Severe B cell deficiency and disrupted splenic architecture in transgenic mice expressing the E41K mutated form of Bruton's tyrosine kinase

EMBO Journal

Volumn 17, Issue 18, 1998, Pages 5309-5320

  Dingjan, Gemma M ^a   Maas, Alex ^a   Nawijn, Martijn C ^a   Smit, Linda ^b   Voerman, Jane S A ^a   Grosveld, Frank ^a   Hendriks, Rudolf W ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

B cell antigen receptor; B lymphocytes; Btk; xid; XLA

Indexed keywords

B LYMPHOCYTE ANTIGEN; IMMUNOGLOBULIN; IMMUNOGLOBULIN M; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MUTANT PROTEIN; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; BLAST CELL; CONTROLLED STUDY; DISEASE SEVERITY; GENE LOCUS; GENE MAPPING; GENE OVEREXPRESSION; IMMUNE DEFICIENCY; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; IMMUNOSTIMULATION; LYMPH NODE; MOUSE; NONHUMAN; PERITONEAL CAVITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SPLEEN; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS; ANTIGENS, T-INDEPENDENT; B-LYMPHOCYTES; BONE MARROW; GENES, MHC CLASS II; IMMUNOGLOBULIN ISOTYPES; IMMUNOLOGIC DEFICIENCY SYNDROMES; LINKAGE (GENETICS); LOCUS CONTROL REGION; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; PERITONEAL CAVITY; POINT MUTATION; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; SPLEEN; X CHROMOSOME;

ANIMALIA; MUS MUSCULUS;

EID: 0032530937     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.18.5309     Document Type: Article

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