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1
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0031892802
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Isoforms and splice variant of transforming growth factor b-binding protein in rat hepatic stellate cells
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Gong WR, Roth S, Michel K, Gressner AM: Isoforms and splice variant of transforming growth factor b-binding protein in rat hepatic stellate cells. Gastroenterology 1998, 114:352-363.
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Gong, W.R.1
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2
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0031972755
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Expression of interleukin-10 by in vitro and in vivo activated hepatic stellate cells
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Wang SC, Ohata M, Schrum L, Rippe RA, Tsukamoto H: Expression of interleukin-10 by in vitro and in vivo activated hepatic stellate cells. J Biol Chem 1998, 273:302-308.
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3
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0031962057
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Interleukin-10 expression is autoregulated at the transcriptional level in human and murine Kupffer cells
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Knolle PA, Uhrig A, Protzer U, Trippler M, Duchmann R, Zum Buschenfelde KHM, Gerken G: Interleukin-10 expression is autoregulated at the transcriptional level in human and murine Kupffer cells. Hepatology 1998, 27:93-99.
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Knolle, P.A.1
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4
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0031957325
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Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis
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Zhu NL, Khoshnan A, Schneider R, Matsumoto M, Dennert G, Ware C, Lai MMC: Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis. J Virol 1998, 72:3691-3697. The HCV core protein binds to the cytoplasmic domain of the lymphotoxin β receptor, a member of the TNFR family. This study now shows that the HCV core protein also binds to the cytoplasmic domain of TNFR1. These results raise the possibility that HCV interaction with TNF-α signaling pathways plays a role in the regulation of cell death.
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Zhu, N.L.1
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Lai, M.M.C.7
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5
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0031892177
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Inhibition of tumor necrosis factor (TNF-α)-mediated apoptosis by hepatitis C virus core protein
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Ray RB, Meyer K, Steele R, Shrivastava A, Aggarwal BB, Ray R: Inhibition of tumor necrosis factor (TNF-α)-mediated apoptosis by hepatitis C virus core protein. J Biol Chem 1998, 273:2256-2259. To explore the effects of the HCV on hepatocyte proliferation, the authors tested the effect of expressing the HCV core protein in a human breast carcinoma cell line on TNF-α-induced apoptosis. The HCV core protein reduced TNF-α-induced apoptotic cell death by apparently inhibiting the TNF-α-mediated cell death signaling pathway. This may provide a selective advantage for HCV replication, allowing evasion of host antiviral defense mechanisms.
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Ray, R.B.1
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6
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0031887203
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Induction of tumour necrosis factor (TNF) receptor type p55 and p75 in patients with chronic hepatitis C virus (HCV) infection
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Kallinowski B, Haseroth K, Marines G, Hanck C, Stremmel W, Theilmann L, Singer MV, Rossol S: Induction of tumour necrosis factor (TNF) receptor type p55 and p75 in patients with chronic hepatitis C virus (HCV) infection. Clin Exp Immunol 1998, 111:269-277.
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7
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0031931006
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Annexin VI defines an apical endocytic compartment in rat liver hepatocytes
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Ortega D, Pol A, Biermer M, Jäckle S, Enrich C: Annexin VI defines an apical endocytic compartment in rat liver hepatocytes. J Cell Sci 1998, 111:261-269. Annexin VI is a marker for hepatic endosomes; this study demonstrates that it is associated predominantly with endocytic structures surrounding the hepatocyte bile canaliculus. This, then, is the first known structural protein at the apical "early" endosomal compartment. This membrane retrieval pathway is important for the regulation of protein content and membrane composition of the canalicular domain.
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Pol, A.2
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Fujita H, Tuma PL, Finnegan CM, Locco L, Hubbard AL: Endogenous syntaxins 2, 3 and 4 exhibit distinct but overlapping patterns of expression at the hepatocyte plasma membrane. Biochem J 1998, 329:527-538.
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9
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Yoon Y, Tǒrǒk N, Krueger E, Oswald B, McNiven MA: Ethanol-induced alterations of the microtubule cytoskeleton in hepatocytes. Am J Physiol Gastrointest Liver Physiol 1998, 274:G757-G766. Ethanol inhibits hepatocellular secretion of serum proteins in part by disrupting intracellular microtubule-dependent trafficking pathways. The authors demonstrate that ethanol does not impair cellular expression of the constituent protein, tubulin. Rather, the tubulin in livers chronically exposed to ethanol is incapable of assembling into tubules. This may help explain the markedly deranged cytoskeletal structure of ethanol-exposed hepatocytes.
