55:5451-5458, 1995.
99. Nugent, L. J., and R. K. Jain. Extravascular diffusion in normal and neoplastic tissues. Cancer Res. 44:238-244, 1984.
100. Ohkubo, C., D. Bigos, and R. K. Jain. Interleukin 2 induced leukocyte adhesion to the normal and tumor microvascular endothelium in vivo and its inhibition by dextran sulfate: Implications for vascular leak syndrome. Cancer Res. 51:1561-1563, 1991.
101. Patan, S., L. L. Munn, and R. K. Jain. Intussusceptive microvascular growth in solid tumors: A novel mechanism of tumor angiogenesis. Microvasc. Res. 51:260-272, 1996.
102. Pierson, R. N., D. C. Price, J. Wang, and R. K. Jain. Extracellular water measurements: Organ tracer kinetics of bromide and sucrose in rats and man. Am. J. Physiol. 235:254-264, 1978.
103. Rippe, B., and B. Haraldsson. Fluid and protein fluxes across small and large pores in the microvasculature. Application of two-pore equations. Acta Physiol. Scand. 131: 411-428, 1987.
104. Roh, H. D., Y. Boucher, S. Kamicki, R. Buchsbaum, W. D. Bloomer, and R. K. Jain. Interstitial hypertension in carcinoma of uterine cervix in patients: Possible correlation with tumor oxygenation and radiation response. Cancer Res. 51:6695-6698, 1991.
105. Sasaki, A., R. K. Jain. A. A. Maghazachi, R. H. Goldfarb, and R. B. Herberman. Low deformability of lymphokine-activated killer cells as a possible determinant of in vivo distribution. Cancer Res. 49:3742-3746, 1989.
106. Sasaki, A., R. J. Melder, T. L. Whiteside, R. B. Herberman, and R. K. Jain. Preferential localization of human adherent lymphokine-activated killer cells in tumor microcirculation. J. Natl. Cancer Inst. 83:433-437, 1991.
107. Sevick, E. M., and R. K. Jain. Blood flow and venous pH of tissue-isolated Walker 256 carcinoma during hyperglycemia. Cancer Res. 48:1201-1207, 1988.
108. Sevick, E. M., and R. K. Jain. Geometric resistance to blood flow in solid tumors perfused ex vivo: Effects of tumor size and perfusion pressure. Cancer Res. 49:3506-3512, 1989.
109. Sevick, E. M., and R. K. Jain. Viscous resistance to blood flow in solid tumors: Effect of hematocrit on intratumor blood viscosity. Cancer Res. 49:3513-3519, 1989.
110. Sevick, E. M., and R. K. Jain. Effect of red blood cell rigidity on tumor blood flow: Increase in viscous resistance during hyperglycemia. Cancer Res. 51:2727-2730, 1991.
111. Sevick, E. M., and R. K. Jain. Measurement of capillary filtration coefficient in a solid tumor. Cancer Res. 51: 1352-1355, 1991.
112. Stohrer, M., Y. Boucher, M. Stangassinger, and R. K. Jain. Oncotic pressure in human tumor xenografts (abstract). American Association for Cancer Research Meeting, Toronto, 1995.
113. Swabb, E. A., J. Wei, and P. M. Gullino. Diffusion and convection in normal and neoplastic tissues. Cancer Res. 34:2814, 1974.
114. Swartz, M. A., D. A. Berk, and R. K. Jain. Transport in lymphatic capillaries. I. Macroscopic measurements using residence time distribution theory. Am. J. Physiol. 270:H324-H329, 1996.
115. Torres-Filho, I. P., M. Leunig, F. Yuan, M. Intaglietta, and R. K. Jain. Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice. Proc. Natl. Acad. Sci. USA 91:2081-2085, 1994.
116. Traykov, T. T., and R. K. Jain. Effect of glucose and galactose on red blood cell membrane deformability. Int. J. Microcirc. Clin. Exp. 6:35-44, 1987.
