Combinatorial chemistry using polymer-supported reagents

Current Opinion in Chemical Biology

Volumn 1, Issue 1, 1997, Pages 101-106

  Kaldor, Stephen W ^a   Siegel, Miles G ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; POLYMER;

CHEMISTRY; ORGANIC CHEMISTRY; REVIEW;

CHEMISTRY, ORGANIC; INDICATORS AND REAGENTS; POLYMERS;

EID: 0031152048     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1367-5931(97)80115-9     Document Type: Article

References (20)

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3. Sherrington DC, Hodge P (Eds): Syntheses and Separations Using Functional Polymers. Chichester: Wiley; 1988.
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17. Jang SB: Polymer-bound palladium-catalyzed cross-coupling of organoboron compounds with organic halides and organic triflates. Tetrahedron Lett 1997, 38:1793-1796.
18. Kaldor SW, Fritz JE, Tang J, McKinney ER: Discovery of antirhinoviral leads by screening a combinatorial library of ureas prepared using covalent scavengers. Bioorg Med Chem Lett 1996, 6:3041-3044. Covalent scavenging resins are used to construct ten-compound equimolar urea mixtures. Mixture screening in a whole cell assay and iterative deconvolution provide antiviral leads with low cytotoxicities.
19. Gayo LM, Suto MJ: Ion-exchange resins for solution phase parallel synthesis of chemical libraries. Tetrahedron Lett 1997, 38:513-516. Basic ion-exchange resins are used for synthesis and purification of various amide derivatives in parallel array format.
20. Siegel MG, Hahn PJ, Dressman BA, Fritz JE, Grunwell JR, Kaldor SW: Rapid purification of small molecule libraries by ion exchange chromatography. Tetrahedron Lett 1997, 38:3357-3360. Amines are functionalized in traditional solution-phase reactions, then rapidly purified by ion exchange chromatography to yield pure products. The generic purification sequence is applicable to a variety of reactions, and is amenable to automation with commercially available equipment.