Role of μ heavy chain in B cell development. I. Blocked B cell maturation but complete allelic exclusion in the absence of Igα/β

Journal of Immunology

Volumn 161, Issue 1, 1998, Pages 252-259

  Cronin, Frank E ^a   Jiang, Ming ^b   Abbas, Abul K ^a   Grupp, Stephan A ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; IMMUNOGLOBULIN A; IMMUNOGLOBULIN HEAVY CHAIN;

ALLELE; ANIMAL CELL; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; CALCIUM TRANSPORT; CELL MATURATION; GENE EXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ALLELES; ANIMALS; ANTIGENS, CD; ANTIGENS, CD79; B-LYMPHOCYTES; BREEDING; CELL DIFFERENTIATION; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN MU-CHAINS; MICE; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, B-CELL; SIGNAL TRANSDUCTION; TRANSGENES; TUMOR CELLS, CULTURED;

EID: 0031859294     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Sakaguchi, N., S. I. Kashiwamura, M. Kinoto, P. Thalmann, and F. Melchers. 1988. B lymphocyte lineage restricted expression of mb-1, a gene with CD3-like structural properties. EMBO J. 7:3457.
2. Kashiwamura, S.-I., T. Koyama, T. Matsuo, M. Steinmetz, M. Kimoto, and N. Sakaguchi. 1990. Structure of the murine mb-1 gene encoding a putative sIgM-associated molecule. J. Immunol. 145:337.
3. Hermanson, G. G., D. Eisenberg, P. W. Kincade, and R. Wall. 1988. A member of the immunoglobulin gene super-family exclusively expressed on B-lineage cells. Proc. Natl. Acad. Sci. USA 85:6890.
4. Hombach, J., F. Lottspeich, and M. Reth. 1990. Identification of the genes encoding the Ig-Ma and Ig-b components of the IgM antigen receptor complex by amino-terminal sequencing. Eur. J. Immunol. 20:2795.
5. Van Noesel, C. J. M., J. Borst, E. F. R. DeVries, and R. A. W. Van Lier. 1990. Identification of two distinct phosphoproteins as components of the human B cell antigen receptor complex. Eur. J. Immunol. 20:2789.
6. Reth, M. Antigen receptors on B lymphocytes. 1992. Annu. Rev. Immunol. 10:97.
7. Burkhardt, A. L., T. Costa, Z. Misulovin, B. Stealy, J. B. Bolen, and M. C. Nussenzweig. 1994. Igα and Igβ are functionally homologous to the signaling proteins of the T-cell receptor, Mol. Cell. Biol. 14:1095.
8. Grupp, S. A., K. Campbell R. N. Mitchell, J. C. Cambier, and A. K. Abbas. 1993. Signaling-defective mutants of the B lymphocyte antigen receptor fail to associate with Ig-α and Ig-β/γ. J. Biol. Chem. 268:25776.
9. Grupp, S. A., R. N. Mitchell, K. L. Schreiber, D. J. McKean, and A. K. Abbas. 1995. Molecular mechanisms that control expression of the B lymphocyte antigen receptor complex. J. Exp. Med. 181:161.
10. Hombach, J., F. Sablitzky, K. Rajewsky, and M. Reth. 1988. Transfected plasmacytoma cells do not transport the membrane form of IgM to the cell surface. J. Exp. Med. 167:652.
11. Sanchez, M., Z. Misulovin, A. L. Burkhardt, S. Mahajan, T. Costa, R. Franke, J. B. Bolen, and M. Nussenzweig. 1993. Signal transduction by immunoglobulin is mediated through Iga and Igb. J. Exp. Med. 178:1049.
12. Hartwig, J. H., L. S. Jugloff, N. J. Degroot, S. A. Grupp, and J. Jongstra-Bilen. 1995. The ligand-induced mIgM association with the cytoskeletal matrix of B cells is not mediated through the Igα/β heterodimer. J. Immunol. 155:3769.