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Yoon, Y.1
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0031900354
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Functional involvement of proteins, interacting with sphingolipids, in sphingolipid transport to the canalicular membrane in the human hepatocytic cell line, HepG2
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125I-labeled photoreactive ceramide as a biosynthetic precursor of sphingomyelin, the authors demonstrated in HepG2 cells that a 60 kDa cellular protein appeared to play a specific functional role in the transportation of sphingolipids to the bile canalicular membrane. The exact nature of the putative proteins involved remains to be elucidated, but may be important for studies of hepatocyte polarity and bile secretion.
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Hepatology
, vol.27
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Zegers, M.M.P.1
Zaal, K.J.M.2
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11
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0031954420
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Anatomy of the human biliary system studied by quantitative computer-aided three-dimensional imaging techniques
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Ludwig J, Ritman EL, LaRusso NF, Sheedy PF, Zumpe G: Anatomy of the human biliary system studied by quantitative computer-aided three-dimensional imaging techniques. Hepatology 1998, 27:893-899. Three-dimensional reconstruction of normal adult human livers was performed to define the branching anatomy of the biliary system. On the basis of branching, approximately seven orders of intrahepatic ducts were observed, with the terminal ramifications extending beyond the portal tracts into the hepatic parenchyma. The detailed measurements obtained in this study will be extremely useful for the future investigation of site-restricted function of epithelial cells lining the biliary tree.
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Hepatology
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Ludwig, J.1
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12
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0031903289
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The adult human liver biopsy: A quantitative reference standard
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Crawford AR, Lin X-Z, Crawford JM: The adult human liver biopsy: A quantitative reference standard. Hepatology 1998, 28:323-331.
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Hepatology
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Crawford, A.R.1
Lin, X.-Z.2
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in press
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Ekataksin W, Wake K: New concepts in biliary and vascular anatomy of the liver. Prog Liver Dis 1997, in press.
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Prog Liver Dis
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Ekataksin, W.1
Wake, K.2
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0031889039
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The portal lobule in rat liver fibrosis: A re-evaluation of the liver unit
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Bhunchet E, Wake K: The portal lobule in rat liver fibrosis: A re-evaluation of the liver unit. Hepatology 1998, 27;481-487.
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Hepatology
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Bhunchet, E.1
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15
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0032192341
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Expression of cytokeratin 20 in developing rat liver and in experimental models of ductular and oval cell proliferation
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Faa G, Van Eyken P, Roskams T, Miyazaki H, Serreli S, Ambu R, Desmet VJ: Expression of cytokeratin 20 in developing rat liver and in experimental models of ductular and oval cell proliferation. J Hepatol 1998, 29:628-833.
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Faa, G.1
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Miyazaki, H.4
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Ambu, R.6
Desmet, V.J.7
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16
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0031958588
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Heterogeneity of the proliferative capacity of rat cholangiocytes after bite duct ligation
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Alpini G, Glaser SS, Ueno Y, Pham L, Podila PV, Caligiuri A, LeSage G, LaRusso NF: Heterogeneity of the proliferative capacity of rat cholangiocytes after bite duct ligation. Am J Physiol 1998, 274:G767-G775.
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Alpini, G.1
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LaRusso, N.F.8
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17
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0031939313
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Rearrangement of hepatocellular F-actin precedes the formation of rosette-like structures in parenchyma of cholestatic rat liver
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Song JY, Van Noorden CJF, Frederiks WM: Rearrangement of hepatocellular F-actin precedes the formation of rosette-like structures in parenchyma of cholestatic rat liver. Hepatology 1998, 27:765-771.
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Hepatology
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Song, J.Y.1
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18
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Synergy between transforming growth factor α and hepatitis B virus surface antigen in hepatocellular proliferation and carcinogenesis
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Jakubczak JL, Chisari FV, Merino G: Synergy between transforming growth factor α and hepatitis B virus surface antigen in hepatocellular proliferation and carcinogenesis. Cancer Res 1997, 57:3606-3611.
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Jakubczak, J.L.1
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0031888109
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Immunolocalization of putative human liver progenitor cells in livers from patients with end-stage primary biliary cirrhosis and sclerosing cholangitis using the monoclonal antibody OV-6
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Crosby HA, Hubscher S, Fabris L, Joplin R, Sell S, Kelly D, Strain AJ: Immunolocalization of putative human liver progenitor cells in livers from patients with end-stage primary biliary cirrhosis and sclerosing cholangitis using the monoclonal antibody OV-6. Am J Pathol 1998, 152:771-779. The putative hepatic cells responsible for repopulating the liver after severe injury, so-called stem cells or progenitor cells, have been difficult to identify in the human liver. Using livers from patients with end-stage biliary tract disease, the authors demonstrated the presence of cells immunoreactive for hepatocyte and/or bile duct markers. Such cells were essentially absent in normal livers. This study indicates that bipotential progenitor cells are indeed present in the human liver and that the antibody OV-6 is useful for their identification.
