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Volumn 23, Issue 6, 1998, Pages 643-654

High throughput purification methods in combinatorial solution phase synthesis

Author keywords

[No Author keywords available]

Indexed keywords

AVIDIN; CARBON TETRACHLORIDE; CARBOXYLIC ACID; DENDRIMER; ETHER; FLUOROCARBON; GUANIDINE; MACROGOL; POLYMER; RESIN; SOLVENT; TETRAHYDROFURAN; TETRAMIC ACID DERIVATIVE; TIN; TIN DERIVATIVE; UREA;

EID: 0031817880     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.1998.023.06.858429     Document Type: Review
Times cited : (33)

References (70)
  • 2
    • 2842561522 scopus 로고    scopus 로고
    • Design, synthesis, and evaluation of small-molecule libraries
    • Ellman, J.A. Design, synthesis, and evaluation of small-molecule libraries. Acc Chem Res 1996, 29: 132-43.
    • (1996) Acc Chem Res , vol.29 , pp. 132-143
    • Ellman, J.A.1
  • 3
    • 7044263277 scopus 로고    scopus 로고
    • Synthesis and applications of small molecule libraries
    • Thompson, L.A., Ellman, J.A. Synthesis and applications of small molecule libraries. Chem Rev 1996, 96: 555-600.
    • (1996) Chem Rev , vol.96 , pp. 555-600
    • Thompson, L.A.1    Ellman, J.A.2
  • 4
    • 0030939592 scopus 로고    scopus 로고
    • Combinatorial chemistry in drug discovery
    • Hogan, J.C. Jr. Combinatorial chemistry in drug discovery. Nat Biotechnol 1997, 15: 328-30.
    • (1997) Nat Biotechnol , vol.15 , pp. 328-330
    • Hogan Jr., J.C.1
  • 6
    • 0029930278 scopus 로고    scopus 로고
    • Solid-phase organic reactions: A review of the recent literature
    • Hermkens, P.H.H., Ottenheijm, H.C.J., Rees, D. Solid-phase organic reactions: A review of the recent literature. Tetrahedron 1996, 52: 4527-54.
    • (1996) Tetrahedron , vol.52 , pp. 4527-4554
    • Hermkens, P.H.H.1    Ottenheijm, H.C.J.2    Rees, D.3
  • 7
    • 0031001699 scopus 로고    scopus 로고
    • Solid-phase organic reactions. II: A review of the literature Nov 95-Nov 96
    • Hermkens, P.H.H., Ottenheijm, H.C.J., Rees, D.C. Solid-phase organic reactions. II: A review of the literature Nov 95-Nov 96. Tetrahedron 1997, 53: 5643-78.
    • (1997) Tetrahedron , vol.53 , pp. 5643-5678
    • Hermkens, P.H.H.1    Ottenheijm, H.C.J.2    Rees, D.C.3
  • 8
    • 0001655235 scopus 로고    scopus 로고
    • Functionalized resins and linkers for solid-phase synthesis of small molecules
    • Blackburn, C., Albericio, F., Kates, S.A. Functionalized resins and linkers for solid-phase synthesis of small molecules. Drugs Fut 1997, 22: 1007-25.
    • (1997) Drugs Fut , vol.22 , pp. 1007-1025
    • Blackburn, C.1    Albericio, F.2    Kates, S.A.3
  • 9
    • 0000987024 scopus 로고    scopus 로고
    • Solution-phase synthesis in combinatorial chemistry: Applications in drug discovery
    • Storer, R. Solution-phase synthesis in combinatorial chemistry: Applications in drug discovery. Drug Discov Today 1996, 1: 248-54.
    • (1996) Drug Discov Today , vol.1 , pp. 248-254
    • Storer, R.1
  • 10
    • 0001534308 scopus 로고    scopus 로고
    • Novel solution- and solid-phase strategies for the parallel and combinatorial synthesis of low-molecular-weight compound libraries
    • Chucholowski, A., Masquelin, T., Obrecht, D., Stadlwieser, J., Villalgordo, J.M. Novel solution-and solid-phase strategies for the parallel and combinatorial synthesis of low-molecular-weight compound libraries. Chimia 1996, 50: 525-30.