13. Mitchell, R. N., A. C. Shaw, Y. K. Weaver, P. Leder, and A. K. Abbas. 1991. Cytoplasmic tail delection converts membrane immunoglobulin to a phosphatidylinositol-linked form lacking signaling and efficient antigen internalization functions. J. Biol. Chem. 266:8856.
14. Shaw, A. C., R. N. Mitchell, Y. K. Weaver, J. Campos-Torres, A. K. Abbas, and P. Leder. 1990. Mutations of immunoglobulin transmembrane and cytoplasmic domains: effects on intracellular signaling and antigen presentation. Cell 63:381.
15. Patel, K. J., and M. S. Neuberger. 1993. Antigen presentation by the B cell antigen receptor is driven by the alpha/beta sheath and occurs independently of its cytoplasmic tyrosines. Cell 74:939.
16. Mitchell, R. N., K. A. Barnes, S. A. Grupp, M. Sanchez, Z. Misulovin, M. C. Nussenzweig, and A. K. Abbas. 1995. Intracellular targeting of antigens internalized by membrane immunoglobulin in B lymphocytes. J. Exp. Med. 181:1705.
17. Hardy, R. R., C. E. Carmack, S. A. Shinton, J. D. Kemp, and K. Hayakawa. 1991. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173:1213.
18. Melchers, F, H. Karasuyama, D. Haasner, S. Bauer, A. Kudo, N. Sakaguchi, B. Jameson, and A. Rolink. 1993. The surrogate light chain in B-cell development. Immunol. Today 14:60.
19. Karasuyama, H., A. Rolink, and F. Melchers. 1993. A complex of glycoproteins is associated with VpreB/lambda 5 surrogate light chain on the surface of mu heavy chain-negative early precursor B cell lines. J. Exp. Med. 178:469.
20. Rolink, A., H. Karasuyama, D. Haasner, U. Grawunder, I. L. Martensson, A. Kudo, and F. Melchers. 1994. Two pathways of B-lymphocyte development in mouse bone marrow and the roles of surrogate L chain in this development. Immunol. Rev. 137:185.
21. Papavasiliou, F., Z. Misulovin, H. Suh, and M. C. Nussenzweig. 1995. The role of Ig beta in precursor B cell transition and allelic exclusion. Science 268:408.
22. Kitamura, D., A. Kudo, S. Schaal, W. Muller, F. Melchers, and K. Rajewsky. 1992. A critical role of lambda 5 protein in B cell development. Cell 69:823.
23. Rolink, A., H. Karasuyama, U. Grawunder, D. Haasner, A. Kudo, and F. Melchers. 1993. B cell development in mice with a defective lambda 5 gene. Eur. J. Immunol. 23:1284.
24. Kitamura, D., J. Roes, R. Kuhn, and K. Rajewsky. 1991. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature 350:423.
25. Chen, J., M. Trounstine F. W. Alt, F. Young, C. Kurahara, J. F. Loring, and D. Huszar. 1993. Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus. Int. Immunol. 5:647.
26. Yel, L., Y. Minegishi, E. Coustan-Smith, R. H. Buckley, H. Trubel, L. M. Pachman, G. R. Kitchingman, D. Campana, J. Rohrer, and M. E. Conley. 1996. Mutations in the mu heavy-chain gene in patients with agammaglobulinemia. N. Engl. J. Med. 335:1486.
27. Tsukada, S., D. C. Saffran, D. J. Rawlings, O. Parolini, R. C. Allen, I. Klisak, R. S. Sparkes, H. Kubagawa, T. Mohandas, S. Quan, and O. N. Witte. 1993. Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. Cell 72:279.
28. Tsukada, S., D. J. Rawlings, and O. N. Witte. 1994. Role of Bruton's tyrosine kinase in immunodeficiency. Curr. Opin. Immunol. 6:623.
29. Khan, W. N., F. W. Alt, R. M. Gerstein, B. A. Malynn, I. Larsson, G. Rathbun, L. Davidson, S. Muller, A. B. Kantor, L. A. Herzenberg, F. S. Rosen, and P. Sideras. 1995. Defective B cell development and function in btk-deficient mice. Immunity 3:283.