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Am J Pathol
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Crosby, H.A.1
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Kelly, D.6
Strain, A.J.7
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20
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0031891207
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Comparison of liver progenitor cells in human atypical ductular reactions with those seen in experimental models of liver injury
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Sell S: Comparison of liver progenitor cells in human atypical ductular reactions with those seen in experimental models of liver injury. Hepatology 1998, 27:317-331. In examining human livers exhibiting the ductular proliferative response characteristic of severe parenchymal injury, Sell finds that white primitive progenitor cells may exist, there are a variety of different proliferating cells on the basis of morphology. These morphologic findings leave open the possibility that proliferating populations of stem cells within the liver may be very different from one another under various disease conditions.
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Hepatology
, vol.27
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Sell, S.1
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21
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0031898873
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Hepatic oval cell activation in response to injury following chemically induced periportal or pericentral damage in rats
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Petersen BE, Zajac VF, Michalopoulos GK: Hepatic oval cell activation in response to injury following chemically induced periportal or pericentral damage in rats. Hepatology 1998, 27:1030-1038.
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Hepatology
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Petersen, B.E.1
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Michalopoulos, G.K.3
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22
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Gadolinium chloride suppresses hepatic oval cell proliferation in rats with biliary obstruction
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Olynyk JK, Yeoh GC, Ramm GA, Clarke SL, Hall PDLM, Britton RS, Bacon BR, Tracy TF: Gadolinium chloride suppresses hepatic oval cell proliferation in rats with biliary obstruction. Am J Pathol 1998, 152:347-352.
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Am J Pathol
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Olynyk, J.K.1
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Hall, P.D.L.M.5
Britton, R.S.6
Bacon, B.R.7
Tracy, T.F.8
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23
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0031938718
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Hepatic oval cells express the hematopoietic stem cell marker Thy-1 in the rat
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Petersen BE, Goff JP, Greenberger JS, Michalopoulos GK: Hepatic oval cells express the hematopoietic stem cell marker Thy-1 in the rat. Hepatology 1998, 27:433-445.
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Hepatology
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Petersen, B.E.1
Goff, J.P.2
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24
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0030914459
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Mutations in the human Jagged1 gene are responsible for Alagille syndrome
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Oda T, Elkahloun AG, Pike BL, Okajima K, Krantz ID, Genin A, Piccoli DA, et al.: Mutations in the human Jagged1 gene are responsible for Alagille syndrome. Nat Genet 1997, 16:235-242. Alagille syndrome is an autosomal dominant disorder characterized by intrahepatic cholestasis and abnormalities of the heart, eye, vertebrae, and facial features. This report maps the gene locus for Alagille syndrome to a 250 kb region of chromosome 20p. Within this region a candidate gene, JAG1, was identified. JAG1 is the human homologue of rat Jagged1, which encodes a ligand for the Notch receptor. As cell-cell Jagged1:Notch interactions appear to be critical determinants of cell fate in developing embryos, this discovery indicates that haploinsufficiency of JAG1 can have wide-ranging effects on tissue formation and function.
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Nat Genet
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Oda, T.1
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Genin, A.6
Piccoli, D.A.7
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25
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Gap junctional communication coordinates vasopressin-induced glycogenolysis in rat hepatocytes
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Eugenin EA, Gonzalez H, Saez CG, Saez CS: Gap junctional communication coordinates vasopressin-induced glycogenolysis in rat hepatocytes. Am J Physiol 1998, 274:G1109-G1116.
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Eugenin, E.A.1
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26
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0031790424
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Downregulation of connexin32 protein and gap-junctional intercellular communication by cytokine-mediated acute-phase response in immodalized mouse hepatocytes
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Temme A, Traub O, Willecke K: Downregulation of connexin32 protein and gap-junctional intercellular communication by cytokine-mediated acute-phase response in immodalized mouse hepatocytes. Cell Tissue Res 1998, 294:345-350.
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Rapid disruption of gap junctional communication and phosphorylation of connexin43 by platelet-derived growth factor in T51B rat liver epithelial cells expressing platelet-derived growth factor receptor
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Hossain MZ, Ao P, Boynton AL: Rapid disruption of gap junctional communication and phosphorylation of connexin43 by platelet-derived growth factor in T51B rat liver epithelial cells expressing platelet-derived growth factor receptor. J Cell Physiol 1998, 174:66-77.
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Hepatocellular ATP-binding cassette protein expression enhances ATP release and autocrine regulation of cell volume
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Roman RM, Wang Y, Lidofsky SD, Feranchak AP, Lomri N, Scharschmidt BF, Fitz JG: Hepatocellular ATP-binding cassette protein expression enhances ATP release and autocrine regulation of cell volume. J Biol Chem 1997, 272:21970-21976.