    • (1996) Chimia , vol.50 , pp. 525-530
    • Chucholowski, A.1    Masquelin, T.2    Obrecht, D.3    Stadlwieser, J.4    Villalgordo, J.M.5
  • 11
    • 0001334659 scopus 로고    scopus 로고
    • Solution phase synthesis of chemical libraries for lead discovery
    • Garr, C.D., Peterson, J.R., Schultz, L. et al. Solution phase synthesis of chemical libraries for lead discovery. J Biomol Screen 1996, 1: 179-86.
    • (1996) J Biomol Screen , vol.1 , pp. 179-186
    • Garr, C.D.1    Peterson, J.R.2    Schultz, L.3
  • 13
    • 0001537457 scopus 로고    scopus 로고
    • Solution-phase combinatorial chemistry in lead discovery
    • Bailey, N., Cooper, A.W.J., Deal, M.J. et al. Solution-phase combinatorial chemistry in lead discovery. Chimia 1997, 51: 832-7.
    • (1997) Chimia , vol.51 , pp. 832-837
    • Bailey, N.1    Cooper, A.W.J.2    Deal, M.J.3
  • 14
    • 0030964314 scopus 로고    scopus 로고
    • Solution-phase synthesis of a combinatorial thiohydantoin library
    • Sim, M.M., Ganesan, A. Solution-phase synthesis of a combinatorial thiohydantoin library. J Org Chem 1997, 62: 3230-5.
    • (1997) J Org Chem , vol.62 , pp. 3230-3235
    • Sim, M.M.1    Ganesan, A.2
  • 15
    • 0000965816 scopus 로고    scopus 로고
    • Combinatorial synthesis of 2-thioxo-4-dihydropyrimidinones
    • Sim, M.M., Lee, C.L., Ganesan, A. Combinatorial synthesis of 2-thioxo-4-dihydropyrimidinones. J Org Chem 1997, 62: 9358-60.
    • (1997) J Org Chem , vol.62 , pp. 9358-9360
    • Sim, M.M.1    Lee, C.L.2    Ganesan, A.3
  • 16
    • 0030745360 scopus 로고    scopus 로고
    • Rapid in-plate generation of benzimidazole libraries and amide formation using EEDQ
    • Thomas, J.B., Fall, M.J., Cooper, J.B., Burgess, J.P., Carroll, F.I. Rapid in-plate generation of benzimidazole libraries and amide formation using EEDQ. Tetrahedron Lett 1997, 38: 5099-102.
    • (1997) Tetrahedron Lett , vol.38 , pp. 5099-5102
    • Thomas, J.B.1    Fall, M.J.2    Cooper, J.B.3    Burgess, J.P.4    Carroll, F.I.5
  • 17
    • 0001534480 scopus 로고
    • Novel method for preparation of libraries of small organic molecules
    • Carell, T., Wintner, E.A., Bashir-Hashemi, A., Rebek, J. Jr. Novel method for preparation of libraries of small organic molecules. Angew Chem 1994, 106: 2159-62.
    • (1994) Angew Chem , vol.106 , pp. 2159-2162
    • Carell, T.1    Wintner, E.A.2    Bashir-Hashemi, A.3    Rebek Jr., J.4
  • 18
    • 33751134981 scopus 로고    scopus 로고
    • A strategy of "random glycosidation" for the production of oligosaccharide libraries
    • Kanie, O., Barresi, F., Ding, Y. et al. A strategy of "random glycosidation" for the production of oligosaccharide libraries. Angew Chem Int Ed Engl 1996, 34: 2720-2.
    • (1996) Angew Chem Int Ed Engl , vol.34 , pp. 2720-2722
    • Kanie, O.1    Barresi, F.2    Ding, Y.3
  • 19
    • 0029257836 scopus 로고
    • New promise in combinatorial chemistry: Synthesis, characterization, and screening of small-molecule libraries in solution
    • Carell, T., Wintner, E.A., Sutherland, A.J., Rebek, J.J., Dunayevskiy, Y.M., Vouros, P. New promise in combinatorial chemistry: Synthesis, characterization, and screening of small-molecule libraries in solution. Chem Biol 1995, 2: 171-83.
