Solid phase synthesis of N-acyl-2-substituted-dihydro-4-pyridone: Resin activation/capture approach/REACAP technology

Tetrahedron Letters

Volumn 39, Issue 38, 1998, Pages 6781-6784

  Chen, Chixu ^a   Munoz, Benito ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PYRIDONE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; TECHNOLOGY;

EID: 0032541679     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)01489-0     Document Type: Article

References (13)

1. 1) For reviews see: a) Brown, R. Contemp. Org. Synth. 1997, 4, 216-237.
2. b) Hermkens, P.H.H.; Ottenheijm, H.C.J.; Rees, D. Tetrahedron. 1996, 52, 4527-4554.
3. c) Thompson, L.A.; Ellman, J. A. Chem. Rev. 1996, 96, 555-600.
4. d) Terrett, N.K.; Gardner, M.; Gordon, D.W.; Kobylecki, R.J.; Steele, J. Tetrahedron 1995, 51, 8135-8173.
5. 2) Chen, C.; McDonald, I.A.; Munoz, B. Tetrahedron Lett. 1998,39, 217-220.
6. 3) Chen, C.; Munoz, B. Tetrahedron Lett. 1998, 39, 3401-3404.
7. 4) Wang, Y.; Wilson, S.R. Tetrahedron Lett. 1997, 38, 4021-4024.
8. 5) Rano, T.A.; Chapman, K.T. Tetrahedron Lett. 1995, 36, 3789-3792.
9. 6) Cleavage of the resin-bound ether (5) indicated a 92% loading efficiency based on isolation of 4-hydroxypyridine (4).
10. 7) a) Kaldor, S.W.; Siegel, M.G.; Fritz, J.E.; Dressman, B.A.; Hahn, P.J. Tetrahedron Lett. 1996, 37, 7193-7196.
11. b) Booth, R.J.; Hodges, J.C. J. Am. Chem. Soc. 1997, 119, 4882-4886.
12. c) Xu, W.; Mohan, R. Morrissey, M. Tetrahedron Lett. 1997, 38, 7337-7340.
13. + 296.1087, found 296.1101.