117. Vaupel, P., and R. K. Jain. Tumor Blood Supply and Metabolic Environment. Stuttgart, Germany: Gustav Fischer Verlag, 1991, pp. 1-340.
118. Ward, K. A., and R. K. Jain. Response of tumours to hyperglycemia: Characterization, significance and role in hyperthermia. Int. J. Hyperthermia 4:223-250, 1988.
119. Yamada, S., T. N. Mayadas, F Yuan, D. D. Wagner, R. O. Hynes, R. J. Melder and R. K. Jain. Rolling in P-selectin deficient mice is reduced but not eliminated in the dorsal skin. Blood 86:3487-3492, 1995.
120. Yamada, S., R. J. Melder, M. Leunig, C. Ohkubo, and R, K. Jain. Leukocyte-rolling increases with age. Blood 86:4707-4708, 1995.
121. Yuan F., L. T. Baxter, and R. K. Jain. Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies. Cancer Res. 51:3119-3130, 1991.
122. Yuan, F., M. Dellian, D. Fukumura, M. Leunig, D. A. Berk, V. P. Torchillin, and R. K. Jain. Vascular permeability in a human tumor xenograft: Molecular size-dependence and cut-off size. Cancer Res. 55:3752-3756, 1995.
123. Yuan F., M. Leunig, D. A. Berk, and R. K. Jain. Microvascular permeability of albumin, vascular surface area, and vascular volume measured in human adenocarcinoma LS174T using dorsal chamber in SCID mice. Microvasc. Res. 45:269-289, 1993.
124. Yuan, F., M. Leunig, S. K. Huang, D. A. Berk, D. Papahadjopoulos, and R. K. Jain. Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft. Cancer Res. 54: 3352-3356, 1994.
125. Yuan, F., H. A. Salehi, Y. Boucher, U. S. Vasthare, R. F. Tuma, and R. K. Jain. Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows. Cancer Res. 54:4564-4568, 1994.
126. Zawicki, D. F., R. K. Jain, G. W. Schmid-Schoenbein. and S. Chien. Dynamics of neovascularlization in normal tissue. Microvasc. Res. 21:27-47, 1981.
127. Zhu, H., R. Melder, L. Baxter, and R. K. Jain. Physiologically-based kinetic model of effector cell biodistribution in mammals: Implications for adoptive immunotherapy. J. Nuclear Med. in press, 1996.
128. Zlotecki, R. A., L. T. Baxter, Y. Boucher, and R. K. Jain. Pharmacologic modification of tumor blood flow and interstitial fluid pressure in a human tumor xenograft: Network analysis and mechanistic interpretation. Microvasc. Res. 50:429-443, 1995.
129. Zlotecki, R. A., Y. Boucher, I. Lee, L. T. Baxter, and R. K. Jain. Effect of angiotensin II induced hypertension on tumor blood flow and interstitial fluid pressure. Cancer Res. 53:2466-2468, 1993.
130. Znati, C. A., Y. Boucher, M. Rosenstein, D. Turner, S. Watkins, and R. K. Jain. Effect of radiation on the interstitial matrix and hydraulic conductivity of tumors (abstract). American Association for Cancer Research Meeting, Washington. DC, 1996.
131. Znati, C. A., K. Karasek, C. Faul, H.-D. Roh, Y. Boucher, M. Rosenstein, S. Kalnicki, R. Buchsbaum, A. Chen, W. D. Bloomer, and R. K. Jain. Interstitial fluid pressure changes in cervical carcinoma patients undergoing radiation therapy: A potential prognostic factor (abstract). Radiation Research Society Meeting, Chicago, 1996.
132. Znati, C. A., M. Rosenstein, Y. Boucher, M. W. Epperly, W. D. Bloomer, and R. K. Jain. Effect of radiation on interstitial fluid pressure and oxygenation in a human colon carcinoma xenograft. Cancer Res. 56:964-968, 1996.