    • (1995) Chem Biol , vol.2 , pp. 171-183
    • Carell, T.1    Wintner, E.A.2    Sutherland, A.J.3    Rebek, J.J.4    Dunayevskiy, Y.M.5    Vouros, P.6
  • 20
    • 0030607193 scopus 로고    scopus 로고
    • Solution phase combinatorial chemistry. I. Synthesis of polyazacyclophane scaffolds and tertiary amine libraries
    • An, H., Cook, P.D. Solution phase combinatorial chemistry. I. Synthesis of polyazacyclophane scaffolds and tertiary amine libraries. Tetrahedron Lett 1996, 37: 7233-6.
    • (1996) Tetrahedron Lett , vol.37 , pp. 7233-7236
    • An, H.1    Cook, P.D.2
  • 21
    • 0030743265 scopus 로고    scopus 로고
    • Solution phase combinatorial chemistry. Synthesis of novel linear pyridinopolyamine libraries with potent antibacterial activity
    • An, H., Haly, B.D., Fraser, A.S., Guinosso, C.J., Cook, P.D. Solution phase combinatorial chemistry. Synthesis of novel linear pyridinopolyamine libraries with potent antibacterial activity. J Org Chem 1997, 62: 5156-64.
    • (1997) J Org Chem , vol.62 , pp. 5156-5164
    • An, H.1    Haly, B.D.2    Fraser, A.S.3    Guinosso, C.J.4    Cook, P.D.5
  • 22
    • 0030959257 scopus 로고    scopus 로고
    • Solution phase combinatorial chemistry. Discovery of novel polyazapyridinophanes with potent antibacterial activity by a solution phase simultaneous addition of functionalities approach
    • An, H., Cummins, L.L., Griffey, R.H. et al. Solution phase combinatorial chemistry. Discovery of novel polyazapyridinophanes with potent antibacterial activity by a solution phase simultaneous addition of functionalities approach. J Am Chem Soc 1997, 119: 3696-708.
    • (1997) J Am Chem Soc , vol.119 , pp. 3696-3708
    • An, H.1    Cummins, L.L.2    Griffey, R.H.3
  • 23
    • 0029926720 scopus 로고    scopus 로고
    • Novel solution phase strategy for the synthesis of chemical libraries containing small organic molecules
    • Cheng, S., Comer, D.D., Williams, J.P., Myers, P.L., Boger, D.L. Novel solution phase strategy for the synthesis of chemical libraries containing small organic molecules. J Am Chem Soc 1996, 118: 2567-73.
    • (1996) J Am Chem Soc , vol.118 , pp. 2567-2573
    • Cheng, S.1    Comer, D.D.2    Williams, J.P.3    Myers, P.L.4    Boger, D.L.5
  • 24
    • 0029950789 scopus 로고    scopus 로고
    • A solution-phase strategy for the synthesis of chemical libraries containing small organic molecules: A universal and dipeptide mimetic template
    • Cheng, S., Tarby, C.M., Comer, D.D. et al. A solution-phase strategy for the synthesis of chemical libraries containing small organic molecules: A universal and dipeptide mimetic template. Bioorg Med Chem 1996, 4: 727-37.
    • (1996) Bioorg Med Chem , vol.4 , pp. 727-737
    • Cheng, S.1    Tarby, C.M.2    Comer, D.D.3
  • 25
    • 0029987185 scopus 로고    scopus 로고
    • Generalized dipeptidomimetic template: Solution phase parallel synthesis of combinatorial libraries
    • Boger, D.L., Tarby, C.M., Myers, P.L., Caporale, L.H. Generalized dipeptidomimetic template: Solution phase parallel synthesis of combinatorial libraries. J Am Chem Soc 1996, 118: 2109-10.
    • (1996) J Am Chem Soc , vol.118 , pp. 2109-2110
    • Boger, D.L.1    Tarby, C.M.2    Myers, P.L.3    Caporale, L.H.4
  • 26
    • 0030744021 scopus 로고    scopus 로고
    • Generation of targeted C2-symmetrical compound libraries by solution-phase combinatorial chemistry
    • Boger, D.L., Ozer, R.S., Andersson, C.-M. Generation of targeted C2-symmetrical compound libraries by solution-phase combinatorial chemistry. Bioorg Med Chem Lett 1997, 7: 1903-8.