30. Papavasiliou F., M. Jankovic, H. Suh, and M. C. Nussenzweig. 1995. The cytoplasmic domains of immunoglobulin (Ig) alpha and Ig beta can independently induce the precursor B cell transition and allelic exclusion. J. Exp. Med. 182:1389.
31. Gong, S., and M. Nussenzweig. 1996. Regulation of an early developmental checkpoint in the B cell pathway by Igβ. Science 272:411.
32. Torres, R. M., H. Flaswinkel, M. Reth, and K. Rajewsky. 1996. Aberrant B cell development and immune response in mice with a compromised BCR complex. Science 272:1804.
33. Danner, D., and P. Leder. 1985. Role of an RNA cleavage/poly(A) addition site in the production of membrane-bound and secreted IgM mRNA. Proc. Natl. Acad. Sci. USA 82:8658.
34. Hogan, B. L. M., F. Constantini, and E. Lacy. 1986. Manipulation of the Mouse Embryo: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
35. Kenny, J. J., D. G. Sieckmann, C. Freter, R. Hodes, K. Hathcock, and D. L. Longo. 1992. Modulation of signal transduction in phosphocholine-specific B cells from mu kappa transgenic mice. Curr. Top. Microbiol. Immunol. 182:95.
36. Sethna, M. P., L. van Parijs, A. H. Sharpe, A. K. Abbas, and G. J. Freeman. 1994. A negative regulatory function of B7 revealed in B7-1 transgenic mice. Immunity 1:415.
37. + modulation in human B cell lines. J. Immunol. 149:4074.
38. Marshall, A. J., G. E. Wu, and C. J. Paige. 1996. Frequency of VH81x usage during B cell development. J. Immunol. 156:2077.
39. Schlissel, M. S., L. M. Corcoran, and D. Baltimore. 1991. Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription. J. Exp. Med. 173:711.
40. Shinkai, Y., S. Koyasu, K. Nakayama, K. M. Murphy, D. Y. Loh, E. Y. Reinherz, and F. W. Alt. 1993. Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes. Science 259:822.
41. Spanopoulou, E., C. A. J. Roman, L. M. Corcoran, M. S. Schlissel, S. P. Silver, D. Nemazee, M. C. Nussenzweig, S. A. Shinton, R. R. Hardy, and D. Baltimore. 1994. Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice. Genes Dev. 8:1030.
42. Kerner, J. D., M. W. Appleby, R. N. Mohr, S. Chien, D. J. Rawlings, C. R. Maliszewski O. N. Witte, and R. M. Perlmutter. 1995. Impaired expansion of mouse B cell progenitors lacking Btk. Immunity 3:301.
43. Bykowsky, M. J., R. N. Haire, Y. Ohta, H. Tang, S.-S. J. Sung, E. S. Veksler, J. M. Greene, S. M. Fu, G. W. Litman, and K. E. Sullivan. 1996. Discordant phenotype in siblings with X-linked agammaglobulinemia. Am. J. Hum. Genet. 58:477.
44. Kornfeld, S. J., R. A. Good, and G. W. Litman. 1994. Atypical X-linked agammaglobulinemia. N. Engl. J. Med. 331:949.
45. Kenya, U., G. B. Beck-Engeser, J. Jongstra, S. E. Applequist, and H. M. Jack. 1995. Surrogate light chain-dependent selection of Ig heavy chain V regions. J. Immunol. 155:5536.
46. Ye, J., S. K. McCray, and S. H. Clarke. 1996. The transition of pre-BI to pre-BII cells is dependent on the VH structure of the mu/surrogate L chain receptor. EMBO J. 15:1524.
47. Papavasiliou, F., M. Jankovic, and M. C., Nussenzweig. 1996. Surrogate or conventional light chains are required for membrane immunoglobulin mu to activate the precursor B cell transition. J. Exp. Med. 184:2025.