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Roman, R.M.1
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Fitz, J.G.7
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30
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Regulation of biliary secretion through apical purinergic receptors in cultured rat cholangiocytes
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Schlenker T, Romac JMJ, Sharara AI, Roman RM, Kim SJ, LaRusso N, Liddle RA, Fitz JG: Regulation of biliary secretion through apical purinergic receptors in cultured rat cholangiocytes. Am J Physiol Gastrointest Liver Physiol 1997, 273:G1108-G1117.
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Fitz, J.G.8
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31
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Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter
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Craddock AL, Love MW, Daniel RW, Kirby LC, Walters HC, Wang MH, Dawson PA: Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. Am J Physiol 1998, 274:G157-G169.
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Am J Physiol
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Craddock, A.L.1
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32
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Increased expression of interleukin-6 and tumor necrosis factor-α in pathologic biliary epithelial cells: In situ and culture study
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Yasoshima M, Kono N, Sugawara H, Katayanagi K, Harada K, Nakanuma Y: Increased expression of interleukin-6 and tumor necrosis factor-α in pathologic biliary epithelial cells: In situ and culture study. Lab Invest 1998, 78:89-100.
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33
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0031788501
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Interleukin-6, hepatocyte growth factor, and their receptors in biliary epithelial cells during a Type I ductular reaction in mice: Interactions between the periductal inflammatory and stromal cells and the biliary epithelium
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Liu Z, Sakamoto T, Ezure T, Yokomuro S, Murase N, Michalopoulos G, Demetris AJ: Interleukin-6, hepatocyte growth factor, and their receptors in biliary epithelial cells during a Type I ductular reaction in mice: Interactions between the periductal inflammatory and stromal cells and the biliary epithelium. Hepatology 1998, 28:1260-1268. Biliary epithelial cell proliferation is stimulated by the IL-6:GP-80 and hepatocyte growth factor:met ligand:receptor systems. Using bile duct ligation to stimulate bile ductular proliferation, the authors demonstrate that periductal lymphoid and stromal cells are the source of biliary epithelial cell growth factors, with concomitant upregulation of biliary epithelial cell receptors. Such interactions among inflammatory, stromal, and biliary epithelial cells result in dysmorphic repair responses, which may play a role in the development of cirrhosis.
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Hepatology
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Liu, Z.1
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Crawford JM: Cellular and molecular biology of the inflamed liver. Curr Opin Gastroenterol 1997, 13:175-185.
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Primary role of Kupffer cell-hepatocyte communication in the expression of oxidative stress in the post-ischaemic liver
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Cutrin JC, Llesuy S, Boveris A: Primary role of Kupffer cell-hepatocyte communication in the expression of oxidative stress in the post-ischaemic liver. Cell Biochem Funct 1998, 16:65-72.
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Cell Biochem Funct
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Cellular localization of endothelin-1 and increased production in liver injury in the rat: Potential for autocrine and paracrine effects on stellate cells
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Rockey DC, Fouassier L, Chung JJ, Carayon A, Valise P, Rey C, Housset C: Cellular localization of endothelin-1 and increased production in liver injury in the rat: Potential for autocrine and paracrine effects on stellate cells. Hepatology 1998, 27:472-480.
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Hepatology
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37
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0031948431
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(Latent) transforming growth factor β in liver parenchymal cells, its injury-dependent release, and paracrine effects on rat hepatic stellate cells
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Roth S, Michel K, Gressner AM: (Latent) transforming growth factor β in liver parenchymal cells, its injury-dependent release, and paracrine effects on rat hepatic stellate cells. Hepatology 1998, 27:1003-1012.
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Hepatology
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Am J Pathol
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Increased P-selectin gene expression in the liver vasculature and its role in the pathophysiology of neutrophil-induced liver injury in murine endotoxin shock
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Essani NA, Fisher MA, Simmons CA, Hoover JL, Farhood A, Jaeschke H: Increased P-selectin gene expression in the liver vasculature and its role in the pathophysiology of neutrophil-induced liver injury in murine endotoxin shock. J Leukocyte Biol 1998, 63:288-296.
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J Leukocyte Biol
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41
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Role of PECAM-1 (CD31) in neutrophil transmigration in murine models of liver and peritoneal inflammation
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Chosay JG, Fisher MA, Farhood A, Ready KA, Dunn CJ, Jaeschke H: Role of PECAM-1 (CD31) in neutrophil transmigration in murine models of liver and peritoneal inflammation. Am J Physiol 1998, 274:G776-G782.
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Am J Physiol
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42
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