    • (1997) Bioorg Med Chem Lett , vol.7 , pp. 1903-1908
    • Boger, D.L.1    Ozer, R.S.2    Andersson, C.-M.3
  • 27
    • 0031576842 scopus 로고    scopus 로고
    • Solution-phase combinatorial synthesis via the olefin metathesis reaction
    • Boger, D.L., Chai, W., Ozer, R.S., Anderson C.-M. Solution-phase combinatorial synthesis via the olefin metathesis reaction. Bioorg Med Chem Lett 1997, 7: 463-8.
    • (1997) Bioorg Med Chem Lett , vol.7 , pp. 463-468
    • Boger, D.L.1    Chai, W.2    Ozer, R.S.3    Anderson, C.-M.4
  • 28
    • 0030910078 scopus 로고    scopus 로고
    • Solution phase combinatorial synthesis of arylpiperazines
    • Neuville, L., Zhu, Z. Solution phase combinatorial synthesis of arylpiperazines. Tetrahedron Lett 1997, 38: 4091-4.
    • (1997) Tetrahedron Lett , vol.38 , pp. 4091-4094
    • Neuville, L.1    Zhu, Z.2
  • 29
    • 0028116495 scopus 로고
    • Facile catalyst separation without water: Fluorous biphase hydroformylation of olefins
    • Horvath, I.T., Rabai, J. Facile catalyst separation without water: Fluorous biphase hydroformylation of olefins. Science 1994, 266: 72-5.
    • (1994) Science , vol.266 , pp. 72-75
    • Horvath, I.T.1    Rabai, J.2
  • 30
    • 0030772233 scopus 로고    scopus 로고
    • Fluorous biphase systems: The new phase-separation and immobilization technique
    • Cornils, B. Fluorous biphase systems: The new phase-separation and immobilization technique. Angew Chem Int Ed Engl 1997, 36: 2057-9.
    • (1997) Angew Chem Int Ed Engl , vol.36 , pp. 2057-2059
    • Cornils, B.1
  • 31
    • 0002813543 scopus 로고    scopus 로고
    • Combinatorial organic synthesis and phase separation: Back to the future
    • Curran, D.P. Combinatorial organic synthesis and phase separation: Back to the future. Chemtracts: Org Chem 1996, 9: 75-87.
    • (1996) Chemtracts: Org Chem , vol.9 , pp. 75-87
    • Curran, D.P.1
  • 32
    • 0031029886 scopus 로고    scopus 로고
    • Fluorous synthesis: A fluorous-phase strategy for improving separation efficiency in organic synthesis
    • Studer, A., Hadida, S., Ferritto, R. et al. Fluorous synthesis: A fluorous-phase strategy for improving separation efficiency in organic synthesis. Science 1997, 275: 823-6
    • (1997) Science , vol.275 , pp. 823-826
    • Studer, A.1    Hadida, S.2    Ferritto, R.3
  • 33
    • 0000974143 scopus 로고    scopus 로고
    • Benzotrifluoride: A useful alternative solvent for organic reactions currently conducted in dichloromethane and related solvents
    • Ogawa, A., Curran, D.P. Benzotrifluoride: A useful alternative solvent for organic reactions currently conducted in dichloromethane and related solvents. J Org Chem 1997, 62: 450-1.
    • (1997) J Org Chem , vol.62 , pp. 450-451
    • Ogawa, A.1    Curran, D.P.2
  • 34
    • 0029914650 scopus 로고    scopus 로고
    • Tris(2-(perfluorohexyl)ethyl)tin hydride: A new fluorous reagent for use in traditional organic synthesis and liquid phase combinatorial synthesis
    • Curran, D.P., Hadida, S. Tris(2-(perfluorohexyl)ethyl)tin hydride: A new fluorous reagent for use in traditional organic synthesis and liquid phase combinatorial synthesis. J Am Chem Soc 1996, 118: 2531-2.
    • (1996) J Am Chem Soc , vol.118 , pp. 2531-2532
    • Curran, D.P.1    Hadida, S.2
  • 35
    • 0030830706 scopus 로고    scopus 로고
    • Hydroxymethylation of organic halides. Evaluation of a catalytic system involving a fluorous tin hydride reagent for radical carbonylation
    • Ryu, I., Niguma, T., Minakata, S., Komatsu, M., Hadida, S., Curran, D.P. Hydroxymethylation of organic halides. Evaluation of a catalytic system involving a fluorous tin hydride reagent for radical carbonylation. Tetrahedron Lett 1997, 38: 7883-6.
