A Novel Cleavage Technique to Generate Small Molecule Compounds and Libraries via a Two-Resin System

Journal of Organic Chemistry

Volumn 63, Issue 4, 1998, Pages 1027-1032

  Ouyang, Xiaohu ^a   Armstrong, Robert W ^a   Murphy, Martin M ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0000140378     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo971347w     Document Type: Article

References (28)

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18. 1H NMR spectra of the compounds were found to contain a large excess of triethylamine. An example in the Supporting Information is provided.
19. The resin with a quaternary ammonium compound in DMF was simply heated at 60-80°C.
20. 1H NMR spectra of the compounds were found to contain a unidentified polymeric contamination.
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27. 3 to effectively deprotonate the diisopropylethylamine salt in situ. See ref 4b.
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