Polymer-supported quenching reagents for parallel purification

Journal of the American Chemical Society

Volumn 119, Issue 21, 1997, Pages 4882-4886

  Booth, R John ^a   Hodges, John C ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHYL ISOCYANATE; POLYMER; POLYSTYRENE DERIVATIVE; POLYVINYLBENZENE; REAGENT; TRIS(2 AMINOETHYL)AMINE; UNCLASSIFIED DRUG;

ARTICLE; AUTOMATION; CHEMICAL REACTION; METHODOLOGY; PURIFICATION; REACTION ANALYSIS; SYNTHESIS;

EID: 0030987922     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9634637     Document Type: Article

References (24)

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13. During the course of review of this manuscript a similar strategy was published: Kaldor, S. W.; Siegel, M. G.; Fritz, J. E.; Dressman, B. A.; Hahn, P. J. Tetrahedron Lett. 1996, 37, 7193. Kaldor, S. W.; Fritz, J. E.; Tang, J.; McKinney, E. R. Bioorg. Med. Chem. Lett. 1996, 6, 3041.
14. During the course of review of this manuscript a similar strategy was published: Kaldor, S. W.; Siegel, M. G.; Fritz, J. E.; Dressman, B. A.; Hahn, P. J. Tetrahedron Lett. 1996, 37, 7193. Kaldor, S. W.; Fritz, J. E.; Tang, J.; McKinney, E. R. Bioorg. Med. Chem. Lett. 1996, 6, 3041.
15. Other polyamine resins have been reported: Yamskov, I. A.; Budanov, M. V.; Davankov, V. A. Bioorg. Khim. 1979, 5, 757.
16. Previously prepared at 110°C. Metelko, M.; Zupan, M. Synth. Commun. 1988, 18, 1821.
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19. Murray, W.; Wachter, M.; Barton, D.; Forero-Kelly, Y. Synthesis 1991, 18.
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21. 2: C, 56.75; H, 5.44; S, 21.6. Found: C, 56.97; H, 5.37; S, 21.52.
22. 3: C, 75.54; H, 6.71. Found: C, 75.76; H, 6.71.
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24. The hydrate of 18 has previously been described, mp 159-160°C (EtOH).