    • (1997) Tetrahedron Lett , vol.38 , pp. 7883-7886
    • Ryu, I.1    Niguma, T.2    Minakata, S.3    Komatsu, M.4    Hadida, S.5    Curran, D.P.6
  • 36
    • 0030980882 scopus 로고    scopus 로고
    • Rate constants for reaction of a fluorous tin hydride reagent with primary alkyl radicals
    • Horner, J.H., Martinez, F.N., Newcomb, M., Hadida, S., Curran, D.P. Rate constants for reaction of a fluorous tin hydride reagent with primary alkyl radicals. Tetrahedron Lett 1997, 38: 2783-6.
    • (1997) Tetrahedron Lett , vol.38 , pp. 2783-2786
    • Horner, J.H.1    Martinez, F.N.2    Newcomb, M.3    Hadida, S.4    Curran, D.P.5
  • 38
    • 0001591221 scopus 로고    scopus 로고
    • Fluorous synthesis: Fluorous protocols for the Ugi and Biginelli multicomponent condensations
    • Studer, A., Jeger, P., Wipf, P., Curran, D.P. Fluorous synthesis: Fluorous protocols for the Ugi and Biginelli multicomponent condensations. J Org Chem 1997, 62: 2917-24.
    • (1997) J Org Chem , vol.62 , pp. 2917-2924
    • Studer, A.1    Jeger, P.2    Wipf, P.3    Curran, D.P.4
  • 39
    • 0031000561 scopus 로고    scopus 로고
    • A strategic alternative to solid phase synthesis: Preparation of a small isoxazoline library by "fluorous synthesis"
    • Studer, A., Curran, D.P. A strategic alternative to solid phase synthesis: Preparation of a small isoxazoline library by "fluorous synthesis". Tetrahedron 1997, 53: 6681-96.
    • (1997) Tetrahedron , vol.53 , pp. 6681-6696
    • Studer, A.1    Curran, D.P.2
  • 40
    • 0344565329 scopus 로고    scopus 로고
    • Palladium-catalyzed Stille couplings with fluorous tin reactants
    • Hoshino, M., Degenkolb, P., Curran, D.P. Palladium-catalyzed Stille couplings with fluorous tin reactants. J Org Chem 1997, 62: 8341-9.
    • (1997) J Org Chem , vol.62 , pp. 8341-8349
    • Hoshino, M.1    Degenkolb, P.2    Curran, D.P.3
  • 41
    • 0000361705 scopus 로고    scopus 로고
    • Stille couplings with fluorous tin reactants: Attractive features for preparative organic synthesis and liquid-phase combinatorial synthesis
    • Curran, D.P., Hoshino, M. Stille couplings with fluorous tin reactants: Attractive features for preparative organic synthesis and liquid-phase combinatorial synthesis. J Org Chem 1996, 61: 6480-1.
    • (1996) J Org Chem , vol.61 , pp. 6480-6481
    • Curran, D.P.1    Hoshino, M.2
  • 42
    • 0001377704 scopus 로고    scopus 로고
    • Rapid fluorous Stille coupling reactions conducted under microwave irradiation
    • Larhed, M., Hoshino, M., Hadida, S., Curran, D.P., Hallberg, A. Rapid fluorous Stille coupling reactions conducted under microwave irradiation. J Org Chem 1997, 62: 5583-7.
    • (1997) J Org Chem , vol.62 , pp. 5583-5587
    • Larhed, M.1    Hoshino, M.2    Hadida, S.3    Curran, D.P.4    Hallberg, A.5
  • 43
    • 0028945510 scopus 로고
    • A review of solid phase extraction: Basic principles and new developments
    • Berrueta, L.A., Gallo, B., Vicente, F. A review of solid phase extraction: Basic principles and new developments. Chromatographia 1995, 40: 474-83.
