A convenient method for the preparation of acylsulfonamide libraries

Tetrahedron Letters

Volumn 39, Issue 33, 1998, Pages 5891-5894

  Sturino, Claudio F ^a   Labelle, Marc ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLSULFONAMIDE; SULFONAMIDE; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; CONTAMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATION PROCEDURE; PROTON NUCLEAR MAGNETIC RESONANCE; PURIFICATION; SYNTHESIS;

EID: 0032514499     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)01240-4     Document Type: Article

References (14)

1. [1] For recent review see: Fruchtel, J.S.; Jung, G. Angew. Chem. Int. Ed. Eng. 1996, 35, 17.
2. [2] Hermkens, P.H.H.; Ottenheijm, H.C.J.; Rees, D. Tetrahedron 1996, 52, 4527.
3. [3] Madden, D.; Krchnak, V.; Lebl, M. Perspectives in Drug Discovery and Design 1995, 2, 269.
4. [4] Gordon, E.M; Barrett, R.W.; Dower, W.J.; Fudor, S.P.A.; Gallop, M.A.; J. Med. Chem. 1994, 37, 1385.
5. [5] Thompson, L.A.; Ellman, J.A.; Chem. Rev. 1996, 96, 555.
6. [6] For a recent review on the use of scavengers in purifcation procedures see: Kaldor, S.W.; Siegel, M.G. Current Opinion in Chemical Biology 1997, 1, 101 and references therein.
7. [7] Kaldor, S.W.; Siegel, M.G.; Fritz, J.E.; Dressman, B.A.; Hahn, P.J. Tetrahedron Lett. 1996, 37, 7193.
8. [8] Siegel, M.G.; Hahn, P.J.; Dressman, B.A.; Fritz, J.E.; Grunwell, J.R.; Kaldor, S.W. Tetrahedron Lett. 1997, 37, 3357.
9. [9] For a recent review on the use of functionalized polymers in organic synthesis see: Shuttleworth, S.J.; Allin, S.M.; Sharma, P.K. Synthesis 1997, 1217 and references therein.
10. [10] A traceless linker approach can be used in this situation. This would, however, require additional synthetic efforts. Plunkett, M.J.; Ellman, J.A. J. Org. Chem. 1997, 62, 2885.
11. [11] Desai, M.C.; Stramiello, L.M.S. Tetrahedron Lett. 1993, 37, 7685.
12. [12] The polymer supported carbodiimide N-cyclohexylcarbodiimide N'-methylpolystyrene is now available from Novabiochcm. catalog number 01-64-0211.
13. [13] Amberlyst-15 can be purchased from the Aldrich Chemical Company.
14. 11CN). 0-5 minutes 75%A:25%B, 5-20 minutes linear gradient to 10%A:90%B; retention time of 11.8 minutes.