    • (1995) Chromatographia , vol.40 , pp. 474-483
    • Berrueta, L.A.1    Gallo, B.2    Vicente, F.3
  • 44
    • 0000035623 scopus 로고    scopus 로고
    • Thermal allylations of aldehydes with a fluorous allylstannane. Separation of organic and fluorous products by solid phase extraction with fluorous reverse phase silica gel
    • Curran, D.P., Hadida, S., He, M. Thermal allylations of aldehydes with a fluorous allylstannane. Separation of organic and fluorous products by solid phase extraction with fluorous reverse phase silica gel. J Org Chem 1997, 62: 6714-5.
    • (1997) J Org Chem , vol.62 , pp. 6714-6715
    • Curran, D.P.1    Hadida, S.2    He, M.3
  • 46
    • 0031021840 scopus 로고    scopus 로고
    • Ion-exchange resins for solution phase parallel synthesis of chemical libraries
    • Gayo, L.M., Suto, M.J. Ion-exchange resins for solution phase parallel synthesis of chemical libraries. Tetrahedron Lett 1997, 38: 513-6.
    • (1997) Tetrahedron Lett , vol.38 , pp. 513-516
    • Gayo, L.M.1    Suto, M.J.2
  • 47
    • 0030973401 scopus 로고    scopus 로고
    • Automated synthesis and purification of amides. Exploitation of automated solid-phase extraction in organic synthesis
    • Lawrence, R.M., Biller, S.A., Fryszman, O.M., Poss, M.A. Automated synthesis and purification of amides. Exploitation of automated solid-phase extraction in organic synthesis. Synthesis 1997, 553-8.
    • (1997) Synthesis , pp. 553-558
    • Lawrence, R.M.1    Biller, S.A.2    Fryszman, O.M.3    Poss, M.A.4
  • 48
    • 0031452355 scopus 로고    scopus 로고
    • Ion-exchange resins for combinatorial synthesis: 2,4-Pyrrolidinediones by Dieckmann condensation
    • Kulkarni, B.A., Ganesan, A. Ion-exchange resins for combinatorial synthesis: 2,4-Pyrrolidinediones by Dieckmann condensation. Angew Chem Int Ed Engl 1997, 36: 2454-5.
    • (1997) Angew Chem Int Ed Engl , vol.36 , pp. 2454-2455
    • Kulkarni, B.A.1    Ganesan, A.2
  • 49
    • 0028783302 scopus 로고
    • Purification of synthetic peptide libraries by affinity chromatography using the avidin-biotin system
    • Quesnel, A., Delmas, A., Trudelle, Y. Purification of synthetic peptide libraries by affinity chromatography using the avidin-biotin system. Anal Biochem 1995, 231: 182-7.
    • (1995) Anal Biochem , vol.231 , pp. 182-187
    • Quesnel, A.1    Delmas, A.2    Trudelle, Y.3
  • 50
    • 0030445494 scopus 로고    scopus 로고
    • Orthogonal glycosylation strategy for rapid assembly of oligosaccharides on a polymer support
    • Ito, Y., Kanie, O., Ogawa, T. Orthogonal glycosylation strategy for rapid assembly of oligosaccharides on a polymer support. Angew Chem Int Ed Engl 1996, 35: 2510-12.
    • (1996) Angew Chem Int Ed Engl , vol.35 , pp. 2510-2512
    • Ito, Y.1    Kanie, O.2    Ogawa, T.3
  • 51
    • 0030607141 scopus 로고    scopus 로고
    • Use of solid supported nucleophiles and electrophiles for the purification of non-peptide small molecule libraries
    • Kaldor, S.W., Siegel, M.G., Fritz, J.E., Dressman, B.A., Hahn, P.J. Use of solid supported nucleophiles and electrophiles for the purification of non-peptide small molecule libraries. Tetrahedron Lett 1996, 37: 7193-6.
    • (1996) Tetrahedron Lett , vol.37 , pp. 7193-7196
    • Kaldor, S.W.1    Siegel, M.G.2    Fritz, J.E.3    Dressman, B.A.4    Hahn, P.J.5
  • 52
    • 0030839735 scopus 로고    scopus 로고
    • The application of high-throughput synthesis and purification to the preparation of ethanolamines
    • Shuker, A.J., Siegel, M.G., Matthews, D.P., Weigel, L.O. The application of high-throughput synthesis and purification to the preparation of ethanolamines. Tetrahedron Lett 1997, 38: 6149-52.
    • (1997) Tetrahedron Lett , vol.38 , pp. 6149-6152
    • Shuker, A.J.1    Siegel, M.G.2    Matthews, D.P.3    Weigel, L.O.4
  • 53
    • 0030591840 scopus 로고    scopus 로고
    • Discovery of antirhinoviral leads by screening a combinatorial library of ureas prepared using covalent scavengers
    • Kaldor, S.W., Fritz, J.E., Tang, J., McKinney, E.R. Discovery of antirhinoviral leads by screening a combinatorial library of ureas prepared using covalent scavengers. Bioorg Med Chem Lett 1996, 6: 3041-4.
    • (1996) Bioorg Med Chem Lett , vol.6 , pp. 3041-3044
    • Kaldor, S.W.1    Fritz, J.E.2    Tang, J.3    McKinney, E.R.4
  • 54
    • 0030987922 scopus 로고    scopus 로고
    • Polymer-supported quenching reagents for parallel purification
    • Booth, R.J., Hodges, J.C. Polymer-supported quenching reagents for parallel purification. J Am Chem Soc 1997, 119: 4882-6.
    • (1997) J Am Chem Soc , vol.119 , pp. 4882-4886
    • Booth, R.J.1    Hodges, J.C.2
  • 55
    • 0030062225 scopus 로고    scopus 로고
    • Synthesis of tetrasubstituted ethylenes on solid support via resin capture
    • Brown, S.D., Armstrong, R.W. Synthesis of tetrasubstituted ethylenes on solid support via resin capture. J Am Chem Soc 1996, 118: 6331-2.
    • (1996) J Am Chem Soc , vol.118 , pp. 6331-6332
    • Brown, S.D.1    Armstrong, R.W.2
  • 56
    • 0029963887 scopus 로고    scopus 로고
    • Postcondensation modifications of Ugi four-component condensation products: 1-Isocyanocyclohexene as a convertible isocyanide. Mechanism of conversion, synthesis of diverse structures, and demonstration of resin capture
    • Keating, T.A., Armstrong, R.W. Postcondensation modifications of Ugi four-component condensation products: 1-Isocyanocyclohexene as a convertible isocyanide. Mechanism of conversion, synthesis of diverse structures, and demonstration of resin capture. J Am Chem Soc 1996, 118: 2574-83.
    • (1996) J Am Chem Soc , vol.118 , pp. 2574-2583
    • Keating, T.A.1    Armstrong, R.W.2
  • 57
    • 0030831922 scopus 로고    scopus 로고
    • Parallel synthesis of tamoxifen and derivatives on solid support via resin capture
    • Brown, S.D., Armstrong, R.W. Parallel synthesis of tamoxifen and derivatives on solid support via resin capture. J Org Chem 1997, 62: 7076-7.
    • (1997) J Org Chem , vol.62 , pp. 7076-7077
    • Brown, S.D.1    Armstrong, R.W.2
  • 58
    • 0018834654 scopus 로고
    • Use of polymeric nucleophiles for the selective binding and removal of alpha-methylene-gamma-butyrolactone allergens from complex mixtures
    • Cheminat, A., Benezra, C., Farral, M.J., Frechet, J. Use of polymeric nucleophiles for the selective binding and removal of alpha-methylene-gamma-butyrolactone allergens from complex mixtures. Tetrahedron Lett 1980, 21: 617-8.
    • (1980) Tetrahedron Lett , vol.21 , pp. 617-618
    • Cheminat, A.1    Benezra, C.2    Farral, M.J.3    Frechet, J.4
  • 59
    • 0001272596 scopus 로고
    • Removal of allergens from natural oils by selective binding to polymer supports. II. Application of aminated resins to isoalantolactone and costus oil
    • Cheminat, A., Benezra, C., Farrall, M.J., Frechet, J.M.J. Removal of allergens from natural oils by selective binding to polymer supports. II. Application of aminated resins to isoalantolactone and costus oil. Can J Chem 1981, 59: 1405-14.
    • (1981) Can J Chem , vol.59 , pp. 1405-1414
    • Cheminat, A.1    Benezra, C.2    Farrall, M.J.3    Frechet, J.M.J.4
  • 61
    • 0030952762 scopus 로고    scopus 로고
    • Chemical library purification strategies based on principles of complementary molecular reactivity and molecular recognition
    • Flynn, D.L., Crich, J.Z., Devraj, R.V. et al. Chemical library purification strategies based on principles of complementary molecular reactivity and molecular recognition. J Am Chem Soc 1997, 119: 4874-81.
    • (1997) J Am Chem Soc , vol.119 , pp. 4874-4881
    • Flynn, D.L.1    Crich, J.Z.2    Devraj, R.V.3
  • 62
    • 0001768317 scopus 로고    scopus 로고
    • Utility of complementary molecular reactivity and molecular recognition (CMR/R) technology and polymer-supported reagents in the solution-phase synthesis of heterocyclic carboxamides
    • Parlow, J.J., Mischke, D.A., Woodard, S.S. Utility of complementary molecular reactivity and molecular recognition (CMR/R) technology and polymer-supported reagents in the solution-phase synthesis of heterocyclic carboxamides. J Org Chem 1997, 62: 5908-19.
    • (1997) J Org Chem , vol.62 , pp. 5908-5919
    • Parlow, J.J.1    Mischke, D.A.2    Woodard, S.S.3
  • 63
    • 0030813190 scopus 로고    scopus 로고
    • In situ chemical tagging: Tetrafluorophthalic anhydride as a "sequestration enabling reagent"
    • Parlow, J.J., Naing, W., South, M.S., Flynn, D.L. In situ chemical tagging: Tetrafluorophthalic anhydride as a "sequestration enabling reagent". Tetrahedron Lett 1997, 38: 7959-62.
    • (1997) Tetrahedron Lett , vol.38 , pp. 7959-7962
    • Parlow, J.J.1    Naing, W.2    South, M.S.3    Flynn, D.L.4
  • 64
    • 0031098534 scopus 로고    scopus 로고
    • Organic synthesis on soluble polymer supports: Liquid-phase methodologies
    • Gravert, D.J., Janda, K.D. Organic synthesis on soluble polymer supports: Liquid-phase methodologies. Chem Rev 1997, 97: 489-509.
    • (1997) Chem Rev , vol.97 , pp. 489-509
    • Gravert, D.J.1    Janda, K.D.2
  • 65
    • 0031436222 scopus 로고    scopus 로고
    • Soluble polyethylene glycol supports for liquid-phase combinatorial synthesis
    • Gravert, D.J., Janda, K.D. Soluble polyethylene glycol supports for liquid-phase combinatorial synthesis. Drugs Fut 1997, 22: 1147-50.
    • (1997) Drugs Fut , vol.22 , pp. 1147-1150
    • Gravert, D.J.1    Janda, K.D.2
  • 66
    • 0029992806 scopus 로고    scopus 로고
    • Combinatorial chemistry: A liquid-phase approach
    • Janda, K.D., Han, H. Combinatorial chemistry: A liquid-phase approach. Methods Enzymol 1996, 267: 234-47.
    • (1996) Methods Enzymol , vol.267 , pp. 234-247
    • Janda, K.D.1    Han, H.2
  • 67
    • 0011529741 scopus 로고
    • Alternating liquid-solid phase peptide synthesis
    • Frank, H., Meyer, H., Hagenmaier, H. Alternating liquid-solid phase peptide synthesis. Chem Ztg 1977, 101: 188-93.
    • (1977) Chem Ztg , vol.101 , pp. 188-193
    • Frank, H.1    Meyer, H.2    Hagenmaier, H.3
  • 68
    • 0016234729 scopus 로고
    • Synthesis of the biologically active undecapeptide substance P with the liquid-phase method
    • Bayer, E., Mutter, M. Synthesis of the biologically active undecapeptide substance P with the liquid-phase method. Chem Ber 1974, 107: 1344-52.
    • (1974) Chem Ber , vol.107 , pp. 1344-1352
    • Bayer, E.1    Mutter, M.2
  • 70
    • 0029810688 scopus 로고    scopus 로고
    • Dendrimer-supported combinatorial chemistry
    • Kim, R.M., Manna, M., Hutchins, S.M. et al. Dendrimer-supported combinatorial chemistry. Proc Natl Acad Sci USA 1996, 93: 10012-7.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 10012-10017
    • Kim, R.M.1    Manna, M.2    Hutchins, S.M.3


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